scholarly journals Sex Differences and Commonalities in the Impact of a Palatable Meal on Thalamic and Insular Connectivity

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1627
Author(s):  
Lisa Kilpatrick ◽  
Teodora Pribic ◽  
Barbara Ciccantelli ◽  
Carolina Malagelada ◽  
Dan M. Livovsky ◽  
...  
Keyword(s):  
Sex Differences ◽  
Well Being ◽  
Neural Mechanisms ◽  
Healthy Individuals ◽  
Resonance Imaging ◽  
Subjective Responses ◽  
Biological Variable ◽  
Before And After ◽  
Meal Ingestion ◽  
The Impact

The neural mechanisms underlying subjective responses to meal ingestion remain incompletely understood. We previously showed in healthy men an increase in thalamocortical, and a decrease in insular-cortical connectivity in response to a palatable meal. As sex is increasingly recognized as an important biological variable, we aimed to evaluate sex differences and commonalities in the impact of a well-liked meal on thalamic and anterior insular connectivity in healthy individuals. Participants (20 women and 20 age-matched men) underwent resting-state magnetic resonance imaging (rsMRI) before and after ingesting a palatable meal. In general, the insula showed extensive postprandial reductions in connectivity with sensorimotor and prefrontal cortices, while the thalamus showed increases in connectivity with insular, frontal, and occipital cortices, in both women and men. However, reductions in insular connectivity were more prominent in men, and were related to changes in meal-related sensations (satiety and digestive well-being) in men only. In contrast, increases in thalamic connectivity were more prominent in women, and were related to changes in satiety and digestive well-being in women only. These results suggest that brain imaging may provide objective and sex-specific biomarkers of the subjective feelings associated with meal ingestion.

scholarly journals Lively Social Space, Well-Being Activity, and Urban Design: Findings From a Low-Cost Community-Led Public Space Intervention

2016 ◽  
Vol 49 (6) ◽  
pp. 685-716 ◽  
Author(s):  
Jamie Anderson ◽  
Kai Ruggeri ◽  
Koen Steemers ◽  
Felicia Huppert
Keyword(s):  
Public Space ◽  
Urban Design ◽  
Design Research ◽  
Local Community ◽  
Social Space ◽  
Low Cost ◽  
Well Being ◽  
Observation Data ◽  
Before And After ◽  
The Impact

Empirical urban design research emphasizes the support in vitality of public space use. We examine the extent to which a public space intervention promoted liveliness and three key behaviors that enhance well-being (“connect,” “be active,” and “take notice”). The exploratory study combined directly observed behaviors with self-reported, before and after community-led physical improvements to a public space in central Manchester (the United Kingdom). Observation data ( n = 22,956) and surveys (subsample = 212) were collected over two 3-week periods. The intervention brought significant and substantial increases in liveliness of the space and well-being activities. None of these activities showed increases in a control space during the same periods. The findings demonstrate the feasibility of the research methods, and the impact of improved quality of outdoor neighborhood space on liveliness and well-being activities. The local community also played a key role in conceiving of and delivering an effective and affordable intervention. The findings have implications for researchers, policy makers, and communities alike.

“Mother’s Health and Well-Being Matters: Is a Mediated Social Cohesion Public Health Intervention Feasible?”

2021 ◽  
pp. 089011712110553
Author(s):  
Cheryl Jones ◽  
Marley Gibbons ◽  
Kate Magsamen-Conrad ◽  
Kathleen T. Ulanday ◽  
Jessica Watterson ◽  
...  
Keyword(s):  
New York ◽  
Low Socioeconomic Status ◽  
Public Health Intervention ◽  
Well Being ◽  
Careful Consideration ◽  
Before And After ◽  
Washington Heights ◽  
Additional Support ◽  
Risk Of Cancer ◽  
The Impact

Purpose To test the feasibility of introducing ‘Free Time for Wellness’ (FT4W) an intervention to increase healthy behaviours and reduce the risk of cancer. Design Feasibility study; Setting: Washington Heights, New York, USA is a low socioeconomic status area. Subjects Mothers aged 18 and above with children under 12 years of age and living in Washington Heights were recruited. Intervention FT4W, a community-based intervention delivered through a neighbourhood-based app, offering weekly dance and yoga classes, food pantry visits and group playdates. Childcare professionals cared for participants' children during wellness activities. Measures A bespoke before and after survey was designed and tested for its ability to collect relevant data to assess the impact of FT4W. Outcomes included recruitment rates, participation, attrition, acceptability, and success of the community champion. Analysis Comparisons of proportions and means Results Twenty-one mothers participated in the study of which 90% attended ≥ 1 FT4W activity; 65% ≥ 2; 52% ≥ 3. The survey was completed by a 100% of participants indicating it was easy to understand and not too burdensome. All measures detected change in constructs from baseline to follow-up. Availability of childcare was the most commonly (66%) reported reason participants were able to engage in the offered wellness activities. Conclusion Conducting a larger-scale trial to assess the impact of FT4W is feasible considering 4 major lessons. (1) Recruitment, retention, and acceptability rates were high; however, moms need additional support to increase participation in wellness activities and improve tech literacy. (2) Research measures were sensitive enough to detect change, but the timing of assessments needs to be considered. (3) Participants greatly valued access to professional childcare. (4) The Community Champion is a necessary, but difficult role to fill that requires careful consideration by the Institutional Review Board (IRB).

scholarly journals Sex Differences in Endocrine and Psychological Responses to Psychosocial Stress in Healthy Elderly Subjects and the Impact of a 2-Week Dehydroepiandrosterone Treatment1

1998 ◽  
Vol 83 (5) ◽  
pp. 1756-1761 ◽  
Author(s):  
Brigitte M. Kudielka ◽  
Juliane Hellhammer ◽  
Dirk H. Hellhammer ◽  
Oliver T. Wolf ◽  
Karl-Martin Pirke ◽  
...  
Keyword(s):  
Sex Differences ◽  
Stress Responses ◽  
Psychosocial Stress ◽  
Stress Test ◽  
Well Being ◽  
Trier Social Stress Test ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Free Cortisol ◽  
The Impact

Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.

Effect of Median Design on Rural Freeway Safety

2008 ◽  
Vol 2060 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Andrew P. Tarko ◽  
Natalie M. Villwock ◽  
Nicolas Blond
Keyword(s):  
Opposite Direction ◽  
Negative Binomial ◽  
Prediction Models ◽  
Negative Binomial Regression ◽  
Well Being ◽  
Crash Severity ◽  
Before And After ◽  
Single Vehicle ◽  
Median Width ◽  
The Impact

Although median barriers are an absolute means of preventing drivers from crossing road medians and colliding with vehicles moving in the opposite direction, they may cause additional crashes. This perhaps complex safety effect of median barriers has not been investigated well. Being able to predict the safety impact of most types of median barriers on rural freeways is becoming more desirable because some state departments of transportation plan to expand many of their four-lane rural freeways to six lanes to accommodate increases in traffic volume. Realistic crash prediction models sensitive to the median design would provide the needed guidance useful in designing adequate median treatments on widened freeways. The impact of median designs on crash frequency was investigated in this study through negative binomial regression and before-and-after studies based on data collected in eight participating states. The impact on crash severity was investigated with a logit model. The separate effects of changes in median geometry were quantified for single-vehicle, multiple-vehicle same direction, and multiple-vehicle opposite direction crashes. The results were significantly different and indicated that reducing the median width without adding barriers (the remaining median width is still reasonably wide) increases the severity of crashes, particularly opposite direction crashes. Further, reducing the median and installing concrete barriers eliminates opposite direction crashes but doubles the frequency of single-vehicle crashes and tends to lessen the frequency of same direction crashes. The crash severity also tends to increase.

scholarly journals Impact of The HEROES Project on First Responders’ Well-Being

2020 ◽  
Vol 5 (1) ◽  
pp. 8 ◽  
Author(s):  
Daniel M. Blumberg ◽  
Luciano Giromini ◽  
Konstantinos Papazoglou ◽  
A. Renee Thornton
Keyword(s):  
First Responders ◽  
Well Being ◽  
Future Research ◽  
Psychological Resources ◽  
Trauma Symptoms ◽  
Breathing Exercises ◽  
Before And After ◽  
And Performance ◽  
The Impact

First responders experience a myriad of stressors (e.g., operational, organizational, personal) over the course of their career. An abundance of empirical evidence shows that the impact of those stressors on first responders’ health, well-being, and performance can be detrimental. Nevertheless, previous research has mainly focused on the role of a specific technique (e.g., mindfulness, breathing exercises, psychoeducation) towards the promotion of well-being among first responders. This allows us to explore the role of a single technique in supporting first responders. However, given the complexity of stressors experienced by this population, it appears that a synergistic role of multileveled intervention is imperative to promote lasting improvement in first responders’ well-being. To this end, The HEROES Project, an eight-week online training program, was developed to address the aforementioned gap in the literature. The HEROES Project incorporates lessons that aim to build a cluster of skills that together promote first responders’ wellbeing. In the present study, a sample of first responders (n = 124) from the US Midwest were recruited and completed The HEROES Project. They were assessed before and after completion of the program, and then follow-up measurements were obtained for two years following the baseline assessment. Results showed that participants with higher distress and lower psychological resources before the training benefited most from The HEROES Project, but that the training significantly improved psychological capital and reduced stress, depression, anxiety, and trauma symptoms for all participants. Clinical and training implications as well as future research directions are discussed.

Emotional well-being and quality of life in patients undergoing radiation therapy for pancreatic and hepatobiliary malignancies.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 297-297
Author(s):  
B. T. Samuelson ◽  
E. K. Fromme ◽  
J. Waller ◽  
C. R. Thomas
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Positive Response ◽  
Well Being ◽  
Definitive Treatment ◽  
Hepatobiliary Malignancies ◽  
Before And After ◽  
Patient Related Outcome ◽  
The Impact

297 Background: Therapy for GI malignancies has long been known to have a marked impact on quality of life, yet this relationship remains poorly understood. The specific aim of this analysis was to evaluate the impact of radiation therapy (RT) on emotional well-being and QOL in patients receiving RT for pancreatic and hepatobiliary malignancies. Methods: A retrospective, IRB-approved chart review was performed of 722 patients receiving RT for any cancer diagnosis between 1/1/2006 and 12/31/2008. Subjects completed the Functional Assessment of Cancer Therapy General (FACT-G) questionnaire before and after RT. Pre- and immediately post-RT course scores were compared using student t-tests with Bonferroni correction for multiple comparisons (7 comparisons, alpha =.007). Results: 722 of 1369 (52.7%) patients participated in the Patient Related Outcome database. Complete pre and post RT spirituality data were available for 73 (64.6%) patients with GI malignancies, including 24 (33%) with pancreatic or hepatobiliary disease. Average age was 61, 15 (63%) were male and 14 (58%) received definitive treatment. A decrease in both functional and physical well-being was demonstrated in post-RT scores as compared to pre-RT. Emotional well-being, however, increased (17.60 to 18.72, p=0.051), a trend not replicated in any of the other GI malignancies. Further analysis demonstrated this improvement was largely due to a decrease in positive response to the statements “I feel nervous” (1.21 to 0.67, p=0.009) and “I worry my condition will get worse” (1.58 to 1.25, p=0.043). A decrease in positive response to “I feel sad” and an increase in positive response to “I am satisfied with how I am coping with my illness” were also noted, but differences were not significant. Conclusions: Emotional well-being of those receiving RT for pancreatic and hepatobiliary malignancies appears to improve over the course of therapy, even while other measures of QOL decline. Additional investigations in larger populations are warranted to further elucidate this relationship. Documentation of PROs may have potential for impact on QOL for patients with these and other malignancies. No significant financial relationships to disclose.

Selected health issues related to high altitude trekking

2021 ◽  
Vol 33 (1) ◽  
pp. 41-65
Author(s):  
Hanna Prószyńska-Bordas ◽  
Katarzyna Baranowska
Keyword(s):  
High Altitude ◽  
Physical Exertion ◽  
Well Being ◽  
The Body ◽  
High Mountain ◽  
Heavy Equipment ◽  
Before And After ◽  
Unbalanced Diet ◽  
The Right ◽  
The Impact

The aim of the paper was to investigate health aspects of high altitude trekking such as preparation for the physical exertion during trekking at high altitude, the impact of mountaineering on the daily life before and after the expedition, the effect of high-mountain conditions on health and well-being. It was found that in the pre-departure period trekkers commonly train to ensure that they are physically fit for the expedition. They train alone or under the supervision of a trainer. Self-prepared workouts may turn out to be insufficient due to the lack of appropriate training plans. The most challenging aspects of high altitude trekking for the body include carrying too heavy equipment, dealing with illegibly marked routes, wearing inappropriate clothing, having an unbalanced diet, not having enough water, which can lead to dehydration and infections. Misconduct by other people poses a risk. The specific type of effort involved in mountaineering requires balanced nutrition in terms of both micro- and macro-elements. To find the right combination, one has to either experiment or seek advice from a dietitian. However, relatively few people consult a nutrition coach. Among sanitary problems, the most serious one is inappropriate human waste disposal, the resulting lack of drinkable water. Some of the observed problems result from insufficient regulations regarding the conduct in the mountains and from trekkers’ lack of awareness regarding good practices in such extreme conditions.

A pilot study on the impact of a pottery workshop on the well-being of people with dementia

Dementia ◽  
2018 ◽  
Vol 19 (6) ◽  
pp. 2056-2072 ◽  
Author(s):  
Enrique Pérez-Sáez ◽  
Elena M Cabrero-Montes ◽  
María Llorente-Cano ◽  
Elena González-Ingelmo
Keyword(s):  
Repeated Measures ◽  
Mood State ◽  
Well Being ◽  
Self Esteem ◽  
Global Deterioration Scale ◽  
Repeated Measures Design ◽  
Reference Centre ◽  
People With Dementia ◽  
Before And After ◽  
The Impact

Objective This study seeks to assess the impact of a pottery workshop as a creative arts programme and discover the extent to which people with dementia taking part in an artistic and creative activity engage with it, experience a feeling of well-being, and improve their mood state. In addition, the study will seek to answer the question of whether taking part in a programme of creative activities improves the self-esteem of people with dementia. Method The research used an uncontrolled, repeated measures design. Thirty users of the National Reference Centre for Alzheimer’s and Dementia care in Salamanca (Spain) in a moderate to advanced stage of dementia (Global Deterioration Scale 4, 5, or 6) were divided into five intervention groups that received ten 45-minute sessions in which they were helped by facilitators to make different ceramic pieces. The participants were assessed before and after the intervention with a self-esteem scale, and they rated their mood before and after the sessions on a graphic scale. During the art sessions, two observers recorded the presence of multiple indicators of well-being. Results The intervention was found to have a significant impact on mood and self-esteem that was independent of the participants’ Global Deterioration Scale. Regarding the tool used to observe well-being, the participants scored highly in the domains of sustained attention, pleasure, self-esteem, and normalcy, with low scores in negative affect and sadness. Conclusions Pottery may be a highly suitable activity for people with dementia, as they may enjoy both the activity and the creative process, with it triggering a positive mood during the sessions, providing psychological well-being and reinforcing their self-esteem.

scholarly journals ‘You come because it is an interesting place’: The impact of attending a heritage programme on the well-being of people living with dementia and their care partners

Dementia ◽  
2021 ◽  
pp. 147130122098538
Author(s):  
Anthea Innes ◽  
Helen F Scholar ◽  
Jana Haragalova ◽  
Monika Sharma
Keyword(s):  
United Kingdom ◽  
Social Inclusion ◽  
Well Being ◽  
Primary Data ◽  
Data Sets ◽  
Heritage Sites ◽  
The United Kingdom ◽  
Care Partners ◽  
Before And After ◽  
The Impact

Promoting access to heritage settings has been acknowledged as a way to promote well-being in the United Kingdom for people living with dementia and their care partners. Yet there is a lack of information available internationally on the contribution of heritage sites to promote well-being and social inclusion for those living with dementia. This study addresses this gap by reporting on the impact for 48 people of participating in the ‘Sensory Palaces’ (SP) programme run by Historic Royal Palaces at Hampton Court and Kew Palaces in the United Kingdom. Two primary data sources were used; post-session interviews involving 30 participants (the person living with dementia and/or their care partners), and 131 sets of self-complete pre- and post-session mood questionnaires administered directly before and after SP session attendance. Analysis of the data sets is presented under three themes: enjoyment and engagement; connecting and learning and place, space and time. The findings demonstrate that participants highly valued the heritage sessions and reported positively on the impact this had for their individual well-being and their relationships with one another. This study highlights the opportunity for heritage sites to contribute to promoting well-being for people living with dementia.

scholarly journals Does a social prescribing ‘holistic’ link-worker for older people with complex, multimorbidity improve well-being and frailty and reduce health and social care use and costs? A 12-month before-and-after evaluation

2019 ◽  
Vol 20 ◽  
Author(s):  
Julian Elston ◽  
Felix Gradinger ◽  
Sheena Asthana ◽  
Caroline Lilley-Woolnough ◽  
Sue Wroe ◽  
...  
Keyword(s):  
Older People ◽  
Service Use ◽  
Social Care ◽  
Patient Activation ◽  
Well Being ◽  
Long Term Conditions ◽  
Social Prescribing ◽  
Health And Social Care ◽  
Before And After ◽  
The Impact

Abstract Aim: To evaluate the impact of ‘holistic’ link-workers on service users’ well-being, activation and frailty, and their use of health and social care services and the associated costs. Background: UK policy is encouraging social prescribing (SP) as a means to improve well-being, self-care and reduce demand on the NHS and social services. However, the evidence to support this policy is generally weak and poorly conceptualised, particularly in relation to frail, older people and patient activation. Torbay and South Devon NHS Foundation Trust, an integrated care organisation, commissioned a Well-being Co-ordinator service to support older adults (≥50 years) with complex health needs (≥2 long-term conditions), as part of its service redesign. Methods: A before-and-after study measuring health and social well-being, activation and frailty at 12 weeks and primary, community and secondary care service use and cost at 12 months prior and after intervention. Findings: Most of the 86 participants achieved their goals (85%). On average health and well-being, patient activation and frailty showed a statistically significant improvement in mean score. Mean activity increased for all services (some changes were statistically significant). Forty-four per cent of participants saw a decrease in service use or no change. Thirteen high-cost users (>£5000 change in costs) accounted for 59% of the overall cost increase. This was largely due to significant, rapid escalation in morbidity and frailty. Co-ordinators played a valuable key-worker role, improving the continuity of care, reducing isolation and supporting carers. No entry-level participant characteristic was associated with change in well-being or service use. Larger, better conceptualised, controlled studies are needed to strengthen claims of causality and develop national policy in this area.

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