scholarly journals Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Increases Muscle Strength in Elderly Adults with Limited Mobility: A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1866 ◽  
Author(s):  
Claire Boutry-Regard ◽  
Gerard Vinyes-Parés ◽  
Denis Breuillé ◽  
Toshio Moritani

Age-related sarcopenia is a progressive and generalized skeletal muscle disorder associated with adverse outcomes. Herein, we evaluate the effects of a combination of electrical muscle stimulation (EMS) and a whey-based nutritional supplement (with or without polyphenols and fish oil-derived omega-3 fatty acids) on muscle function and size. Free-living elderly participants with mobility limitations were included in this study. They received 2 sessions of EMS per week and were randomly assigned to ingest an isocaloric beverage and capsules for 12 weeks: (1) carbohydrate + placebo capsules (CHO, n = 12), (2) whey protein isolate + placebo capsules (WPI, n = 15) and (3) whey protein isolate + bioactives (BIO) capsules containing omega-3 fatty acids, rutin, and curcumin (WPI + BIO, n = 10). The change in knee extension strength was significantly improved by 13% in the WPI + BIO group versus CHO on top of EMS, while WPI alone did not provide a significant benefit over CHO. On top of this, there was the largest improvement in gait speed (8%). The combination of EMS and this specific nutritional intervention could be considered as a new approach for the prevention of sarcopenia but more work is needed before this approach should be recommended. This trial was registered at the Japanese University Hospital Medical Information Network (UMIN) clinical trial registry (UMIN000008382).

2014 ◽  
Vol 5 (11) ◽  
pp. 2743-2750 ◽  
Author(s):  
Divya Eratte ◽  
Bo Wang ◽  
Kim Dowling ◽  
Colin. J. Barrow ◽  
Benu P. Adhikari

Tuna oil rich in omega-3 fatty acids was microencapsulated in whey protein isolate (WPI)–gum arabic (GA) complex coacervates, and subsequently dried using spray and freeze drying to produce solid microcapsules.


2015 ◽  
Vol 19 ◽  
pp. 882-892 ◽  
Author(s):  
Divya Eratte ◽  
Stafford McKnight ◽  
Thomas R. Gengenbach ◽  
Kim Dowling ◽  
Colin J. Barrow ◽  
...  

2018 ◽  
Vol 9 (11) ◽  
pp. 5598-5606 ◽  
Author(s):  
Michelle C. Lee ◽  
Xiaofei Jiang ◽  
J. Thomas Brenna ◽  
Alireza Abbaspourrad

The fish oil is encapsulated in a multi-compartment system featuring β-cyclodextrin complexation within whey protein isolate (WPI) coated oleogel particles.


2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 499-499
Author(s):  
Aubree Hawley ◽  
Caroline Baughn ◽  
Angela Tacinelli ◽  
Sam Walker ◽  
Xinya Liang ◽  
...  

Abstract Objectives Approximately 30% of adults ≥ 50 years of age suffer from poor sleep quality and the prevalence of sleep disruption is notably higher in postmenopausal women, with 35 to 60% reporting significant sleep disruption.  Sleep deprivation and low sleep quality are associated with increased energy intake, insulin resistance, elevated glucose, and mood disturbances (e.g., stress, cortisol, and depression). The objective of this study was to determine if the effect of protein and/or omega-3 fatty acid (O3FA) supplementation improves mood and sleep in postmenopausal women. Methods Thirty-nine postmenopausal women (age: 61.3 ± 8.7 years; BMI: 27.6 ± 6.6 kg/m2) were randomly allocated to one of 5 groups: 1) control (CON; no intervention free-living; n = 6), 2) whey protein isolate (PRO; 25 g/d; n = 7), 3) O3FA (DHA/EPA; 4.3 g/d; n = 10), 4) PRO + placebo soybean oil (PRO + PLA; 4.1 g/d; n = 7), or 5) PRO + O3FA (n = 9). Sleep and mood states were assessed at 0, 4, 8, 12, and 16 weeks, except objective sleep, which was assessed at 0, 8, and 16 weeks.  Sleep was measured using the Pittsburgh Sleep quality Index (PSQI) and wrist actigraphy, mood was measured using the Profile of Mood States (POMS), and markers of sleep and mood, orexin, BDNF, and cortisol, were measured using commercially available kits. Results A significant time effect (P < 0.05) was observed on subjective sleep (PSQI), subjective mood states, BDNF, and cortisol concentrations. Although not significant, a greater % decrease in PSQI Global Sleep Score was observed in PRO (-30.3%), O3FA (-23.3%), PRO + PLA (−20.2%), and PRO + O3FA (−26.4%) when compared to an increase in CON (+18%). Similarly, a decrease trend in POMS Total Mood Disturbances from baseline was observed in PRO (−10 ± 27.7), O3FA (−6.7 ± 18.2), and PRO + O3FA (−6.9 ± 27.7) compared to no change in PRO + PLA (0.1 ± 11.5) and an increase in CON (5 ± 15.8). We observed a significant treatment effect on orexin (OXA; pg/mL; P < 0.05). OXA increased significantly in PRO + O3FA compared to all other groups (P < 0.05). Conclusions Although not significant, the data suggests individual and combined supplementation of protein and O3FA have the potential to improve sleep, mood, and orexin levels in postmenopausal women. NCT0303041 Funding Sources Arkansas Biosciences Institute


Foods ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 671 ◽  
Author(s):  
Nancy A. Chasquibol ◽  
Gabriela Gallardo ◽  
Raquel B. Gómez-Coca ◽  
Diego Trujillo ◽  
Wenceslao Moreda ◽  
...  

Sacha inchi (Plukenetia huayllabambana L. and Plukenetia volubilis L.) edible oils were microencapsulated and the lipid fraction of the microparticles was characterized. Hi-cap®, Capsule®, Arabic gum, and the binary combination of Arabic gum + maltodextrin and the ternary combination of Arabic gum + maltodextrin + whey protein isolate, were used as coating materials for the encapsulation process using spray-drying. The surface and the total oils obtained from the microparticles were evaluated in terms of fatty acid composition, minor glyceride polar compounds, polymers, oxidized triglycerides, diglycerides, monoglycerides, and free fatty acids, along with their unsaponifiable components, sterols, and tocopherols. Differences between the original oils and the microencapsulated ones were determined. The most remarkable results included the presence of polymers when there were none in the original oils, the slight loss in ω3-fatty acids, up to 6%, the loss in tocopherols, in some of the cases around 30%, the maintaining of the phytosterol in their initial levels and the presence of cholesterol in the oils encapsulated with whey protein isolate.


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