scholarly journals Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1811
Author(s):  
Edyta Mądry ◽  
Ida Judyta Malesza ◽  
Mehala Subramaniapillai ◽  
Agata Czochralska-Duszyńska ◽  
Marek Walkowiak ◽  
...  
Keyword(s):  
Body Composition ◽  
Adipose Tissue ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Body Fat ◽  
Controlled Trial ◽  
Obese Women ◽  
Overweight Women ◽  
Liver Safety ◽  
Fat Composition

Preliminary evidence suggests that conjugated linoleic acid (CLA) may reduce body weight and affect body composition. The present study assessed the effect of CLA supplementation on body fat composition in overweight and obese women, while also evaluating the liver safety of CLA use. Seventy-four obese or overweight women were randomly assigned to receive 3 g/day CLA or placebo for 12 weeks. Body composition (dual-energy X-ray absorptiometry) and liver function (13C-methacetin breath test and serum liver enzymes) were assessed before and after the trial. Patients receiving CLA experienced a significant reduction of total body fat expressed as mass (p = 0.0007) and percentage (p = 0.0006), android adipose tissue (p = 0.0002), gynoid adipose tissue (p = 0.0028), and visceral adipose tissue (p = 4.2 × 10−9) as well as a significant increase in lean body mass to height (p = 6.1 × 10−11) when compared to those receiving a placebo. The maximum momentary 13C recovery changes and end-point values were significantly higher in the CLA group when compared to the placebo group (p = 0.0385 and p = 0.0076, respectively). There were no significant changes in alanine aminotransferase, asparagine aminotransferase, and gamma-glutamyl transpeptidase activities between the groups. In conclusion, CLA supplementation was well tolerated and safe for the liver, which shows beneficial effects on fat composition in overweight and obese women.

Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-Blinded, and Placebo-Controlled Trial

2016 ◽  
Vol 26 (2) ◽  
pp. 135-144 ◽  
Author(s):  
Alex S. Ribeiro ◽  
Fábio Luiz C. Pina ◽  
Soraya R. Dodero ◽  
Danilo R. P. Silva ◽  
Brad J. Schoenfeld ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Aerobic Exercise ◽  
Lipid Profile ◽  
Conjugated Linoleic Acid ◽  
Body Fat ◽  
Controlled Trial ◽  
Plasma Lipoproteins ◽  
Obese Women ◽  
Food Record ◽  
Double Blinded

The aim of this study was to analyze the effects of 8 weeks of conjugated linoleic acid (CLA) supplementation associated with aerobic exercise on body fat and lipid profile on obese women. We performed a randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/day of CLA or 4 g/day of olive oil (placebo group) while performing an 8-week protocol of aerobic exercise. Dietary intake (food record), body fat (dual-energy X-ray absorptiometry), and biochemical analysis (blood sample) were assessed before and after the intervention period. Independent of CLA supplementation, both groups improved (p < .05) oxygen uptake (CLA group, 13.2%; PLC group, 14.8%), trunk fat (CLA group, −1.0%; PLC group, −0.5%), leg fat (CLA group, −1.0%; PLC group, −1.6%), and total body fat (CLA group, −1.7%; PLC group, −1.3%) after the 8-week intervention. No main effect or Group × Time interaction was found for total cholesterol, triglycerides, and plasma lipoproteins (p > .05). We conclude that CLA supplementation associated with aerobic exercise has no effect on body fat reduction and lipid profile improvements over placebo in young adult obese women.

Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake

1999 ◽  
Vol 276 (4) ◽  
pp. R1172-R1179 ◽  
Author(s):  
James P. DeLany ◽  
Fawn Blohm ◽  
Alycia A. Truett ◽  
Joseph A. Scimeca ◽  
David B. West
Keyword(s):  
Body Composition ◽  
Linoleic Acid ◽  
Food Intake ◽  
Conjugated Linoleic Acid ◽  
Energy Intake ◽  
Body Fat ◽  
Metabolic Effects ◽  
Protein Accumulation ◽  
High Fat ◽  
Fat Accumulation

Recent reports have demonstrated that conjugated linoleic acid (CLA) has effects on body fat accumulation. In our previous work, CLA reduced body fat accumulation in mice fed either a high-fat or low-fat diet. Although CLA feeding reduced energy intake, the results suggested that some of the metabolic effects were not a consequence of the reduced food intake. We therefore undertook a study to determine a dose of CLA that would have effects on body composition without affecting energy intake. Five doses of CLA (0.0, 0.25, 0.50, 0.75, and 1.0% by weight) were studied in AKR/J male mice ( n = 12/group; age, 39 days) maintained on a high-fat diet (%fat 45 kcal). Energy intake was not suppressed by any CLA dose. Body fat was significantly lower in the 0.50, 0.75, and 1.0% CLA groups compared with controls. The retroperitoneal depot was most sensitive to the effects of CLA, whereas the epididymal depot was relatively resistant. Higher doses of CLA also significantly increased carcass protein content. A time-course study of the effects of 1% CLA on body composition showed reductions in fat pad weights within 2 wk and continued throughout 12 wk of CLA feeding. In conclusion, CLA feeding produces a rapid, marked decrease in fat accumulation, and an increase in protein accumulation, at relatively low doses without any major effects on food intake.

scholarly journals Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects

2007 ◽  
Vol 97 (2) ◽  
pp. 273-280 ◽  
Author(s):  
Julie-Anne Nazare ◽  
Aude Brac de la Perrière ◽  
Fabrice Bonnet ◽  
Michel Desage ◽  
Jocelyne Peyrat ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Composition ◽  
Adipose Tissue ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Fat Mass ◽  
Healthy Subjects ◽  
Dairy Product ◽  
Mrna Levels ◽  
Ppar Γ

Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. The present study was designed to determine whether 14-week CLA supplementation as triacylglycerols (3·76 g) with a 50 : 50 combination of the two main isomers (35 %cis-9,trans-11 and 35 %trans-10,cis-12) added to flavoured yoghurt-like products was able to alter body composition in healthy subjects and to alter the expression of several key adipose tissue genes (PPAR γ, lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and uncoupling protein 2 (UCP-2)). Forty-four healthy subjects were randomly assigned to consume daily either a CLA-supplemented yoghurt-like product or a placebo yoghurt for 98 d. There were no significant effects of CLA supplementation on body weight, fat mass or free fat mass. Basal energy expenditure expressed as kg free fat mass increased significantly in the CLA group (123·3 (sem2·5) kJ/kg free fat mass per d on day 98v.118·7 (sem2·3) kJ/kg free fat mass per d on day 0,P = 0·03). PPAR γ mRNA gene expression increased significantly with CLA supplementation (53 (sem20) %,P < 0·01) and a significant reduction in mRNA levels of HSL was observed ( − 42 (sem7) %,P = 0·01). The levels of UCP-2 and LPL mRNA were not affected. The present results suggest that a 98 d supplementation diet with a 50 : 50 mixture of the two CLA isomerscis-9,trans-11 andtrans-10,cis-12 in a dairy product was unable to alter body composition, although a significant increase in the RMR has been induced. Moreover, changes in mRNA PPAR γ and HSL in adipose tissue were recorded.

scholarly journals Conjugated Linoleic Acid (CLA) Effect on Body Weight and Body Composition in Women (Systematic Review and Meta-Analysis).

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Hanady Hamdallah ◽  
H. Elyse Ireland ◽  
John Williams
Keyword(s):  
Body Weight ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Body Mass ◽  
Body Fat ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Obese Women ◽  
Menopausal Women ◽  
Post Menopausal

AbstractIntroduction:Conjugated linoleic acid (CLA) is a food supplement that is proposed as an anti-obesity supplement in animal and human studies. Animal studies have shown a significant anti-obesity effect of CLA, but results in humans were inconsistent, where some of the studies found an anti-obesity effect while other studies failed to find any decline in obesity markers after CLA supplementation. This meta-analysis aimed to determine if oral CLA supplementation has been shown to reduce obesity-related markers in women.Method:Pub Med, Cochrane Library, and Google Scholar were used to identify the eligible trials using two main searching strategies: the first one was to search eligible trials using keywords “Conjugated linoleic acid”, “CLA”, “Women”, and the second strategy was to extract the eligible trials from previously published systematic reviews and meta-analyses. The eligible trials were placebo control trials where women supplemented with CLA mixture in the form of oral capsules for 6 months or less. Furthermore, eligible trials reported body weight (BW), body mass index (BMI), total body fat (TBF), percentage body fat (BF%), and/ or lean body mass (LBM). The quality of each included study was assessed using both JADAD scale and an adapted CONSERT checklist.Results:Meta-analysis of 8 eligible trials showed that CLA supplementation was significantly associated with reduced BW (Mean ± SD, 1.2 ± 0.26 kg, p < 0.001), BMI (0.6 ± 0.13kg/m2, p < 0.001) and TBF (0.76 ± 0.26 kg, p = 0.003) in women, when supplemented over 6–16 weeks. Subgroup meta-analysis demonstrated a significant reduction in BW (1.29 ± 0.31 kg, p < 0.001), BMI (0.60 ± 0.14 kg/m2, p < 0.001) and TBF (0.82 ± 0.28 kg, p = 0.003) in the trials that had recruited overweight-obese women. The second subgroup meta-analysis, that considered the menopausal status of the participants, found that CLA was significantly associated with reduced BW (1.35 ± 0.37 kg, p < 0.001; 1.05 ± 0.36 kg, p = 0.003) and BMI (0.50 ± 0.17 kg/m2, p = 0.003; 0.75 ± 0.2 kg/m2, p < 0.001) in both pre and post-menopausal age women, respectively. A reduction in TBF (1.09 ± 0.37 kg, p = 0.003) was only significant in post-menopausal women.Discussion:This meta-analysis suggests a moderate anti-obesity effect of CLA on BW, BMI and TBF reduction in women, when supplemented over 6–16 weeks, particularly in overweight-obese women and post-menopausal women. More well-designed trials are required to confirm this meta-analysis results.

scholarly journals Trans-10,cis-12-conjugated linoleic acid does not increase body fat loss induced by energy restriction

2008 ◽  
Vol 100 (6) ◽  
pp. 1245-1250 ◽  
Author(s):  
Arrate Lasa ◽  
Itziar Churruca ◽  
Edurne Simón ◽  
Alfredo Fernández-Quintela ◽  
Victor Manuel Rodríguez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Body Fat ◽  
Body Weight Loss ◽  
Energy Restriction ◽  
Hormone Sensitive Lipase ◽  
Epididymal Adipose Tissue ◽  
Fat Reduction ◽  
Hormone Sensitive

Very little evidence exists concerning the effects of conjugated linoleic acid (CLA) on body fat reduction induced by energy restriction. Moreover, although an effect oftrans-10,cis-12-CLA on lipolysis has been suggested, it has not been consistently shown. The aims of the present study were to determine whethertrans-10,cis-12-CLA increases the reduction of body fat induced by energy restriction, and to analyse its effect on lipolysis and adipose tissue lipase expression (hormone-sensitive lipase (HSL) and adipose tissue TAG lipase (ATGL)). Male Syrian Golden hamsters were fed a high-fat diet during 7 weeks in order to make them fatter. Then they were submitted to a mild energy restriction (25 %) without or with supplementation of 0·5 %trans-10,cis-12-CLA for 3 weeks. Basal glycerol release and lipolysis stimulated by several drugs acting at different levels of the lipolytic cascade were measured in epididymal adipose tissue. The expression of HSL and ATGL was assessed by real-time RT-PCR. No differences were found in adipose tissues size between the experimental groups. Medium adipocyte size and total number of adipocytes were similar in both experimental groups. Animals fed the CLA-enriched diet showed similar lipolytic rates as well as HSL and ATGL expressions to the controls. In conclusion,trans-10,cis-12-CLA does not promote adipose tissue lipid mobilisation nor does it heighten body fat reduction induced by energy restriction. Consequently, this CLA isomer does not seem to be a useful tool to be included in body weight-loss strategies followed in obesity treatment.

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