scholarly journals Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2034
Author(s):  
Zaida Agüera ◽  
Cristina Vintró-Alcaraz ◽  
Isabel Baenas ◽  
Roser Granero ◽  
Isabel Sánchez ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Potential Role ◽  
Normal Weight ◽  
Weight Changes ◽  
Phenotypic Marker ◽  
General Psychopathology ◽  
High Reward ◽  
Bmi Trajectories ◽  
Bmi Trajectory

The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED.

The potential role of stimulants in treating eating disorders

2021 ◽  
Author(s):  
Aaron Keshen ◽  
Sara Bartel ◽  
Guido K.W. Frank ◽  
Nils Erik Svedlund ◽  
Abraham Nunes ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Potential Role

Weight Gain Trajectory and Pain Interference in Young Adulthood: Evidence from a Longitudinal Birth Cohort Study

Pain Medicine ◽  
2019 ◽  
Vol 21 (3) ◽  
pp. 439-447 ◽  
Author(s):  
Dmitry Tumin ◽  
Adrianne Frech ◽  
Jamie L Lynch ◽  
Vidya T Raman ◽  
Tarun Bhalla ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Birth Cohort ◽  
Transition To Adulthood ◽  
Multivariable Analysis ◽  
Normal Weight ◽  
Pain Interference ◽  
Birth Cohort Study ◽  
Bmi Trajectories ◽  
Bmi Trajectory

AbstractObjectiveObesity is associated with chronic pain, but the contribution of body mass index (BMI) trajectories over the life course to the onset of pain problems remains unclear. We retrospectively analyzed how BMI trajectories during the transition to adulthood were associated with a measure of pain interference obtained at age 29 in a longitudinal birth cohort study.MethodsData from the National Longitudinal Survey of Youth, 1997 Cohort (follow-up from 1997 to 2015), were used to determine BMI trajectories from age 14 to 29 via group trajectory modeling. At age 29, respondents described whether pain interfered with their work inside and outside the home over the past four weeks (not at all, a little, or a lot). Multivariable ordinal logistic regression was used to evaluate pain interference according to BMI trajectory and study covariates.ResultsAmong 7,875 respondents, 11% reported “a little” and 4% reported “a lot” of pain interference at age 29. Four BMI trajectory groups were identified, varying in starting BMI and rate of weight gain. The “obese” group (8% of respondents) had a starting BMI of 30 kg/m2 and gained an average of 0.7 kg/m2/y. On multivariable analysis, this group was the most likely to have greater pain interference, compared with “high normal weight” (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.14–1.88), “low normal weight” (OR = 1.45, 95% CI = 1.13–1.87), and “overweight” trajectories (OR = 1.33, 95% CI = 1.02–1.73).ConclusionsObesity and rapid weight gain during the transition to adulthood were associated with higher risk of pain interference among young adults.

scholarly journals Trajectories of Body Mass Index from Young Adulthood to Middle Age among Canadian Men and Women

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Meng Wang ◽  
Yanqing Yi ◽  
Barbara Roebothan ◽  
Jennifer Colbourne ◽  
Victor Maddalena ◽  
...  
Keyword(s):  
Young Adulthood ◽  
Low Income ◽  
Latent Class ◽  
Middle Age ◽  
Normal Weight ◽  
Physically Active ◽  
Aboriginal Women ◽  
Bmi Trajectories ◽  
Bmi Trajectory

Knowledge regarding the heterogeneity of BMI trajectories is limited for the Canadian population. Using latent class growth modelling, four distinct BMI trajectories of individuals from young adulthood to middle age were identified for both women and men from the longitudinal data of the National Population Health Survey. The associations between BMI trajectories and the individuals’ sociodemographic characteristics and behavioural factors were also examined. Aboriginal women were found more likely to be in the long-term overweight or obese groups. It reveals that increased years of smoking, drinking, and being physically active were associated with lowering the BMI trajectory in all groups for both women and men, with some exceptions in the long-term normal weight group for men. Increased years of rural living, being employed, and living with low income were associated with raising the BMI trajectory in all groups for women and in some groups for men. Food insecurity was associated with raising the BMI trajectory in each group for both women and men.

The Role of Coping and General Psychopathology in the Prediction of Treatment Outcome in Eating Disorders

2011 ◽  
Vol 19 (3) ◽  
pp. 246-258 ◽  
Author(s):  
Michelle M. Davies ◽  
Marrie H. J. Bekker ◽  
Maries A. Roosen
Keyword(s):  
Eating Disorders ◽  
Treatment Outcome ◽  
General Psychopathology

scholarly journals The potential role of appetite in predicting weight changes during treatment with olanzapine

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael Case ◽  
Tamas Treuer ◽  
Jamie Karagianis ◽  
Vicki Poole Hoffmann
Keyword(s):  
Potential Role ◽  
Weight Changes

scholarly journals Maternal obesity and stillbirth at term; placental pathology—A case control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250983
Author(s):  
Hanna Åmark ◽  
Magnus Westgren ◽  
Meeli Sirotkina ◽  
Ingela Hulthén Varli ◽  
Martina Persson ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Potential Role ◽  
Maternal Obesity ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Obese Women ◽  
Control Study ◽  
Velamentous Cord Insertion

Objective The aim was to explore the potential role of the placenta for the risk of stillbirth at term in pregnancies of obese women. Methods This was a case-control study comparing placental findings from term stillbirths with placental findings from live born infants. Cases were singleton term stillbirths to normal weight or obese women, identified in the Stockholm stillbirth database, n = 264 and n = 87, respectively. Controls were term singletons born alive to normal weight or obese women, delivered between 2002–2005 and between 2018–2019. Placentas were compared between women with stillborn and live-born infants, using logistic regression analyses. Results A long and hyper coiled cord, cord thrombosis and velamentous cord insertion were stronger risk factors for stillbirth in obese women compared to normal weight women. When these variables were adjusted for in the logistic regression analysis, also adjusted for potential confounders, the odds ratio for stillbirth in obese women decreased from 1.89 (CI 1.24–2.89) to 1.63 (CI 1.04–2.56). Conclusion Approximately one fourth of the effect of obesity on the risk of stillbirth in term pregnancies is explained by umbilical cord associated pathology.

Neuropeptides in Eating Disorders

CNS Spectrums ◽  
2004 ◽  
Vol 9 (7) ◽  
pp. 516-522 ◽  
Author(s):  
David C. Jimerson ◽  
Barbara E. Wolfe
Keyword(s):  
Eating Disorders ◽  
Body Weight ◽  
Eating Disorder ◽  
Eating Behavior ◽  
Weight Changes ◽  
Body Weight Changes ◽  
The Past ◽  
Clinical Investigations ◽  
Orexigenic Peptide

AbstractThe past decade has witnessed a dramatic acceleration in research on the role of the neuropeptides in the regulation of eating behavior and body weight homeostasis. This expanding research focus has been driven in part by increasing public health concerns related to obesity and the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN). Preclinical advances have been facilitated by the development of new molecular and behavioral research methodologies. With a focus on clinical investigations in AN and BN, this article reviews research on selected hypothalamic and gut-related peptide systems with prominent effects on eating behavior. Studies of the orexigenic peptides neuropeptide Y and the opioid peptides have shown state-related abnormalities in patients with eating disorders. With respect to gut-related peptides, there appears to be substantial evidence for blunting in the meal-related release of the satiety promoting peptide cholecystokinin in BN. Fasting plasma levels of the orexigenic peptide ghrelin have been found to be elevated in patients with AN. As discussed in this review, additional studies will be needed to assess the role of nutritional and body weight changes in neuropeptide alterations observed in symptomatic eating disorder patients, and to identify stable trait-related abnormalities in neuropeptide regulation that persist in individuals who have recovered from an eating disorder.

The impact of COVID-19 lockdown and of the following “re-opening” period on specific and general psychopathology in people with Eating Disorders: the emergent role of internalizing symptoms

2021 ◽  
Vol 285 ◽  
pp. 77-83
Author(s):  
Alessio Maria MONTELEONE ◽  
Francesca MARCIELLO ◽  
Giammarco CASCINO ◽  
Giovanni ABBATE-DAGA ◽  
Simona ANSELMETTI ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Internalizing Symptoms ◽  
General Psychopathology ◽  
The Impact

scholarly journals Is activation of human brown adipose tissue a viable target for weight management?

2018 ◽  
Vol 315 (3) ◽  
pp. R479-R483 ◽  
Author(s):  
Kara L. Marlatt ◽  
Kong Y. Chen ◽  
Eric Ravussin
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Weight Control ◽  
Potential Role ◽  
Metabolic Adaptation ◽  
Weight Changes ◽  
Brown Adipose ◽  
Pharmacological Studies

To date, human studies show that brown adipose tissue (BAT) contributes a small yet highly variable amount to overall energy expenditure. No studies have shown a decrease in body weight with cold-induced BAT activation, and existing pharmacological studies suggest that BAT activation via the sympathetic nervous system may result in increased heart rate and systolic blood pressure. Furthermore, even though the amount and/or activity of BAT have been shown to vary with seasons, such variation does not seem to be translated into weight changes. Collectively, these findings do not support the use of BAT activation for weight loss in humans; however, the potential role of BAT in counteracting the metabolic adaptation observed with weight loss is suggested. Although the role of BAT in weight control is currently unsubstantiated, BAT may play a role in improving insulin sensitivity in humans.

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