scholarly journals Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2091
Author(s):  
Yasuhisa Tamura ◽  
Kumi Takata ◽  
Kiminori Matsubara ◽  
Yosky Kataoka
Keyword(s):  
Healthy Volunteers ◽  
Human Study ◽  
Reward Processing ◽  
Anxiety And Depression ◽  
Emotional States ◽  
Before And After ◽  
Scale Test ◽  
Acetylcholine Concentration ◽  
The Brain ◽  
Single Blind

Alpha-glycerylphosphorylcholine (αGPC) is a precursor of acetylcholine and can increase acetylcholine concentration in the brain. In addition, αGPC has a role in cholinergic function as well as monoaminergic transmission, including dopaminergic and serotonergic systems. These monoaminergic systems are related to feelings and emotions, including motivation, reward processing, anxiety, and depression. However, the precise effects of αGPC on human feelings and emotions remain to be elucidated. In this study, we investigated changes in the subjective feelings of healthy volunteers using the KOKORO scale before and after administering αGPC. Thirty-nine volunteers participated in a single-blind, placebo-controlled design. Participants completed a KOKORO scale test to quantify self-reported emotional states, three times each day for two weeks preceding treatment and then for a further two weeks while self-administering treatment. αGPC treatment show a tendency to increase motivation during the intervention period. Furthermore, motivation at night was significantly higher in the αGPC group than in the placebo group (p < 0.05). However, αGPC did not show any effects on anxiety. These data suggest that αGPC can be used to increase motivation in healthy individuals.

scholarly journals Effect of Wrist Tapping on Interhemispheric Coherence in Patients with Juvenile Myoclonic Epilepsy

2021 ◽  
Vol 11 (1) ◽  
pp. 73-77
Author(s):  
Ekaterina Narodova ◽  
Natalia Shnayder ◽  
Vladislav Karnaukhov ◽  
Olesya Bogomolova ◽  
Kirill Petrov ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Epileptic Seizures ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Control Group ◽  
Alpha Band ◽  
Epileptiform Discharges ◽  
Interhemispheric Coherence ◽  
Before And After ◽  
The Brain

The aim of this study was to assess the dynamics of interhemispheric coherence (IC) as an indicator of integration of different areas of the brain and their participation in the performance of certain functions before and after wrist tapping (WT), using the author's method in juvenile myoclonic epilepsy (JME). Methods and Results: The study included 81 subjects of working age, including 51 clinically healthy volunteers (median age of 39[21;56] years) and 30 patients (median age of 27[23;38] years) with JME. Analysis of IC in the electrode pairs Fp1-Fp2, F3-F4, C3-C4, T3-T4 was performed using a computer encephalographic complex. A coherent EEG analysis was used to identify and evaluate the relationships between different areas of the brain. Based on the change in the coherence coefficients (CCs), the level of integrative activity of brain structures was quantified. In healthy volunteers, before and after WT, we observed a statistically significant decrease in CCs for the beta-1 band in the pairs Fp1-Fp2, F3-F4, and C3-C4 (P<0.05), while in the pair T3-T4, changes in CCs were not statistically significant (P>0.05). At the same time, a statistically significant decrease in CCs in the alpha band was found only in the frontal regions in the pairs Fp1-Fp2 and F3-F4 (P<0.05). No statistically significant changes were found in all the studied pairs in the theta band. When comparing CCs in JME patients in beta–1 and theta bands, before and after WT, we did not find statistically significant changes in CCs in all the studied electrode pairs. However, in the alpha band, we found a statistically significant decrease in CCs in the frontal region in the F3-F4 (P=0.0038) and C3-C4 electrode pairs (P=0.034). The results of the study of interhemispheric integration showed statistically significant differences between patients with JME and the control group. Conclusion: WT according to the author's method does not provoke the occurrence of interictal epileptiform discharges on the EEG and epileptic seizures in patients with JME. Coherent analysis showed positive changes in interhemispheric integrations of neurons in the beta–1 and alpha frequency ranges, mainly in the anterior hemispheres.

Elevation of serum globulin levels in Chelidonium majus 6c provers

1989 ◽  
Vol 78 (02) ◽  
pp. 97-99 ◽  
Author(s):  
A.E. Vakil ◽  
Y.e. Vakil ◽  
A.S. Nanabhai
Keyword(s):  
Healthy Volunteers ◽  
Total Cholesterol ◽  
Prothrombin Time ◽  
Total Bilirubin ◽  
The Other ◽  
Chelidonium Majus ◽  
Serum Samples ◽  
Serum Globulin ◽  
Before And After ◽  
Single Blind

AbstractTen healthy volunteers were administered orally 0.04 ml. of Chelidonium majus 6c t.d.s. for 21 days. Seven healthy volunteers were kept as controls and administered orally 0.04 ml. of 90% ethanol t.d.s. The trial was single blind. Fasting venous samples were collected before and after the trial. Serum samples were analysed for total bilirubin, albumin, globulin, total cholesterol, prothrombin time and GPT. Serum globulins registered an increase of 58%, while the other parameters showed no changes.

Effect of Emotions in a Lexical Decision Task

2017 ◽  
Vol 76 (2) ◽  
pp. 71-79 ◽  
Author(s):  
Hélène Maire ◽  
Renaud Brochard ◽  
Jean-Luc Kop ◽  
Vivien Dioux ◽  
Daniel Zagar
Keyword(s):  
Lexical Decision ◽  
Lexical Decision Task ◽  
Emotional State ◽  
Control Group ◽  
Decision Task ◽  
Attentional Orienting ◽  
Emotional States ◽  
Sequence Effect ◽  
Emotion Induction ◽  
Before And After

Abstract. This study measured the effect of emotional states on lexical decision task performance and investigated which underlying components (physiological, attentional orienting, executive, lexical, and/or strategic) are affected. We did this by assessing participants’ performance on a lexical decision task, which they completed before and after an emotional state induction task. The sequence effect, usually produced when participants repeat a task, was significantly smaller in participants who had received one of the three emotion inductions (happiness, sadness, embarrassment) than in control group participants (neutral induction). Using the diffusion model ( Ratcliff, 1978 ) to resolve the data into meaningful parameters that correspond to specific psychological components, we found that emotion induction only modulated the parameter reflecting the physiological and/or attentional orienting components, whereas the executive, lexical, and strategic components were not altered. These results suggest that emotional states have an impact on the low-level mechanisms underlying mental chronometric tasks.

PENGARUH PIJAT BAYI TERHADAP KUALITAS TIDUR BAYI UMUR 0 – 3 BULAN DI WILAYAH KERJA PUSKESMAS SOSIAL PALEMBANG TAHUN 2016

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Juliana Widyastuti Wahyuningsih Juliana Widyastuti Wahyuningsih
Keyword(s):  
Experimental Design ◽  
Growth And Development ◽  
Sampling Technique ◽  
P Value ◽  
Development Phase ◽  
Quality Of Sleep ◽  
Infant Massage ◽  
Before And After ◽  
The Brain

ABSTRAK Tidur merupakan kebutuhan yang harus terpenuhi terutama pada fase perkembangan karena selama tidur akan terjadi perkembangan otak maupun tubuh, sehingga gangguan tidur merupakan masalah yang akan menimbulkan dampak buruk terhadap pertumbuhan dan perkembangan bayi. Kualitas tidur bayi yang baik dapat diciptakan dengan memberikan pemijatan bayi secara rutin. Penelitian ini bertujuan untuk membuktikan bahwa pemijatan dapat mempengaruhi kualitas tidur bayi umur 0-3 bulan. Penelitian ini menggunakan desain penelitian Quasy Eksperimental dengan metode One Group Pretest-Postest. Sampel 22 bayi yang dipilih dengan tehnik Total Sampling yang di observasi sebelum dan sesudah diberikan pemijatan. Variabel yang diukur dalam penelitian ini adalah kualitas tidur bayi 0-3 bulan. Hasil penelitian menunjukkan bahwa ada pengaruh pijat bayi terhadap kualitas tidur bayi umur 0-3 bulan (p value  0,008 < α = 0,05).Berdasarkan hasil penelitian ini disarankan agar keluarga dan masyarakat memberikan pemijatan secara rutin dan mandiri untuk meningkatkan kebutuhan tidur bayi yang berkualitas.   ABSTRACT Sleep is a human necessity that must be met, especially in the development phase because during sleep will occur the brain and body developments, so that sleep disturbance is a problem that would cause adverse effects on infants’ growth and development. The good quality of sleep can be created by providing the infants massage routinely. This study aimed to prove that the massage could affect the quality of sleep on the 0-3 months old baby. This study used Quasy-experimental design with One Group Pretest-Posttest. The sample 22 infants selected by total sampling technique observed on before and after the massage. The variables measured in this study are the quality of sleep. The results of study indicate that there is an effect of infant massage to the sleep quality on 0-3 months old babies (p value 0,008 < α = 0,05).Based on the results of this study it recommended for the families and communities to provide infant massage regularly and independently to increase the quality of sleep on the baby.  

Sources of the Scalp-Recorded Amplitude-Modulation Following Response

2002 ◽  
Vol 13 (04) ◽  
pp. 188-204 ◽  
Author(s):  
Shigeyuki Kuwada ◽  
Julia S. Anderson ◽  
Ranjan Batra ◽  
Douglas C. Fitzpatrick ◽  
Natacha Teissier ◽  
...  
Keyword(s):  
Animal Model ◽  
Amplitude Modulation ◽  
Single Unit ◽  
Modulation Frequency ◽  
Multiple Sources ◽  
High Modulation ◽  
Before And After ◽  
Single Unit Recordings ◽  
Composite Response ◽  
The Brain

The scalp-recorded amplitude-modulation following response (AMFR)” is gaining recognition as an objective audiometric tool, but little is known about the neural sources that underlie this potential. We hypothesized, based on our human studies and single-unit recordings in animals, that the scalp-recorded AMFR reflects the interaction of multiple sources. We tested this hypothesis using an animal model, the unanesthetized rabbit. We compared AMFRs recorded from the surface of the brain at different locations and before and after the administration of agents likely to enhance or suppress neural generators. We also recorded AMFRs locally at several stations along the auditory neuraxis. We conclude that the surface-recorded AMFR is indeed a composite response from multiple brain generators. Although the response at any modulation frequency can reflect the activity of more than one generator, the AMFRs to low and high modulation frequencies appear to reflect a strong contribution from cortical and subcortical sources, respectively.

scholarly journals Vision-Based Structural FE Model Updating Using Genetic Algorithm

2021 ◽  
Vol 11 (4) ◽  
pp. 1622
Author(s):  
Gun Park ◽  
Ki-Nam Hong ◽  
Hyungchul Yoon
Keyword(s):  
Genetic Algorithm ◽  
Model Updating ◽  
Structural Parameters ◽  
Fe Model ◽  
Structural Members ◽  
Stiffness Reduction ◽  
Before And After ◽  
Scale Test ◽  
Fe Model Updating ◽  
Story Building

Structural members can be damaged from earthquakes or deterioration. The finite element (FE) model of a structure should be updated to reflect the damage conditions. If the stiffness reduction is ignored, the analysis results will be unreliable. Conventional FE model updating techniques measure the structure response with accelerometers to update the FE model. However, accelerometers can measure the response only where the sensor is installed. This paper introduces a new computer-vision based method for structural FE model updating using genetic algorithm. The system measures the displacement of the structure using seven different object tracking algorithms, and optimizes the structural parameters using genetic algorithm. To validate the performance, a lab-scale test with a three-story building was conducted. The displacement of each story of the building was measured before and after reducing the stiffness of one column. Genetic algorithm automatically optimized the non-damaged state of the FE model to the damaged state. The proposed method successfully updated the FE model to the damaged state. The proposed method is expected to reduce the time and cost of FE model updating.

scholarly journals Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takehiro Matsumura ◽  
Kentaro Iwasaki ◽  
Shogo Arimura ◽  
Ryuji Takeda ◽  
Yoshihiro Takamura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Inflammatory Cytokines ◽  
Aqueous Humour ◽  
Ophthalmic Solution ◽  
Vascular Endothelial ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Before And After ◽  
Endothelial Growth Factor ◽  
Single Blind

AbstractIntraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0.1% bromfenac sodium ophthalmic solution and 0.02% fluorometholone ophthalmic suspension in the inhibition of multiple inflammatory cytokines in the aqueous humour of 26 patients with pseudophakic eyes who had undergone phacoemulsification and intraocular lens implantation. The patients were randomly assigned to one of the trial drugs, and aqueous humour samples were collected before and after drug administration. Platelet-derived growth factor-AA levels significantly decreased in both drug groups, but they were significantly higher in the fluorometholone group than in the bromfenac group (P = 0.034). Bromfenac also significantly decreased vascular endothelial growth factor level (P = 0.0077), as well as monocyte chemoattractant protein-1 level (P = 0.013), which was elevated for a prolonged period after phacoemulsification. These data suggest that bromfenac is useful to alleviate prolonged microenvironmental alterations in the aqueous humour of pseudophakic eyes.

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