scholarly journals Work Shift, Lifestyle Factors, and Subclinical Atherosclerosis in Spanish Male Workers: A Mediation Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1077
Author(s):  
José L. Peñalvo ◽  
Elly Mertens ◽  
Ainara Muñoz-Cabrejas ◽  
Montserrat León-Latre ◽  
Estíbaliz Jarauta ◽  
...  
Keyword(s):  
Mediation Analysis ◽  
Subclinical Atherosclerosis ◽  
Night Shift ◽  
Logistic Models ◽  
Health Study ◽  
Lifestyle Habits ◽  
Potential Association ◽  
Workplace Wellness Programs ◽  
Working Shift ◽  
Work Shifts

(1) Background: Working night shifts has been associated with altered circadian rhythms, lifestyle habits, and cardiometabolic risks. No information on the potential association of working shift and the presence of atherosclerosis is available. The aim of this study was to quantify the association between different work shifts and the presence of subclinical atherosclerosis objectively measured by imaging. (2) Methods: Analyses were conducted on the baseline data of the Aragon Workers Health Study (AWHS) cohort, including information on 2459 middle-aged men. Categories of shift work included central day shift, rotating morning-evening or morning-evening-night shift, and night shift. The presence of atherosclerotic plaques was assessed by 2D ultrasound in the carotid and femoral vascular territories. Multivariable logistic models and mediation analysis were conducted to characterize and quantify the association between study variables. (3) Results: Participants working night or rotating shifts presented an overall worse cardiometabolic risk profile, as well as more detrimental lifestyle habits. Workers in the most intense (morning-evening-night) rotating shift presented higher odds of subclinical atherosclerosis (odds ratio: 1.6; 95% confidence interval: 1.12 to 2.27) compared to workers in the central shift, independently of the presence of lifestyle and metabolic risk factors. A considerable (21%) proportion of this association was found to be mediated by smoking, indicating that altered sleep-wake cycles have a direct relationship with the early presence of atherosclerotic lesions. (4) Conclusions: Work shifts should be factored in during workers health examinations, and when developing effective workplace wellness programs.

O35-2 Current and cumulative night shift work and subclinical atherosclerosis – results of the gutenberg health study

2016 ◽  
Author(s):  
Sylvia Jankowiak ◽  
Eva-Maria Backé ◽  
Falk Liebers ◽  
Andreas Schulz ◽  
Janice Hegewald ◽  
...  
Keyword(s):  
Shift Work ◽  
Subclinical Atherosclerosis ◽  
Night Shift ◽  
Health Study ◽  
Night Shift Work ◽  
Gutenberg Health Study

scholarly journals Daily Sitting for Long Periods Increases the Odds for Subclinical Atheroma Plaques

2021 ◽  
Vol 10 (6) ◽  
pp. 1229
Author(s):  
Jose Luis Perez-Lasierra ◽  
Martin Laclaustra ◽  
Pilar Guallar-Castillón ◽  
Jose Antonio Casasnovas ◽  
Jose Antonio Casajús ◽  
...  
Keyword(s):  
Physical Activity ◽  
Subclinical Atherosclerosis ◽  
Sitting Time ◽  
Health Study ◽  
Activity Levels ◽  
Cross Sectional ◽  
Trained Personnel ◽  
Atherosclerosis Development ◽  
Sectional Analysis ◽  
The Relationship

Sedentarism is a risk factor for cardiovascular disease (CVD), but currently it is not clear how a sedentary behavior such as long sitting time can affect atherosclerosis development. This study examined the relationship between sitting time and the prevalence of carotid and femoral subclinical atherosclerosis. A cross-sectional analysis based on a subsample of 2082 participants belonging to the Aragon Workers’ Health Study was carried out. Ultrasonography was used to assess the presence of plaques in carotid and femoral territories; the validated Spanish version of the questionnaire on the frequency of engaging in physical activity used in the Nurses’ Health Study and the Health Professionals’ was used to assess physical activity and sitting time; and demographic, anthropometric, and clinical data were obtained by trained personnel during the annual medical examination. Participants were categorized into <9 h/day and ≥9 h/day sitting time groups. After adjusting for several confounders, compared with participants that remain seated <9 h/day, those participants who remain seated ≥9 h/day had, respectively, OR = 1.25 (95%CI: 1.01, 1.55, p < 0.05) and OR = 1.38 (95%CI: 1.09, 1.74, p < 0.05) for carotid and any-territory plaque presence. Remaining seated ≥9 h/day is associated with higher odds for carotid and any-territory plaque presence independently of physical activity levels and other cardiovascular risk factors.

scholarly journals Pre-diagnostic Circulating Concentrations of Fat-soluble Vitamins and Risk of Glioma in Three Cohort Studies

2020 ◽  
Author(s):  
Yiyang Yue ◽  
Jordan Creed ◽  
David Cote ◽  
Meir Stampfer ◽  
Molin Wang ◽  
...  
Keyword(s):  
Proportional Hazards ◽  
Conditional Logistic Regression ◽  
Plasma Concentrations ◽  
Cox Proportional Hazards ◽  
Health Study ◽  
Hydroxyvitamin D ◽  
Potential Association ◽  
25 Hydroxyvitamin D ◽  
Glioma Risk ◽  
Fat Soluble Vitamins

Abstract Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we investigated associations of pre-diagnostic concentrations of fat-soluble vitamins D, A, and E with incident glioma. In 346,785 participants (444 cases) in UKB, associations with vitamin D (25-hydroxyvitamin D [25(OH)D]) were evaluated by Cox proportional hazards regression. In NHS (52 cases, 104 controls) and HPFS (32 cases, 64 controls), associations with 25(OH)D, vitamin A (retinol), and vitamin E (α- and γ-tocopherol) were assessed using conditional logistic regression. Our results suggested plasma concentrations of 25(OH)D and retinol were not associated with glioma risk. Comparing the highest to lowest tertile, the multivariable hazard ratio (MVHR) for 25(OH)D was 0.87 (95% confidence interval [CI]: 0.68-1.11) in UKB and the multivariable risk ratio (MVRR) was 1.08 (95%CI: 0.55-2.09) in NHS and HPFS. In NHS and HPFS, the MVRR for the same comparison for retinol was 1.16 (95%CI: 0.56-2.38). Nonsignificant associations were observed for α-tocopherol (MVRRtertile3vs1=0.61, 95%CI: 0.29-1.32) and γ-tocopherol (MVRR tertile3vs1=1.30, 95%CI: 0.63-2.69) that became stronger in 4-year lagged analyses. Further investigation is warranted on a potential association between α- and γ-tocopherol and glioma risk.

scholarly journals Sleep duration and subclinical atherosclerosis: The Aragon Workers' Health Study

2018 ◽  
Vol 274 ◽  
pp. 35-40 ◽  
Author(s):  
Elena Blasco-Colmenares ◽  
Belén Moreno-Franco ◽  
Montserrat León Latre ◽  
Eusebio Mur-Vispe ◽  
Miguel Pocovi ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Subclinical Atherosclerosis ◽  
Health Study

scholarly journals Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses

BMJ ◽  
2018 ◽  
pp. k4641 ◽  
Author(s):  
Zhilei Shan ◽  
Yanping Li ◽  
Geng Zong ◽  
Yanjun Guo ◽  
Jun Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Shift Work ◽  
Night Shift ◽  
Health Study ◽  
Lifestyle Factor ◽  
Unhealthy Lifestyle ◽  
Additive Interaction ◽  
Night Shift Work ◽  
Female Nurses

AbstractObjectivesTo prospectively evaluate the joint association of duration of rotating night shift work and lifestyle factors with risk of type 2 diabetes risk, and to quantitatively decompose this joint association to rotating night shift work only, to lifestyle only, and to their interaction.DesignProspective cohort study.SettingNurses’ Health Study (1988-2012) and Nurses’ Health Study II (1991-2013).Participants143 410 women without type 2 diabetes, cardiovascular disease, or cancer at baseline.ExposuresRotating night shift work was defined as at least three night shifts per month in addition to day and evening shifts in that month. Unhealthy lifestyles included current smoking, physical activity levels below 30 minutes per day at moderate to vigorous intensity, diet in the bottom three fifths of the Alternate Healthy Eating Index score, and body mass index of 25 or above.Main outcome measuresIncident cases of type 2 diabetes were identified through self report and validated by a supplementary questionnaire.ResultsDuring 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred. The multivariable adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five year increment of duration of rotating night shift work and 2.30 (1.88 to 2.83) per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity). For the joint association of per five year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001). The proportions of the joint association were 17.1% (14.0% to 20.8%) for rotating night shift work alone, 71.2% (66.9% to 75.8%) for unhealthy lifestyle alone, and 11.3% (7.3% to 17.3%) for their additive interaction.ConclusionsAmong female nurses, both rotating night shift work and unhealthy lifestyle were associated with a higher risk of type 2 diabetes. The excess risk of rotating night shift work combined with unhealthy lifestyle was higher than the addition of risk associated with each individual factor. These findings suggest that most cases of type 2 diabetes could be prevented by adhering to a healthy lifestyle, and the benefits could be greater in rotating night shift workers.

scholarly journals Multimorbidity, physical frailty, and self-rated health in older patients with atrial fibrillation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hawa O. Abu ◽  
Jane Saczynski ◽  
Jordy Mehawej ◽  
Tenes Paul ◽  
Hamza Awad ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Health Status ◽  
Older Patients ◽  
Logistic Models ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Self Rated Health ◽  
Patient Reported ◽  
Fair Poor

Abstract Background Holistic care models emphasize management of comorbid conditions to improve patient-reported outcomes in treatment of atrial fibrillation (AF). We investigated relations between multimorbidity, physical frailty, and self-rated health (SRH) among older adults with AF. Methods Patients (n = 1235) with AF aged 65 years and older were recruited from five medical centers in Massachusetts and Georgia between 2015 and 2018. Ten previously diagnosed cardiometabolic and 8 non-cardiometabolic conditions were assessed from medical records. Physical Frailty was assessed with the Cardiovascular Health Study frailty scale. SRH was categorized as either “excellent/very good”, “good”, and “fair/poor”. Separate multivariable ordinal logistic models were used to examine the associations between multimorbidity and SRH, physical frailty and SRH, and multimorbidity and physical frailty. Results Overall, 16% of participants rated their health as fair/poor and 14% were frail. Hypertension (90%), dyslipidemia (80%), and heart failure (37%) were the most prevalent cardiometabolic conditions. Arthritis (51%), anemia (31%), and cancer (30%), the most common non-cardiometabolic diseases. After multivariable adjustment, patients with higher multimorbidity were more likely to report poorer health status (Odds Ratio (OR): 2.15 [95% CI: 1.53–3.03], ≥ 8 vs 1–4; OR: 1.37 [95% CI: 1.02–1.83], 5–7 vs 1–4), as did those with more prevalent cardiometabolic and non-cardiometabolic conditions. Patients who were pre-frail (OR: 1.73 [95% CI: 1.30–2.30]) or frail (OR: 6.81 [95% CI: 4.34–10.68]) reported poorer health status. Higher multimorbidity was associated with worse frailty status. Conclusions Multimorbidity and physical frailty were common and related to SRH. Our findings suggest that holistic management approaches may influence SRH among older patients with AF.

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