scholarly journals Current Evidence on the Efficacy of Gluten-Free Diets in Multiple Sclerosis, Psoriasis, Type 1 Diabetes and Autoimmune Thyroid Diseases

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2316
Author(s):  
Moschoula Passali ◽  
Knud Josefsen ◽  
Jette Lautrup Frederiksen ◽  
Julie Christine Antvorskov
Keyword(s):  
Multiple Sclerosis ◽  
Type 1 Diabetes ◽  
Thyroid Diseases ◽  
Current Evidence ◽  
Gluten Free ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Beneficial Effects ◽  
Gliadin Antibodies

In this review, we summarize the clinical data addressing a potential role for gluten in multiple sclerosis (MS), psoriasis, type 1 diabetes (T1D) and autoimmune thyroid diseases (ATDs). Furthermore, data on the prevalence of celiac disease (CD) and gluten-related antibodies in the above patient groups are presented. Adequately powered and properly controlled intervention trials investigating the effects of a gluten-free diet (GFD) in non-celiac patients with MS, psoriasis, T1D or ATDs are lacking. Only one clinical trial has studied the effects of a GFD among patients with MS. The trial found significant results, but it is subject to major methodological limitations. A few publications have found beneficial effects of a GFD in a subgroup of patients with psoriasis that were seropositive for anti-gliadin or deamidated gliadin antibodies, but no effects were seen among seronegative patients. Studies on the role of gluten in T1D are contradictive, however, it seems likely that a GFD may contribute to normalizing metabolic control without affecting levels of islet autoantibodies. Lastly, the effects of a GFD in non-celiac patients with ATDs have not been studied yet, but some publications report that thyroid-related antibodies respond to a GFD in patients with concomitant CD and ATDs. Overall, there is currently not enough evidence to recommend a GFD to non-celiac patients with MS, psoriasis, ATDs or T1D.

scholarly journals The role of common genetic markers in susceptibility to type 1 diabetes and autoimmune thyroid diseases

2011 ◽  
Vol 14 (2) ◽  
pp. 23-31 ◽  
Author(s):  
Ekaterina Alexandrovna Repina
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Markers ◽  
Current Data ◽  
Thyroid Diseases ◽  
Single Patient ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

This review generalizes current data on the genes responsible for combined susceptibility to type 1 diabetes and autoimmune thyroid diseases. Analysisof the role of common genetic markers facilitates understanding their contribution to the development of each of the two or several concomitantautoimmune diseases affecting a single patient

scholarly journals Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes

2020 ◽  
Vol 8 ◽  
Author(s):  
Hanna Borysewicz-Sańczyk ◽  
Beata Sawicka ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Barbara Głowińska-Olszewska ◽  
Anna Kadłubiska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases

2019 ◽  
Vol 32 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Marta Rydzewska ◽  
Justyna Michalak ◽  
Anna Bossowska ◽  
Shu Chen ◽  
Sarah Black ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Study Groups ◽  
Thyroid Diseases ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Glutamic Acid Decarboxylase Autoantibodies ◽  
Group 2

Abstract Background Zinc transporter 8 autoantibodies (ZnT8Abs) together with glutamic acid decarboxylase autoantibodies (GADAbs), insulinoma antigen 2 autoantibodies (IA-2Abs) and insulin autoantibodies (IAbs) are markers of type 1 diabetes mellitus (T1DM). We studied the prevalence of ZnT8Ab in children with autoimmune thyroid diseases (AITDs) to assess the association of AITDs and T1DM at the serological level. Methods The study groups consisted of 44 children with Graves’ disease (GD), 65 children with Hashimoto’s thyroiditis (HT), 199 children with T1DM with or without AITDs and 58 control children. ZnT8Ab, GADAb, IA-2Ab, IAb, 21-hydroxylase autoantibodies (21-OHAbs) and acetylcholine receptor autoantibodies (AChRAbs) were measured. Results ZnT8Abs were found in 4/44 (9.1%) patients with GD, and 4/44 (9.1%) patients with GD were positive for GADAb. Of the 65 HT patients, six (9.2%) were positive for ZnT8Ab, while four (6.2%) were positive for GADAb. In the T1DM group, 128/199 (64%) of the patients were positive for ZnT8Ab, 133/199 (67%) for GADAb and 109/199 (55%) for IA-2Ab. One GD patient and one HT patient were positive for all the four diabetes-associated autoantibodies. Two HT patients were positive for three diabetes autoantibodies. Two GD (4.5%) and five HT (7.7%) patients were positive for 21-OHAb only. None of the patients had AChRAb. In the control group, 2/58 (3.4%) were positive for GADAb and 2/58 (3.4%) were positive for ZnT8Ab. Conclusions Diabetes-associated autoantibodies including ZnT8Ab were found in children and adolescents with GD and HT.

Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases

2018 ◽  
Vol 47 (5) ◽  
pp. 534-542 ◽  
Author(s):  
Naoya Inoue ◽  
Mikio Watanabe ◽  
Yuka Katsumata ◽  
Naoko Ishido ◽  
Yoh Hidaka ◽  
...  
Keyword(s):  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Iodothyronine Deiodinase ◽  
Autoimmune Thyroid ◽  
Functional Polymorphisms

Autoimmune polyglandular syndromes in the adults: the genetic and immunological diagnostic criteria

2014 ◽  
Vol 60 (3) ◽  
pp. 43-52 ◽  
Author(s):  
A A Larina ◽  
E A Troshina ◽  
O N Ivanova
Keyword(s):  
Adrenal Insufficiency ◽  
Thyroid Diseases ◽  
Primary Adrenal Insufficiency ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Aire Gene ◽  
Patients At Risk ◽  
Type 3 ◽  
Cortical Dysfunction

At present, four main types of autoimmune polyglandular syndromes (APS) are distinguished. Type 1 APS is associated with candidiasis, primary hypoparathyroidism, and primary adrenal insufficiency developing in the childhood as a result of mutations in the AIRE gene. Type 2 APS involves primary adrenal insufficiency in combination with autoimmune thyroid diseases and/or type 1 diabetes mellitus. Type 3 APS is characterized by the combination of autoimmune thyroid diseases with other endocrine and non-endocrine autoimmune pathologies in the absence of adrenal cortical dysfunction and hypoparathyriodism. Type 4 APS is presented by the combinations of autoimmune diseases other than the aforementioned ones. The above syndromes usually manifest themselves at the age between 20 and 60 years; they are of the polygenic type and associated with the genetic markers, such as HLAII-complex haplotypes, CTLA-4, PTPN22, FOXP3 genes, etc. In addition, the latent forms of APS have been described that occur in the populations much more frequently than the manifest disorders. These latent diseases can exert strong influence on the compensation and risk of complications of the underlying pathology. Of great importance in this context is the timely identification of the groups of patients at risk of developing clinical forms of APS among the subjects presenting with a single endocrine pathology.

Świadomość prewencyjnego działania diety oraz nawyki żywieniowe kobiet z chorobami tarczycy w wieku 20-50 lat

2018 ◽  
Vol 21 (2A) ◽  
Author(s):  
Marta Sorbal ◽  
Marta Palacz-Wróbel
Keyword(s):  
Dairy Products ◽  
Eating Habits ◽  
Significant Proportion ◽  
The Elderly ◽  
Thyroid Diseases ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Doctor's Office

Introduction. Thyroid diseases are becoming increasingly common not only among the elderly, but also in young people. In the world of sciences, the number of studies confirming the correlation between lifestyle, diet, use of stimulants, and a milder course or regression of the disease is constantly growing. Aim. The aim of the study was to assess the awareness of women aged 20-50 years who suffer from thyroid diseases of the preventive impact of diet in thyroid diseases, and the eating habits of the respondents. Material and methods. An original questionnaire was used to conduct the research. Results. The results of the study showed that most women do not pay attention to their dietary choices, the level of knowledge on the subject of adequate nutrition is low among the respondents and their eating habits are far from those recommended by the Institute of Food and Nutrition. However, a significant proportion of women – 33% of the respondents – admitted that they use a gluten-free diet or a diet that limits the use of dairy products, which significantly improved their health and diminished the unpleasant symptoms related to the course of the disease. There are more and more studies on gluten-free diet and diet with the restriction of dairy products having a positive effect on the course of autoimmune thyroid diseases. Conclusions. Women’s education in the doctor’s office is low. Only 17% of the respondents admitted that they had received tips regarding the introduction of proper diet or changes in their eating habits. Based on the results of the research, it is concluded that the nutritional education of people suffering from thyroid disease should be enhanced.

scholarly journals Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study

SpringerPlus ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Jannet Svensson ◽  
Stine Møller Sildorf ◽  
Christian B. Pipper ◽  
Julie N. Kyvsgaard ◽  
Julie Bøjstrup ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pilot Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Newly Diagnosed ◽  
Beneficial Effects

scholarly journals Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1769 ◽  
Author(s):  
Jovana Knezevic ◽  
Christina Starchl ◽  
Adelina Tmava Berisha ◽  
Karin Amrein
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Diseases ◽  
Bacterial Strains ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Beneficial Effects ◽  
The Impact

A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on thyroid function. Thyroid and intestinal diseases prevalently coexist—Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are the most common autoimmune thyroid diseases (AITD) and often co-occur with Celiac Disease (CD) and Non-celiac wheat sensitivity (NCWS). This can be explained by the damaged intestinal barrier and the following increase of intestinal permeability, allowing antigens to pass more easily and activate the immune system or cross-react with extraintestinal tissues, respectively. Dysbiosis has not only been found in AITDs, but has also been reported in thyroid carcinoma, in which an increased number of carcinogenic and inflammatory bacterial strains were observed. Additionally, the composition of the gut microbiota has an influence on the availability of essential micronutrients for the thyroid gland. Iodine, iron, and copper are crucial for thyroid hormone synthesis, selenium and zinc are needed for converting T4 to T3, and vitamin D assists in regulating the immune response. Those micronutrients are often found to be deficient in AITDs, resulting in malfunctioning of the thyroid. Bariatric surgery can lead to an inadequate absorption of these nutrients and further implicates changes in thyroid stimulating hormone (TSH) and T3 levels. Supplementation of probiotics showed beneficial effects on thyroid hormones and thyroid function in general. A literature research was performed to examine the interplay between gut microbiota and thyroid disorders that should be considered when treating patients suffering from thyroid diseases. Multifactorial therapeutic and preventive management strategies could be established and more specifically adjusted to patients, depending on their gut bacteria composition. Future well-powered human studies are warranted to evaluate the impact of alterations in gut microbiota on thyroid function and diseases.

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