scholarly journals Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2310
Author(s):  
Mai Matsumoto ◽  
Naoko Waki ◽  
Hiroyuki Suganuma ◽  
Ippei Takahashi ◽  
Sizuka Kurauchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Healthy Population ◽  
Model Assessment ◽  
Young Males ◽  
Homeostatic Model Assessment ◽  
Carotenoid Level

Several studies have demonstrated that carotenoid-rich vegetables are useful against cardiovascular diseases (CVDs). However, it is still unclear when a healthy population should start eating these vegetables to prevent CVDs. In this study, we evaluated the role of carotenoids in CVD markers in healthy subjects using age-stratified analysis. We selected 1350 subjects with no history of apparent illness who were undergoing health examinations. We then evaluated the relationship between the serum concentrations of six major carotenoids as well as their total, and nine CVD markers (i.e., body mass index (BMI), pulse wave velocity (PWV), systolic blood pressure (SBP), diastolic blood pressure (DBP), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), blood insulin, fasting blood glucose (FBG), triglycerides (TGs), and high-density lipoprotein (HDL) cholesterol) using multiple regression analysis. It was found that the total carotenoid level was significantly associated with seven markers other than BMI and FBG in males and with eight markers other than DBP in females. Many of these relationships were independent of lifestyle habits. Many significant relationships were found in young males (aged 20–39) and middle-aged females (aged 40–59). These findings can be used as lifestyle guidance for disease prevention although the causal relationships should be confirmed.

scholarly journals Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects

2008 ◽  
Vol 159 (4) ◽  
pp. 389-397 ◽  
Author(s):  
Annamaria Colao ◽  
Carolina Di Somma ◽  
Teresa Cascella ◽  
Rosario Pivonello ◽  
Giovanni Vitale ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Glucose Tolerance ◽  
Model Assessment ◽  
Exclusion Criteria ◽  
Homeostatic Model Assessment ◽  
History Of ◽  
Normotensive Subjects ◽  
Homeostatic Model

BackgroundIn the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality.ObjectiveTo investigate the relationships between IGF1 levels, blood pressure (BP), and glucose tolerance (GT).SubjectsFour-hundred and four subjects (200 men aged 18–80 years). Exclusion criteria: personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (>2 weeks), estrogens, or testosterone (>12 weeks); smoking of >15 cigarettes/day and alcohol abuse (>3 glasses of wine/day).ResultsTwo hundred and ninety-six had normal BP (73.3%), 86 had mild (21.3%), and 22 had severe (5.4%) hypertension; 322 had normal GT (NGT (79.7%)), 53 had impaired glucose tolerance (IGT (13.1%)), 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF1 levels (0.11±0.94 SDS) than those with mild (−0.62±1.16 SDS, P<0.0001) or severe (−1.01±1.07 SDS, P<0.0001) hypertension. IGF1 SDS (t=−3.41, P=0.001) independently predicted systolic and diastolic BP (t=−2.77, P=0.006) values. NGT subjects had significantly higher IGF1 levels (0.13±0.90 SDS) than those with IGT (−0.86±1.14 SDS, P<0.0001) or diabetes mellitus (−1.31±1.13 SDS, P<0.0001). IGF1 SDS independently predicted fasting glucose (t=−3.49, P=0.0005) and homeostatic model assessment (HOMA)-R (t=−2.15, P=0.033) but not insulin (t=−1.92, P=0.055) and HOMA-β (t=−0.19, P=0.85).ConclusionIGF1 levels in the low normal range are associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases.

Dietary inflammatory index potentially increases blood pressure and markers of glucose homeostasis among adults: findings from an updated systematic review and meta-analysis

2019 ◽  
Vol 23 (8) ◽  
pp. 1362-1380 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Leila Nikniaz ◽  
Zeinab Nikniaz ◽  
Parvin Dehghan
Keyword(s):  
Blood Pressure ◽  
Glucose Homeostasis ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Model Assessment ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

AbstractObjective:In the current meta-analysis, we aimed to systematically review and summarize eligible studies for the association between dietary inflammatory index (DII) and blood pressure, hypertension (HTN) and glucose homeostasis biomarkers.Design/Setting:In a systematic search of PubMed, Scopus and Google Scholar electronic databases up to February 2019, relevant studies were included in the literature review. Observational studies evaluating the association between DII and HTN, hyperglycaemia, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and glycated Hb (HbA1c) were included.Participants:Not applicable.Results:Total numbers of studies were as follows: OR for DII and HTN (n 12), OR for DII and hyperglycaemia (n 9), HTN prevalence (n 9), mean (sd) of SBP and DII (n 12), mean (sd) of DBP and DII (n 10), mean (sd) of FBS and DII (n 13), mean (sd) of HbA1c and DII (n 3), mean (sd) of insulin and DII (n 6), mean (sd) of HOMA-IR and DII (n 7). Higher DII scores were associated with higher odds of HTN (OR = 1·13; 95 % CI 1·01, 1·27; P < 0·001), SBP (weighted mean difference (WMD) = 1·230; 95 % CI 0·283, 2·177; P = 0·011), FBS (WMD = 1·083; 95 % CI 0·099, 2·068; P = 0·031), insulin (WMD = 0·829; 95 % CI 0·172, 1·486; P = 0·013), HbA1c (WMD = 0·615; 95 % CI 0·268, 0·961; P = 0·001) and HOMA-IR (WMD = 0·192; 95 % CI 0·023, 0·361; P = 0·026) values compared with lowest DII categories.Conclusions:Lower inflammatory content of diets for prevention of cardiovascular risk factors is recommended.

scholarly journals Insulin Resistance in Patients with Essential Hypertension Using Homeostatic Model Assessment

2018 ◽  
Vol 3 (3) ◽  
pp. 104
Author(s):  
Mohammad Hossein Rasoulzadegan ◽  
Hamid Reza Soltani ◽  
Masoud Rahmanian ◽  
Nakisa Amid
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Plasma Insulin ◽  
Density Lipoprotein ◽  
Uncontrolled Hypertension ◽  
Model Assessment ◽  
Fasting Plasma ◽  
Homeostatic Model Assessment ◽  
Fasting Plasma Insulin ◽  
Homeostatic Model

Introduction: Insulin resistance has a strong relationship with the incidence of type II diabetes. It also has a direct relationship with other risk factors of diabetes, which together are known as metabolic syndrome. The aim of this study was to investigate the relationship between insulin resistance and hypertension.Materials and Methods: In this historical cohort study, 90 patients were divided into three different groups: those without hypertension, those with controlled hypertension, and those with uncontrolled hypertension. Systolic and diastolic blood pressure, body mass index, and laboratory test results such as cholesterol, triglycerides, low- density lipoprotein, high-density lipoprotein, fasting plasma glucose, and fasting plasma insulin were compared among the three groups. Data were analyzed with t-tests and the analysis of variance test, which were performed using statistical package for the social sciences version 20 software.Results: Age and sex were the same among the three groups; however, BMI, systolic blood pressure, and diastolic blood pressure in the uncontrolled-hypertension group were higher than in the controlled-hypertension and without-hypertension groups (P<0.05). Lipid profile (P<0.05), creatinine (P=0.77), and uric acid (P=0.233) were not significantly different among the groups, although fasting plasma insulin (P=0.012) and homeostatic model assessment of insulin resistance (P=0.038) were significantly higher in the uncontrolled-hypertension group than in the other groups.Conclusion: Homeostasis model assessment of insulin resistance in patients with uncontrolled hypertension was higher than in patients with controlled hypertension and those without hypertension. Therefore, homeostatic model assessment of insulin resistance can be used as a predictive clinical test for the early diagnosis of diabetes in patients with uncontrolled hypertension.

scholarly journals Metabolic syndrome among obese patients attending the medical clinics of the three teaching hospitals at Sana’s City, Yemen

2011 ◽  
Vol 1 (6) ◽  
pp. 214 ◽  
Author(s):  
Mohammed A. Bamashmoos ◽  
Abdul W. Al Serouri
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Teaching Hospitals ◽  
Medical Clinics ◽  
Co Morbidity ◽  
Rising Incidence

Background: Yemen faces major challenges in improving the health status of its population as it is entering an epidemiological transition with rising non-communicable diseases e.g. obesity, diabetes and cardiovascular diseases (CVDs). We designed this study to find out the prevalence of Metabolic Syndrome (MS) and its components among obese Yemeni patients. Methods: All obese (waist circumference >102 cm (40 inch) in male and >88 cm (35 inch) in female) attending the outpatients medical clinics at the three teaching hospitals in Sana'a city, were examined and their blood pressure (BP), fasting samples of plasma glucose, triglycerides, and HDL cholesterol were measured. The prevalence of MS obtained based on the Adult Treatment Panel III and presence of at least 3 of the following: systolic BP ≥130 mm Hg and/or diastolic BP ≥ 85 mm Hg or on treatment for high BP, fasting glucose ≥110 mg/dl or on diabetes treatment, triglycerides ≥150 mg/dl, and HDL cholesterol <40 mg/dl in men and <50 mg/dl in women. Results: 200 obese were identified during study period with an overall MS prevalence of 46%. The metabolic co-morbidities were raised BP (68%), high triglycerides (66%), reduced high density lipoprotein (64%), and raised fasting blood glucose (40%).Conclusion: Prevalence of MS is high among obese Yemeni patients and high BP was the commonest co-morbidity. These findings highlight an urgent need to develop strategies for prevention, detection, and treatment of MS that could contribute to decreasing the rising incidence of CVD and diabetes. Keywords: Metabolic syndrome, obesity, cardiovascular diseases, diabetes mellitus, Yemen.

Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population

2009 ◽  
Vol 34 (6) ◽  
pp. 1032-1039 ◽  
Author(s):  
Nan F. Li ◽  
Hong M. Wang ◽  
Jin Yang ◽  
Ling Zhou ◽  
Xiao G. Yao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Lipoprotein Cholesterol ◽  
Model Assessment

The prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight–obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR). This study sought to investigate the relationships between serum uric acid (UA) and these risk factors in this population. A cross-sectional study was conducted in Uygurs (859 males, 1268 females) aged 20 to 70 years. Demographic data, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and fasting and postprandial blood were obtained, and biological measurements were determined. The mean of BMI, SBP, DBP, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, fasting blood glucose, fasting insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), and the prevalence of hypertension, IR, hyperglycemia, overweight–obesity, hypercholesteremia, hyper-LDL-c, and hypertriglyceridemia increased with UA but the prevalence of hypo-HDL-c decreased (p < 0.05). Logistic regression analysis showed that the odds ratios for IR, overweight–obesity, hypercholesteremia, hyper-LDL-c, and hypertriglyceridemia against the lowest UA group increased but decreased for hypo-HDL-c (p < 0.05). The UA in the hypo-HDL-c group was lower than that of the controls; the prevalence of hypo-HDL-c in hyperuricemia subjects was lower than in those with normal UA (p < 0.05). But the opposite results were observed between overweight–obesity, hyperglycemia, IR, hypercholesteremia, hypertriglyceridemia, and hyper-LDL-c and correspondence controls, respectively (p < 0.05). In Uygur, elevated UA is associated with overweight–obesity, hypercholesteremia, hyper-LDL-c, hypertriglyceridemia, hyperglycemia, and IR. The HDL-c level significantly increases with UA, whereas the prevalence of hypo-HDL-c decreases. Further studies are needed to clarify why UA is positively correlated to HDL-c.

scholarly journals Greater Protein Intake at Breakfast or with Snacks and Less at Dinner Is Associated with Improved Metabolic Health in US Adults (P18-003-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Claire Berryman ◽  
Harris R Lieberman ◽  
Victor Fulgoni ◽  
Stefan Pasiakos
Keyword(s):  
Blood Pressure ◽  
Protein Intake ◽  
Hdl Cholesterol ◽  
Metabolic Health ◽  
Activity Level ◽  
Model Assessment ◽  
Cvd Risk ◽  
Funding Sources ◽  
Homeostatic Model Assessment ◽  
Total Fat

Abstract Objectives Greater protein intakes have been associated with decreased weight, BMI, waist circumference (WC) and increased HDL-cholesterol (HDL-C) concentrations. However, the relationship between protein intake during specific eating occasions and metabolic health is not well described. This study measured protein intake at meals (breakfast, lunch, dinner) and snacks and evaluated associations between protein intake at meals or snacks and markers of metabolic health in US adults. Methods Using the National Cancer Institute method, deciles of individual usual intake (IUI) for protein at meals and combined snacking occasions were calculated using NHANES 2013–2016 data (n = 10,112; ≥19 y). Relationships between protein intake at meals and snacks and markers of metabolic health were determined using regression analysis. Covariates included age, age2, sex, ethnicity, physical activity level, poverty income ratio, IUI of carbohydrate at specific meal/snack, IUI of total fat at specific meal/snack, BMI (non-weight-related variables), and IUI of protein at other meals/snacks. P < 0.01 was considered significant. Results Deciles of protein intake ranged (10th and 90th percentiles, mean ± SE) from 5.9 ± 0.1 to 22.6 ± 0.3 g/d at breakfast, 14.0 ± 0.1 to 34.6 ± 0.4 g/d at lunch, 24.3 ± 0.3 to 46.8 ± 0.2 g/d at dinner, and 4.9 ± 0.1 to 16.5 ± 0.2 g/d at snacking occasions. Greater protein intake at breakfast was positively related to HDL-C (0.51 ± 0.17 mg/dL per decile, P = 0.004). Protein intake at dinner was positively associated with the homeostatic model assessment of insulin resistance (0.23 ± 0.08 per decile, P = 0.008). Protein intake from snacks was inversely associated with diastolic blood pressure (−0.27 ± 0.09 mm Hg per decile, P = 0.004) and positively associated with HDL-C (0.68 ± 0.20 mg/dL per decile, P = 0.002). Protein intakes at meals and snacks were not associated with BMI, WC, systolic blood pressure, insulin, glucose, total cholesterol, LDL-cholesterol, triglycerides, or CVD risk. Conclusions In US adults, consuming greater protein at breakfast or with snacks and less protein at dinner may be related to improved metabolic health. Funding Sources The views expressed herein are those of the authors and do not reflect official policy of the Army, DoD, or U.S. Government. Supported by DMRP/USAMRMC.

Risk factors for cardiovascular diseases and development of prehypertension

2018 ◽  
pp. 37-43
Author(s):  
В.В. Шерстнев ◽  
М.А. Грудень ◽  
В.П. Карлина ◽  
В.М. Рыжов ◽  
А.В. Кузнецова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Left Ventricular ◽  
Optimal Blood Pressure

Цель - исследование взаимосвязи факторов риска сердечно-сосудистых заболеваний и развития предгипертонии. Методика. Проведен сравнительный и корреляционный анализы показателей модифицируемых и немодифицируемых факторов риска сердечно-сосудистых заболеваний у обследованных лиц в возрасте 30-60 лет с «оптимальным» артериальным давлением, (n = 63, АД <120/80 мм рт.ст.) и лиц с предгипертонией (n = 52, АД = 120-139/80-89 мм рт.ст.). Результаты. Показано, что лица с предгипертонией по сравнению с группой лиц, имеющих «оптимальное» артериальное давление характеризуются статистически значимо повышенным содержанием холестерина и холестерина липопротеидов низкой плотности, интеллектуальным характером трудовой деятельности, а также значимыми сочетаниями факторов риска: повышенный уровень холестерина липопротеидов низкой плотности с интеллектуальным характером трудовой деятельности; повышенное содержание креатинина с уровнем триглициридов; наследственная отягощенность по заболеваниям почек и интеллектуальным характером трудовой деятельности; наследственная отягощенность по сахарному диабету и гипертрофия левого желудочка сердца. У лиц с предгипертонией документированы перестройки структуры взаимосвязи (количество, направленность и сила корреляций) между показателями факторов риска в сравнении с лицами, имеющими «оптимальное» артериальное давление. Заключение. Выявленные особенности взаимосвязей факторов риска сердечно-сосудистых заболеваний при предгипертонии рассматриваются как проявление начальной стадии дизрегуляционной патологии и нарушения регуляции физиологических систем поддержания оптимального уровня артериального давления. The aim of the study was to investigate the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable risk factors for cardiovascular disease were performed in subjects aged 30-60 with «optimal» blood pressure (n = 63, BP <120/80 mm Hg) and prehypertension (n = 52, BP = 120-139 / 80-89 mm Hg). Results. The group with prehypertension compared with the «optimal» blood pressure group had significantly increased serum levels of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol, sedentary/intellectual type of occupation, and significant combinations of risk factors. The risk factor combinations included an increased level of LDL cholesterol and a sedentary/intellectual occupation; increased serum levels of creatinine and triglycerides; hereditary burden of kidney disease and a sedentary/intellectual occupation; hereditary burden of diabetes mellitus and cardiac left ventricular hypotrophy. In subjects with prehypertension compared to subjects with «optimal» blood pressure, changes in correlations (correlation number, direction, and strength) between parameters of risk factors were documented. Conclusion. The features of interrelationships between risk factors for cardiovascular disease observed in prehypertension are considered a manifestation of early dysregulation pathology and disordered regulation of physiological systems, which maintain optimal blood pressure.

scholarly journals Impact of the Level of Adherence to Mediterranean Diet on the Parameters of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1514
Author(s):  
Dimitra Rafailia Bakaloudi ◽  
Lydia Chrysoula ◽  
Evangelia Kotzakioulafi ◽  
Xenophon Theodoridis ◽  
Michail Chourdakis
Keyword(s):  
Metabolic Syndrome ◽  
Mediterranean Diet ◽  
Observational Studies ◽  
Positive Impact ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Central Registry ◽  
High Adherence ◽  
The Impact

High adherence to the Mediterranean diet (MD) has been associated with a lower prevalence of Metabolic Syndrome (MetS). The present study aimed to investigate the impact of MD adherence on parameters of MetS. A systematic literature search was performed in PubMed, Cochrane Central Registry of Clinical Trials (CENTRAL), Scopus, EMBASE, Web of Science and Google Scholar databases. Observational studies that recorded adherence to MD and components/measures of the MetS, such as waist circumference (WC), blood pressure (BP), fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol and triglycerides (TG), were included in this study. A total of 58 studies were included in our study. WC and TG were significantly lower in the high adherence MD group (SMD: −0.20, (95%CI: −0.40, −0.01), SMD: −0.27 (95%CI: −0.27, −0.11), respectively), while HDL cholesterol was significantly higher in the same group (SMD: −0.28 (95%CI: 0.07, 0.50). There was no difference in FBG and SBP among the two groups (SMD: −0.21 (95%CI: −0.54, 0.12) & SMD: −0.15 (95%CI: −0.38, 0.07), respectively). MD may have a positive impact on all parameters of MetS. However, further research is needed in this field.

scholarly journals Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Richard K. D. Ephraim ◽  
Patrick Adu ◽  
Edem Ake ◽  
Hope Agbodzakey ◽  
Prince Adoba ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Steady State ◽  
Sickle Cell Disease ◽  
Total Cholesterol ◽  
Sickle Cell ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Cell Disease ◽  
Cross Sectional

Background.Abnormal lipid homeostasis in sickle cell disease (SCD) is characterized by defects in plasma and erythrocyte lipids and may increase the risk of cardiovascular disease. This study assessed the lipid profile and non-HDL cholesterol level of SCD patients.Methods.A hospital-based cross-sectional study was conducted in 50 SCD patients, in the steady state, aged 8–28 years, attending the SCD clinic, and 50 healthy volunteers between the ages of 8–38 years. Serum lipids were determined by enzymatic methods and non-HDL cholesterol calculated by this formula: non-HDL-C = TC-HDL-C.Results.Total cholesterol (TC) (p=0.001) and high-density lipoprotein cholesterol (HDL-C) (p<0.0001) were significantly decreased in cases compared to controls. The levels of non-HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were similar among the participants. The levels of decrease in TC and HDL were associated with whether a patient was SCD-SS or SCD-SC. Systolic blood pressure and diastolic blood pressure were each significantly associated with increased VLDL [SBP,p=0.01, OR: 0.74 (CI: 0.6–0.93); DBP,p=0.023, OR: 1.45 (CI: 1.05–2.0)].Conclusion.Dyslipidemia is common among participants in this study. It was more pronounced in the SCD-SS than in SCD-SC. This dyslipidemia was associated with high VLDL as well as increased SBP and DBP.

HDL-enriched miR-30a-5p is associated with HDL-cholesterol levels and glucose metabolism in healthy men and women

Epigenomics ◽  
2021 ◽  
Author(s):  
Andrée-Anne Clément ◽  
Véronique Desgagné ◽  
Cécilia Légaré ◽  
Simon-Pierre Guay ◽  
Marjorie Boyer ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Resistance Index ◽  
Hdl Cholesterol ◽  
Model Assessment ◽  
Women Patients ◽  
Men And Women ◽  
Healthy Men ◽  
Cholesterol Levels ◽  
Cardiometabolic Markers ◽  
Generation Sequencing

Aim: To investigate the associations between high-density lipoprotein (HDL)-enriched miRNAs and the cardiometabolic profile of healthy men and women. Patients & methods: miRNAs were quantified using next-generation sequencing of miRNAs extracted from purified HDL and plasma from 17 healthy men and women couples. Results: Among the HDL-enriched miRNAs, miR-30a-5p correlated positively with HDL-cholesterol levels, whereas miR-144-5p and miR-30a-5p were negatively associated with fasting insulin levels and Homeostasis model assessment of insulin resistance index. Overall, miR-30a-5p, miR-150-5p and sex contributed to 45% of HDL-cholesterol variance. A model containing only miR-30a-5p, age and sex explained 41% of fasting glucose variance. Conclusion: HDL-enriched miRNAs, notably miR-30a-5p, are associated with cardiometabolic markers. These miRNAs could play a role in HDL’s protective functions, particularly regarding glucose-insulin homeostasis.

Sign in / Sign up

Export Citation Format

Share Document