scholarly journals Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2422
Author(s):  
Chun-De Liao ◽  
Yen-Tzu Wu ◽  
Jau-Yih Tsauo ◽  
Pey-Rong Chen ◽  
Yu-Kang Tu ◽  
...  
Keyword(s):  
Older Adults ◽  
Muscle Strength ◽  
Exercise Training ◽  
Muscle Mass ◽  
Joint Replacement ◽  
Lower Limb ◽  
Functional Outcomes ◽  
Total Joint Replacement ◽  
Meta Analysis ◽  
Protein Supplementation

Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement.

scholarly journals Protein-enriched, milk-based supplement to counteract sarcopenia in acutely ill geriatric patients offered resistance exercise training during and after hospitalisation: study protocol for a randomised, double-blind, multicentre trial

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e019210 ◽  
Author(s):  
Josephine Gade ◽  
Anne Marie Beck ◽  
Christian Bitz ◽  
Britt Christensen ◽  
Tobias Wirenfeldt Klausen ◽  
...  
Keyword(s):  
Older Adults ◽  
Muscle Strength ◽  
Exercise Training ◽  
Lower Extremity ◽  
Muscle Mass ◽  
Protein Supplementation ◽  
Resistance Exercise Training ◽  
Double Blind ◽  
Lower Extremity Muscle ◽  
Enriched Milk

IntroductionAge-related loss of muscle mass and strength, sarcopaenia, burdens many older adults. The process is accelerated with bed rest, protein intakes below requirements and the catabolic effect of certain illnesses. Thus, acutely ill, hospitalised older adults are particularly vulnerable. Protein supplementation can preserve muscle mass and/or strength and, combining this with resistance exercise training (RT), may have additional benefits. Therefore, this study investigates the effect of protein supplementation as an addition to offering RT among older adults while admitted to the geriatric ward and after discharge. This has not previously been investigated.Methods and analysisIn a block-randomised, double-blind, multicentre intervention study, 165 older adults above 70 years, fulfilling the eligibility criteria, will be included consecutively from three medical departments (blocks of n=20, stratified by recruitment site). After inclusion, participants will be randomly allocated (1:1) to receive either ready-to-drink, protein-enriched, milk-based supplements (a total of 27.5 g whey protein/day) or isoenergetic placebo products (<1.5 g protein/day), twice daily as a supplement to their habitual diet. Both groups will be offered a standardised RT programme for lower extremity muscle strength (daily while hospitalised and 4×/week after discharge). The study period starts during their hospital stay and continues 12 weeks after discharge. The primary endpoint is lower extremity muscle strength and function (30 s chair-stand-test). Secondary endpoints include muscle mass, measures of physical function and measures related to cost-effectiveness.Ethics and disseminationApproval is given by the Research Ethic Committee of the Capital Region of Denmark (reference no. H-16018240) and the Danish Data Protection Agency (reference no. HGH-2016-050). There are no expected risks associated with participation, and each participant is expected to benefit from the RT. Results will be published in peer-reviewed international journals and presented at national and international congresses and symposiums.Trial registration numberNCT02717819 (9 March 2016).

Lower limb muscle mass is associated with insulin resistance more than lower limb muscle strength in non‐diabetic older adults

2019 ◽  
Vol 19 (12) ◽  
pp. 1254-1259
Author(s):  
Toshiaki Seko ◽  
Hiroshi Akasaka ◽  
Masayuki Koyama ◽  
Nobuaki Himuro ◽  
Shigeyuki Saitoh ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Older Adults ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Lower Limb ◽  
Lower Limb Muscle ◽  
Limb Muscle

scholarly journals Effects of vibration therapy on muscle mass, muscle strength and physical function in older adults with sarcopenia: a systematic review and meta-analysis

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Shuang Wu ◽  
Hong-Ting Ning ◽  
Su-Mei Xiao ◽  
Ming-Yue Hu ◽  
Xin-Yin Wu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Muscle Strength ◽  
Physical Function ◽  
Muscle Mass ◽  
Meta Analysis ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Local Vibration ◽  
Vibration Therapy

Abstract Background Sarcopenia, a progressive loss of muscle mass and function with advancing age, is a prevalent condition among older adults. As most older people are too frail to do intensive exercise and vibration therapy has low risk and ease of participation, it may be more readily accepted by elderly individuals. However, it remains unclear whether vibration therapy would be effective among older adults with sarcopenia. This systematic review and meta-analysis examined the effect of vibration therapy including local vibration therapy and whole-body vibration therapy, for enhancing muscle mass, muscle strength and physical function in older people with sarcopenia. Methods A systematic literature search was conducted in March 2019 in the following 5 electronic databases: PubMed, CINAHL, Embase, PEDro, and the Cochrane Central Register of Controlled Trials, with no restriction of language or the year of publication. Randomized controlled trials and quasi-experimental studies examining effects of vibration therapy on muscle mass, muscle strength or physical function in older adults with sarcopenia were included in this systematic review. Two reviewers independently assessed the methodological quality of the selected studies. Results Of the 1972 identified studies, seven publications from six studies involving 223 participants were included in this systematic review. Five of them conducted whole-body vibration therapy, while two conducted local vibration therapy. A meta-analysis of randomized controlled studies indicated that muscle strength significantly increased after whole-body vibration therapy (SMD 0.69, 95% CI 0.28 to 1.11, I2 = 0%, P = 0.001) and local vibration therapy (SMD 3.78, 95% CI 2.29 to 5.28, P < 0.001). Physical performance measured by the sit-to-stand test and the timed-up-and-go test were significantly improved after the intervention (SMD -0.79, 95% CI − 1.21 to − 0.37, I2 = 0%, P < 0.001) and SMD -0.83, 95% CI − 1.56 to − 0.11, I2 = 64%, P = 0.02, respectively). Conclusion Vibration therapy could be a prospective strategy for improving muscle strength and physical performance in older adults with sarcopenia. However, due to the limited number of the included studies, caution is needed when interpreting these results. More well-designed, large sample size studies should be conducted to further explore and validate the benefits of vibration therapy for this population.

Effects of Muscle Strength Training on Muscle Mass Gain and Hypertrophy in Older Adults With Osteoarthritis: A Systematic Review and Meta‐Analysis

2020 ◽  
Vol 72 (12) ◽  
pp. 1703-1718 ◽  
Author(s):  
Chun‐De Liao ◽  
Hung‐Chou Chen ◽  
Yu‐Chi Kuo ◽  
Jau‐Yih Tsauo ◽  
Shih‐Wei Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Muscle Strength ◽  
Strength Training ◽  
Muscle Mass ◽  
Meta Analysis ◽  
Mass Gain
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