scholarly journals Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1503
Author(s):  
Millie Porzi ◽  
Kathryn J. Burton-Pimentel ◽  
Barbara Walther ◽  
Guy Vergères
Keyword(s):  
Lactose Intolerance ◽  
Therapeutic Interventions ◽  
Personalized Nutrition ◽  
Treatment Optimization ◽  
Potential Health ◽  
Diagnosis And Management ◽  
Nutrition Research ◽  
Strategic Plans ◽  
Substantial Progress ◽  
Multiple Challenges

Recent discoveries in the “omics” field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. The diagnosis and management of lactose intolerance (LI), a common condition with a strong inter-individual component, is explored as an interesting example for the potential role of these technologies and the challenges of PN. From the development of genetic and metabolomic LI diagnostic tests that can be carried out in the home, to advances in the understanding of LI pathology and individualized treatment optimization, PN in LI care has shown substantial progress. However, there are still many research gaps to address, including the understanding of epigenetic regulation of lactase expression and how lactose is metabolized by the gut microbiota, in order to achieve better LI detection and effective therapeutic interventions to reverse the potential health consequences of LI.

Metabolomics for Personalized Nutrition Research and Clinical Applications

2010 ◽  
Vol 8 (3) ◽  
pp. 202-217
Author(s):  
Laura Schnackenberg ◽  
Jinchun Sun ◽  
Lisa Pence ◽  
Sudeepa Bhattacharyya ◽  
Bakary Sonko ◽  
...  
Keyword(s):  
Clinical Applications ◽  
Personalized Nutrition ◽  
Nutrition Research

scholarly journals Nutraceutical potentials of synergic foods: a systematic review

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Tharani Devi Natarajan ◽  
Janci Rani Ramasamy ◽  
Kirthika Palanisamy
Keyword(s):  
Chronic Diseases ◽  
Health Benefits ◽  
Nutrient Deficiency ◽  
Value Added ◽  
Well Being ◽  
Active Role ◽  
The Body ◽  
Health Food ◽  
Potential Health ◽  
Nutrition Research

AbstractFood synergy is a concept of linking foods to health. Food consists of mixtures of nutrients, serving as a fuel for the body. When synergistic foods are put together, the evidence for potential health benefits becomes stronger than individual foods. Nutrient deficiency is a known phenomenon in many individuals, and synergy plays a very important role in combating the nutritional deficiency. Today’s consumer expresses high interest to build knowledge on the active role of food in their well-being, as well as in the prevention of non-transmissible chronic diseases. Functional foods and their active compounds play a vital role in preventing chronic diseases, improving immunity, and decreasing infections. The concept of synergy is an overthinking in nutrition research which can enhance effective dietary planning value added to the forthcoming nutrition research. This paper gives an overview of various synergic combinations of food components and their interactions within the food and with the human system to attain ideal health benefits.

Lactose intolerance: Diagnosis and management

2000 ◽  
Vol 26 (4) ◽  
pp. 246-250 ◽  
Author(s):  
Yogeshkumar T. Patel ◽  
Anil Minocha
Keyword(s):  
Lactose Intolerance ◽  
Diagnosis And Management

scholarly journals Recent Advances in the Application of Metabolomics for Nutrition and Health

2019 ◽  
Vol 10 (1) ◽  
pp. 479-519 ◽  
Author(s):  
Diana González-Peña ◽  
Lorraine Brennan
Keyword(s):  
Small Molecules ◽  
Biological Samples ◽  
Large Scale ◽  
Dietary Assessment ◽  
Personalized Nutrition ◽  
Nutrition And Health ◽  
Successful Development ◽  
Nutrition Research ◽  
Epidemiology Studies ◽  
Further Development

Metabolomics is the study of small molecules called metabolites in biological samples. Application of metabolomics to nutrition research has expanded in recent years, with emerging literature supporting multiple applications. Key examples include applications of metabolomics in the identification and development of objective biomarkers of dietary intake, in developing personalized nutrition strategies, and in large-scale epidemiology studies to understand the link between diet and health. In this review, we provide an overview of the current applications and identify key challenges that need to be addressed for the further development of the field. Successful development of metabolomics for nutrition research has the potential to improve dietary assessment, help deliver personalized nutrition, and enhance our understanding of the link between diet and health.

scholarly journals Efficacy Evaluation and Dose Prediction of a Novel Botanical Formula on Eye Fatigue and Dry Eye to Provide a Personalized Nutrition Solution

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 112-112
Author(s):  
Juntao Kan ◽  
Zhensheng Gu ◽  
Jun Du
Keyword(s):  
Dry Eye ◽  
External Validation ◽  
Real Life ◽  
Machine Learning Algorithms ◽  
Dietary Habit ◽  
Personalized Nutrition ◽  
Nutrition Research ◽  
Eye Fatigue ◽  
Significant Difference ◽  
Break Time

Abstract Objectives With the frequent use of video display units, eye fatigue is more and more common globally. We aimed to evaluate the protective effect of a novel botanical combination of lutein ester, zeaxanthin, extracts of black currant, chrysanthemum and goji berry on adults with eye fatigue in a randomized controlled trial, and predict personalized dose for each individual in real-life consumption. Methods 360 participants were randomized to receive our formula with 3 different doses (containing 6 mg, 10 mg, and 14 mg of lutein, respectively) or placebo once daily for 90 days. Each participant had a total of 3 visits at baseline (V1), 45 days (V2) and 90 days (V3) throughout the study. Results The formula intervention improved individual score of eye fatigue symptoms, including eye soreness, photophobia, blurred vision, dry eye, foreign body sensation and tearing. Compared with placebo, the formula with all 3 doses significantly decreased the total score of eye fatigue symptoms and increased the visuognosis persistence time at both V2 and V3. For Schirmer test, the formula with 10 mg and 14 mg of lutein improved the tear secretion at V3. For Keratography, first tear break time, average tear break time and tear meniscus height were significantly increased after formula intervention. The intervention of formula with all 3 doses significantly increased macular pigment optical density at V2 and V3, while optical coherence tomography showed that there was no significant difference in retinal thickness and retinal volume among all groups at both visits. Different machine-learning algorithms were used to predict personalized dose based on the eye-related indexes and other features, such as anthropometrics, physical activity, dietary habit, and blood biomarkers under 3 different dosages. Among them, XGBoost performed best with R = 0.649 for training set, R = 0.638 for test set, and R = 0.685 for external validation set. Conclusions The formula improves eye fatigue, dry eye, and macular function without changing the structure, providing a nutritional alternative strategy. XGBoost could successfully predict dose to provide a personalized nutrition solution. Funding Sources This study was supported by National Key R&D Program of China and Nutrition Research Foundation of Chinese Nutrition Society.

The evolution of nutrition research

2013 ◽  
Vol 91 (4) ◽  
pp. 257-267 ◽  
Author(s):  
Cara K. Isaak ◽  
Yaw L. Siow
Keyword(s):  
Public Health ◽  
Nutrient Content ◽  
New Age ◽  
Gene Interactions ◽  
Personalized Nutrition ◽  
Individual Health ◽  
Nutrition Research ◽  
The World ◽  
The Future

“The doctor of the future will no longer treat the human frame with drugs, but will rather cure and prevent disease with nutrition”. Thomas Edison's contemplation may come to fruition if the nutritional revolution continues in its current course. Two realizations have propelled the world into a new age of personalized nutrition: (i) food can provide benefits beyond its intrinsic nutrient content, and (ii) we are not all created equal in our ability to realize to these benefits. Nutrigenomics is concerned with delineating genomic propensities to respond to various nutritional stimuli and the resulting impact on individual health. This review will examine the current technologies utilized by nutrigeneticists, the available literature regarding nutrient-gene interactions, and the translation of this new awareness into public health.

scholarly journals Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2143
Author(s):  
Ahmed Ismaeel ◽  
K. Leigh Greathouse ◽  
Nathan Newton ◽  
Dimitrios Miserlis ◽  
Evlampia Papoutsi ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Functional Outcomes ◽  
Functional Disability ◽  
Treatment Options ◽  
Therapeutic Interventions ◽  
Muscle Pathology ◽  
Peripheral Artery ◽  
Potential Health ◽  
Walking Performance ◽  
Artery Disease

Peripheral artery disease (PAD) affects over 200 million people worldwide, resulting in significant morbidity and mortality, yet treatment options remain limited. Among the manifestations of PAD is a severe functional disability and decline, which is thought to be the result of different pathophysiological mechanisms including oxidative stress, skeletal muscle pathology, and reduced nitric oxide bioavailability. Thus, compounds that target these mechanisms may have a therapeutic effect on walking performance in PAD patients. Phytochemicals produced by plants have been widely studied for their potential health effects and role in various diseases including cardiovascular disease and cancer. In this review, we focus on PAD and discuss the evidence related to the clinical utility of different phytochemicals. We discuss phytochemical research in preclinical models of PAD, and we highlight the results of the available clinical trials that have assessed the effects of these compounds on PAD patient functional outcomes.

scholarly journals Congenital Diaphragmatic Hernia: A Major Challenge for Neonatologists

2020 ◽  
Author(s):  
Rameshwar Prasad
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Therapeutic Interventions ◽  
High Morbidity ◽  
Fetal Life ◽  
Extra Corporeal Membrane Oxygenation ◽  
Weak Evidence ◽  
Improved Outcomes ◽  
Major Congenital Anomaly ◽  
Substantial Progress

Congenital diaphragmatic hernia (CDH) is a major congenital anomaly of the neonates, characterized by the herniation of abdominal contents into the thoracic cavity during fetal life. This results in significant pulmonary hypertension and hypoxemia after birth, which responds poorly to therapeutic interventions. CDH is associated with high morbidity and mortality. The exact pathogenesis is not well understood, and genetic factors have been proposed. The management starts in utero, with antenatal diagnosis and identification of prenatal predictors for the outcomes, which help in the selection of cases suitable for fetal therapy. The postnatal management is complicated by the need for variable cardio-respiratory support and even extra corporeal membrane oxygenation (ECMO), before corrective surgery is undertaken. Improvement in the understanding of the pathophysiology of the underdeveloped lungs and pulmonary vessels has contributed to substantial progress in the management of CDH, which has translated into improved outcomes and survival. Still, many questions regarding CDH remain unanswered and the management is largely based on weak evidence.

scholarly journals Urgent considerations for the neuro-oncologic treatment of patients with gliomas during the COVID-19 pandemic

2020 ◽  
Vol 22 (7) ◽  
pp. 912-917 ◽  
Author(s):  
Nimish A Mohile ◽  
Jaishri O Blakeley ◽  
Na Tosha N Gatson ◽  
Andreas F Hottinger ◽  
Andrew B Lassman ◽  
...  
Keyword(s):  
Health Care ◽  
Care Delivery ◽  
Health Care Systems ◽  
Therapeutic Interventions ◽  
Ethical Challenges ◽  
Potential Health ◽  
Care Systems ◽  
Novel Coronavirus ◽  
Ventilator Care ◽  
Oncologic Treatment

Abstract The COVID-19 outbreak is posing unprecedented risks and challenges for all communities and health care systems, worldwide. There are unique considerations for many adult patients with gliomas who are vulnerable to the novel coronavirus due to older age and immunosuppression. As patients with terminal illnesses, they present ethical challenges for centers that may need to ration access to ventilator care due to insufficient critical care capacity. It is urgent for the neuro-oncology community to develop a proactive and coordinated approach to the care of adults with gliomas in order to provide them with the best possible oncologic care while also reducing their risk of viral infection during times of potential health care system failure. In this article, we present an approach developed by an international multidisciplinary group to optimize the care of adults with gliomas during this pandemic. We recommend measures to promote strict physical distancing and minimize exposures for patients, address risk and benefit of all therapeutic interventions, proactively develop end-of-life plans, educate patients and caregivers, and ensure the health of the multidisciplinary neuro-oncology workforce. This pandemic is already changing neuro-oncologic care delivery around the globe. It is important to highlight opportunities to maximize the benefit and minimize the risk of glioma management during this pandemic and potentially, in the future.

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