scholarly journals Long-Term Effect of a Gluten-Free Diet on Diarrhoea- or Bloating-Predominant Functional Bowel Disease: Role of the ‘Low-Grade Coeliac Score’ and the ‘Coeliac Lymphogram’ in the Response Rate to the Diet

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1812
Author(s):  
Fernando Fernández-Bañares ◽  
Beatriz Arau ◽  
Agnès Raga ◽  
Montserrat Aceituno ◽  
Eva Tristán ◽  
...  
Keyword(s):  
Response Rate ◽  
Term Effect ◽  
Gluten Free Diet ◽  
Watery Diarrhoea ◽  
Low Grade ◽  
Gluten Free ◽  
Long Term Effect ◽  
Long Term Treatment

1. Background: The long-term effect of a gluten-free diet (GFD) on functional bowel disorders (FBDs) has been scarcely studied. The aim was to assess the effect of a GFD on FBD patients, and to assess the role of both the low-grade coeliac score and coeliac lymphogram in the probability of response to a GFD. 2. Methods: 116 adult patients with either predominant diarrhoea or abdominal bloating, fulfilling Rome IV criteria of FBD, were treated with a GFD. Duodenum biopsies were performed for both pathology studies and intraepithelial lymphocyte subpopulation patterns. Coeliac lymphogram was defined as an increase in TCRγδ+ cells plus a decrease in CD3− cells. A low-grade coeliac score >10 was considered positive. 3. Results: Sustained response to GFD was observed in 72 patients (62%) after a median of 21 months of follow-up, who presented more often with coeliac lymphogram (37.5 vs. 11.4%; p = 0.02) and a score >10 (32 vs. 11.4%; p = 0.027) compared to non-responders. The frequency of low-grade coeliac enteropathy was 19.8%. 4. Conclusion: A GFD is effective in the long-term treatment of patients with previously unexplained chronic watery diarrhoea- or bloating-predominant symptoms fulfilling the criteria of FBD. The response rate was much higher in the subgroup of patients defined by the presence of both a positive low-grade coeliac score and coeliac lymphogram.

Long-Term Effect of Gluten-Free Diet on Growth Velocity in Turkish Children with Celiac Disease

2008 ◽  
Vol 54 (10) ◽  
pp. 2183-2187 ◽  
Author(s):  
Sema Aydogdu ◽  
Levent Midyat ◽  
Murat Cakir ◽  
Gokhan Tumgor ◽  
Hasan Ali Yuksekkaya ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Growth Velocity ◽  
Term Effect ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Turkish Children ◽  
Long Term Effect

scholarly journals Ablation of the inferior olive prevents H-reflex down-conditioning in rats

2016 ◽  
Vol 115 (3) ◽  
pp. 1630-1636 ◽  
Author(s):  
Xiang Yang Chen ◽  
Yu Wang ◽  
Yi Chen ◽  
Lu Chen ◽  
Jonathan R. Wolpaw
Keyword(s):  
Spinal Cord ◽  
Inferior Olive ◽  
H Reflex ◽  
Term Effect ◽  
New Approach ◽  
Simple Motor ◽  
Long Term Effect ◽  
Cortical Inputs

We evaluated the role of the inferior olive (IO) in acquisition of the spinal cord plasticity that underlies H-reflex down-conditioning, a simple motor skill. The IO was chemically ablated before a 50-day exposure to an operant conditioning protocol that rewarded a smaller soleus H-reflex. In normal rats, down-conditioning succeeds (i.e., H-reflex size decreases at least 20%) in 80% of animals. Down-conditioning failed in every IO-ablated rat ( P < 0.001 vs. normal rats). IO ablation itself had no long-term effect on H-reflex size. These results indicate that the IO is essential for acquisition of a down-conditioned H-reflex. With previous data, they support the hypothesis that IO and cortical inputs to cerebellum enable the cerebellum to guide sensorimotor cortex plasticity that produces and maintains the spinal cord plasticity that underlies the down-conditioned H-reflex. They help to further define H-reflex conditioning as a model for understanding motor learning and as a new approach to enhancing functional recovery after trauma or disease.

Relationship Among Serum and Urine Neopterin, Fibrinogen, and Other Serum Analytes in Atherosclerotic Patients and the Long-term Effect of H.E.L.P. Therapy

Pteridines ◽  
1999 ◽  
Vol 10 (4) ◽  
pp. 190-196
Author(s):  
Karoline Vrecko ◽  
Manfred Walz ◽  
Erwin Tafeit ◽  
G. Reibnegger
Keyword(s):  
Term Treatment ◽  
Term Effect ◽  
Long Term Effect ◽  
Long Term Treatment ◽  
Cellular Immune System ◽  
Before And After ◽  
Immune Activation Marker ◽  
Cellular Immune ◽  
Serum And Urine

Summary In 30 atherosclerotic patients different serum analytes and neopterin concentrations in serum and urine were determined before and after Heparin-Induced Extracorporeal LDL and Fibrinogen Precipitation therapy. Neopterin concentrations in serum of all 30 patients were increased (mean=9.18 nmol/l, SD=3.23) compared to age matched healthy people (mean=5.34 nmol/l, SD=2.70) and were significantly lowered after H.E.L.P therapy (mean=S.22 nmol/l; SD=3.22, p=0.002, t-test) . These results suggest the involvement of the cellular immune system in the occurrence of atherosclerosis. Further neopterin, the macrophagederived immune activation marker, is significantly correlated with fibrinogen (linear correlation coefficient r=0.36, p=0.05). Long-term neopterin concentrations in serum of 4 patients (three with coronary heart disease and one with Papilla edema), from the first up to the 9th, respectively 12th therapy decreased, in contrast to fibrinogen which stayed stable or even increased during long-term treatment.

scholarly journals The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity

2020 ◽  
Vol 21 (7) ◽  
pp. 525-530
Author(s):  
Arturo S. Herrera ◽  
Paola E. Solís Arias ◽  
María del C.A. Esparza ◽  
Luis F.T. Bernal ◽  
Andrey D. Bondarev ◽  
...  
Keyword(s):  
Molecular Hydrogen ◽  
Term Treatment ◽  
Term Effect ◽  
Metabolic Energy ◽  
Potential Implication ◽  
Carbon Chains ◽  
Long Term Effect ◽  
Long Term Treatment ◽  
Promising Application

Background: The ability of the human body to produce metabolic energy from light modifies fundamental concepts of biochemistry. Objective: This review discusses the relationships between the long-accepted concept is that glucose has a unique dual role as an energy source and as the main source of carbon chains that are precursors of all organic matter. The capability of melanin to produce energy challenges this premise. Methods: The prevalent biochemical concept, therefore, needs to be adjusted to incorporate a newly discovered state of Nature based on melanin’s ability to dissociate water to produce energy and to reform water from molecular hydrogen and oxygen. Results and Discussion: Our findings regarding the potential implication of QIAPI-1 as a melanin precursor that has bioenergetics capabilities. Conclusion: Specifically, we reported its promising application as a means for treating retinopathy of prematurity (ROP). The instant report focuses on the long-term treatment medical effects of melanin in treating ROP.

scholarly journals The Effect of Chronic Methamphetamine Treatment on Schizophrenia Endophenotypes in Heterozygous Reelin Mice: Implications for Schizophrenia

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 940
Author(s):  
Camilla Hume ◽  
Shelley Massey ◽  
Maarten van den Buuse
Keyword(s):  
Locomotor Activity ◽  
Social Behaviour ◽  
Social Preference ◽  
Term Effect ◽  
Spontaneous Locomotor Activity ◽  
Brain Dopamine ◽  
Locomotor Hyperactivity ◽  
Long Term Effect

Reelin has been implicated in the development of schizophrenia but the mechanisms involved in this interaction remain unclear. Chronic methamphetamine (Meth) use may cause dopaminergic sensitisation and psychosis and has been proposed to affect brain dopamine systems similarly to changes seen in schizophrenia. We compared the long-term effect of chronic Meth treatment between heterozygous reelin mice (HRM) and wildtype controls (WT) with the aim of better understanding the role of reelin in schizophrenia. Meth pretreatment induced sensitisation to the effect of an acute Meth challenge on locomotor activity, but it had no effect on baseline PPI or sociability and social preference. In all behavioural models, HRM did not significantly differ from WT at baseline, except spontaneous exploratory locomotor activity which was higher in HRM than WT, and sociability which was enhanced in HRM. Locomotor hyperactivity sensitisation was not significantly different between HRM and WT. Chronic Meth treatment reduced spontaneous locomotor activity to the level of WT. No deficits in PPI or social behaviour were induced by chronic Meth pretreatment in either strain. In conclusion, these data do not support a role of reelin in schizophrenia, at least not in HRM and in the methamphetamine sensitisation model.

scholarly journals Gluten-Free Diet and Its ‘Cousins’ in Irritable Bowel Syndrome

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1727 ◽  
Author(s):  
Anupam Rej ◽  
David Sanders
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Common Condition ◽  
Long Term Outcomes ◽  
Functional Bowel Disorder ◽  
Recent Interest ◽  
Irritable Bowel

Functional disorders are common, with irritable bowel syndrome (IBS) being the commonest and most extensively evaluated functional bowel disorder. It is therefore paramount that effective therapies are available to treat this common condition. Diet appears to play a pivotal role in symptom generation in IBS, with a recent interest in the role of dietary therapies in IBS. Over the last decade, there has been a substantial increase in awareness of the gluten-free diet (GFD), with a recent focus of the role of a GFD in IBS. There appears to be emerging evidence for the use of a GFD in IBS, with studies demonstrating the induction of symptoms following gluten in patients with IBS. However, there are questions with regards to which components of wheat lead to symptom generation, as well as the effect of a GFD on nutritional status, gut microbiota and long-term outcomes. Further studies are required, although the design of dietary studies remain challenging. The implementation of a GFD should be performed by a dietitian with a specialist interest in IBS, which could be achieved via the delivery of group sessions.

M2033 Role of Antibodies in the Long Term Follow Up of Patients with Celiac Disease to Predict the Adherence to Gluten-Free Diet

2009 ◽  
Vol 136 (5) ◽  
pp. A-471
Author(s):  
Adriana Mohaidle ◽  
José M. Mella ◽  
Lisandro Pereyra ◽  
Pablo Luna ◽  
Carolina Fischer ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Long Term Follow Up
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