scholarly journals The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 86
Author(s):  
Zuqun Wang ◽  
Rui Ding ◽  
Juan Wang
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Cochrane Library ◽  
Vitamin D Status ◽  
Case Control Studies ◽  
Lower Vitamin

The association between vitamin D status and autism spectrum disorder (ASD) is well-investigated but remains to be elucidated. We quantitatively combined relevant studies to estimate whether vitamin D status was related to ASD in this work. PubMed, EMBASE, Web of Science, and the Cochrane Library were searched to include eligible studies. A random-effects model was applied to pool overall estimates of vitamin D concentration or odds ratio (OR) for ASD. In total, 34 publications involving 20,580 participants were identified in this present study. Meta-analysis of 24 case–control studies demonstrated that children and adolescents with ASD had significantly lower vitamin D concentration than that of the control group (mean difference (MD): −7.46 ng/mL, 95% confidence interval (CI): −10.26; −4.66 ng/mL, p < 0.0001, I2 = 98%). Quantitative integration of 10 case–control studies reporting OR revealed that lower vitamin D was associated with higher risk of ASD (OR: 5.23, 95% CI: 3.13; 8.73, p < 0.0001, I2 = 78.2%). Analysis of 15 case–control studies barring data from previous meta-analysis reached a similar result with that of the meta-analysis of 24 case–control studies (MD: −6.2, 95% CI: −9.62; −2.78, p = 0.0004, I2 = 96.8%), which confirmed the association. Furthermore, meta-analysis of maternal and neonatal vitamin D showed a trend of decreased early-life vitamin D concentration in the ASD group (MD: −3.15, 95% CI: −6.57; 0.26, p = 0.07, I2 = 99%). Meta-analysis of prospective studies suggested that children with reduced maternal or neonatal vitamin D had 54% higher likelihood of developing ASD (OR: 1.54, 95% CI: 1.12; 2.10, p = 0.0071, I2 = 81.2%). These analyses indicated that vitamin D status was related to the risk of ASD. The detection and appropriate intervention of vitamin D deficiency in ASD patients and pregnant and lactating women have clinical and public significance.

scholarly journals Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study

2019 ◽  
Vol 12 (6) ◽  
pp. 976-988 ◽  
Author(s):  
Rebecca J. Schmidt ◽  
Qiaojuan Niu ◽  
Darryl W. Eyles ◽  
Robin L. Hansen ◽  
Ana‐Maria Iosif
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Developmental Delay ◽  
Case Control Study ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Vitamin D Status ◽  
Control Study

Vitamin D status of children with Autism Spectrum Disorder: Case-control study from India

2017 ◽  
Vol 30 ◽  
pp. 200-201 ◽  
Author(s):  
Salah Basheer ◽  
Archana Natarajan ◽  
Therese van Amelsvoort ◽  
Manjunatha M. Venkataswamy ◽  
Vasanthapuram Ravi ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Case Control Study ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Vitamin D Status ◽  
Control Study

scholarly journals The Association between Autism Spectrum Disorder and Pre- and Postnatal Antibiotic Exposure in Childhood—A Systematic Review with Meta-Analysis

2019 ◽  
Vol 16 (20) ◽  
pp. 4042 ◽  
Author(s):  
Eunmi Lee ◽  
Jeonghyun Cho ◽  
Ka Young Kim
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Disorder ◽  
Web Of Science ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cochrane Library ◽  
Antibiotic Exposure ◽  
Children With Asd ◽  
Meta Analyses

Autism spectrum disorder (ASD) is a developmental disorder that begins in early childhood and has been associated with several environmental and genetic factors. We aimed to conduct two-side meta-analyses to determine the association between ASD and pre- and postnatal antibiotic exposure in childhood. We searched PubMed, Embase, Web of Science, and Cochrane Library for articles published up to February 2019. We evaluated observational studies that assessed the association between ASD and antibiotic exposure. Of 1459 articles, nine studies were used in the meta-analysis. We found that early antibiotic exposure, including pre- and postnatal, significantly increased the ASD risk in children. Furthermore, early antibiotic exposure, including pre- and postnatal, was significantly increased in children with ASD. Specifically, prenatal antibiotic exposure was significantly increased in children with ASD; however, postnatal antibiotic exposure was not. Our results indicate an association between ASD and early antibiotic exposure; specifically, that prenatal antibiotic exposure is an important risk factor of ASD in children.

scholarly journals Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lei Chen ◽  
Xiao-Jie Shi ◽  
Hua Liu ◽  
Xiao Mao ◽  
Lue-Ning Gui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorder ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Oxidative Stress Marker ◽  
Cochrane Library ◽  
Stress Profile ◽  
Stress Marker ◽  
Children With Asd

AbstractThere is increasing awareness that oxidative stress may be implicated in the pathophysiology of autism spectrum disorder (ASD). Here we aimed to investigate blood oxidative stress marker profile in ASD children by a meta-analysis. Two independent investigators systematically searched Web of Science, PubMed, and Cochrane Library and extracted data from 87 studies with 4928 ASD children and 4181 healthy control (HC) children. The meta-analysis showed that blood concentrations of oxidative glutathione (GSSG), malondialdehyde, homocysteine, S-adenosylhomocysteine, nitric oxide, and copper were higher in children with ASD than that of HC children. In contrast, blood reduced glutathione (GSH), total glutathione (tGSH), GSH/GSSG, tGSH/GSSG, methionine, cysteine, vitamin B9, vitamin D, vitamin B12, vitamin E, S-adenosylmethionine/S-adenosylhomocysteine, and calcium concentrations were significantly reduced in children with ASD relative to HC children. However, there were no significance differences between ASD children and HC children for the other 17 potential markers. Heterogeneities among studies were found for most markers, and meta-regressions indicated that age and publication year may influence the meta-analysis results. These results therefore clarified blood oxidative stress profile in children with ASD, strengthening clinical evidence of increased oxidative stress implicating in pathogenesis of ASD. Additionally, given the consistent and large effective size, glutathione metabolism biomarkers have the potential to inform early diagnosis of ASD.

scholarly journals The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 26
Author(s):  
Monia Kittana ◽  
Asma Ahmadani ◽  
Lily Stojanovska ◽  
Amita Attlee
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Cochrane Library ◽  
Children With Asd

Children with autism spectrum disorder (ASD) present with persistent deficits in both social communication and interactions, along with the presence of restricted and repetitive behaviors, resulting in significant impairment in significant areas of functioning. Children with ASD consistently reported significantly lower vitamin D levels than typically developing children. Moreover, vitamin D deficiency was found to be strongly correlated with ASD severity. Theoretically, vitamin D can affect neurodevelopment in children with ASD through its anti-inflammatory properties, stimulating the production of neurotrophins, decreasing the risk of seizures, and regulating glutathione and serotonin levels. A Title/Abstract specific search for publications on Vitamin D supplementation trials up to June 2021 was performed using two databases: PubMed and Cochrane Library. Twelve experimental studies were included in the synthesis of this review. Children with ASD reported a high prevalence of vitamin D deficiency or insufficiency. In general, it was observed that improved vitamin D status significantly reduced the ASD severity, however, this effect was not consistently different between the treatment and control groups. The variations in vitamin D dose protocols and the presence of concurrent interventions might provide an explanation for the variability of results. The age of the child for introducing vitamin D intervention was identified as a possible factor determining the effectiveness of the treatment. Common limitations included a small number of participants and a short duration of follow-ups in the selected studies. Long-term, well-designed randomized controlled trials are warranted to confirm the effect of vitamin D on severity in children with ASD.

Sign in / Sign up

Export Citation Format

Share Document