scholarly journals Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3603
Author(s):  
Daniel Collado-Mateo ◽  
Ana Myriam Lavín-Pérez ◽  
Eugenio Merellano-Navarro ◽  
Juan Del Coso
Keyword(s):  
Systematic Review ◽  
Oxidation Rate ◽  
Meta Analysis ◽  
Fat Oxidation ◽  
Caffeine Intake ◽  
Fasting Period ◽  
Fitness Level ◽  
Recreational Athletes ◽  
Other Substances ◽  
Dose Response Effect

A number of previous investigations have been designed to determine the effect of acute caffeine intake on the rate of fat oxidation during exercise. However, these investigations have shown contradictory results due to the differences in the exercise protocols used or the co-ingestion of caffeine with other substances. Hence, to date, there is no consensus about the effect of caffeine on fat oxidation during exercise. The purpose of this study was to conduct a systematic review followed by a meta-analysis to establish the effect of acute intake of caffeine (ranging from 2 to 7 mg/kg of body mass) on the rate of fat oxidation during exercise. A total of 19 studies published between 1978 and 2020 were included, all of which employed crossover experimental designs in which the ingestion of caffeine was compared to a placebo. Studies were selected if the exercise intensity was consistent in the caffeine and placebo trials and if these were preceded by a fasting protocol. A subsequent meta-analysis was performed using the random effects model to calculate the standardized mean difference (SMD). The meta-analysis revealed that caffeine significantly (p = 0.008) increased the fat oxidation rate (SMD = 0.73; 95% CI = 0.19 to 1.27). This increment was consistent with a significant (p = 0.04) reduction of the respiratory exchange ratio (SMD = −0.33; 95% CI = −0.65 to −0.01) and a significant (p = 0.049) increase in the oxygen uptake (SMD = 0.23; 95% CI = 0.01 to 0.44). The results also showed that there was a dose–response effect of caffeine on the fat oxidation rate, indicating that more than 3.0 mg/kg is necessary to obtain a statistically significant effect of this stimulant on fat oxidation during exercise. Additionally, the ability of caffeine to enhance fat oxidation during exercise was higher in sedentary or untrained individuals than in trained and recreational athletes. In conclusion, pre-exercise intake of a moderate dose of caffeine may effectively increase fat utilization during aerobic exercise of submaximal intensity performed after a fasting period. However, the fitness level of the participant may modulate the magnitude of the effect of caffeine on fat oxidation during exercise.

scholarly journals Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 868
Author(s):  
Jorge Lorenzo Calvo ◽  
Xueyin Fei ◽  
Raúl Domínguez ◽  
Helios Pareja-Galeano
Keyword(s):  
Systematic Review ◽  
Reaction Time ◽  
Cognitive Performance ◽  
Cognitive Functions ◽  
Web Of Science ◽  
Meta Analysis ◽  
Caffeine Intake ◽  
Inclusion Criteria ◽  
Research Protocols ◽  
The Relationship

Cognitive functions are essential in any form of exercise. Recently, interest has mounted in addressing the relationship between caffeine intake and cognitive performance during sports practice. This review examines this relationship through a structured search of the databases Medline/PubMed and Web of Science for relevant articles published in English from August 1999 to March 2020. The study followed PRISMA guidelines. Inclusion criteria were defined according to the PICOS model. The identified records reported on randomized cross-over studies in which caffeine intake (as drinks, capsules, energy bars, or gum) was compared to an identical placebo situation. There were no filters on participants’ training level, gender, or age. For the systematic review, 13 studies examining the impacts of caffeine on objective measures of cognitive performance or self-reported cognitive performance were selected. Five of these studies were also subjected to meta-analysis. After pooling data in the meta-analysis, the significant impacts of caffeine only emerged on attention, accuracy, and speed. The results of the 13 studies, nevertheless, suggest that the intake of a low/moderate dose of caffeine before and/or during exercise can improve self-reported energy, mood, and cognitive functions, such as attention; it may also improve simple reaction time, choice reaction time, memory, or fatigue, however, this may depend on the research protocols.

scholarly journals Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ka Ying Bonnie Ng ◽  
George Cherian ◽  
Alexandra J. Kermack ◽  
Sarah Bailey ◽  
Nick Macklon ◽  
...  
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Meta Analysis ◽  
Lifestyle Factors ◽  
Caffeine Intake ◽  
Increased Risk ◽  
Secondary Outcomes

AbstractIt is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the context of BMI, smoking, alcohol and caffeine intake were included. The primary and secondary outcomes were odds of having RPL in the general population and odds of further miscarriage, respectively. Underweight and women with BMI > 25 are at higher odds of RPL in the general population (OR 1.2, 95% CI 1.12–1.28 and OR 1.21, 95% CI 1.06–1.38, respectively). In women with RPL, having BMI > 30 and BMI > 25 has increased odds of further miscarriages (OR 1.77, 95% CI 1.25–2.50 and OR 1.35, 95% CI 1.07–1.72, respectively). The quality of the evidence for our findings was low or very low. Being underweight and BMI > 25 contributes significantly to increased risk of RPL (general population). BMI > 25 or BMI > 30 increases the risk of further miscarriages (RPL population). Larger studies addressing the effects of alcohol, cigarette smoking and caffeine on the risk of RPL with optimisation of BMI in this cohort of women are now needed.

Substrate oxidation during exercise in taekwondo athletes: impact of aerobic fitness status

2020 ◽  
Vol 16 (5) ◽  
pp. 371-376
Author(s):  
B. Taati ◽  
H. Rohani
Keyword(s):  
Aerobic Fitness ◽  
Oxidation Rate ◽  
Fat Oxidation ◽  
Potential Effect ◽  
Substrate Oxidation ◽  
Training Experience ◽  
Male Athletes ◽  
Fitness Level ◽  
Oxidation Rates ◽  
Maximal Fat Oxidation

The present study aimed to investigate the potential effect of different aerobic fitness levels on substrate oxidation in trained taekwondo athletes. 57 male athletes (age 21.10±7.79 years; VO2max 50.67±6.67 ml/kg/min) with regular weekly taekwondo training and training experience of at least three years completed a graded exercise test to exhaustion on a treadmill. Maximal fat oxidation (MFO), the exercise intensity related to MFO (Fatmax), and carbohydrate (CHO) oxidation rate were measured using indirect calorimetry methods. The athletes then were divided into a low (<50 ml/kg/min, n=18) and high (>50 ml/kg/min, n=39) VO2max group. The average MFO was higher in the high VO2max group than in the low VO2max group (0.46±0.19 vs 0.28±0.11 g/min; P<0.001). Although Fatmax tended toward higher values in the high VO2max group, no difference was observed between the groups (49.15±15.22 vs 42.42±12.37% of VO2max; P=0.18). It was also shown that the high VO2max group had a lower CHO oxidation rate and a higher fat oxidation rate at given exercise intensities. In conclusion, it seems that MFO and substrate oxidation rates in taekwondo athletes can be influenced by aerobic fitness level such that the athletes with higher VO2max appeared to use more fat as a fuel source for energy supply during a given exercise.

scholarly journals Ischemia-Reperfusion Intervention: From Enhancements in Exercise Performance to Accelerates Performance Recovery - A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Rhaí André Arriel ◽  
Jéssica Ferreira Rodrigues ◽  
Hiago Leandro Rodrigues de Souza ◽  
Anderson Meireles ◽  
Luís Filipi Moutinho Leitão ◽  
...  
Keyword(s):  
Systematic Review ◽  
Creatine Kinase ◽  
Exercise Performance ◽  
Muscle Soreness ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Ischemic Conditioning ◽  
Fitness Level ◽  
Positive Effects ◽  
Performance Recovery

It has been demonstrated that brief cycles of ischemia followed by reperfusion (IR) applied before exercise can improve performance and, IR intervention, applied immediately after exercise (post-exercise ischemic conditioning &ndash; PEIC) exerts a potential ergogenic effect to accelerate recovery. Thus, the purpose of this systematic review with meta-analysis was to identify the effects of PEIC on exercise performance, recovery and the responses of associated physiological parameters, such as creatine kinase, perceived recovery and muscle soreness, over 24 h after its application. From 3281 studies, six involving 106 subjects fulfilled the inclusion criteria. Compared to sham (cuff administration with low pressure) and control interventions (no cuff administration), PEIC led to faster performance recovery (p=0.004; ES=-0.49) and lower increase in creatine kinase (p&amp;lt;0.001; ES=-0.71) and muscle soreness (p&amp;lt;0.001; ES=-0.89) over 24 h. The effectiveness of this intervention is more pronounced in subjects with low/moderate fitness level and at least a total time of 10 min of ischemia (e.g. 2 cycles of 5 min) is necessary to promote positive effects.

scholarly journals Acute effects of caffeine intake on athletic performance: A systematic review and meta-analysis

2017 ◽  
Vol 44 (3) ◽  
pp. 283-283 ◽  
Author(s):  
Beatriz Gonçalves Ribeiro ◽  
Anderson Pontes Morales ◽  
Felipe Sampaio-Jorge ◽  
Felipe de Souza Tinoco ◽  
Alessandra Alegre de Matos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Athletic Performance ◽  
Meta Analysis ◽  
Caffeine Intake ◽  
Acute Effects

scholarly journals Immune response to nucleotide-supplemented infant formulae: systematic review and meta-analysis

2007 ◽  
Vol 98 (S1) ◽  
pp. S64-S67 ◽  
Author(s):  
Pedro Gutiérrez-Castrellón ◽  
Ignacio Mora-Magaña ◽  
Luisa Díaz-García ◽  
Carlos Jiménez-Gutiérrez ◽  
Jaime Ramirez-Mayans ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Infant Health ◽  
Respiratory Infections ◽  
Meta Analysis ◽  
Oral Polio Vaccine ◽  
Infant Formulae ◽  
Mean Differences ◽  
Dose Response Effect ◽  
Randomised Controlled

Human milk is recommended as the only alimentary source for the first six months of life. Additionally there is a medical and social need for safe and effective alternative forms of nutrition for infants who cannot be fed with breast milk. Recently the safety and efficacy of some ingredients in infant formulae, such as nucleotides have been discussed. This systematic review analyzed the available evidence to establish the efficacy, safety and dose-response effect of ribonucleotide-supplemented infant formulae (RSIFs). Randomised controlled clinical trials (RCTs) comparing RSIFs to formulae without nucleotides or breast milk were considered in this review. Outcome measures were: antibody titres to common paediatric vaccinations, total lymphocytes, lymphocyte subclasses and NK-cells, episodes of diarrhoea and acute respiratory infection. Publication quality was determined using Jadad and CONSORT guidelines. Results were combined using a random effects model and reported through standardised mean differences (WMD) or risk ratio (RR). Systematic review and meta-analysis showed that RSIFs were associated with a better antibody response to immunisation with Haemopillus influenzae vaccine [SMD 1·74 (99 %CI 1·43–2·05), P = 0·001], diphtheria toxoid [SMD 0·94 (0·75–1·12), P = 0·001], oral polio vaccine [SMD 0·73 (0·51–0·95), P = 0·001], and fewer episodes of diarrhoea [RR 0·67 (0·58–0·76), P = 0·02]. We did not find a major risk of upper respiratory infections [RR 1·11 (0·90–1·36), P = 0·50]. Available evidence suggests a positive benefit of RSFIs on infant health without any risk. These benefits begin with nucleotide addition of 1·9 mg/418·4 kJ and are maintained or increased with 10·78 mg/418·4 kJ.

scholarly journals The relationship between pregnancy intentions and diet or physical activity behaviours in the preconception and antenatal periods: A systematic review and meta-analysis

2019 ◽  
Author(s):  
Isaac Nkrumah ◽  
Madelon North ◽  
Emily Jane Kothe ◽  
Tze Lin Chai ◽  
Stephanie Pirotta ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Meta Analysis ◽  
Pregnancy Intention ◽  
Risk Of Bias ◽  
Folate Intake ◽  
Caffeine Intake ◽  
Pregnancy Intentions ◽  
Diet And Physical Activity ◽  
Meta Analyses

Introduction: Healthy preconception and antenatal diet and physical activity behaviours are crucial to prevent adverse maternal and offspring outcomes. These behaviours are thought to be linked to pregnancy intentions. The aim of this study was to conduct a systematic review and meta-analysis to determine the association between women’s pregnancy intentions and diet or physical activity behaviours in the preconception and antenatal periods. Methods: Medline Complete, PsycINFO, CINAHL Complete, Global Health, Embase, and INFORMIT: Health Subset were searched in September 2018 for studies that evaluated relationships between pregnancy intentions and dietary and physical activity behaviours. Risk of bias was assessed and random effects meta-analyses were conducted for dietary (food groups; energy and macronutrients; diet quality; and caffeine, iodine and folate intake) and physical activity outcomes.Results: Of 2623 screened records, 19 eligible studies were identified. Overall risk of bias was moderate to high. Twelve studies measured diet/physical activity behaviours during preconception, 5 during pregnancy, and 2 across both periods. Eleven studies measured pregnancy intention retrospectively, and 8 prospectively measured pregnancy intention. The number of studies available for meta-analyses of individual dietary and physical activity outcomes ranged from 2 to 5. Pregnancy intentions were not associated with preconception fruit, vegetable, or caffeine intake or physical activity. Antenatally, women with intended pregnancies were more likely to report healthier diets, lower caffeine intake and higher physical activity. Insufficient studies were available to conduct subgroup comparisons for prospective/retrospective assessment.Discussion: Pregnancy intentions were not associated with preconception diet or physical activity behaviours. In contrast, antenatally, women with intended pregnancies demonstrated better diet and physical activity behaviours. Given the small number of studies available for meta-analyses, further research is needed to consolidate our findings. Meanwhile, health professionals can assess women’s pregnancy intentions during preconception and pregnancy and encourage a healthy lifestyle.PROSPERO registration number CRD42018107854.

scholarly journals Relationship between caffeine intake and infertility: a systematic review of controlled clinical studies

2020 ◽  
Author(s):  
Bu Fanlong ◽  
Xue Feng ◽  
Xiao-Ying Yang ◽  
Jun Ren ◽  
Hui-juan Cao
Keyword(s):  
Systematic Review ◽  
Cohort Study ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Average Score ◽  
Caffeine Intake ◽  
High Dose ◽  
Case Control Studies ◽  
High Doses

Abstract Background: Previous studies showed that high dose of caffeine intake may induce some specific human reproductive system diseases, even lead to infertility. This review is aimed to systematically review the evidence from all controlled clinical studies of caffeine intake for infertility.Methods: Relevant randomized/quasi-randomized controlled trials, non-randomized clinical studies, cohort studies, and case-control studies were included. Participants were either those without a history of infertility who are willing to have a baby (for prospective studies) or infertile patients with confirmed diagnosis (for retrospective studies). Caffeine or caffeine-containing beverage was observed as the exposure factor. The key outcome was the diagnosis of infertility.Results: Four studies (one cohort study and three case-control studies) involving 12912 participants were included. According Newcastle - Ottawa Scale (NOS), the average score of case-control studies was 6, and the cohort study achieved 9. Meta-analysis and subgroup analysis were conducted. The results showed that low (OR 0.95, 95%CI 0.78-1.16), medium (OR 1.14, 95%CI 0.69-1.86) and high doses (OR 1.86, 95%CI 0.28-12.22) of caffeine intake may not increase the risk of infertility. The GRADE method was used to assess the certainty of the evidence and the results showed that the quality of the three evidence bodies were all low.Conclusion: Our study provides low quality evidence that regardless of low, medium and high doses of caffeine intake do not appear increase the risk of infertility. But the conclusion should be treated with caution. Systematic review registration: PROSPERO CRD42015015714

scholarly journals Caffeine Intake and Dementia: Systematic Review and Meta-Analysis

2010 ◽  
Vol 20 (s1) ◽  
pp. S187-S204 ◽  
Author(s):  
Catarina Santos ◽  
João Costa ◽  
João Santos ◽  
António Vaz-Carneiro ◽  
Nuno Lunet
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Caffeine Intake

Coffee and caffeine intake and risk of ovarian cancer: a systematic review and meta-analysis

2019 ◽  
Vol 29 (3) ◽  
pp. 579-584 ◽  
Author(s):  
Fateme Shafiei ◽  
Asma Salari-Moghaddam ◽  
Alireza Milajerdi ◽  
Bagher Larijani ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Effect Sizes ◽  
Caffeine Intake ◽  
Case Control Studies ◽  
Coffee Intake ◽  
Decaffeinated Coffee ◽  
Caffeinated Coffee

BackgroundResults from earlier publications on the association of coffee and caffeine and risk of ovarian cancer are inconsistent.ObjectiveTo evaluate the link between coffee, caffeine, caffeinated coffee, and decaffeinated coffee consumption and risk of ovarian cancer.MethodsWe searched PubMed/Medline, ISI Web of Science, Scopus, and Google Scholar to identify relevant publications up to April 2018. All case–control studies that considered coffee, caffeine, caffeinated coffee, or decaffeinated coffee as the exposure variables and ovarian cancer as the main outcome variable or as one of the outcomes were included in the systematic review. Publications in which odds ratios (ORs) or rate or risk ratios (RRs) and 95% confidence intervals (CIs) were reported, were included in the meta-analysis.ResultsA total of 22 case–control studies were included in the systematic review, and 20 studies in the meta-analysis. Overall, 40 140 participants, including 8568 patients with ovarian cancer, aged ≥ 17 years were included. Combining 21 effect sizes from 18 studies, no significant association was observed between total coffee intake and risk of ovarian cancer (OR=1.09; 95% CI 0.94 to 1.26). There was no significant association between total caffeine intake and ovarian cancer risk (OR=0.89; 95% CI 0.55 to 1.45). In addition, caffeinated coffee intake was not significantly associated with ovarian cancer (OR=1.05; 95% CI 0.87 to 1.28). However, combining effect sizes from five studies, we found an inverse significant association between decaffeinated coffee intake and risk of ovarian cancer (OR=0.72; 95% CI 0.58 to 0.90).ConclusionsOur findings indicated an inverse association between decaffeinated coffee consumption and risk of ovarian cancer. No significant association was found between coffee, caffeine or caffeinated coffee intake and risk of ovarian cancer.

Sign in / Sign up

Export Citation Format

Share Document