scholarly journals Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1605
Author(s):  
Kokichi Arisawa ◽  
Sakurako Katsuura-Kamano ◽  
Hirokazu Uemura ◽  
Nguyen Van Tien ◽  
Asahi Hishida ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Cohort Study ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Carbohydrate Intake ◽  
Baseline Survey ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12–1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.

scholarly journals The Relationship Between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study

2021 ◽  
Author(s):  
Molian Tang ◽  
Yiquan Zhou ◽  
Jialu Wang ◽  
Yanping Wan ◽  
Renying Xu
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Cohort Study ◽  
High Risk ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Cox Proportional Hazards ◽  
Incident Diabetes ◽  
Chinese Elderly ◽  
Aged Population

Abstract BackgroundPrevious studies reported that aged population with overweight had a lower mortality after cardiovascular diseases attack, indicating being thinner might not be better. However, the debate is ongoing what is optimal range of body mass index (BMI) for aged population. We aimed to evaluate the association between BMI and incident diabetes mellitus (DM) in Chinese elderly people.Methods6,489 Chinese elderly people (3,828 men and 2,661 women) with medium age of 69 years (interquartile range: 67-74 years) were included in this cohort study. BMI was measured at baseline (2014). All the participants were further classified into eight groups based on baseline BMI with 2.0 kg/m2 interval: ≤17.9 kg/m2, 18.0-19.9 kg/m2, 20.0-21.9 kg/m2, 22.0-23.9 kg/m2, 24.0-25.9 kg/m2, 26.0-27.9 kg/m2, 28.0-29.9 kg/m2, and ≥30.0 kg/m2. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were annually measured during follow-up (2014-2019). DM was confirmed if either FBG ≥7.0 mmol/L or HbA1c ≥6.5%. We used the Cox proportional hazards regression model to evaluate the association between BMI and incident DM.ResultsComparing individuals with a BMI range of 20.0~21.9 kg/m2 (reference), the hazards ratio for incident DM was 2.07 (95% CI: 1.33, 3.22), 2.07 (95% CI: 1.33, 3.23), 2.18 (95% CI: 1.37, 3.47), 2.68 (95% CI: 1.61, 4.46), and 2.26 (95% CI: 1.17, 4.37) for the group with a BMI range of 22.0-23.9 kg/m2, 24.0-25.9 kg/m2, 26.0-27.9 kg/m2, 28.0-29.9 kg/m2, and ≥30.0 kg/m2 after adjusting baseline age, sex, blood pressure, lipid profiles, and eGFR. Each unit increase of BMI (=1.0 kg/m2) was associated with a high risk of 9% (HR=1.09, 95% CI: 1.05, 1.14, P for trend<0.001) after adjusting for above-mentioned confounders.ConclusionsHigh BMI was associated with high risk of developing DM in Chinese aged population. To lower the incidence of DM, it is better to be thinner than heavier.

scholarly journals The Relationship between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
M. L. Tang ◽  
Y. Q. Zhou ◽  
A. Q. Song ◽  
J. L. Wang ◽  
Y. P. Wan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Cohort Study ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Incident Diabetes ◽  
Chinese Elderly ◽  
Aged Population ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Regression

Objectives. Previous studies reported that overweight older adults had a lower mortality after cardiovascular diseases attack, indicating being thinner might not always be better. However, there is an ongoing debate about what is the optimal range of body mass index (BMI) for the aged population. We aimed to evaluate the value of BMI for the prediction of incident diabetes mellitus (DM) in the Chinese elderly population. Methods. A total number of 6,911 Chinese elderly people (4,110 men and 2,801 women, aged 71 ± 6.0 years) were included in this cohort study. BMI was measured at baseline (Jan 1, 2014, to Dec 31, 2014). All the participants were further classified into six groups: <18.5 kg/m2, 18.5 to <22.5 kg/m2, 22.5 to <25.0 kg/m2, 25.0 to <27.5 kg/m2, 27.5 to <30.0 kg/m2, and ≥30.0 kg/m2. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were annually measured during follow-up (Jan 1, 2015-May 31, 2019). DM was confirmed if either FBG ≥ 7.0   mmol / L or HbA 1 c ≥ 6.5 % . We used the Cox proportional hazard regression model to evaluate the association between BMI and the prediction of incident DM. Results. Comparing individuals with a BMI range of 18.5 to <22.5 kg/m2 (reference), the hazard ratio for incident DM was 2.13 (95% CI: 1.54~2.95), 2.14 (95% CI: 1.53~3.00), 3.17 (95% CI: 2.19~4.59), 3.15 (95% CI: 1.94~5.09), and 3.14 (95% CI: 1.94~5.09) for the group with a BMI range of 22.5 to <25.0 kg/m2, 25.0 to <27.5 kg/m2, 27.5 to <30.0 kg/m2, and ≥30.0 kg/m2 after adjusting for baseline age, sex, blood pressure, lipid profiles, and eGFR ( P trend < 0.001), after adjusting for the abovementioned confounders. The association tended to be closer in men and young participants, compared with their counterparts. Conclusions. High BMI was associated with a high risk of developing DM in the Chinese aged population. Thus, it is optimal for the aged population to maintain their body weight within a reasonable range to prevent chronic diseases.

Gender-specific association between dietary acid load and total lean body mass and its dependency on protein intake in seniors

2017 ◽  
Vol 28 (12) ◽  
pp. 3451-3462 ◽  
Author(s):  
A. M. Faure ◽  
K. Fischer ◽  
B. Dawson-Hughes ◽  
A. Egli ◽  
H. A. Bischoff-Ferrari
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Protein Intake ◽  
Dietary Acid Load ◽  
Total Lean Body Mass ◽  
Dietary Acid ◽  
Acid Load ◽  
Specific Association ◽  
Gender Specific

scholarly journals Dietary acid load berhubungan dengan sindrom metabolik dan kesehatan mental pada mahasiswi obesitas

2021 ◽  
Vol 17 (3) ◽  
pp. 113
Author(s):  
Firdananda Fikri Jauharany ◽  
Martha Irene Kartasurya ◽  
Apoina Kartini ◽  
Fillah Fithra Dieny ◽  
Dian Ratna Sawitri ◽  
...  
Keyword(s):  
Mental Health ◽  
Metabolic Syndrome ◽  
Health Status ◽  
Linear Regression ◽  
Risk Score ◽  
Self Esteem ◽  
Mental Health Status ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

The dietary acid load was associated with metabolic syndrome and mental health among obese college studentsBackground: The prevalence of metabolic syndrome has been increasing every year in the young population. The western diet is one of the causes that makes excess acid in the body called a dietary acid load. On the other hand, the high dietary acid load was associated with decreased mental health status.Objective: To examine the association between dietary acid load and the risk of metabolic syndrome and mental health.Methods: This was a cross-sectional study conducted with 115 female students in Semarang aged 18-22 years. The dietary acid load was evaluated through a potential renal acid load (PRAL), the risk score for metabolic syndrome was calculated by Metabolic syndrome risk score. Mental health status was assessed through levels of self-esteem and levels of anxiety. The level of self-esteem was measured by the Rosenberg Self-Esteem Scale questionnaire, while the level of anxiety was measured by the State Anxiety Inventory questionnaire. Multiple linear regression models with adjustment for a potential cofounding variable were used to evaluate the association between dietary acid load with metabolic syndrome scores, self-esteem scores, and anxiety scores.Results: The mean PRAL score was 6.11 ± 9.72 mEq/day indicated the intake of the subjects was the dietary acid load. 13% of subjects had metabolic syndrome, and 87% had a pre-metabolic syndrome. 36.5% of the subjects have low self-esteem scores. The anxiety level score calculation shows that 59.1% of the subjects are at high risk of anxiety. Pearson test showed that PRAL scores were correlated with anxiety scores (r=0,669; p<0,001). The linear regression test showed that PRAL scores were correlated with metabolic syndrome scores (β=0.899; p<0.001) and self-esteem scores (β =-0.069; p=0.047).Conclusions: High dietary acid load may be a risk factor related to the development of metabolic disorders and decreased mental health status in females with obesity.

High dietary acid load score is not associated with the risk of metabolic syndrome in Iranian adults

2020 ◽  
pp. 1-12
Author(s):  
Noushin Mohammadifard ◽  
Golgis Karimi ◽  
Alireza Khosravi ◽  
Nizal Sarrafzadegan ◽  
Mahnaz Jozan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Net Endogenous Acid Production ◽  
Increased Risk ◽  
Dietary Acid ◽  
Acid Load

Abstract. Background and objective: The association between dietary acid load and metabolic syndrome (MetS) risk is not well-known. Therefore, we aimed to investigate the relationship between dietary acid load and the risk of MetS among Iranian adults. Methods: This cross-sectional study was carried out on 1430 Iranian adults. Dietary intakes were assessed using a validated food frequency questionnaire. Dietary acid load was estimated using potential renal acid load (PRAL) and net endogenous acid production (NEAP). MetS was defined according to the ATP-III criteria. The risk of MetS and its components was explored using logistic regression test. Results: Totally, 205 individuals were identified to have MetS. No significant association for MetS was found across the quartiles of PRAL and NEAP either in the crude model [Q4 PRAL: OR (95% CI): 0.94 (0.67–1.32), and NEAP: OR (95% CI): 0.88 (0.63–1.25)] or fully-adjusted model [Q4 PRAL: OR (95% CI): 0.90 (0.61–1.33), and NEAP: OR (95% CI): 1.05 (0.70–1.57)]. Amongst the components of MetS, higher scores of NEAP was associated with an increased risk of impaired blood sugar after adjustment for potential confounders [OR (95% CI): 1.35 (0.93–1.96)]. No significant association was found for other components either with PRAL or with NEAP. Conclusion: Our findings suggest no association between dietary acid load and MetS risk in Iranian adults. However, higher dietary acid load, measured by NEAP, but not PRAL, was associated with increased risk of impaired fasting blood sugar. Longitudinal studies are warranted to explore whether a diet low in potential acid load could reduce MetS risk.

scholarly journals Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1568
Author(s):  
Stefania Antonia Noli ◽  
Elena Ricci ◽  
Sonia Cipriani ◽  
Stefania Ferrari ◽  
Marta Castiglioni ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cohort Study ◽  
In Vitro Fertilization ◽  
Body Mass ◽  
Assisted Reproduction ◽  
Glycemic Load ◽  
Carbohydrate Intake ◽  
Dietary Carbohydrate ◽  
Vitro Fertilization

In recent decades, increasing attention has been paid to the influence of diet on reproductive health. Carbohydrates in diet affect glucose metabolism and multiple evidences showed the key role of insulin sensitivity in regulating female fertility. We designed a prospective cohort study to investigate the relation between dietary carbohydrate intake, glycemic load (GL) and the outcomes of assisted reproduction. A population of 494 female partners of couples referring to an Italian Fertility Center and eligible for in vitro fertilization (IVF) were enrolled in the study. On the day of the oocyte retrieval, information on their diet was obtained using a validated food frequency questionnaire (FFQ). We calculated the relative risk and 95% confidence interval of embryo transfer, clinical pregnancy and live birth according to the following dietary exposures: GL, glycemic index (GI) as well as the daily carbohydrate and fiber intake. A multiple regression model was used to account for the confounders. After adjusting for age, college degree, body mass index (BMI), leisure physical activity and previous assisted reproduction techniques (ART) cycles, no significant association was observed between the considered dietary exposures and the IVF outcomes. The roles of GL, carbohydrate intake and GI were assessed in strata of the cause of infertility and body mass index and no relation emerged in this further analysis. We found no clear association between the dietary carbohydrate quantity and quality and IVF outcomes in a cohort of infertile Italian women.

scholarly journals Dietary Acid Load and Its Interaction with IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) Polymorphisms on Metabolic Traits among Postmenopausal Women

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2161
Author(s):  
Sook Yee Lim ◽  
Yoke Mun Chan ◽  
Vasudevan Ramachandran ◽  
Zalilah Mohd Shariff ◽  
Yit Siew Chin ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Fasting Blood Glucose ◽  
Community Dwelling ◽  
Nucleotide Polymorphisms ◽  
Significant Interaction Effect ◽  
Single Nucleotide ◽  
Dietary Acid Load ◽  
Metabolic Traits ◽  
Dietary Acid ◽  
Acid Load

The objective of this study was to explore the effects of dietary acid load (DAL) and IGF1 and IL6 gene polymorphisms and their potential diet–gene interactions on metabolic traits. A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid load (PRAL). Blood was drawn for biochemical parameters and DNA was extracted and Agena® MassARRAY was used for genotyping analysis to identify the signalling of IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) polymorphisms. Interactions between diet and genetic polymorphisms were assessed using regression analysis. The result showed that DAL was positively associated with fasting blood glucose (FBG) (β = 0.147, p < 0.05) and there was significant interaction effect between DAL and IL6 with systolic blood pressure (SBP) (β = 0.19, p = 0.041). In conclusion, these findings did not support the interaction effects between DAL and IGF1 and IL6 single nucleotide polymorphisms (rs35767, rs7136446, and rs1800796) on metabolic traits, except for SBP. Besides, higher DAL was associated with higher FBG, allowing us to postulate that high DAL is a potential risk factor for diabetes.

scholarly journals The relationship between body mass index and incident diabetes mellitus in Chinese aged population: a cohort study

2021 ◽  
Author(s):  
Molian Tang ◽  
Yiquan Zhou ◽  
Anqi Song ◽  
Jialu Wang ◽  
Yanping Wan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Cohort Study ◽  
Body Mass ◽  
Proportional Hazards ◽  
Fasting Blood Glucose ◽  
Cox Proportional Hazards ◽  
Incident Diabetes ◽  
Chinese Elderly ◽  
Aged Population

Abstract ObjectivesPrevious studies reported that overweight older adults had a lower mortality after cardiovascular diseases attack, indicating being thinner might not always be better. However, there is ongoing debate about what is the optimal range of body mass index (BMI) for the aged population. We aimed to evaluate the value of BMI for the prediction of incident diabetes mellitus (DM) in Chinese elderly population.MethodsA total number of 6,911 Chinese elderly people (4,110 men and 2,801 women, aged 71±6.0 years) were included in this cohort study. BMI was measured at baseline (Jan 1st 2014 to Dec 31st 2014). All the participants were further classified into six groups: < 18.5kg/m2, 18.5 to < 22.5 kg/m2, 22.5 to < 25.0 kg/m2, 25.0 to < 27.5 kg/m2, 27.5 to < 30.0 kg/m2, and ≥ 30.0 kg/m2. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were annually measured during follow-up (Jan 1st 2015-May 31st 2019). DM was confirmed if either FBG ≥ 7.0 mmol/L or HbA1c ≥ 6.5%. We used the Cox proportional hazards regression model to evaluate the association between BMI and the prediction of incident DM. ResultsComparing individuals with a BMI range of 18.5 to < 22.5 kg/m2 (reference), the hazards ratio for incident DM was 2.13 (95% CI: 1.54~2.95), 2.14 (95% CI: 1.53~3.00), 3.17 (95% CI: 2.19~4.59), 3.15 (95% CI: 1.94~5.09), and 3.14 (95% CI: 1.94~5.09) for the group with a BMI range of 22.5 to < 25.0 kg/m2, 25.0 to < 27.5 kg/m2, 27.5 to < 30.0 kg/m2, and ≥ 30.0 kg/m2 after adjusting for baseline age, sex, blood pressure, lipid profiles, and eGFR (P trend <0.001), after adjusting for the above-mentioned confounders. The association tended to be closer in men and young participants, compared with their counterparts.ConclusionsHigh BMI was associated with high risk of developing DM in Chinese aged population. Thus, it is optimal for the aged population to maintain their body weight within a reasonable range to prevent chronic diseases.

scholarly journals A Technology-Mediated Interventional Approach to the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (2) ◽  
pp. 512
Author(s):  
Gaeun Kim ◽  
Ji-Soo Lee ◽  
Soo-Kyoung Lee
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Large Scale ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Prevention Programs ◽  
Diet And Exercise ◽  
Prevention Methods ◽  
The Impact

Background: Technology-mediated interventions help overcome barriers to program delivery and spread metabolic syndrome prevention programs on a large scale. A meta-analysis was performed to evaluate the impact of these technology-mediated interventions on metabolic syndrome prevention. Methods: In this meta-analysis, from 30 January 2018, three databases were searched to evaluate interventions using techniques to propagate diet and exercise lifestyle programs for adult patients with metabolic syndrome or metabolic risk. Results: Search results found 535 citations. Of these, 18 studies met the inclusion criteria analyzed in this article. The median duration of intervention was 4 months and the follow-up period ranged from 1.5 to 30 months. The standardized mean difference (SMD) between the two groups was waist circumference −0.35 (95% CI −0.54, −0.15), triglyceride −0.14 (95% CI −0.26, −0.03), fasting blood glucose −0.31 (95% CI −0.42, −0.19), body weight −1.34 (95% CI −2.04, −0.64), and body mass index −1.36 (95% CI −2.21, −0.51). There was no publication bias in this study. Conclusion: Technology-mediated intervention improved clinically important metabolic syndrome related indicators such as excess body fat around the waist, fasting glucose, and body mass index. These interventions will play an important role in the dissemination of metabolic syndrome prevention programs.

scholarly journals Keseimbangan asam-basa tubuh dan kejadian sindrom metabolik pada remaja obesitas

2017 ◽  
Vol 14 (1) ◽  
pp. 36
Author(s):  
Firdananda Fikri Jauharany ◽  
Nurmasari Widyastuti
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Dietary Acid Load ◽  
Base Balance ◽  
Dietary Acid ◽  
Acid Load

Background: The prevalence of metabolic syndrome increased in young population, indicated by the rise in obesity among children and adolescent. The Western dietary pattern was one of the causes. A Western diet rich in animal protein can produce acid during the metabolic process and may cause an acid-excess in the body (dietary acid load). This process was contributed to acid-base balance through the metabolism of sulfur-containing amino acids (cysteine and methionine) which produce H+ ions as well as lowering the pH.Objective: To examine the association between acid-base balance and components of metabolic syndrome among obese adolescent.Method: A cross-sectional study was conducted on 40 obese adolescents in Semarang high school. We measured Potential Renal Acid Load (PRAL) score and pH urine as an acid-base indicator. MetS are defined ≥ 3 following risk factors: waist circumference ≥90th percentile, blood pressure ≥90th percentile, triglycerides ≥110 mg/dl, HDL levels ≤40 mg/dl, and fasting blood glucose levels ≥110 mg/dl. Normality test used the Shapiro-Wilk test (n <50). The bivariate analysis used Pearson test, Rank-Spearman test, and Chi-Square test. The multivariate analysis used Multivariate Linear Regression analysis of Backward.Results: PRAL score was associated with waist circumference (r=0,347; p=0,028), sistolic blood pressure (r=0,590; p=<0,001), diastolic blood pressure (r=0,668; p=<0,001), and triglyceride levels (r=0,362; p=0,022). pH urin was not associated with any risk factors of MetS.Conclusion: High dietary acid load may be a risk factor for the development of MetS.

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