scholarly journals Erratum: Lee et al. Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats. Nutrients 2020, 12, 2383

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1656
Author(s):  
Jee Youn Lee ◽  
Chan Sol Park ◽  
Hae Young Choi ◽  
Sung Hyun Chung ◽  
Mi Kyung Pyo ◽  
...  
Keyword(s):  
Cell Death ◽  
Blood Brain Barrier ◽  
Hippocampal Neurons ◽  
Apoptotic Cell ◽  
Diabetic Rats ◽  
Apoptotic Cell Death ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Brain Barrier Disruption

The authors have requested that the following changes be made to their paper [...]

scholarly journals Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2383
Author(s):  
Jee Youn Lee ◽  
Chan Sol Park ◽  
Hae Young Choi ◽  
Tae Young Yune
Keyword(s):  
Diabetes Mellitus ◽  
Cell Death ◽  
Blood Brain Barrier ◽  
Hippocampal Neurons ◽  
Apoptotic Cell ◽  
Diabetic Rats ◽  
Apoptotic Cell Death ◽  
Brain Barrier ◽  
Blood Brain

Type 1 diabetes mellitus is known to be linked to the impairment of blood–brain barrier (BBB) integrity following neuronal cell death. Here, we investigated whether GS-KG9 and GS-E3D, bioactive ginseng extracts from Korean ginseng (Panax ginseng Meyer), inhibit BBB disruption following neuronal death in the hippocampus in streptozotocin-induced diabetic rats showing type 1-like diabetes mellitus. GS-KG9 and GS-E3D (50, 150, or 300 mg/kg, twice a day for 4 weeks) administered orally showed antihyperglycemic activity in a dose-dependent manner and significantly attenuated the increase in BBB permeability and loss of tight junction proteins. GS-KG9 and GS-E3D also inhibited the expression and activation of matrix metalloproteinase-9 and the infiltration of macrophages into the brain parenchyma, especially into the hippocampal region. In addition, microglia and astrocyte activation in the hippocampus and the expression of proinflammatory mediators such as tnf-α, Il-1β, IL-6, cox-2, and inos were markedly alleviated in GS-KG9 and GS-E3D-treated group. Furthermore, apoptotic cell death of hippocampal neurons, especially in CA1 region, was significantly reduced in GS-KG9 and GS-E3D-treated groups as compared to vehicle control. These results suggest that GS-KG9 and GS-E3D effectively prevent apoptotic cell death of hippocampal neurons by inhibiting BBB disruption and may be a potential therapy for the treatment of diabetic patients.

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Rose Marie Tyson ◽  
Dale F Kraemer ◽  
Matthew A Hunt ◽  
Leslie L Muldoon ◽  
Peter Orbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Early Experience ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption
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