scholarly journals The Gluten Free Diet’s Impact on Growth in Children with Celiac Disease in Two Different Countries

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1547
Author(s):  
Naire Sansotta ◽  
Stefano Guandalini ◽  
Simone Romano ◽  
Karine Amirikian ◽  
Marco Cipolli ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Celiac Disease ◽  
Retrospective Study ◽  
Cultural Differences ◽  
Pediatric Patients ◽  
Growth Parameters ◽  
Gluten Free ◽  
Z Score ◽  
American Children ◽  
The University

The effects of gluten free diet (GFD) on body mass index (BMI) and growth parameters in pediatric patients with celiac disease (CD) and their dependence on different socio-cultural environments are poorly known. We conducted an international retrospective study on celiac patients diagnosed at the University of Verona, Italy, and at the University of Chicago, Chicago, IL, USA, as underweight. A total of 140 celiac children and 140 controls (mean age 8.4 years) were enrolled in Chicago; 125 celiac children and 125 controls (mean age 7.3 years, NS) in Verona. At time of diagnosis, Italian celiac children had a weight slightly lower (p = 0.060) and a BMI z-score significantly (p < 0.001) lower than their American counterparts. On GFD, Italian celiac children showed an increased prevalence of both underweight (19%) as well as overweight (9%), while American children showed a decrease prevalence of overweight/obese. We concluded that while the GFD had a similar impact on growth of celiac children in both countries, the BMI z-score rose more in American than in Italian celiac children. Additionally, in Italy, there was an alarming increase in the proportion of celiac children becoming underweight. We speculate that lifestyle and cultural differences may explain the observed variations.

Celiac Disease Nutritional Status and Poor Adherence to Follow-up

2020 ◽  
Vol 59 (7) ◽  
pp. 649-655
Author(s):  
Diana A. Moya ◽  
Colleen A. Nugent ◽  
Robert D. Baker ◽  
Susan S. Baker
Keyword(s):  
Primary Care ◽  
Body Mass Index ◽  
Vitamin D ◽  
Celiac Disease ◽  
Gluten Free ◽  
Z Score ◽  
Vitamin Status ◽  
Nutritional Health ◽  
New Strategies

Introduction. Celiac disease, an autoimmune enteropathy, occurs in susceptible individuals and is treatable with a gluten-free diet. These may not be supplemented with vitamins. Objective. To assess the nutritional health of children who have biopsy-proven celiac disease. Methods. Charts were reviewed between July 1, 2007, and June 30, 2017. Results. A total of 252 children ages 0 to 21 years had biopsy-proven celiac disease, mean age 11 ± 4.1 years. Body mass index Z-score was 0.2 ± 1.2 at diagnosis. Except for vitamin D, few had deficiencies at diagnosis. At 1-year follow-up, there was no significant change in anthropomorphics or vitamin status. Adherence to follow-up was poor; at 5 years after diagnosis, 39% adhered to follow-up. Conclusion. Despite a rigorous, proactive protocol for contacting and following children with celiac disease, adherence to follow-up was poor. New strategies, such as follow-up through the primary care provider, are needed.

scholarly journals Anthropometric Parameters in Celiac Disease: A Review on the Different Evaluation Methods and Disease Effects

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Allysson Costa ◽  
Gleisson A. P. Brito
Keyword(s):  
Body Mass Index ◽  
Celiac Disease ◽  
Body Mass ◽  
Bone Mineral ◽  
Fat Free Mass ◽  
Gluten Free Diet ◽  
Control Group ◽  
Gluten Free ◽  
Mineral Density ◽  
Anthropometric Parameters

This review compiled anthropometric data from 29 original articles, published between 1995 and 2015, corresponding to a total sample of 6368 celiac disease subjects. Body mass index was the main parameter for measuring anthropometry (82.1%), followed by body mass (78.6%), body fat (51.7%), bone mineral density and bone mineral content (46.4%), and fat-free mass (44.8%). The main evaluation method was dual x-ray absorptiometry (83.3%), followed by bioimpedance (16.6%), skinfold thickness (16.6%), and isotope dilution (5.5%). This compilation suggests that celiac disease patients without a gluten-free diet (WGFD) and celiac disease patients with a gluten-free diet (GFD) show a lower body mass than the control group, with inconclusive data about WGFD versus GFD. Body mass index is lower in WGFD and GFD compared to control group, and is lower in WGFD compared to GFD. We observed lower values of FM and FFM in WGFD and GFD versus the control group. No difference was found between WGFD versus GFD. BMD and BMC are lower in WGFD versus GFD and GFD versus the control group, with inconclusive data about WGFD versus GFD. The findings of this review suggest that celiac disease patients must be periodically evaluated through anthropometric parameters, since the pathology has the potential to modulate such values even in a gluten-free diet, with these variables reflecting their healthy status. In parallel, the screening of different anthropometric assessment methodologies can provide support for more accurate evaluations by scientists and clinical professionals who work with celiac disease patients.

scholarly journals TMPRSS6 rs855791 Polymorphism Status in Children with Celiac Disease and Anemia

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2782
Author(s):  
Klaudia Urbaszek ◽  
Natalia Drabińska ◽  
Anna Szaflarska-Popławska ◽  
Elżbieta Jarocka-Cyrta
Keyword(s):  
Celiac Disease ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Statistical Significance ◽  
Blood Parameters ◽  
Chronic Inflammatory Disease ◽  
Gluten Free ◽  
Iron Deficient ◽  
Potential Link ◽  
First Time

Celiac disease (CD) is an autoimmune chronic inflammatory disease occurring in genetically predisposed individuals in response to the intake of gluten. Clinical presentation can be heterogeneous. Iron-deficient anemia (IDA) is one of the most common extra-intestinal manifestations of CD. Although IDA usually reverts with a gluten-free diet (GFD), some patients show persistent IDA, the mechanisms of which are poorly understood. Recent studies suggest an association between the rs855791 polymorphism in the TMPRSS6 gene and persistent IDA in adults with CD. The current study aimed to assess the potential link between rs855791 and persistent IDA in pediatric patients with CD. The study included 106 children diagnosed with CD between 2015 and 2019. Clinical and blood parameters (including blood count, serum iron) were collected at diagnosis and after ≥12 months of GFD, and the rs855791 genotype was assessed for each patient. IDA was present at diagnosis in 25 patients (23.6%); only three (3%) had persistent IDA after GFD. The prevalence of rs855791 genotypes was 9% (n = 10) for TT, 53% (n = 56) for CT, and 38% (n = 40) for CC. There was a tendency toward a higher proportion of the T allele in patients with IDA and lower hemoglobin in the TT genotype but without statistical significance. An association between rs855791 and persistent IDA was not observed. These findings suggest that persistent IDA is uncommon in pediatric patients with CD. The prevalence of rs855791 in children with CD is reported for the first time.

Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet

2018 ◽  
Vol 37 (3) ◽  
pp. 243-247 ◽  
Author(s):  
Ashish Joshi ◽  
Sushil Falodia ◽  
Naveen Kumar ◽  
Pawan Gupta ◽  
P. C. Khatri
Keyword(s):  
Celiac Disease ◽  
Pediatric Patients ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Cryptogenic Cirrhosis

The impact of a gluten-free diet on the growth pattern of Saudi children with celiac disease

2021 ◽  
pp. 1-17
Author(s):  
Omar Ibrahim Saadah
Keyword(s):  
Celiac Disease ◽  
Growth Pattern ◽  
Laboratory Data ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Z Score ◽  
The Mean ◽  
The Impact ◽  
Igfbp 3

Objective: To describe the growth pattern of children with celiac disease (CD) after introduction of a gluten-free diet (GFD). Methods: In this retrospective, children 2–16 years old with biopsy-proven CD in 2015–2018 were included in the study conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Serial measurements of height-for-age z-score (HAZ) and weight-for-age z-score (WAZ), were recorded at 0, 4, 8, 12, and 16 months. Data on insulin-like growth hormone-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) obtained at diagnosis and during follow-up were retrieved. Clinical, demographic, and laboratory data were extracted from patients' medical files. Results: The median age for the patients was 8.9 years (range, 2.4–16 years). Males constituted 53.2%. The mean WAZ at diagnosis was -2.8±1.9 and the mean HAZ was -3±0.99. Trend analysis indicated a significant time effect for WAZ (p<0.001) and for HAZ (p<0.001). The mean IGF-1 was 133.4±96.8 ng/ml and the mean IGFBP-3 was 3174±1081 ng/ml. There was significant increase in the secretion of IGF-1 (p=0.01) and IGFBP-3 (p=0.004) during the first 8 months of a GFD. Conclusion: The administration of a GFD for Saudi children with CD normalizes their growth parameters within 16 months of follow-up and improves the endogenous secretion of growth factors. Keywords: Celiac disease, growth, child, Continuous...

The effect of gluten‐free diet on body mass index in paediatric celiac disease

2021 ◽  
Author(s):  
Adi Anafy ◽  
Shlomi Cohen ◽  
Amir Ben Tov ◽  
Achiya Amir ◽  
Yael Weintraub ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Celiac Disease ◽  
Body Mass ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Baseline Fecal Microbiota in Pediatric Patients With Celiac Disease Is Similar to Controls But Dissimilar After 1 Year on the Gluten-Free Diet

JPGN Reports ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. e127
Author(s):  
Dory Sample ◽  
Janelle Fouhse ◽  
Seema King ◽  
Hien Q. Huynh ◽  
Levinus A. Dieleman ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Pediatric Patients ◽  
Fecal Microbiota ◽  
Gluten Free Diet ◽  
Gluten Free
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