scholarly journals Vitamin K Status in Adherent and Non-Adherent Patients with Phenylketonuria: A Cross-Sectional Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1772
Author(s):  
Renata Mozrzymas ◽  
Dariusz Walkowiak ◽  
Sławomira Drzymała-Czyż ◽  
Patrycja Krzyżanowska-Jankowska ◽  
Monika Duś-Żuchowska ◽  
...  
Keyword(s):  
Vitamin K ◽  
Cross Sectional Study ◽  
Dietary Vitamin ◽  
Dietary Recommendations ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
Dietary Compliance ◽  
Dietary Consumption ◽  
Vitamin Intake ◽  
K Deficiency

This is the first study to evaluate vitamin K status in relation to dietary intake and phenylalanine dietary compliance in patients with phenylketonuria (PKU). The dietary and PKU formula intake of vitamin K was calculated in 34 PKU patients, with vitamin K status determined by the measurement of prothrombin induced by vitamin K absence (PIVKA-II). Blood phenylalanine concentrations in the preceding 12 months were considered. There were significantly more phenylalanine results exceeding 6 mg/dL in patients with normal PIVKA-II concentrations than in those with abnormal PIVKA-II levels (p = 0.035). Similarly, a higher total intake of vitamin K and dietary vitamin intake expressed as μg/day (p = 0.033 for both) and %RDA (p = 0.0002 and p = 0.003, respectively) was observed in patients with normal PIVKA-II levels. Abnormal PIVKA-II concentrations were associated with a lower OR (0.1607; 95%CI: 0.0273–0.9445, p = 0.043) of having a median phenylalanine concentration higher than 6 mg/dL. In conclusion, vitamin K deficiency is not uncommon in phenylketonuria and may also occur in patients with adequate vitamin K intake. PKU patients with better dietary compliance have a higher risk of vitamin K deficiency. The present findings highlight the need for further studies to re-evaluate dietary recommendations regarding vitamin K intake, both concerning formula-based and dietary consumption of natural products.

Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

10.20883/181 ◽  
2016 ◽  
Vol 85 (4) ◽  
pp. 276
Author(s):  
Jan Krzysztof Nowak ◽  
Andrzej Wykrętowicz ◽  
Patrycja Krzyżanowska ◽  
Agnieszka Górna ◽  
Jarosław Tobolski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Vitamin K ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
K Deficiency ◽  
The Relationship

Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification. However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors. Material and Methods. We performed a pilot cross‑sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people. The concentration of protein induced by vitamin K absence‑II (PIVKA‑II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA. Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results. Twenty‑three healthy subjects were enrolled (16 female; mean age 21.3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2). The diastolic blood pressure (DBP) was lower in vitamin K‑deficient subjects (58 ± 9 vs. 67 ± 5 mmHg, p = 0.01). The mean arterial blood pressure also differed (75 ± 9 vs. 83 ± 6, p = 0.02). PIVKA‑II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ρ ns.). Stepwise regression identified PIVKA‑II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.1%; PIVKA‑II: β = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p < 0.05).Conclusions. The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.

scholarly journals Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

2016 ◽  
Vol 85 (4) ◽  
pp. 276-280
Author(s):  
Jan Krzysztof Nowak ◽  
Andrzej Wykrętowicz ◽  
Patrycja Krzyżanowska ◽  
Agnieszka Górna ◽  
Jarosław Tobolski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Vitamin K ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
K Deficiency ◽  
The Relationship

Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification. However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors. Material and Methods. We performed a pilot cross-sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people. The concentration of protein induced by vitamin K absence-II (PIVKA-II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA. Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results. Twenty-three healthy subjects were enrolled (16 female; mean age 21.3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2). The diastolic blood pressure (DBP) was lower in vitamin K-deficient subjects (58 ± 9 vs. 67 ± 5 mmHg, p = 0.01). The mean arterial blood pressure also differed (75 ± 9 vs. 83 ± 6, p = 0.02). PIVKA-II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ? ns.). Stepwise regression identified PIVKA-II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.1%; PIVKA-II: ß = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p < 0.05).Conclusions. The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.

Letter To The Editor

PEDIATRICS ◽  
1970 ◽  
Vol 45 (5) ◽  
pp. 892-892
Author(s):  
Herbert I. Goldman
Keyword(s):  
Vitamin K ◽  
Dietary Vitamin ◽  
Vitamin K Deficiency ◽  
Letter To The Editor ◽  
K Deficiency

Dr. Goldman commented as follows: The letter of Drs. Burgio and Vaccaro presents additional evidence that dietary vitamin K deficiency may occur during the course of diarrhea and/or the use of antimicrobials. We are continuing to study this matter in an attempt to define the vitamin K requirement under these circumstances.

scholarly journals P1485SEVELAMER USE IS ASSOCIATED WITH DECREASED VITAMIN K LEVELS IN HEMODIALYSIS PATIENTS: RESULTS FROM VITAMIN K ITALIAN (VIKI) STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Maria Fusaro ◽  
Andrea Aghi ◽  
Pascale Khairallah ◽  
Maurizio Gallieni ◽  
Mario Gennaro Cozzolino ◽  
...  
Keyword(s):  
Vitamin K ◽  
Vertebral Fractures ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Matrix Gla Protein ◽  
Phosphate Binding ◽  
Cross Sectional ◽  
K Deficiency ◽  
Causal Nature ◽  
The Relationship

Abstract Background and Aims Sevelamer (S) is a phosphate binding drug used to treat hyperphosphatemia in patients with CKD. Our aim was to evaluate the hypothesis that the use of (S) could interfere with Vitamin K absorption in hemodialysis (HD) patients of VIKI study. Method We tested this hypothesis in VIKI, a cross-sectional study of 387 hemodialysis patients, we established the prevalence of vitamin K deficiency and to assessed the relationship between vitamin K status, vertebral fractures, vascular calcification. We determined serum concentrations of vitamin 25(OH)D; alkaline phosphatase (ALP); vitamers K1, MK4, MK5, MK6, MK7; osteocalcin (BGP) and Matrix Gla Protein (MGP). We highlighted that MK4 deficiency was the strongest predictor of aortic calcification (OR, 2.82; 95% CI, 1.14–7.01) while vitamin K1 deficiency was the strongest predictor of vertebral fractures fractures (OR: 2.94; 95% CI, 1.38–6.26). Results 163 of 387 patients (42.1%) were treated with Sevelamer. There were no differences in levels of 25(OH)D, K1, MK5, MK6 and MK7 among patients treated with and without Sevelamer. Remarkably, the prevalence of MK4 deficiency was higher in Sevelamer treated patients (13.5% vs 5.4%, p=0.005). Sevelamer treated patients also had higher median levels of ALK (89 UI/L vs 77.5 UI/L, p=0.001) and total BGP (210 mcg/L vs 152 mcg/L, p=0.002) and lower median levels of total MGP (16.4 nmol/L vs 20.3 nmol/L, p=0.037) (Table 1 and Figure 1). In multivariable logistic regression, the odds ratio of MK4 deficiency (dependent variable) in patients treated with compared to without Sevelamer was ∼3-fold higher (OR: 2.64, 95% CI: 1.25-5.58, p=0.011) after adjustment for confounders of Vitamin K levels, including older age, previous myocardial infarction, type of HD, ALP, PTH, MGP, BGP, cholesterol and albumin. Conclusion These data support the hypothesis that Sevelamer could interfere with MK4 absorption in HD patients. Longitudinal interventional studies are needed to prove the causal nature of these associations.

scholarly journals Factors That Affect Vitamin K Injection To Newborn By Midwives At Bukittinggi Area on 2017

2018 ◽  
Vol 9 (1) ◽  
pp. 44
Author(s):  
Mutia Felina ◽  
Marlina Marlina
Keyword(s):  
Vitamin K ◽  
Random Sampling ◽  
Blood Clotting ◽  
Health Workers ◽  
Sampling Technique ◽  
Clotting Factors ◽  
Vitamin K Deficiency ◽  
Chi Square ◽  
Cross Sectional ◽  
K Deficiency

Vitamin K is a fat-soluble vitamin that has an important role in activating substances that play a role in blood clotting, including substances known as prothrombin and clotting factors. The purpose of this research is to know the knowledge factor of midwife toward vitamin K in the newborn with midwifery in the prevention of vitamin K deficiency in the newborn in Bukitinggi city. This type of research is cross-sectional, and this research is done in Bukittinggi City Year 2017. Sampling technique with Random Sampling or randomly. The research will be carried out in the Working Area of Bukittinggi City in 2017. The population and sample in this study are all midwives who have BPM in Bukittinggi City with a sample size of 21 midwives. Data analysis with chi-square showed that there was no correlation between midwife knowledge on vitamin K administration in BBL with the working period and availability of midwife in preventing vitamin K deficiency on BBL with p = 0,0001 (p> 0,05). It is recommended for health workers in Kota Bukittinggi to improve the standard services of Midwifery, especially to newborns.

Vitamin K deficiency from dietary vitamin K restriction in humans

1988 ◽  
Vol 47 (3) ◽  
pp. 475-480 ◽  
Author(s):  
J W Suttie ◽  
L L Mummah-Schendel ◽  
D V Shah ◽  
B J Lyle ◽  
J L Greger
Keyword(s):  
Vitamin K ◽  
Dietary Vitamin ◽  
Vitamin K Deficiency ◽  
K Deficiency

scholarly journals Gambaran Pengetahuan Bidan dan Perawat Tentang VKDB di Puskesmas Prabumulih Sumatera Selatan

2021 ◽  
Vol 2 (1) ◽  
pp. 23-29
Author(s):  
Sri Utami ◽  
Muhamad Yunus ◽  
Deviani Utami
Keyword(s):  
Health Center ◽  
Vitamin K ◽  
Health Workers ◽  
Cerebral Atrophy ◽  
Intracranial Bleeding ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
K Deficiency ◽  
Level Of Knowledge ◽  
The Impact

 Intracranial hemorrhage is a dangerous bleeding in infants. The impact of intracranial bleeding is in the form of death and sequelae, such as hydrocephalus, cerebral atrophy, encephalopathy, and epilepsy which will interfere with growth and development. One of the causes of intracranial bleeding is bleeding due to Vitamin K deficiency (VKDB). Meanwhile, intracranial bleeding due to vitamin K deficiency can be prevented by giving vitamin K1 to newborns. This study aimed to know the description of the level of knowledge of health workers about spontaneous intracranial bleeding caused by vitamin K deficiency bleeding at the Prabumulih Health Center, South Sumatra in 2020. The type of research used in this research is descriptive with a cross sectional design. The samples used in this study were nurses and midwives who worked at the Prabumulih Health Center in South Sumatra who had met the criteria in this study. The result showed that the frequency of sufficient knowledge of respondents was found as many as 31 people with a percentage of 46.3%. In conclusion Midwives at the Prabumulih health center in South Sumatra have a sufficient level of knowledge about intracranial bleeding due to vitamin K deficiency. It is hoped that this study can provide information to the public about the knowledge of intracranial bleeding due to vitamin K deficiency, so that the incidence of intracranial bleeding due to vitamin K deficiency and infant mortality can be reduced.

scholarly journals Intracranial hemorrhage in hemorrhagic disease of the newborn

2016 ◽  
Vol 43 (3) ◽  
pp. 82
Author(s):  
Irawan Mangunatmadja ◽  
Rina W Sundariningrum ◽  
Hardiono D Pusponegoro ◽  
Endang Windiastuti
Keyword(s):  
Intracranial Hemorrhage ◽  
Vitamin K ◽  
Coagulation Factors ◽  
Cross Sectional Study ◽  
Hemorrhagic Disease ◽  
Anterior Fontanel ◽  
Cross Sectional ◽  
Normal Delivery ◽  
K Deficiency ◽  
Almost All

Background Hemorrhagic disease of the newborn (HDN) repre-sents a special case of vitamin K deficiency because the four vita-min K-coagulation factors (factors II,VII,IX,X) are already at physi-ologically low levels in the newborn. It responds to vitamin Ktherapy.Objective The aim of this study was to review the incidence, clini-cal manifestation, and outcome of HDN.Methods This was a retrospective cross sectional study on 22patients hospitalized for HDN in the Department of Child Health,Cipto Mangunkusumo Hospital from January 1997 until Decem-ber 2001. Data were obtained from medical records.Results The commonest age group (17 out of 22) was 1–3 month-old. Normal delivery was found in 19 patients and only 3 patientsreceived prophylaxis vitamin K. Almost all of them (20 out of 22)were exclusively breastfed. Seizure, pallor, decreased conscious-ness, and bulging of the anterior fontanel were significant clinicalmanifestations found in 21, 21, 13, and 9 patients respectively.Based on brain USG and/or CT scan, intracranial hemorrhage wasfound in 19 patients. Six out of 22 patients died and 7 patientssurvived with handicapConclusion Intracranial hemorrhage due to vitamin K mostly oc-curred at the age of 1 to 3 month-old. The commonest clinical mani-festations were seizure, pallor, decreased consciousness, andbulging of the anterior fontanel. Prevention by giving vitamin K rou-tinely to all newborn babies is recommended

The Impact Of Dietary Vitamin K On The Pharmacological Activity Of FXa Inhibitor, Rivaroxaban, In Man

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 4808-4808
Author(s):  
Farhad Kamali ◽  
Salah Abohelaika ◽  
Tina T. Biss ◽  
Judith Coulson ◽  
Hilary Wynne ◽  
...  
Keyword(s):  
Vitamin K ◽  
Pharmacological Activity ◽  
Healthy Subjects ◽  
The Elderly ◽  
Dietary Vitamin ◽  
Elderly Subjects ◽  
Vitamin K Deficiency ◽  
K Deficiency ◽  
The Mean ◽  
The Impact

Introduction/Background Over several decades, warfarin has been used as the drug of choice for prevention and treatment of thromboembolic disorders. The impact of dietary vitamin K intake on anticoagulation response to warfarin is well established. However, the effect of dietary vitamin K on the activity of the novel oral anticoagulants is less well known. Since the activation of both factor X and thrombin is inextricably linked to the vitamin K cycle in the coagulation cascade, there is the possibility that the pharmacological activity of agents that inhibit these proteins could be influenced by alterations in vitamin K availability. Aim To examine the influence of dietary vitamin K intake on the pharmacological activity of rivaroxaban in man. Methods The pharmacological activity of rivaroxaban was evaluated ex-vivo. Thirty one medically stable elderly inpatients (12 males) with a poor dietary intake in terms of calories and nutrients including vitamin K (12 males) and 28 healthy subjects (7 males) with adequate diets were enrolled into the study. An overnight fasted venous blood sample (20 ml) was taken from each subject. The plasma was stored at -80 degree C for the later measurement of the effects of rivaroxaban on clotting times and clotting factor activity. Each subject completed a validated dietary questionnaire for quantification of vitamin K content of foods eaten in the past week. The plasma samples from each subject were incubated with a range of rivaroxaban concentrations (100 - 500 ng/ml) in order to simulate the therapeutic drug plasma concentrations. Normal prothrombin time (PT), modified prothrombin time (mPT), and vitamin K dependent clotting factors activity were measured according to established in-house methods. Results The mean±SD age of elderly patients and healthy subjects was 87±6 and 36±10 years, respectively. Rivaroxaban produced a greater prolongation of both PT (P=0.01) and m-PT (P=0.02) in the plasma of elderly subjects than the younger healthy subjects over the drug concentration range studied. The mean difference in PT between the two groups ranged from 1.8s to 5.0s at 100 ng/ml and 500 ng/ml plasma rivaroxaban concentrations respectively. The mean difference in m-PT between the two groups ranged from 10.0s to 34.0s at 100 ng/ml and 500 ng/ml plasma rivaroxaban concentrations respectively. There was also a greater inhibition of factor Xa (P=0.005) activity by rivaroxaban in the elderly subjects compared to the healthy subjects, whereas factor IXa (P=0.03) activity was significantly inhibited in the healthy subjects compared to the elderly subjects. However, there were no significant differences between the two groups in factors II and VII activity and fibrinogen concentration. The analysis of dietary questionnaires for vitamin K intake and plasma for fasting vitamin K levels is in progress and the results will be presented. Conclusion We have previously demonstrated in a proof-of-concept study in rats that vitamin K deficiency significantly enhanced the pharmacological activity of the prototype DTI, ximelagatran [1]. The present study findings suggest that the anticoagulation response to rivaroxaban may be influenced by poor dietary vitamin K intake. Assessment of whether dietary vitamin K influences anticoagulation response as well as any influence of age, co morbidities and drug intake in patients taking rivaroxaban is warranted. [1] Kamali F, Wood P, Ward A. Vitamin K deficiency amplifies anticoagulation response to ximelagatran: possible implications for direct thrombin inhibitors and their clinical safety. Annals of Hematology 2009; 88:141-149. Disclosures: No relevant conflicts of interest to declare.

Placental Transfer of Vitamin K1 and Its Implications in Fetal Hemostasis

1988 ◽  
Vol 60 (01) ◽  
pp. 039-043 ◽  
Author(s):  
L Mandelbrot ◽  
M Guillaumont ◽  
M Leclercq ◽  
J J Lefrère ◽  
D Gozin ◽  
...  
Keyword(s):  
Vitamin K ◽  
High Performance ◽  
Ultrasound Guidance ◽  
Placental Transfer ◽  
Vitamin K1 ◽  
Vitamin K Deficiency ◽  
Prothrombin Activity ◽  
Oral Supplementation ◽  
K Deficiency ◽  
The Mean

SummaryVitamin K status was evaluated using coagulation studies and/ or vitamin IQ assays in a total of 53 normal fetuses and 47 neonates. Second trimester fetal blood samples were obtained for prenatal diagnosis under ultrasound guidance. Endogenous vitamin K1 concentrations (determined by high performance liquid chromatography) were substantially lower than maternal levels. The mean maternal-fetal gradient was 14-fold at mid trimester and 18-fold at birth. Despite low vitamin K levels, descarboxy prothrombin, detected by a staphylocoagulase assay, was elevated in only a single fetus and a single neonate.After maternal oral supplementation with vitamin K1, cord vitamin K1 levels were boosted 30-fold at mid trimester and 60 fold at term, demonstrating placental transfer. However, these levels were substantially lower than corresponding supplemented maternal levels. Despite elevated vitamin K1 concentrations, supplemented fetuses and neonates showed no increase in total or coagulant prothrombin activity. These results suggest that the low prothrombin levels found during intrauterine life are not due to vitamin K deficiency.

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