scholarly journals Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1225
Author(s):  
Rosa Anna Siciliano ◽  
Anna Reale ◽  
Maria Fiorella Mazzeo ◽  
Stefano Morandi ◽  
Tiziana Silvetti ◽  
...  

Probiotics are live microorganisms that confer health benefits on the host. However, in recent years, several concerns on their use have been raised. In particular, industrial processing and storage of probiotic products are still technological challenges as these could severely impair cell viability. On the other hand, safety of live microorganisms should be taken into account, especially when administered to vulnerable people, such as the elderly and immunodeficient individuals. These drawbacks have enhanced the interest toward new products based on non-viable probiotics such as paraprobiotics and postbiotics. In particular, paraprobiotics, defined as “inactivated microbial cells (non-viable) that confer a health benefit to the consumer,” hold the ability to regulate the adaptive and innate immune systems, exhibit anti-inflammatory, antiproliferative and antioxidant properties and exert antagonistic effect against pathogens. Moreover, paraprobiotics can exhibit enhanced safety, assure technological and practical benefits and can also be used in products suitable for people with weak immunity and the elderly. These features offer an important opportunity to prompt the market with novel functional foods or nutraceuticals that are safer and more stable. This review provides an overview of central issues on paraprobiotics and highlights the urgent need for further studies aimed at assessing safety and efficacy of these products and their mechanisms of action in order to support decisions of regulatory authorities. Finally, a definition is proposed that unambiguously distinguishes paraprobiotics from postbiotics.

2021 ◽  
Author(s):  
Fabrice Cognasse ◽  
Kathryn Hally ◽  
Sebastien Fauteux-Daniel ◽  
Marie-Ange Eyraud ◽  
Charles-Antoine Arthaud ◽  
...  

AbstractAside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and the release of biological response modifiers (BRMs). As a consequence, platelet concentrates (PCs) accumulate BRMs during processing and storage, and these BRMs are ultimately transfused alongside platelets. It has been shown that BRMs present in PCs can induce immune responses and posttransfusion reactions in the transfusion recipient. Several recent reports within the transfusion literature have investigated the concept of platelets as immune cells. Nevertheless, current and future investigations will face the challenge of encompassing the immunological role of platelets in the scope of transfusion.


2007 ◽  
Vol 227 (1) ◽  
pp. 125-134 ◽  
Author(s):  
A. M. Jiménez ◽  
M. Martínez-Tomé ◽  
I. Egea ◽  
F. Romojaro ◽  
M. A. Murcia

2016 ◽  
Vol 51 (4) ◽  
pp. 894-901 ◽  
Author(s):  
Muhammed Majeed ◽  
Shaheen Majeed ◽  
Kalyanam Nagabhushanam ◽  
Sankaran Natarajan ◽  
Arumugam Sivakumar ◽  
...  

2021 ◽  
Author(s):  
D. Risso ◽  
V. Leoni ◽  
C. Fania ◽  
M. Arveda ◽  
L. Falchero ◽  
...  

Oxysterols are products of enzymatic and/or chemical cholesterol oxidation. Their measurement during and after a milk production chain could represent a useful tool to monitor and increase the commercial and nutritional value of milk.


2015 ◽  
Vol 55 (10) ◽  
pp. 1332 ◽  
Author(s):  
Suzanne Mashtoub ◽  
Darin C. Bennett ◽  
Cuong D. Tran ◽  
Gordon S. Howarth

Treatments for diseases such as coronary artery disease and gastrointestinal disorders seek to minimise oxidative damage by free radicals through the use of antioxidants. Oils derived from ratites (flightless birds) have therapeutic potential, with varying fatty acid composition between species. The current study investigated the influence of farm location, rendering method, duration and storage mode on radical scavenging activity (RSA) and primary oxidation status of ratite oils. Emu Oil (n = 8; EO1, EO2a/b, EO3–7; varying processing and storage factors), Ostrich Oil (OsO), Rhea Oil (RO) and olive oil (OlO) were tested for free RSA against 2,2-diphenyl-1-picryl hydracyl (expressed as 1/IC50 g/mL) and primary oxidation (peroxide mEqO2/kg). RSA (g/mL) of EO1 (558 ± 22) was greater than EO2a (8 ± 0.6), EO5 (413 ± 26), EO6 (16 ± 0.3) and EO7 (2 ± 0.2), OsO (313 ± 12), RO (32 ± 12) and OlO (196 ± 4), and less than EO3 (717 ± 32; P < 0.001). Antioxidant properties of OsO were more pronounced than RO (P < 0.001). Primary oxidation (mEqO2/kg) of EO1 (97 ± 0.6) was greater than EO2a (57 ± 0.6), EO2b (28 ± 0.2), EO5 (11 ± 0.6), OsO (50 ± 0.9) and OlO (61 ± 0.9). The wide variability in RSA of oils highlights the need for standardisation of farm location, diet composition, rendering procedures, time of render and duration of storage. Regulatory control of these parameters is recommended in order to minimise differences in therapeutic efficacy of ratite oils.


2011 ◽  
Vol 44 (7) ◽  
pp. 2243-2251 ◽  
Author(s):  
Anne-Laure Gancel ◽  
Aurélien Feneuil ◽  
Oscar Acosta ◽  
Ana Mercedes Pérez ◽  
Fabrice Vaillant

Author(s):  
Cláudio Teixeira ◽  
Joaquim Sousa Pinto ◽  
Flávio Ferreira ◽  
André Oliveira ◽  
António Teixeira ◽  
...  

As life expectancy increases, so does the number of Ambient Assisted Living (AAL) initiatives. The Living Usability Lab is a user-centered living laboratory aimed at open-innovation and evaluation of new approaches to AAL applications and services, where the different stakeholders may develop and evaluate innovative services for the elderly in near-real life conditions. These AAL initiatives often traverse several research fields, from embedded devices to multiple data streams analysis. Advanced processing, reasoning, and storage of such data streams poses a complex problem usually solved using local processing and storage resources. This chapter presents an overview of the LUL initiative, its services, and applications, and explores the problem of advanced processing, reasoning, and storage from a cloud computing perspective.


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