scholarly journals Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2701
Author(s):  
Hatim Azaryah ◽  
Juan Verdejo-Román ◽  
Cristina Martin-Pérez ◽  
José Antonio García-Santos ◽  
Cristina Martínez-Zaldívar ◽  
...  
Keyword(s):  
Fish Oil ◽  
Cognitive Processing ◽  
Resting State ◽  
Controlled Trial ◽  
Angular Gyrus ◽  
Long Term Effects ◽  
Maternal Supplementation ◽  
Methyl Tetrahydrofolate

Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5–10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided into groups according to mother’s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE < 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother’s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´s cognitive processing.

scholarly journals Effect of iron supplementation during pregnancy on the behaviour of children at early school age: long-term follow-up of a randomised controlled trial

2008 ◽  
Vol 99 (5) ◽  
pp. 1133-1139 ◽  
Author(s):  
Annie G. Parsons ◽  
Shao J. Zhou ◽  
Nicola J. Spurrier ◽  
Maria Makrides
Keyword(s):  
Placebo Group ◽  
Controlled Trial ◽  
Child Behaviour ◽  
School Age ◽  
Long Term Effects ◽  
Early School ◽  
Early School Age ◽  
In Pregnancy

Although routine Fe supplementation in pregnancy is a common practice, its clinical benefits or risks are uncertain. Children born to mothers in the Fe group in a trial of Fe supplementation in pregnancy have been found to have a significantly higher risk of abnormal behaviour at 4 years of age than those born to mothers in the placebo group. The objective of the present study therefore was to determine whether Fe supplementation in pregnancy influences child behaviour at early school age. The study was a follow-up of children at 6–8 years of age after women (n 430) were randomly allocated to receive a daily Fe supplement (20 mg) or placebo from 20 weeks gestation until delivery. The supplement reduced the incidence of Fe-deficiency anaemia at delivery from 9 % to 1 %. Child behaviour and temperament were assessed using the Strengths and Difficulties Questionnaire and the Short Temperament Scale for Children. Of the children, 264 (61 %) participated in the follow-up. Mean behaviour and temperament scores and the proportion of parent-rated and teacher-rated abnormal total difficulties scores did not differ between the Fe and placebo groups. However, the incidence of children with an abnormal teacher-rated peer problems subscale score was higher in the Fe group (eleven of 112 subjects; 8 %) than in the placebo group (three of 113 subjects; 2 %); the relative risk was 3·70 (95 % CI 1·06, 12·91; P = 0·026). We conclude that prenatal Fe supplementation had no consistent effect on child behaviour at early school age in this study population. Further investigation regarding the long-term effects of this common practice is warranted.

Long-term effects of routine morphine infusion in mechanically ventilated neonates on children’s functioning: Five-year follow-up of a randomized controlled trial

Pain ◽  
2011 ◽  
Vol 152 (6) ◽  
pp. 1391-1397 ◽  
Author(s):  
Joke de Graaf ◽  
Richard A. van Lingen ◽  
Sinno H.P. Simons ◽  
Kanwaljeet J.S. Anand ◽  
Hugo J. Duivenvoorden ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Long Term Effects ◽  
Mechanically Ventilated ◽  
Randomized Controlled ◽  
Morphine Infusion

scholarly journals Lasting Effects of Workplace Strength Training for Neck/Shoulder/Arm Pain among Laboratory Technicians: Natural Experiment with 3-Year Follow-Up

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Peter Mortensen ◽  
Anders I. Larsen ◽  
Mette K. Zebis ◽  
Mogens T. Pedersen ◽  
Gisela Sjøgaard ◽  
...  
Keyword(s):  
Public Sector ◽  
Strength Training ◽  
Natural Experiment ◽  
Controlled Trial ◽  
Working Hours ◽  
Long Term Effects ◽  
Arm Pain ◽  
Private And Public

Objectives. This study investigated long-term effects and implementation processes of workplace strength training for musculoskeletal disorders.Methods. 333 and 140 laboratory technicians from private and public sector companies, respectively, replied to a 3-year follow-up questionnaire subsequent to a 1-year randomized controlled trial (RCT) with high-intensity strength training for prevention and treatment of neck, shoulder, and arm pain. Being a natural experiment, the two participating companies implemented and modified the initial training program in different ways during the subsequent 2 years after the RCT.Results. At 3-year follow-up the pain reduction in neck, shoulder, elbow, and wrist achieved during the first year was largely maintained at both companies. However, the private sector company was rated significantly better than the public sector company in (1) training adherence, (2) training culture, that is, relatively more employees trained at the workplace and with colleagues, (3) self-reported health changes, and (4) prevention of neck and wrist pain development among initially pain-free employees.Conclusions. This natural experiment shows that strength training can be implemented successfully at different companies during working hours on a long-term basis with lasting effects on pain in neck, shoulder, and arm.

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