scholarly journals Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1896
Author(s):  
Tatsuki Kimizuka ◽  
Natsumi Seki ◽  
Genki Yamaguchi ◽  
Masahiro Akiyama ◽  
Seiichiro Higashi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Water Intake ◽  
Body Water ◽  
Enteric Pathogen ◽  
Infection Model ◽  
Intestinal Damage ◽  
Citrobacter Rodentium ◽  
Infectious Diarrhea ◽  
Important Health ◽  
Amino Acid Balance

Infectious diarrhea is one of the most important health problems worldwide. Although nutritional status influences the clinical manifestation of various enteric pathogen infections, the effect of diet on enteric infectious diseases remains unclear. Using a fatal infectious diarrheal model, we found that an amino acid-based diet (AD) protected susceptible mice infected with the enteric pathogen Citrobacter rodentium. While the mice fed other diets, including a regular diet, were highly susceptible to C. rodentium infection, AD-fed mice had an increased survival rate. An AD did not suppress C. rodentium colonization or intestinal damage; instead, it prevented diarrhea-induced dehydration by increasing water intake. An AD altered the plasma and fecal amino acid levels and changed the gut microbiota composition. Treatment with glutamate, whose level was increased in the plasma and feces of AD-fed mice, promoted water intake and improved the survival of C. rodentium-infected mice. Thus, an AD changes the systemic amino acid balance and protects against lethal infectious diarrhea by maintaining total body water content.

Amino Acid Balance and Imbalance

1959 ◽  
Vol 69 (1) ◽  
pp. 58-64 ◽  
Author(s):  
S. M. Munaver ◽  
A. E. Harper
Keyword(s):  
Amino Acid ◽  
Amino Acid Balance

Ideal amino acid balance for sows during gestation and lactation1

2009 ◽  
Vol 87 (suppl_14) ◽  
pp. E123-E132 ◽  
Author(s):  
S. W. Kim ◽  
W. L. Hurley ◽  
G. Wu ◽  
F. Ji
Keyword(s):  
Amino Acid ◽  
Amino Acid Balance

scholarly journals Rabbit Carcasses for Use in Feline Diets: Amino Acid Concentrations in Fresh and Frozen Carcasses With and Without Gastrointestinal Tracts

2021 ◽  
Vol 7 ◽  
Author(s):  
Tammy J. Owens ◽  
Andrea J. Fascetti ◽  
C. Christopher Calvert ◽  
Jennifer A. Larsen
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Crude Protein ◽  
Protein Body ◽  
National Research Council ◽  
Body Water ◽  
Taurine Supplementation ◽  
Frozen Ground ◽  
Taurine Deficiency ◽  
Amino Acid Concentrations

Whole-prey diets for exotic feline species are common, and this practice has also increased in popularity for domestic cats. However, prior analyses of prey indicate possible essential amino acid inadequacy, and dilated cardiomyopathy from taurine deficiency was reported in cats fed whole ground rabbit. Crude protein, body water, and amino acid concentrations were evaluated in fresh and frozen ground rabbits with (n=10) or without (n = 10) gastrointestinal tracts. Amino acids were greater in fresh samples without gastrointestinal tracts (p < 0.05) except taurine, glycine, and cysteine. When normalized for protein content, only glutamate, alanine, methionine, isoleucine, tyrosine, lysine, histidine, and arginine were greater in fresh rabbits without gastrointestinal tracts (g/16 g N basis; p < 0.05). Freezing at −18°C for 30 days had no effect on crude protein or body water content. After freezing, only methionine was lower and only proline was higher when gastrointestinal tracts were omitted (g/16 g N basis; p < 0.05). Regardless, all essential amino acids except taurine exceeded Association of American Feed Control Officials and National Research Council nutrient recommendations for all feline life stages. In contrast, there was minimal impact of treatment on taurine concentrations. However, although feline taurine requirements for prey and other raw or fresh food diets remain undefined, none of the rabbit samples met any recommendation for taurine concentrations for commercial canned or dry extruded diets, ranging from 20 to 90% of the minimum values. Taurine supplementation is recommended when feeding rabbit to cats. Determination of taurine requirements of cats fed whole-prey diets is warranted.

scholarly journals Supplementation of Holstein dairy calves fed two levels of crude protein with methionine and lysine

2020 ◽  
Vol 50 (3) ◽  
pp. 442-451
Author(s):  
M. Niroumand ◽  
K. Rezayazdi ◽  
M. Ganjkhanlou
Keyword(s):  
Amino Acid ◽  
Crude Protein ◽  
Average Daily Gain ◽  
Dairy Calves ◽  
Clear Trend ◽  
Reduced Body ◽  
Holstein Calves ◽  
Amino Acid Balance ◽  
Immunoglobin G ◽  
Daily Gain

This study aimed to investigate various levels of crude protein (CP) in starter diets and their supplementation with amino acids (AAs) on efficiency, health, and serum metabolites of dairy calves. Ninety-six newborn Holstein calves were allocated to eight treatments, namely T1) 18% CP unsupplemented starter, T2) T1 supplemented with additional 20% methionine, T3) T1 with additional 20% lysine and 20% methionine, T4) T1 with additional 20% lysine, T5) 22% CP unsupplemented starter, T6) T5 supplemented with additional 20% methionine, T7) T5 supplemented with additional 20% lysine and 20% methionine, and T8) T5 supplemented with additional 20% lysine. Consumption of the starter was not influenced by the level of CP. Calves that received the unsupplemented 22% CP starter had higher average daily gain (ADG) and final weight. But no significant differences among diets were found in feed efficiency. Skeletal growth did not exhibit a clear trend. Calves that received T3 had fewer bouts of diarrhea and reduced body temperature. However, there were no significant dietary effects on immunoglobin G (IgG) or total protein concentration in blood. T1–T3 decreased serum urea concentration. Thus, use of T3 resulted in an improved amino acid balance, and was less expensive than the 22% CP starter.Keywords: amino acid, feed intake, immunity, pre-ruminant calf

Nitrogen Homoeostasis in man: Influence of Protein Intake on the Amplitude of Diurnal Cycling of Body Nitrogen

1994 ◽  
Vol 86 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Gill M. Price ◽  
David Halliday ◽  
Paul J. Pacy ◽  
Marcelo R. Quevedo ◽  
D. Joe Millward
Keyword(s):  
Amino Acid ◽  
Protein Intake ◽  
The Body ◽  
N Balance ◽  
N Losses ◽  
Body Protein ◽  
Fed State ◽  
Excretion Rates ◽  
Amino Acid Balance ◽  
Diurnal Cycling

1. The diurnal nature of nitrogen (N) homoeostasis was investigated in adults fed increasing protein intakes. N balance was estimated during a 48 h period of consecutive 12 h periods of feeding hourly meals and fasting, after 12 days of adaptation to diets containing 0.36 +0.01, 0.77 + 0.03, 1.59 +0.08 and 2.31 +0.65 g of protein day−1 kg−1. N losses were determined from measured urinary N excretion corrected for changes in the body urea pool, and estimated faecal and miscellaneous losses. [13C] Leucine and [2H5]phenylalanine balances were measured during a primed, continuous infusion of the two amino acids during the fasting and feeding phase on the second day. 2. Increasing fasting N losses were observed (47 +7, 60+6, 95+15 and 140+36 mg day−1 kg−1) on the four intakes, with corresponding increasing fed gains of 8.2+3.9, 40.2+7.1, 112+24 and 180+ 56 mg day−1 kg−1. 3. Increasing fed-state amino acid gains with increasing protein intake were observed with both [13C]leucine and [2H5]phenylalanine, whereas increasing fasting amino acid losses were confirmed with [13C]leucine. 4. The N equivalent of the leucine oxidation rate was mostly in the range of 10–50% lower than expected from the N excretion rates. This may reflect the timing of the amino acid balance measurements and non-uniform rates of gain and loss throughout the diurnal cycle. 5. We conclude on the basis of both N and amino acid balances that the amplitude of the diurnal cycling of body protein N in human adults increases with increasing dietary protein intake. Thus one component of the protein requirement for N balance reflects a demand for repletion of fasting losses which increases with increasing habitual protein intake.

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