scholarly journals Sasa quelpaertensis Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3762
Author(s):  
Jeong Yong Park ◽  
Mi Gyeong Jang ◽  
Jung Min Oh ◽  
Hee Chul Ko ◽  
Sung-Pyo Hur ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Signaling Pathway ◽  
Lipid Accumulation ◽  
Leaf Extract ◽  
Metabolic Disorders ◽  
Metabolic Dysfunction ◽  
Hepatic Lipid ◽  
High Fructose Diet ◽  
Hepatic Lipid Accumulation ◽  
High Fructose

Background: Increased dietary fructose consumption is closely associated with lipid and glucose metabolic disorders. Sasa quelpaertensis Nakai possesses various health-promoting properties, but there has been no research on its protective effect against fructose-induced metabolic dysfunction. In this study, we investigated the effects of S. quelpaertensis leaf extract (SQE) on metabolic dysfunction in high-fructose-diet-fed rats. Methods: Animals were fed a 46% carbohydrate diet, a 60% high-fructose diet, or a 60% high-fructose diet with SQE (500 mg/kg of body weight (BW)/day) in drinking water for 16 weeks. Serum biochemical parameters were measured and the effects of SQE on hepatic histology, protein expression, and transcriptome profiles were investigated. Results: SQE improved dyslipidemia and insulin resistance induced in high-fructose-diet-fed rats. SQE ameliorated the lipid accumulation and inflammatory response in liver tissues by modulating the expressions of key proteins related to lipid metabolism and antioxidant response. SQE significantly enriched the genes related to the metabolic pathway, namely, the tumor necrosis factor (TNF) signaling pathway and the PI3K-Akt signaling pathway. Conclusions: SQE could effectively prevent dyslipidemia, insulin resistance, and hepatic lipid accumulation by regulation of metabolism-related gene expressions, suggesting its role as a functional ingredient to prevent lifestyle-related metabolic disorders.

scholarly journals Intake of Farmed Atlantic Salmon Fed Soybean Oil Increases Insulin Resistance and Hepatic Lipid Accumulation in Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53094 ◽  
Author(s):  
Lisa Kolden Midtbø ◽  
Mohammad Madani Ibrahim ◽  
Lene Secher Myrmel ◽  
Ulrike Liisberg Aune ◽  
Anita Røyneberg Alvheim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Atlantic Salmon ◽  
Soybean Oil ◽  
Lipid Accumulation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Farmed Atlantic Salmon

scholarly journals Wheat Flour, Enriched with γ-Oryzanol, Phytosterol, and Ferulic Acid, Alleviates Lipid and Glucose Metabolism in High-Fat-Fructose-Fed Rats

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1697
Author(s):  
Xiao-Xuan Guo ◽  
Zhu Zeng ◽  
Yong-Zhong Qian ◽  
Jing Qiu ◽  
Kai Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Western Blot ◽  
Ferulic Acid ◽  
Wheat Flour ◽  
Lipid Accumulation ◽  
Functional Food ◽  
Metabolic Dysfunction ◽  
High Fat ◽  
Hepatic Lipid Accumulation

(1) Background: Modern dietary patterns with a high intake of fat and fructose, as well as refined carbohydrates, closely relate to lipid/glucose metabolic disorders. The main objective of this study is to provide new thoughts in designing functional food with some lipid/glucose metabolism regulating effects for obese people. (2) Methods: The alleviating abilities of γ-oryzanol, phytosterol or ferulic acid-enriched wheat flour on lipid/glucose metabolic dysfunction were evaluated in male SD rats induced by a high-fat-fructose diet. The underlying mechanisms were clarified using western blot. (3) Results: In an in vitro cell model, γ-oryzanol, phytosterol and ferulic acid regulate lipid/glucose metabolism by increasing the phosphorylation of AMPK and Akt, and PI3K expression, as well as decreasing expressions of DGAT1 and SCD. The in vivo study shows that ferulic acid and γ-oryzanol-enriched flours are beneficial for managing body weight, improving glucose metabolism, hyperlipidemia and hepatic lipid accumulation. Phytosterol-enriched flour exerted remarkable effects in regulating hyperinsulinemia, insulin resistance and hyperuricemia. Western blot analysis of proteins from liver samples reveals that these enriched flours alleviated hepatic lipid accumulation and insulin resistance through their elevation in the phosphorylation of AMPK and Akt. (4) Conclusions: Our study indicates that these enriched flours can serve as a health-promoting functional food to regulate obesity-related lipid/glucose metabolic dysfunction in rats.

scholarly journals Curcumin attenuates insulin resistance and hepatic lipid accumulation in a rat model of intra-uterine growth restriction through insulin signalling pathway and sterol regulatory element binding proteins

2019 ◽  
Vol 122 (6) ◽  
pp. 616-624 ◽  
Author(s):  
Yu Niu ◽  
Jintian He ◽  
Hussain Ahmad ◽  
Chao Wang ◽  
Xiang Zhong ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Accumulation ◽  
Insulin Signalling ◽  
Regulatory Element ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Uterine Growth ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Intra Uterine Growth Restriction

AbstractThe objective of the present study was to investigate the effect of curcumin on insulin resistance (IR) and hepatic lipid accumulation in intra-uterine growth restriction (IUGR). Rats with a normal birth weight (NBW) or IUGR were fed basic diets (NBW and IUGR groups) or basic diets supplemented with curcumin (NBW-C and IUGR-C groups) from 6 to 12 weeks. Rats in the IUGR group showed higher levels of glucose and homeostasis model assessment for insulin resistance index (HOMA-IR) (P< 0·05) than in the NBW group. The livers of IUGR rats exhibited higher (P< 0·05) concentration of TAG and lower (P< 0·05) activities of lipolysis enzymes compared with the normal rats. In response to dietary curcumin supplementation, concentrations of serum insulin, glucose and HOMA-IR, pyruvate, TAG, total cholesterol and NEFA in the liver were decreased (P< 0·05). The concentrations of glycogen and activities of lipolysis enzymes in the liver were increased (P< 0·05) in the IUGR-C group compared with the IUGR group. These results were associated with lower (P< 0·05) phosphorylated insulin receptor substrate 1, protein kinase B or Akt, glycogen synthase kinase 3β and expressions of sterol regulatory element binding protein 1 and fatty acid synthase (FASN); decreased expressions forCd36, sterol regulatory element binding protein 1c (Srebf1) andFasn; increased (P< 0·05) expression of PPARα; and expressions forPparaand hormone-sensitive lipase in the liver of IUGR-C rats than the IUGR rats. Maternal malnutrition caused IR and lipid accumulation in the liver. Curcumin supplementation prevented IR by regulating insulin signalling pathways and attenuated hepatic lipid accumulation.

Effect of neonatal orally administered S-allyl cysteine in high-fructose diet fed Wistar rats

2017 ◽  
Vol 9 (2) ◽  
pp. 160-171 ◽  
Author(s):  
B. W. Lembede ◽  
K. H. Erlwanger ◽  
P. Nkomozepi ◽  
E. Chivandi
Keyword(s):  
Oral Administration ◽  
Adult Life ◽  
Visceral Obesity ◽  
Wistar Rat ◽  
Hepatic Lipid ◽  
High Fructose Diet ◽  
Hepatic Lipid Accumulation ◽  
Treatment Regimens ◽  
Group I ◽  
High Fructose

S-allyl cysteine (SAC) has antioxidant, antidiabetic and antiobesity properties. We hypothesized that neonatal oral administration of SAC would protect rats against neonatal and adulthood high-fructose diet-induced adverse metabolic outcomes in adulthood. In total, 112 (males=56; females=56), 4-day-old Wistar rat pups were randomly allocated to groups and administered the following treatment regimens daily for 15 days from postnatal day (PND) 6–20: group I – 10 ml/kg distilled water, group II – 10 ml/kg 20% fructose solution (FS), group III – 150 mg/kg SAC and group IV – SAC+FS. On PND 21, the pups were weaned and allowed to grow on a standard rat chow (SRC) until PND 56. The rats from each treatment regimen were then randomly split into two subgroups: one on a SRC and plain drinking water and another on SRC and 20% FS as drinking fluid and then subjected to these treatment regimens for 8 weeks after which they were euthanized and tissues collected for analyzes. Neonatal oral administration of SAC attenuated the neonatal high-fructose diet-induced programming for hepatic lipid accretion in adulthood but not against adulthood high-fructose diet-induced visceral obesity. Neonatal oral administration of SAC programmes for protection against neonatal fructose-induced programming for hepatic lipid accumulation thus could potentially protect against fat-mediated liver derangements in adult life.

Supplementation of a High-Fat Diet with Chlorogenic Acid Is Associated with Insulin Resistance and Hepatic Lipid Accumulation in Mice

2013 ◽  
Vol 61 (18) ◽  
pp. 4371-4378 ◽  
Author(s):  
Aidilla Mubarak ◽  
Jonathan M. Hodgson ◽  
Michael J. Considine ◽  
Kevin D. Croft ◽  
Vance B. Matthews
Keyword(s):  
Insulin Resistance ◽  
Chlorogenic Acid ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

scholarly journals Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation inApoe−/−Mice Fed with High-Fat Diet

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Zhan Liu ◽  
Peng Li ◽  
Zhi-Hong Zhao ◽  
Yu Zhang ◽  
Zhi-Min Ma ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Lipid Accumulation ◽  
Vitamin B6 ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Adverse Health Effects ◽  
Liver Functions ◽  
Endothelium Dependent Relaxation

Backgrounds.VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood.Methods.VitB6 (50 mg/kg/day) was given toApoe-/-mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined.Results.VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level inApoe-/-mice fed with HFD. In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions. Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver.Conclusions.Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation inApoe-/-mice fed with HFD. Supplementation of VitB6 should be considered to prevent metabolic syndrome.

Sign in / Sign up

Export Citation Format

Share Document