scholarly journals Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2247 ◽  
Author(s):  
Marzia Giribaldi ◽  
Chiara Peila ◽  
Alessandra Coscia ◽  
Laura Cavallarin ◽  
Sara Antoniazzi ◽  
...  
Keyword(s):  
Human Milk ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Bovine Milk ◽  
Neonatal Intensive Care Units ◽  
Donkey Milk ◽  
Vlbw Infants ◽  
Previous Clinical Trial ◽  
Postnatal Adaptation

Fortification of human milk (HM) for preterm and very low-birth weight (VLBW) infants is a standard practice in most neonatal intensive care units. The optimal fortification strategy and the most suitable protein source for achieving better tolerance and growth rates for fortified infants are still being investigated. In a previous clinical trial, preterm and VLBW infants receiving supplementation of HM with experimental donkey milk-based fortifiers (D-HMF) showed decreased signs of feeding intolerance, including feeding interruptions, bilious gastric residuals and vomiting, with respect to infants receiving bovine milk-based fortifiers (B-HMF). In the present ancillary study, the urinary metabolome of infants fed B-HMF (n = 27) and D-HMF (n = 27) for 21 days was analyzed by 1H NMR spectroscopy at the beginning (T0) and at the end (T1) of the observation period. Results showed that most temporal changes in the metabolic responses were common in the two groups, providing indications of postnatal adaptation. The significantly higher excretion of galactose in D-HMF and of carnitine, choline, lysine and leucine in B-HMF at T1 were likely due to different formulations. In conclusion, isocaloric and isoproteic HM fortification may result in different metabolic patterns, as a consequence of the different quality of the nutrients provided by the fortifiers.

A Retrospective Analysis of the Effects of an Exclusively Human Milk Protein Diet on Neonatal Feeding Tolerance

2020 ◽  
Author(s):  
Jessica Wickland ◽  
Christine Wade ◽  
Becky Micetic ◽  
Keith Meredith ◽  
Gregory Martin
Keyword(s):  
Birth Weight ◽  
Human Milk ◽  
Milk Protein ◽  
Very Low Birth Weight ◽  
Bovine Milk ◽  
Milk Diet ◽  
Vlbw Infants ◽  
Key Points ◽  
Human Milk Protein ◽  
Feeding Tolerance

Objective This study was aimed to evaluate the effect of human milk protein fortifier (HMPF) versus bovine milk protein fortifier (BMPF) on feeding tolerance defined as the time to reach full feeds and necrotizing enterocolitis (NEC) in premature very low birth weight (VLBW) infants. Study Design A retrospective review using the BabySteps Database included 493 infants born ≤33 weeks of gestational age and ≤1,250 g (g) birth weight. A total of 218 infants fed a human milk diet (HMD) with BMPF were compared with 275 infants fed an HMD with HMPF. Results Full feeds were reached significantly sooner in the HMPF group (median: 14 vs. 16 days, p = 0.04). Weight at full feeds was significantly lower in the HMPF group (1,060 vs. 1110 g, p = 0.03). Conclusion Using HMPF to provide an exclusively HMD allowed VLBW infants to achieve full feeds sooner, but did not affect rate of NEC compared with using a BMPF with an HMD. Key Points

scholarly journals The Potential Effects of Human Milk on Morbidity in Very-Low-Birth-Weight Preterm Infants

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1882
Author(s):  
Paola Roggero ◽  
Nadia Liotto ◽  
Orsola Amato ◽  
Fabio Mosca
Keyword(s):  
Quality Of Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Mortality And Morbidity ◽  
Vlbw Infants

Improvements in quality of care have led to a significant reduction in mortality and morbidity in preterm infants, especially very-low-birth-weight (VLBW) infants [...]

scholarly journals Cytomegalovirus Infection among Infants in Neonatal Intensive Care Units, California, 2005 to 2016

2019 ◽  
Vol 37 (02) ◽  
pp. 146-150
Author(s):  
Chinh Tran ◽  
Mihoko V. Bennett ◽  
Jeffrey B. Gould ◽  
Henry C. Lee ◽  
Tatiana M. Lanzieri
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Hospital Stay ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Length Of Hospital Stay ◽  
Neonatal Intensive Care Units ◽  
Cmv Infection ◽  
Vlbw Infants

Aim The main purpose of this article is to assess trends in cytomegalovirus (CMV) infection reported among infants in California neonatal intensive care units (NICUs) during 2005 to 2016. Study Design The California Perinatal Quality Care Collaborative collects data on all very low birth weight (VLBW, birth weight ≤ 1,500 g) and acutely ill infants > 1,500 g, representing 92% of NICUs in California. We compared clinical characteristics and length of hospital stay among infants with and without reported CMV infection (CMV-positive viral culture or polymerase chain reaction). Results During 2005 to 2016, CMV infection was reported in 174 VLBW infants and 145 infants > 1,500 g, or 2.7 (range: 1.5–4.7) and 1.2 (range: 0.8–1.7) per 1,000 infants, respectively (no significant annual trend). Among infants > 1,500 g, 12 (8%) versus 4,928 (4%) of those reported with versus without CMV infection died (p < 0.05). The median hospital stay was significantly longer among infants reported with versus without CMV infection for both VLBW infants (98 vs. 46 days) and infants > 1,500 g (61 vs. 14 days) (p < 0.001). Conclusion Reports of CMV infection remained stable over a 12-year period. Although we were not able to assess whether infection was congenital or postnatal, CMV infection among infants > 1,500 g was associated with increased mortality.

scholarly journals Umbilical Venous Catheters and Peripherally Inserted Central Catheters: Are They Equally Safe in VLBW Infants? A Non-Randomized Single Center Study

Medicina ◽  
2019 ◽  
Vol 55 (8) ◽  
pp. 442 ◽  
Author(s):  
Aikaterini Konstantinidi ◽  
Rozeta Sokou ◽  
Polytimi Panagiotounakou ◽  
Maria Lampridou ◽  
Stavroula Parastatidou ◽  
...  
Keyword(s):  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Study Groups ◽  
Catheter Removal ◽  
Neonatal Intensive Care Units ◽  
Peripherally Inserted Central Catheters ◽  
Vlbw Infants ◽  
Catheter Tip ◽  
Indwelling Time ◽  
Central Catheters

Background and Objective: Peripherally inserted central catheters (PICC) and umbilical venous catheters (UVC) are frequently used for vascular access in neonatal intensive care units (NICUs). While there is a significant need for these devices for critically ill neonates, there are many complications associated with their use. We aimed at investigating the incidence of UVC and PICC complications in very low birth weight (VLBW) infants. Materials and Methods: This is an observational study performed with neonates of the tertiary General Hospital of Piraeus, Greece, during an 18 month-period. Seventy-one neonates were recruited and divided into two groups: 34 neonates with PICC and 37 neonates with UVC. We recorded: Catheter dwell time, the causes of catheter removal, other complications, infections, and catheter tip colonization rates. Results: No significant statistical differences were noticed between the 2 study groups with regards to demographic characteristics, causes for catheter removal, catheter indwelling time or the incidence of nosocomial infection. Eleven UVC tips and no PICC tips were proved colonized (p = 0.001) following catheter removal. Conclusions: The incidence of complications associated with the use of UVCs and PICCs in VLBW infants did not significantly differ in our study. Their use seems to be equally safe. Further studies, with larger samples, are necessary to confirm our results.

If Too Much of a Good Thing Is BAD, Is Too Much of a Bad Thing BPD?

PEDIATRICS ◽  
1996 ◽  
Vol 98 (1) ◽  
pp. 125-127
Author(s):  
George Cassady
Keyword(s):  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Community Centers ◽  
Lower Saxony ◽  
Intermittent Mandatory Ventilation ◽  
German State ◽  
Vlbw Infants ◽  
Level Ii ◽  
Community Population

The report by Poets and Sens1 in this issue clearly shows that raising the criteria required for endotracheal intubation and intermittent mandatory ventilation (ET/IMV) in an entire community population of vulnerable, very low birth weight (VLBW) infants reduces bronchopulmonary dysplasia (BPD). Outcomes in all live-born infants with birth weights of between 500 and 1499 g from the German state of Lower Saxony, cared for in tertiary centers (comparable to level III neonatal intensive care units [NICUs] in this country) as well as in community centers (level II NICUs), from 1992 through 1994 were examined. No apparent price was paid for this improvement in pulmonary outcome.

scholarly journals Necrotizing enterocolitis and focal intestinal perforation in neonatal intensive care units in the state of Baden-Württemberg, Germany

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Thomas Böhler ◽  
Ingo Bruder ◽  
Peter Ruef ◽  
Jörg Arand ◽  
Manfred Teufel ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Intensive Care ◽  
Intestinal Perforation ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Necrotising Enterocolitis ◽  
The State ◽  
Neonatal Intensive Care Units ◽  
Vlbw Infants ◽  
Focal Intestinal Perforation

In preterm infants with very low birth weight (VLBW) &lt;1500 g the most important acquired intestinal diseases are necrotising enterocolitis (NEC) and focal intestinal perforation (FIP). We analyzed data of the neonatology module of national external comparative quality assurance for inpatients in the state of Baden-Württemberg, Germany. Between 2010 and 2012, 59 of 3549 VLBW infants developed FIP (1.7%), 128 of them NEC (3.6%). In approximately 3% of infants with BW&lt;1000 g FIP was diagnosed, which was nearly 9 times more often than in infants with BW between 1250 and 1499 g (FIP frequency 0.36%). NEC frequency increased with decreasing BW and was more than 10 times higher in the smallest infants (BW&lt;750 g: 7.87%) compared to those with BW between 1250 and 1499 g (0.72%). The BW limit of 1250 g differentiates between groups of patients with distinguished risks for NEC and FIP.

scholarly journals The Effects of Genetic Relatedness on the Preterm Infant Gut Microbiota

2021 ◽  
Vol 9 (2) ◽  
pp. 278
Author(s):  
Shen Jean Lim ◽  
Miriam Aguilar-Lopez ◽  
Christine Wetzel ◽  
Samia V. O. Dutra ◽  
Vanessa Bray ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Preterm Infant ◽  
Neonatal Intensive Care ◽  
Genetic Relatedness ◽  
Bovine Milk ◽  
Alpha Diversity ◽  
Neonatal Intensive Care Units ◽  
Rrna Gene ◽  
Microbial Composition ◽  
Operational Taxonomic Units

The preterm infant gut microbiota is influenced by environmental, endogenous, maternal, and genetic factors. Although siblings share similar gut microbial composition, it is not known how genetic relatedness affects alpha diversity and specific taxa abundances in preterm infants. We analyzed the 16S rRNA gene content of stool samples, ≤ and >3 weeks postnatal age, and clinical data from preterm multiplets and singletons at two Neonatal Intensive Care Units (NICUs), Tampa General Hospital (TGH; FL, USA) and Carle Hospital (IL, USA). Weeks on bovine milk-based fortifier (BMF) and weight gain velocity were significant predictors of alpha diversity. Alpha diversity between siblings were significantly correlated, particularly at ≤3 weeks postnatal age and in the TGH NICU, after controlling for clinical factors. Siblings shared higher gut microbial composition similarity compared to unrelated individuals. After residualizing against clinical covariates, 30 common operational taxonomic units were correlated between siblings across time points. These belonged to the bacterial classes Actinobacteria, Bacilli, Bacteroidia, Clostridia, Erysipelotrichia, and Negativicutes. Besides the influence of BMF and weight variables on the gut microbial diversity, our study identified gut microbial similarities between siblings that suggest genetic or shared maternal and environmental effects on the preterm infant gut microbiota.

Device-associated pneumonia of very low birth weight infants in Polish Neonatal Intensive Care Units

2016 ◽  
Vol 61 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Jadwiga Wójkowska-Mach ◽  
T. Allen Merritt ◽  
Maria Borszewska-Kornacka ◽  
Joanna Domańska ◽  
Ewa Gulczyńska ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants

scholarly journals A Clinical Analysis of Physical and Neurological Development in very Low Birth Weight Infants with MEIR (Massage, Exercises, Intelligence training, and Rehabilitation training)

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Yonghong Deng ◽  
Shulian Wang ◽  
Zhaohui Liu ◽  
Qi Liao ◽  
Yan Zeng
Keyword(s):  
Growth And Development ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Clinical Analysis ◽  
Psychomotor Development ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Vlbw Infants ◽  
Development Index ◽  
Rehabilitation Training

Objective: This study aimed to investigate the application of MEIR (Massage, Exercises, Intelligence training, and Rehabilitation training) in Chinese VLBW infants and to observe its effects on infants’ growth and development. Methods: Clinical data of 92 VLBW infants who were treated at the neonatal intensive care unit (NICU) of Loudi Central Hospital were retrospectively analyzed. The patients were grouped as the MEIR group (n=47) and controls (n=45). Physical and neurodevelopment development were compared between the two groups. Results: There were differences in height and weight and head circumference between the two groups at all corrected ages (all P<0.05). Abnormal motions, reflexes, muscular tension, audio-visual reactions, and posture, and the total numbers of abnormalities of 3-, 6-, 9- and 12-corrected month-old infants in the MEIR group were lower than in the control group (all P<0.05). The mental development index and psychomotor development index of 6- and 12- corrected month infants in the MEIR group were higher than in the control group (all P<0.05). Conclusion: MEIR could improve the physical and neurological developments of VLBW infants, reduce the incidence of adverse events, and improve their growth and development.

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