scholarly journals Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet—Results of a Randomized, Placebo-Controlled, Pilot Trial

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1736 ◽  
Author(s):  
Natalia Drabińska ◽  
Urszula Krupa-Kozak ◽  
Elżbieta Jarocka-Cyrta
Keyword(s):  
Celiac Disease ◽  
Intestinal Permeability ◽  
Pilot Trial ◽  
Intestinal Barrier ◽  
Substantial Effect ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Epithelial Surface ◽  
Fatty Acid Binding ◽  
Sugar Absorption

Abnormalities in the intestinal barrier are a possible cause of celiac disease (CD) development. In animal studies, the positive effect of prebiotics on the improvement of gut barrier parameters has been observed, but the results of human studies to date remain inconsistent. Therefore, this study aimed to evaluate the effect of twelve-week supplementation of a gluten-free diet (GFD) with prebiotic oligofructose-enriched inulin (10 g per day) on the intestinal permeability in children with CD treated with a GFD. A pilot, randomized, placebo-controlled nutritional intervention was conducted in 34 children with CD, being on a strict GFD. Sugar absorption test (SAT) and the concentrations of intestinal permeability markers, such as zonulin, intestinal fatty acid-binding protein, claudin-3, calprotectin, and glucagon-like peptide-2, were measured. We found that the supplementation with prebiotic did not have a substantial effect on barrier integrity. Prebiotic intake increased excretion of mannitol, which may suggest an increase in the epithelial surface. Most children in our study seem to have normal values for intestinal permeability tests before the intervention. For individuals with elevated values, improvement in calprotectin and SAT was observed after the prebiotic intake. This preliminary study suggests that prebiotics may have an impact on the intestinal barrier, but it requires confirmation in studies with more subjects with ongoing leaky gut.

PO10 INTESTINAL PERMEABILITY IN CELIAC DISEASE: CORRELATIONS WITH GLUTEN FREE DIET

2012 ◽  
Vol 44 ◽  
pp. S263
Author(s):  
S. Gatti ◽  
V. Romagnoli ◽  
T. Galeazzi ◽  
C. Catassi
Keyword(s):  
Celiac Disease ◽  
Intestinal Permeability ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1832 ◽  
Author(s):  
Giacomo Caio ◽  
Lisa Lungaro ◽  
Nicola Segata ◽  
Matteo Guarino ◽  
Giorgio Zoli ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gut Microbiota ◽  
Intestinal Barrier ◽  
Gluten Free Diet ◽  
Microbiota Composition ◽  
Gluten Free ◽  
Gluten Proteins ◽  
Wheat Sensitivity ◽  
Long Life ◽  
Gut Microbiota Composition

Celiac disease (CD) and non-celiac gluten/wheat sensitivity (NCG/WS) are the two most frequent conditions belonging to gluten-related disorders (GRDs). Both these diseases are triggered and worsened by gluten proteins ingestion, although other components, such as amylase/trypsin inhibitors (ATI) and fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), seem to be involved in the NCG/WS onset. Therefore, the only effective treatment to date is the long-life adherence to a strictly gluten-free diet. Recently, increasing attention has been paid to the intestinal barrier, a dynamic system comprising various components, which regulate the delicate crosstalk between metabolic, motor, neuroendocrine and immunological functions. Among the elements characterizing the intestinal barrier, the microbiota plays a key role, modulating the gut integrity maintenance, the immune response and the inflammation process, linked to the CD and NCG/WS outbreak. This narrative review addresses the most recent findings on the gut microbiota modulation induced by the gluten-free diet (GFD) in healthy, CD and NCG/WS patients.

HPLC determination of polyethylene glycol 400 in urine: oligomeric profile in healthy and celiac disease subjects

1994 ◽  
Vol 40 (8) ◽  
pp. 1571-1574 ◽  
Author(s):  
A Oliva ◽  
H Armas ◽  
J B Fariña
Keyword(s):  
Celiac Disease ◽  
Polyethylene Glycol ◽  
Intestinal Permeability ◽  
Healthy Subjects ◽  
Gluten Free Diet ◽  
Intestinal Biopsy ◽  
Gluten Free ◽  
Polyethylene Glycol 400 ◽  
Hplc Technique

Abstract The absorption of orally administered polyethylene glycol (PEG) has been used to assess intestinal permeability. We describe a simple HPLC technique to determine the oligomeric profile of PEG excreted in urine. We measured the total (%) PEG excreted in 6 h and the ratio of the four smallest oligomers to the three largest oligomers (expressed as mean percentages). The proposed method differentiates distinct groups of subjects with varying degrees of intestinal permeability detected by intestinal biopsy. The percent of PEG excreted and the oligomer ratio values for healthy subjects were, respectively, 30.1 +/- 3.87 and 0.35 +/- 0.03; for celiac patients on a gluten-free diet, 24.5 +/- 6.65 and 0.45 +/- 0.16; and for celiac patients, 15.0 +/- 5.93 and 1.12 +/- 0.55.

scholarly journals Small Bowel Permeability in Diagnosis of Celiac Disease and Monitoring of Compliance of a Gluten-Free Diet (Gut Permeability in Celiac Disease)

2001 ◽  
Vol 44 (3) ◽  
pp. 101-104 ◽  
Author(s):  
Pavel Kohout
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Intestinal Barrier ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Permeability Test ◽  
Gut Permeability ◽  
Non Invasive ◽  
Invasive Test ◽  
Untreated Celiac Disease

Background & Aim: Celiac disease is an autoimmune disease with the damage of the intestinal barrier. The aim of study was to measure gut permeability in patients with untreated celiac disease and during treatment with a gluten free diet. Methods: 30 patients with celiac disease before and during treatment with gluten-free diet were investigated, 30 patients without organic damage of the gastrointestinal tract served as control. Small bowel permeability was measured using lactulose/mannitol and lactulose/D-xylose ratios. The saccharides were examined in the 5 hours collected urine using capillary gas chromatography. Results: Small bowel permeability (indices lactulose/mannitol and/or lactulose/xylose) increased significantly in patients with untreated celiac disease. 23 patients were followed up before and during treatment with a gluten-free diet 2-6 months after beginning of this treatment and small bowel permeability (measured as indices lactulose/ mannitol and/or lactulose/xylose) significantly decreased. Conclusion: Small bowel permeability test is a non-invasive test suitable for the diagnosis of celiac disease and monitoring of compliance to a gluten-free diet in these patients.

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free

Severe Alveolar Hemorrhage – What’s in it for the Gastroenterologist?

2016 ◽  
Vol 25 (4) ◽  
pp. 555-558
Author(s):  
Alina Popp
Keyword(s):  
Celiac Disease ◽  
International Normalized Ratio ◽  
Gluten Free Diet ◽  
Alveolar Hemorrhage ◽  
Severe Anemia ◽  
Gluten Free ◽  
Pulmonary Infiltrates ◽  
Pulmonary Hemosiderosis ◽  
Threatening Condition ◽  
Life Threatening

Background: Alveolar hemorrhage is a potentially life-threatening condition which is usually managed by the pulmonologist. When considering its etiology, there is a rare association that sets the disease into the hands of the gastroenterologist. Case presentation: We report the case of a 48 year-old female who was admitted to the intensive care unit for severe anemia and hemoptysis. On imaging, diffuse pulmonary infiltrates suggestive of alveolar hemorrhage were detected and a diagnosis of pulmonary hemosiderosis was made. She received cortisone therapy and hematologic correction of anemia, with slow recovery. In search of an etiology for the pulmonary hemosiderosis, an extensive workup was done, and celiac disease specific serology was found positive. After confirmation of celiac disease by biopsy, a diagnosis of Lane-Hamilton syndrome was established. The patient was recommended a gluten-free diet and at 6 months follow-up, resolution of anemia and pulmonary infiltrates were observed. Conclusion: Although the association is rare, celiac disease should be considered in a patient with idiopathic pulmonary hemosiderosis. In our case, severe anemia and alveolar infiltrates markedly improved with glucocorticoids and gluten-free diet. Abbreviations: APTT: activated partial thromboplastin time; BAL: bronchoalveolar lavage; CD: celiac disease; Cd: crypt depth; GFD: gluten-free diet; GI: gastrointestinal; IEL: intraepithelial lymphocyte; INR: international normalized ratio; IPH: idiopathic pu

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