scholarly journals Consumption of a High-Protein Meal Replacement Leads to Higher Fat Oxidation, Suppression of Hunger, and Improved Metabolic Profile After an Exercise Session

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 155
Author(s):  
Camila L. P. Oliveira ◽  
Normand G. Boulé ◽  
Aloys Berg ◽  
Arya M. Sharma ◽  
Sarah A. Elliott ◽  
...  
Keyword(s):  
Metabolic Profile ◽  
Fat Oxidation ◽  
High Protein ◽  
Whole Body ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Meal Replacement ◽  
Protein Meal ◽  
High Protein Meal ◽  
The Impact

The aim of this study was to compare the impact of a high-protein meal replacement (HP-MR) versus a control (CON) breakfast on exercise metabolism. In this acute, randomized controlled, cross-over study, participants were allocated into two isocaloric arms: (a) HP-MR: 30% carbohydrate, 43% protein, and 27% fat; (b) CON: 55% carbohydrate, 15% protein, and 30% fat. Following breakfast, participants performed a moderate-intensity aerobic exercise while inside a whole-body calorimetry unit. Energy expenditure, macronutrient oxidation, appetite sensations, and metabolic blood markers were assessed. Forty-three healthy, normal-weight adults (24 males) participated. Compared to the CON breakfast, the HP-MR produced higher fat oxidation (1.07 ± 0.33 g/session; p = 0.003) and lower carbohydrate oxidation (−2.32 ± 0.98 g/session; p = 0.023) and respiratory exchange ratio (−0.01 ± 0.00; p = 0.003) during exercise. After exercise, increases in hunger were lower during the HP-MR condition. Changes in blood markers from the fasting state to post-exercise during the HP-MR condition were greater for insulin, peptide tyrosine-tyrosine, and glucagon-like peptide 1, and lower for low-density lipoprotein cholesterol, triglyceride, and glycerol. Our primary findings were that an HP-MR produced higher fat oxidation during the exercise session, suppression of hunger, and improved metabolic profile after it.

scholarly journals A high-protein total diet replacement increases energy expenditure and leads to negative fat balance in healthy, normal-weight adults

2020 ◽  
Author(s):  
Camila L P Oliveira ◽  
Normand G Boulé ◽  
Arya M Sharma ◽  
Sarah A Elliott ◽  
Mario Siervo ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Dietary Intervention ◽  
Fat Oxidation ◽  
Normal Weight ◽  
High Protein ◽  
Whole Body ◽  
Balance Study ◽  
Oxidation Rates ◽  
Total Diet ◽  
The Impact

ABSTRACT Background High-protein diets and total diet replacements are becoming increasingly popular for weight loss; however, further research is needed to elucidate their impact on the mechanisms involved in weight regulation. Objective The aim of this inpatient metabolic balance study was to compare the impact of a high-protein total diet replacement (HP-TDR) versus a control diet (CON) on select components of energy metabolism in healthy adults of both sexes. Methods The acute intervention was a randomized, controlled, crossover design with participants allocated to 2 isocaloric arms: 1) HP-TDR: 35% carbohydrate, 40% protein, and 25% fat achieved through a nutritional supplement; 2) CON: 55% carbohydrate, 15% protein, and 30% fat. Participants received the prescribed diets for 32 h while inside a whole-body calorimetry unit (WBCU). The first dietary intervention randomly offered in the WBCU was designed to maintain energy balance and the second matched what was offered during the first stay. Energy expenditure, macronutrient oxidation rates and balances, and metabolic blood markers were assessed. Body composition was measured at baseline using DXA. Results Forty-three healthy, normal-weight adults (19 females and 24 males) were included. Compared with the CON diet, the HP-TDR produced higher total energy expenditure [(EE) 81 ± 82 kcal/d, P <0.001], protein and fat oxidation rates (38 ± 34 g/d, P <0.001; 8 ± 20 g/d, P = 0.013, respectively), and a lower carbohydrate oxidation rate (–38 ± 43 g/d, P <0.001). Moreover, a HP-TDR led to decreased energy (–112 ± 85 kcal/d; P <0.001), fat (–22 ± 20 g/d; P <0.001), and carbohydrate balances (–69 ± 44 g/d; P <0.001), and increased protein balance (90 ± 32 g/d; P <0.001). Conclusions Our primary findings were that a HP-TDR led to higher total EE, increased fat oxidation, and negative fat balance. These results suggest that a HP-TDR may promote fat loss compared with a conventional isocaloric diet. These trials were registered at clinicaltrials.gov as NCT02811276 and NCT03565510.

scholarly journals Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise

Aging Cell ◽  
2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Carolyn Chee ◽  
Chris E. Shannon ◽  
Aisling Burns ◽  
Anna L. Selby ◽  
Daniel Wilkinson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Fat ◽  
Fat Oxidation ◽  
Whole Body ◽  
Moderate Intensity ◽  
Older Individuals ◽  
Moderate Intensity Exercise

Effect of a meal containing protein on lithium clearance and plasma immunoreactive atrial natriuretic peptide in man

1988 ◽  
Vol 75 (2) ◽  
pp. 151-157 ◽  
Author(s):  
L. R. Solomon ◽  
J. C. Atherton ◽  
H. Bobinski ◽  
S. L. Cottam ◽  
C. Gray ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Protein Content ◽  
Natriuretic Peptide ◽  
Proximal Tubules ◽  
High Protein ◽  
Lithium Clearance ◽  
Protein Meal ◽  
Low Protein ◽  
High Protein Meal ◽  
Atrial Natriuretic

1. The effect of meals with a high and low protein content and of the fasting state on renal function and plasma atrial natriuretic peptide was studied in water-loaded normal volunteers. 2. Creatinine clearance increased after the high protein meal, but did not change after the low protein meal or while fasting. Observations of similar increases in urine sodium and potassium excretion and a transient decrease in urine flow after both meals suggest that the protein content of the meal is not an important contributory factor in these responses to feeding. 3. Absolute delivery of sodium and water out of the proximal tubules (assessed by the lithium clearance method) was higher after both meals than while fasting; fractional lithium clearance was higher after the low protein meal than the high protein meal and while fasting. Absolute reabsorption from proximal tubules was increased after only the high protein meal. 4. A transient decrease in the fraction of water delivered to distal nephron segments that appeared in the urine (fractional distal water excretion) was observed after both meals. Fractional distal sodium excretion and absolute distal sodium and water reabsorption increased after both meals. 5. Since plasma atrial natriuretic peptide either decreased (high protein meal) or remained unchanged (low protein meal and fasting), it is unlikely that this hormone is involved in the hyperfiltration after the high protein meal and the natriuresis after both high and low protein meals.

scholarly journals Effect of a high protein meal on the bioavailability of verapamil.

1986 ◽  
Vol 21 (3) ◽  
pp. 337-338 ◽  
Author(s):  
BG Woodcock ◽  
N. Kraemer ◽  
N. Rietbrock
Keyword(s):  
High Protein ◽  
Protein Meal ◽  
High Protein Meal

scholarly journals Rapid stimulation of the hepatic glycine-cleavage system in rats fed on a single high-protein meal

1992 ◽  
Vol 283 (2) ◽  
pp. 441-447 ◽  
Author(s):  
H S Ewart ◽  
M Jois ◽  
J T Brosnan
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Rat Liver Mitochondria ◽  
Casein Diet ◽  
Glycine Cleavage System ◽  
Protein Meal ◽  
High Protein Meal ◽  
Protein Feeding ◽  
Glycine Cleavage ◽  
Stimulation Of

Glycine catabolism was studied in isolated rat liver mitochondria by measuring the release of 14CO2 from [1-14C]glycine. Mitochondria isolated from rats fed on a high-protein (60% casein) diet for 5 days showed an enhanced ability to catabolize glycine compared with mitochondria from rats fed on a normal-protein (15% casein) diet. Glycine catabolism was also stimulated in normal protein-fed rats if they ingested a single high-protein meal for 2 h before being killed, thus illustrating the rapid response of the glycine-cleavage system to protein intake. The stimulation of glycine catabolism in rats given a high-protein diet or meal was not evident if the mitochondria were incubated in the absence of P(i) (omitting ADP had no effect on the rate). Mitochondria from high-protein- and normal-protein-fed rats did not differ in their ability to accumulate glycine, a process which occurred far too rapidly to impose a limit on the rate of flux through the glycine-cleavage system. The stimulation of glycine catabolism by high-protein feeding was not associated with a change in mitochondrial matrix volume. Furthermore, mitochondria from rats fed on a high-protein meal maintained an enhanced ability to catabolize glycine compared with those from rats fed on a normal-protein meal when incubated in hypo-osmotic solutions of very low osmolarity. When mitochondria from high-protein- or normal-protein-fed rats were maximally activated by incubation in the presence of 0.25 microM-Ca2+, the rates of glycine catabolism were high, but similar, showing that the stimulation of glycine catabolism by high-protein feeding does not involve an increase in the total capacity of the system. These findings show that hepatic glycine catabolism is stimulated rapidly by high-protein feeding, a response that we suggest is involved in the disposal of the excess glycine in the diet.

scholarly journals Oral Gabapentin Disposition in Patients with Epilepsy After a High-Protein Meal

Epilepsia ◽  
1997 ◽  
Vol 38 (10) ◽  
pp. 1140-1142 ◽  
Author(s):  
P. Benetello ◽  
M. Furlanut ◽  
M. Fortunato ◽  
M. Barldo ◽  
F. Pea ◽  
...  
Keyword(s):  
High Protein ◽  
Protein Meal ◽  
High Protein Meal ◽  
Patients With Epilepsy

Effects of a high-carbohydrate versus high-protein meal on acute responses to hypoxia at rest and exercise

2012 ◽  
Vol 113 (3) ◽  
pp. 691-702 ◽  
Author(s):  
Keyne Charlot ◽  
Aurélien Pichon ◽  
Jean-Paul Richalet ◽  
Didier Chapelot
Keyword(s):  
High Protein ◽  
Protein Meal ◽  
High Carbohydrate ◽  
Acute Responses ◽  
High Protein Meal ◽  
Rest And Exercise
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