scholarly journals Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3550
Author(s):  
Minhee Lee ◽  
Dakyung Kim ◽  
Soo-Jeung Park ◽  
Jeong moon Yun ◽  
Dong Hwan Oh ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Inflammatory Response ◽  
Mrna Expression ◽  
Antarctic Krill ◽  
Krill Oil ◽  
Cartilage Surface ◽  
Articular Cartilage Surface ◽  
Tnf Α ◽  
Monosodium Iodoacetate ◽  
Antarctic Krill Oil

The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and micro-CT. The expression of PGE2, pro-inflammatory cytokines (IL-1β, TNF-α), and arthritics related genes in osteoarthritic rats in response to FJH-KO supplementation was investigated using real time PCR. FJH-KO supplementation in the arthritic rat model reduced tissue damage, cartilage degeneration, and reduced the MIA-induced irregularities in articular cartilage surface. Serum PGE2, IL-1β, IL-6, and TNF-α levels were higher in MIA treated animals, but these levels decreased upon FJH-KO supplementation. When FJH-KO was provided at a dose of 150 mg/kg b.w to MIA-treated animals, it significantly increased the mRNA expression of anabolic factors. The mRNA expression of catabolic factors was significantly decreased MIA-treated animals that were provided FJH-KO at a dose of 100 and 150 mg/kg b.w. Moreover, the mRNA expression of inflammatory mediators was significantly decreased MIA-treated animals supplemented with FJH-KO. These results suggest supplementation with FJH-KO ameliorates the irregularities in articular cartilage surface and improves the inflammatory response in the osteoarthritis. Thus, FJH-KO could serve as a potential therapeutic agent for osteoarthritis treatment.

scholarly journals Effects of Antarctic krill oil on lipid and glucose metabolism in C57BL/6J mice fed with high fat diet

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Dewei Sun ◽  
Liang Zhang ◽  
Hongjian Chen ◽  
Rong Feng ◽  
Peirang Cao ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
High Fat Diet ◽  
Antarctic Krill ◽  
Krill Oil ◽  
High Fat ◽  
Antarctic Krill Oil

scholarly journals Preparation of Antarctic Krill Oil Emulsion and Its Stability under Catalase Treatment

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2797
Author(s):  
Zhenxiao Zheng ◽  
Kai Zhu ◽  
Zhiyuan Dai
Keyword(s):  
Enzyme Activity ◽  
Lipid Oxidation ◽  
Antarctic Krill ◽  
Effective Means ◽  
Thiobarbituric Acid ◽  
Tween 80 ◽  
Iron Porphyrin ◽  
Krill Oil ◽  
Oil Emulsion ◽  
Antarctic Krill Oil

Making Antarctic krill oil into emulsion is a good way to utilize Antarctic krill, but proliferation of microorganisms cannot be ignored. H2O2 is widely used in the sterilization of liquid food since its decomposition products are environmentally friendly, although residual H2O2 should be removed for food safety. Adding catalase (CAT) is an effective means to do this. However, the enzyme activity center of CAT is the iron porphyrin group, which has the risk of accelerating lipid oxidation in the oil emulsion. Therefore, we hypothesized that CAT might not be suitable for the removal of H2O2 in Antarctic krill oil emulsion. In this paper, Antarctic krill oil emulsion was prepared, and then the effect of CAT on the emulsion was studied through visual observation, microscopic morphology observation, turbidity and stability, particle size, and ζ-potential; finally, the mechanism of CAT destroying the emulsion was explored from the perspective of lipid oxidation. The results showed that a stable Antarctic krill emulsion was prepared using Tween-80 as the emulsifier, with the oil concentration of 1% (v/v) and the ratio of surfactant to oil phase of 1:5 (v/v). The emulsion treated with CAT had undergone demulsification, stratification, and coagulation after 2 days of incubation, while the emulsion treated with superoxide dismutase (SOD) and bovine serum albumin (BSA) changed little. In addition, the thiobarbituric acid reactive substances (TBARS) value and the content of hydroxyl radicals in the CAT group increased significantly. The preliminary research results indicated that the effect of CAT on the emulsion related to the lipid oxidation caused by the iron porphyrin group at the center of the enzyme activity. All these results indicated that CAT was not suitable for the removal of residual H2O2 in Antarctic krill oil emulsion. Moreover, it is helpful to avoid the contact of Antarctic krill oil emulsion and CAT during the processing of the krill.

Meniscus and Synovial Membrane: An Electronmicroscopic Study on Rabbits

2001 ◽  
Vol 26 (3) ◽  
pp. 254-260 ◽  
Author(s):  
S.Y. Hu ◽  
S. Wang ◽  
R.T. Zuo ◽  
K.L. Wang ◽  
L. Qin
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Surface Morphology ◽  
Synovial Membrane ◽  
Femoral Condyle ◽  
Joint Capsule ◽  
Cartilage Surface ◽  
Articular Cartilage Surface ◽  
Scanning Electronmicroscopy ◽  
Transmission Electronmicroscopy

Seven healthy mature rabbits were used to study both the surface morphology of the meniscus using both transmission electronmicroscopy (TEM) and scanning electronmicroscopy (SEM) and articular cartilage of the femoral condyle using SEM. Results showed that the membrane covering the meniscus was structurally the extension of synovial membrane of the knee joint capsule. Additionally, the presence of canal-like openings over the membranous surface to the meniscus was noted, which were absent over the articular cartilage surface. Key words: transmission and scanning electronmicroscopy, meniscus, articular cartilage, rabbits

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