scholarly journals Effect of Selected Factors on the Serum 25(OH)D Concentration in Women Treated for Breast Cancer

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 564
Author(s):  
Agnieszka Radom ◽  
Andrzej Wędrychowicz ◽  
Stanisław Pieczarkowski ◽  
Szymon Skoczeń ◽  
Przemysław Tomasik
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Treatment ◽  
Serum Vitamin ◽  
Study Groups ◽  
Breast Cancer Treatment ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Average Dose ◽  
Serum Vitamin D

Maintaining an optimal vitamin D concentration reduces the risk of recurrence and extends survival time in patients after breast cancer treatment. Data on vitamin D deficiency among Polish women after breast cancer therapy are limited. Thus, the aim of the study was the analysis of vitamin D status in post-mastectomy patients, considering such factors as seasons, social habits, vitamin D supplementation and its measurements. The study involved 94 women after breast cancer treatment. Serum vitamin D concentration was measured, and a questionnaire, gathering demographic and clinical data regarding cancer, diet, exposure to sun radiation, and knowledge of recommendations on vitamin D supplementation, was delivered twice, in both winter and in summer. The control group consisted of 94 age-matched women with no oncological history. In women after breast cancer treatment, 25-hydroxyvitamin D (25(OH)D) deficiency was much more frequent than in the general population. Only about half of the patients supplemented vitamin D at the beginning of the study. After the first test and the issuing of recommendations on vitamin D supplementation, the percentage of vitamin D supplemented patients increased by about 30% in study groups. The average dose of supplement also increased. None of the women that were not supplementing vitamin D and were tested again in winter had optimal 25(OH)D concentration. It was concluded that vitamin deficiency is common in women treated for breast cancer. Medical advising about vitamin D supplementation and monitoring of 25(OH)D concentration should be improved.

scholarly journals Vitamin D status in full-term exclusively breastfed infants versus full-term breastfed infants receiving vitamin D supplementation in Thailand: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chayatat Ruangkit ◽  
Sukrit Suwannachat ◽  
Pornchanok Wantanakorn ◽  
Napapailin Sethaphanich ◽  
Surapat Assawawiroonhakarn ◽  
...  
Keyword(s):  
Vitamin D ◽  
Growth Parameters ◽  
Intervention Group ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Full Term ◽  
Control Group ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Breastfed Infants

Abstract Background Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants’ growth parameters were compared between the two groups. Results The infants’ serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of > 20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). There were no significant differences in the maternal 25OHD concentrations between the control and intervention groups (25.08 ± 7.75 vs. 23.75 ± 7.64 ng/mL, p = 0.42). Serum calcium, phosphorus, intact parathyroid hormone, alkaline phosphatase, and infants’ growth parameters were comparable between the two groups. After adjustment for the confounding factors, 25OHD concentration in the intervention group was 25.66 ng/mL higher than the control group (95% confidence interval, 19.07–32.25; p < 0.001). Vitamin D supplement contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01). Conclusions Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency. Trial registration The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

scholarly journals Vitamin D Status in Full-term Exclusively Breastfed Infants versus Full-term Breastfed Infants Receiving Vitamin D Supplementation in Thailand: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Chayatat Ruangkit ◽  
Sukrit Suwannachat ◽  
Pornchanok Wantanakorn ◽  
Napapailin Sethaphanich ◽  
Surapat Assawawiroonhakarn ◽  
...  
Keyword(s):  
Vitamin D ◽  
Intervention Group ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Full Term ◽  
Control Group ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Breastfed Infants ◽  
25Ohd Concentration

Abstract Background: Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods: Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants' growth parameters were compared between the two groups. Results: The infants' serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of >20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). Vitamin D supplementation in breastfed infants increased the mean serum 25OHD concentration by 25.66 ng/mL (95% confidence interval, 19.07–32.25; p < 0.001) and contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01).Conclusions: Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency.Trial registration: The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

Vitamin D and breast cancer

2014 ◽  
Vol 155 (28) ◽  
pp. 1091-1096 ◽  
Author(s):  
Tamás Nagykálnai ◽  
László Landherr ◽  
András Csaba Nagy
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Tumor Suppressor Genes ◽  
Active Form ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Scientific Publications ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The active form of vitamin D, in conjunction with his own receptor, affect a multitude of biological processes in the cell (inter alia it influences the expression of oncogenes and tumor suppressor genes). There is an increasing volume of scientific publications examining the relationships between serum vitamin D levels, vitamin D supplementation and malignant diseases. Some articles suggest inverse relationship between the low serum levels of vitamin D and the breast cancer risk and mortality, whilst other publications do not support this view. Thus the present opinion is conflicted. Vitamin D can exert a beneficial influence on the symptoms and outcomes of a large number of ailments, but its role in affecting cancer is still not completely clear. Orv. Hetil., 2014, 155(28), 1091–1096.

scholarly journals Seven-month Wintertime Supplementation of 1200 IU Vitamin D Has No Effect on Hand Grip Strength in Young, Physically Active Males: A Randomized, Controlled Study.

2021 ◽  
Author(s):  
Leho Rips ◽  
Alar Toom ◽  
Rein Kuik ◽  
Ahti Varblane ◽  
Hanno Mölder ◽  
...  
Keyword(s):  
Vitamin D ◽  
Grip Strength ◽  
Intervention Group ◽  
Winter Season ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Hand Grip Strength ◽  
Control Group ◽  
Serum Vitamin D ◽  
Hand Grip

Abstract BackgroundThere has been a growing interest in the role of vitamin D for the well-being and physical performance of humans; however, there is a lack of long-term supplementation studies performed on members of the young, physically active, male population.The hypothesis of the study was that vitamin D supplementation during wintertime will decrease the prevalence of critically low vitamin D blood serum levels and increase hand grip strength during the winter season among young male conscripts. Study DesignLongitudinal, triple-blinded, randomized, placebo-controlled trial. MethodsFifty-three male conscripts from the Estonian Army were randomized into two groups: 27 to an intervention group and 26 to a placebo group. The groups were comparable in terms of their demographics. The intervention group received 1200 IU (30 µg) capsules of vitamin D3 and the control group received placebo oil capsules once per day. The length of the follow-up was seven months, from October 2016 until April 2017. Blood serum vitamin D (25(OH)D), parathyroid hormone (PTH), calcium (Ca), ionized calcium (Ca-i), testosterone and cortisol values and hand grip strength were measured four times during the study period. ResultsThe mean 25(OH)D level decreased significantly in the control group to a critically low level during the study, with the lowest mean value of 22 nmol/l found in March 2017. At that time point, 65% in the control group vs 15% in the intervention group had 25(OH)D values of less than 25 nmol/l (p < 0.001). In the intervention group the levels of 25(OH)D did not change significantly during the study period. All other blood tests revealed no significant differences at any time point. The corresponding result was found for hand grip strength at all time points. ConclusionLong-term vitamin D supplementation during wintertime results in fewer conscripts in the Estonian Army with critically low serum vitamin D (25(OH)D) levels during the winter season. However, this did not influence their physical performance in the form of the hand grip strength test. Trial registrationClinicalTrials.gov Identifier: NCT04359524. Registered 20 April 2020 - Retrospectively registered. https://register.clinicaltrials.gov

Determination of Vitamin D and D-Dimer Levels in Dogs with Ehrlichia canis Infection

2020 ◽  
Author(s):  
Gozde Atikyilmaz ◽  
C. Cagri Cingi
Keyword(s):  
Vitamin D ◽  
Laboratory Tests ◽  
Serum Vitamin ◽  
Study Groups ◽  
Pcr Analysis ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Test Kit ◽  
D Dimer

Background: Ehrlichiosis is a ricketsial disease transmitted by ticks and characterized by reticuloendothelial hyperplasia, fever, generalized lymphadenopathy, splenomegaly and thrombocytopenia. In this study, it was aimed to determine the blood vitamin D and D-dimer levels in dogs with Ehrlichiosis. Methods: The material of this study consisted of 33 dogs of different breeds, ages and both sexes during the period of 2018-2019. In 33 dogs with and without thrombocytopenia with clinical findings, definitive diagnosis and differential diagnosis were made with clinical examination and laboratory tests. All patients were evaluated for Ehrlichiosis with rapid Snap 4DX test kit. In addition, the diagnosis of the disease was made by PCR analysis. Blood D-Dimer levels were determined in control and study groups. Result: D-Dimer levels were significantly higher in the study groups when compared with the control group. Further, when blood D-vitamin levels of control and study groups were compared, it was found that blood D-vitamin levels were significantly lower in dogs with Ehrlichiosis. In conclusion, in this study, D-dimer levels were significantly increased in dogs with ehlichiosis and can be an adjunct biomarker with other clinical, hematologic and laboratory tests. In addition, serum vitamin D levels were found to be low in both active and acute infected patients in dogs previously exposed to the causative agent, which is closely related to the immune system of vitamin D and serum low vitamin D levels may pave the way for the development of ehrlichiosis disease.

scholarly journals Does vitamin D administration play a role in outcome of patients with acute ischemic stroke? A randomized controlled trial

2021 ◽  
Author(s):  
Omidvar Rezaei ◽  
Mahtab Ramezani ◽  
Mehrdad Roozbeh ◽  
Bahareh Fazeli ◽  
Mohammadreza Hajiesmaeili ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Single Dose ◽  
Acute Ischemic Stroke ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Neurological Outcomes ◽  
Serum Vitamin D ◽  
Tnf Α

Background: Clinical studies have reported improved neurological outcomes in patients who were taking vitamin D supplements. This study investigates the effect of intramuscular (IM) vitamin D supplementation in patients with acute ischemic stroke (AIS) on neurological outcomes and inflammatory marker levels. Methods: This study included patients diagnosed with AIS (n = 60) from the Neurology Unit of Loghman Hakim Hospital, Tehran, Iran, during the year 2019. Patients with AIS were allocated randomly into two groups who received a single dose of 300000 IU IM vitamin D and a control group that did not receive vitamin D supplementation. Serum vitamin D concentration, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) levels, as primary outcomes, and the Modified Rankin Scale (MRS), the National Institute of Health Stroke Scale (NIHSS), and the Mini-Mental State Examination (MMSE), as secondary outcomes, were measured at the baseline and the end of the study (6 weeks). Results: Eventually, 59 patients with AIS completed the intervention study. A single dose of 300000 IU increased vitamin D level; moreover, vitamin D supplementation improved MRS and IL-6 levels significantly (P = 0.01, P = 0.02, respectively). There were reverse correlations between serum vitamin D and NIHSS and TNF-α after vitamin D administration. However, no statistically significant effect of vitamin D on the TNF-α or NIHSS and MMSE was seen compared to the control group. Conclusion: Vitamin D probably due to a single dose

Impact of Vitamin D Supplementation on Attention-Deficit Hyperactivity Disorder in Children

2018 ◽  
Vol 52 (7) ◽  
pp. 623-631 ◽  
Author(s):  
Hatem Hamed Elshorbagy ◽  
Naglaa Fathy Barseem ◽  
Waleed Elsayed Abdelghani ◽  
Hany Abdelaziz Ibrahim Suliman ◽  
Ashraf Hamed Al-shokary ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Function ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Children With Adhd ◽  
Serum Vitamin D ◽  
Hyperactivity Disorder

Background: The role of nutrients and dietary factors in attention-deficit hyperactivity disorder (ADHD) remains unclear. Objectives: The primary objective was to evaluate the serum vitamin D level in children with a diagnosis of ADHD. The secondary objective was to detect the effect of vitamin D supplementation on cognitive function in those with vitamin D deficiency. Methods: A total of 50 children with ADHD and 40 healthy controls were included in the study. We measured the serum level of vitamin D. Patients with vitamin D deficiency were subdivided into 2 groups: one with vitamin D supplementation and the other without vitamin D supplementation. Further assessment and follow-up of children with ADHD was done. The Wisconsin Card Sorting Test, Conners’ Parent Rating Scale, and Wechsler Intelligence Scale for Children were performed at baseline and follow-up in all cohorts with an ADHD diagnosis. Results: The diagnosis of vitamin D deficiency was significantly greater in children with ADHD compared with the control group ( P < 0.05). Children with ADHD had significantly ( P = 0.0009) lower values of serum vitamin D (17.23 ± 8.98) than the control group(31.47 ± 14.42). The group receiving vitamin D supplementation demonstrated improvement in cognitive function in the conceptual level, inattention, opposition, hyperactivity, and impulsivity domains. Conclusion: Vitamin D supplementation in children with ADHD may improve cognitive function.

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