scholarly journals Reply to “The Fallacy of Using Administrative Data in Assessing the Effectiveness of Food Fortification. Comment on: Folic Acid Fortification and Neural Tube Defect Risk: Analysis of the Food Fortification Initiative Dataset. Nutrients 2020, 12, 247”

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1335 ◽  
Author(s):  
Cara J. Westmark ◽  
Michaela E. Murphy
Keyword(s):  
Folic Acid ◽  
Risk Analysis ◽  
Administrative Data ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Food Fortification ◽  
Folic Acid Fortification

We would like to thank Kancherla et al [...]

scholarly journals Role of Folate and Folic Acid During Pregnancy

2021 ◽  
Vol 9 (12) ◽  
pp. 1488-1492
Author(s):  
Saniya Sahar
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Maternal Nutrition ◽  
Tissue Growth ◽  
Food Fortification ◽  
Nucleotide Synthesis ◽  
Folic Acid Fortification ◽  
C1 Metabolism ◽  
Pteroylglutamic Acid

Abstract: Pregnancy represents a period of fast tissue growth of maternal and foetal tissues that's related to enhanced energy and nutrient needs. Maternal nutrition throughout gestation period, has being essential for best offspring development, reducing long unwellness burden and for general health throughout life. Maternal Folate throughout pregnancy might have numerous roles in offspring health, as well as neurodevelopment and psychological feature performance in childhood. Folate is crucial for C1 metabolism, a network of pathways concerned in many biological processes as well as nucleotide synthesis, deoxyribonucleic acid repair and methylation reactions. The periconceptional use of pteroylglutamic acid (Folic Acid ) containing supplements reduces the primary incidence, as well as recurrence of neural tube defects. Folic Acid (FA) are artificial form of a necessary vitamin generically considered Folates or B9. It is concerned in one-carbon metabolism, and it's been connected to lowering neural tube Defect (NTD). National programs to mandate fortification of food with Folic Acid have reduced the prevalence of NTDs worldwide . The indisputable protecting role of Folic Acid in the hindrance of NTD, in addition to the low compliance of women to Folic Acid recommendations, has aroused the choice of mandatory Folic Acid fortification, a policy currently in place in over eighty countries worldwide. Mandatory food fortification needs food makers to feature Folic Acid to certain foods (e.g. starch or grain products), whereas voluntary fortification permits Folic Acid to be added to foods at the discretion of manufacturers. Food fortification with Folic Acid because the intervention is likely to achieve increasing Folic Acid intake among populations throughout the world. The objective of this article is to discuss the Role of Folic Acid and Folate during pregnancy and to review the role of Folate and Folic Acid , metabolism , absorption and Folic Acid effects on maternal on the basis of recent findings that are important for implementation of fortified food to design future studies. Keywords: Neurodevelopment, Methylation Reactions, Pteroylglutamic Acid, Bioavailability, Monoglutamates.

scholarly journals Folic Acid Fortification and Neural Tube Defect Risk: Analysis of the Food Fortification Initiative Dataset

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 247 ◽  
Author(s):  
Michaela E. Murphy ◽  
Cara J. Westmark
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
National Level ◽  
Population Level ◽  
The United States ◽  
Cereal Grains ◽  
Food Fortification ◽  
Folic Acid Fortification ◽  
Vitamin B9 ◽  
Cereal Grain

The United States implemented mandatory fortification of cereal grains with folic acid in 1998 to prevent neural tube defects (NTDs) during pregnancy. The health benefits of folate (vitamin B9) are well documented; however, there are potential risks of exceeding the upper tolerable limit, particularly in vulnerable populations. We conducted a population-based analysis of the Food Fortification Initiative dataset to determine the strength of the evidence regarding reports of decreased NTDs at the national level in response to mandatory folic acid fortification of cereal grains. We found a very weak correlation between NTD prevalence and the level of folic acid fortification, irrespective of the cereal grain fortified (wheat, maize or rice). Stratification of the data based on socioeconomic status (SES) indicated a strong linear relationship between reduced NTDs and better SES. We conclude that national fortification with folic acid is not associated with a significant decrease in the prevalence of NTDs at the population level.

Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America

2003 ◽  
Vol 123A (2) ◽  
pp. 123-128 ◽  
Author(s):  
Eduardo E. Castilla ◽  
I�da M. Orioli ◽  
Jorge S. Lopez-Camelo ◽  
Maria da Gra�a Dutra ◽  
Julio Nazer-Herrera ◽  
...  
Keyword(s):  
Folic Acid ◽  
South America ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Preliminary Data ◽  
Prevalence Rates ◽  
Folic Acid Fortification

scholarly journals Maternal Vitamin B12 Status and Risk of Neural Tube Defects in a Population With High Neural Tube Defect Prevalence and No Folic Acid Fortification

PEDIATRICS ◽  
2009 ◽  
Vol 123 (3) ◽  
pp. 917-923 ◽  
Author(s):  
A. M. Molloy ◽  
P. N. Kirke ◽  
J. F. Troendle ◽  
H. Burke ◽  
M. Sutton ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Folic Acid Fortification ◽  
Maternal Vitamin
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