scholarly journals The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2648
Author(s):  
Felice Crocetto ◽  
Mariarosaria Boccellino ◽  
Biagio Barone ◽  
Erika Di Zazzo ◽  
Antonella Sciarra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Application ◽  
Human Microbiota ◽  
Cancer Initiation ◽  
Prostate Cancer Development ◽  
Potential Therapeutic Application ◽  
Health And Disease ◽  
Prostatic Inflammation ◽  
Urological Diseases ◽  
Nutraceutical Products

The human microbiota shows pivotal roles in urologic health and disease. Emerging studies indicate that gut and urinary microbiomes can impact several urological diseases, both benignant and malignant, acting particularly on prostate inflammation and prostate cancer. Indeed, the microbiota exerts its influence on prostate cancer initiation and/or progression mechanisms through the regulation of chronic inflammation, apoptotic processes, cytokines, and hormonal production in response to different pathogenic noxae. Additionally, therapies’ and drugs’ responses are influenced in their efficacy and tolerability by microbiota composition. Due to this complex potential interconnection between prostate cancer and microbiota, exploration and understanding of the involved relationships is pivotal to evaluate a potential therapeutic application in clinical practice. Several natural compounds, moreover, seem to have relevant effects, directly or mediated by microbiota, on urologic health, posing the human microbiota at the crossroad between prostatic inflammation and prostate cancer development. Here, we aim to analyze the most recent evidence regarding the possible crosstalk between prostate, microbiome, and inflammation.

scholarly journals Role of inflammasomes and their regulators in prostate cancer initiation, progression and metastasis

2013 ◽  
Vol 18 (3) ◽  
Author(s):  
Sudhakar Veeranki
Keyword(s):  
Prostate Cancer ◽  
Older Men ◽  
Considerable Progress ◽  
Cancer Development ◽  
Successful Therapy ◽  
Effective Prevention ◽  
Cancer Initiation ◽  
Prevention And Treatment ◽  
Prostate Cancer Development

AbstractProstate cancer is one of the main cancers that affect men, especially older men. Though there has been considerable progress in understanding the progression of prostate cancer, the drivers of its development need to be studied more comprehensively. The emergence of resistant forms has also increased the clinical challenges involved in the treatment of prostate cancer. Recent evidence has suggested that inflammation might play an important role at various stages of cancer development. This review focuses on inflammasome research that is relevant to prostate cancer and indicates future avenues of study into its effective prevention and treatment through inflammasome regulation. With regard to prostate cancer, such research is still in its early stages. Further study is certainly necessary to gain a broader understanding of prostate cancer development and to create successful therapy solutions.

396: Radiation Induction of Adam9 Expression Promoted Prostate Cancer Cell Survival: Possible Mechanism and Potential Therapeutic Application

2005 ◽  
Vol 173 (4S) ◽  
pp. 108-108
Author(s):  
Cynthia S. Anderson ◽  
Shian-Ying Sung ◽  
Hiroyuki Kubo ◽  
Chia-Ling Hsieh ◽  
Peter Johnstone ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Therapeutic Application ◽  
Cancer Cell Survival ◽  
Potential Therapeutic Application

scholarly journals Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2547 ◽  
Author(s):  
Qing Yao ◽  
Meng-Ting Lin ◽  
Yin-Di Zhu ◽  
He-Lin Xu ◽  
Ying-Zheng Zhao
Keyword(s):  
Biological Activities ◽  
Neurological Diseases ◽  
Extraction Methods ◽  
Flavonoid Glycoside ◽  
Therapeutic Effects ◽  
Therapeutic Application ◽  
Dietary Antioxidant ◽  
Potential Therapeutic Application ◽  
Health And Disease ◽  
Dietary Flavonoid

Didymin (isosakuranetin 7-O-rutinoside) is an orally bioactive dietary flavonoid glycoside first found in citrus fruits. Traditionally, this flavonoid has long been used in Asian countries as a dietary antioxidant. Recent studies have provided newer insights into this pleiotropic compound, which could regulate multiple biological activities of many important signaling molecules in health and disease. Emerging data also presented the potential therapeutic application of dietary flavonoid glycoside didymin against cancer, neurological diseases, liver diseases, cardiovascular diseases, and other diseases. In this review, we briefly introduce the source and extraction methods of didymin, and summarize its potential therapeutic application in the treatment of various diseases, with an emphasis on molecular targets and mechanism that contributes to the observed therapeutic effects. The dietary flavonoid didymin can be used to affect health and disease with multiple therapeutic targets, and it is anticipated that this review will stimulate the future development of this potential dietary medicine.

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