scholarly journals Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3139
Author(s):  
Carlos Vazquez-Madrigal ◽  
Soledad Lopez ◽  
Elena Grao-Cruces ◽  
Maria C. Millan-Linares ◽  
Noelia M. Rodriguez-Martin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Healthy Volunteers ◽  
Human Monocyte ◽  
Serum Levels ◽  
Monounsaturated Fatty Acids ◽  
Dendritic Cell Maturation ◽  
Dietary Fatty Acids ◽  
Gm Csf ◽  
Postprandial Triglyceride ◽  
And Function

Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by modulating dendritic cells (DCs), sentinels of the immunity that link innate and adaptive immune systems. In healthy volunteers, saturated fatty acid (SFA)-enriched meal raised serum levels of granulocyte/macrophage colony-stimulating factor GM-CSF (SFAs > monounsaturated fatty acids (MUFAs) = polyunsaturated fatty acids (PUFAs)) in the postprandial period. Autologous TRL-SFAs upregulated the gene expression of DC maturation (CD123 and CCR7) and DC pro-inflammatory activation (CD80 and CD86) genes while downregulating tolerogenic genes (PD-L1 and PD-L2) in human monocyte-derived DCs (moDCs). These effects were reversed with oleic acid-enriched TRLs. Moreover, postprandial SFAs raised IL-12p70 levels, while TRL-MUFAs and TRL-PUFAs increased IL-10 levels in serum of healthy volunteers and in the medium of TRL-treated moDCs. In conclusion, postprandial TRLs are metabolic entities with DC-related tolerogenic activity, and this function is linked to the type of dietary fat in the meal. This study shows that the intake of meals enriched in MUFAs from olive oil, when compared with meals enriched in SFAs, prevents the postprandial production and priming of circulating pro-inflammatory DCs, and promotes tolerogenic response in healthy subjects. However, functional assays with moDCs generated in the presence of different fatty acids and T cells could increase the knowledge of postprandial TRLs’ effects on DC differentiation and function.

The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells

2013 ◽  
Vol 24 (12) ◽  
pp. 2031-2039 ◽  
Author(s):  
Lourdes M. Varela ◽  
Almudena Ortega-Gomez ◽  
Sergio Lopez ◽  
Rocio Abia ◽  
Francisco J.G. Muriana ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Human Monocyte ◽  
Dietary Fatty Acids ◽  
Macrophage Cells ◽  
Postprandial Triglyceride ◽  
Triglyceride Rich Lipoprotein

Differential Effects of Dietary Fatty Acids on Body Composition and Adiposity

2020 ◽  
Vol 16 (2) ◽  
pp. 142-154 ◽  
Author(s):  
Hadi Emamat ◽  
Zahra Yari ◽  
Hossein Farhadnejad ◽  
Parvin Mirmiran
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Total Body Weight ◽  
Fat Distribution ◽  
Monounsaturated Fatty Acids ◽  
Dietary Fatty Acids ◽  
Dietary Fats ◽  
Total Body

Recent evidence has highlighted that fat accumulation, particularly abdominal fat distribution, is strongly associated with metabolic disturbance. It is also well-recognized that the metabolic responses to variations in macronutrients intake can affect body composition. Previous studies suggest that the quality of dietary fats can be considered as the main determinant of body-fat deposition, fat distribution, and body composition without altering the total body weight; however, the effects of dietary fats on body composition have controversial results. There is substantial evidence to suggest that saturated fatty acids are more obesogen than unsaturated fatty acids, and with the exception of some isomers like conjugate linoleic acid, most dietary trans fatty acids are adiposity enhancers, but there is no consensus on it yet. On the other hand, there is little evidence to indicate that higher intake of the n-3 and the n-6 polyunsaturated fatty acids can be beneficial in attenuating adiposity, and the effect of monounsaturated fatty acids on body composition is contradictory. Accordingly, the content of this review summarizes the current body of knowledge on the potential effects of the different types of dietary fatty acids on body composition and adiposity. It also refers to the putative mechanisms underlying this association and reflects on the controversy of this topic.

scholarly journals Relevance of Fatty Acids to Sperm Maturation and Quality

2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Giulia Collodel ◽  
Cesare Castellini ◽  
Jetty Chung-Yung Lee ◽  
Cinzia Signorini
Keyword(s):  
Biological Sciences ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Profile ◽  
Human Sperm ◽  
Dietary Fatty Acids ◽  
Pathological Conditions ◽  
Sperm Membrane ◽  
And Function

Almost 50% of infertility cases are associated with human male infertility. The sperm membrane is a key structure influencing sperm morphology and function in normal and pathological conditions. The fatty acid profile determines the performance not only of sperm motility but also of acrosomal reaction and sperm-oocyte fusion. This review presents available knowledge on the role of fatty acid composition in human sperm and spermatogenesis and discusses the influence of dietary fatty acids on the sperm fatty acid profile. Recent studies in biological sciences and clinical researches in this field are also reported. The topic object of this review has potential application in medicine by identifying potential causes of infertility.

scholarly journals Distinct Effects of Saturated and Monounsaturated Fatty Acids on  -Cell Turnover and Function

Diabetes ◽  
2001 ◽  
Vol 50 (1) ◽  
pp. 69-76 ◽  
Author(s):  
K. Maedler ◽  
G.A. Spinas ◽  
D. Dyntar ◽  
W. Moritz ◽  
N. Kaiser ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Monounsaturated Fatty Acids ◽  
Cell Turnover ◽  
And Function

scholarly journals Dietary fatty acids influence sperm quality and function

Andrology ◽  
2017 ◽  
Vol 5 (3) ◽  
pp. 423-430 ◽  
Author(s):  
A. Ferramosca ◽  
N. Moscatelli ◽  
M. Di Giacomo ◽  
V. Zara
Keyword(s):  
Fatty Acids ◽  
Sperm Quality ◽  
Dietary Fatty Acids ◽  
And Function

Postprandial dietary fatty acids exert divergent inflammatory responses in retinal-pigmented epithelium cells

2016 ◽  
Vol 7 (3) ◽  
pp. 1345-1353 ◽  
Author(s):  
Sergio Montserrat-de la Paz ◽  
M. Carmen Naranjo ◽  
Beatriz Bermudez ◽  
Sergio Lopez ◽  
Wenceslao Moreda ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Inflammatory Responses ◽  
Dietary Fatty Acids ◽  
Retinal Pigmented Epithelium ◽  
Complex Series ◽  
Postprandial Triglyceride ◽  
Pigmented Epithelium ◽  
Epithelium Cells

Postprandial triglyceride-rich lipoproteins (TRLs) lead to a complex series of events that are potentially oxidative and inflammatory.

scholarly journals Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic  -Cell Turnover and Function

Diabetes ◽  
2003 ◽  
Vol 52 (3) ◽  
pp. 726-733 ◽  
Author(s):  
K. Maedler ◽  
J. Oberholzer ◽  
P. Bucher ◽  
G. A. Spinas ◽  
M. Y. Donath
Keyword(s):  
Fatty Acids ◽  
High Glucose ◽  
Monounsaturated Fatty Acids ◽  
Cell Turnover ◽  
Pancreatic Cell ◽  
And Function

Effects of Dietary Intake and Supplementation of Fatty Acids on Cardiometabolic Disorders in Humans: a Lesson from a Large Number of Meta-Analyses

2019 ◽  
Vol 16 (10) ◽  
pp. 1138-1145
Author(s):  
Sho-ichi Yamagishi ◽  
Takanori Matsui
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cardiovascular Diseases ◽  
Dietary Intake ◽  
Saturated Fatty Acids ◽  
Total Mortality ◽  
Monounsaturated Fatty Acids ◽  
Dietary Fatty Acids ◽  
Clinical Effects ◽  
Cardiometabolic Disorders

Dietary fatty acids have exerted numerous pathophysiological effects in humans. Indeed, monounsaturated fatty acids and ω-3 polyunsaturated fatty acids are generally thought to have favorable cardiometabolic actions via their anti-inflammatory and anti-thrombotic properties, while saturated fatty acids and trans fatty acids are supposed to contribute to the development and progression of atherosclerotic cardiovascular diseases by inducing dyslipidemia and obesity. However, there is much controversy about the effects of dietary intake and supplementation of fatty acids on cardiometabolic disorders. Therefore, in the present study, we limited the scope of this review to metaanalyses (1) of observational studies of dietary intake of fatty acids and (2) of interventional trials with fatty acid supplements to scrutinize the role of fatty acids in various cardiometabolic disorders. We discuss here the clinical effects of fatty acids from dietary intake or supplements on incidence of diabetes, metabolic syndrome, obesity and body weight, cardiovascular diseases and total mortality, and also review the association of fatty acid biomarkers with these cardiometabolic disorders.

scholarly journals Dietary fatty acids in gut health: Absorption, metabolism and function

2021 ◽  
Author(s):  
E. Xu ◽  
Chao Chen ◽  
Jie Fu ◽  
Luoyi Zhu ◽  
Junlan Shu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dietary Fatty Acids ◽  
Gut Health ◽  
And Function
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