scholarly journals Evaluation of Non-Celiac Gluten Sensitivity in Patients with Previous Diagnosis of Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 705 ◽  
Author(s):  
Michele Barone ◽  
Eugenio Gemello ◽  
Maria Teresa Viggiani ◽  
Fernanda Cristofori ◽  
Caterina Renna ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Challenge Test ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Double Blind ◽  
Previous Diagnosis ◽  
Irritable Bowel ◽  
Fodmap Diet

Background. To date, there is no reliable marker for the diagnosis of non-celiac gluten sensitivity (NCGS), which benefits from a gluten-free diet (GFD). This condition is characterized by functional gastrointestinal symptoms similar to those occurring in the course of irritable bowel syndrome (IBS). However, IBS has a higher prevalence, and often benefits from the administration of a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet. The overlap of symptoms between these two pathologies has led to an overestimation of self-made diagnosis NCGS. Aims. To better identify NCGS in subjects with a previous diagnosis of IBS. Methods. All subjects received a low FODMAP diet that was also gluten-free (low FODMAP-GFD), and those presenting an improvement of symptoms were exposed to gluten or placebo (double-blind challenge with wash-out and crossover). The response to dietary treatments was evaluated by visual analogue scale (VAS). Results. Of 30 patients (23 women, seven men, aged 42.2 ± 12.5 years, body mass index (BMI) 24.7 ± 4.1 kg/m2), 26 benefited from the administration of low FODMAP-GFD and were exposed to the gluten/placebo challenge. After the challenge, using an increase of visual analogue scale VAS (Δ-VAS) ≥30%, 46.1% of the patients were NCGS+. However, this percentage became only 19.2% using a different method (mean ∆-VAS score plus two standard deviations). Conclusions. FODMAP intolerance could hide the response to a challenge test with gluten for the identification of NCGS in IBS patients. A low FODMAP-GFD followed by gluten/placebo challenge is able to identify patients with NCGS better. ClinicalTrials.gov registration number NCT04017585.

scholarly journals Low Fermentable Oligo- Di- and Mono-Saccharides and Polyols (FODMAPs) or Gluten Free Diet: What Is Best for Irritable Bowel Syndrome?

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3368 ◽  
Author(s):  
Massimo Bellini ◽  
Sara Tonarelli ◽  
Maria Gloria Mumolo ◽  
Francesco Bronzini ◽  
Andrea Pancetti ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disease ◽  
Scientific Evidence ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Dietary Interventions ◽  
Double Blind ◽  
Close Supervision ◽  
Irritable Bowel ◽  
Fodmap Diet

Irritable Bowel Syndrome (IBS) is a very common functional gastrointestinal disease. Its pathogenesis is multifactorial and not yet clearly defined, and hence, its therapy mainly relies on symptomatic treatments. Changes in lifestyle and dietary behavior are usually the first step, but unfortunately, there is little high-quality scientific evidence regarding a dietary approach. This is due to the difficulty in setting up randomized double-blind controlled trials which objectively evaluate efficacy without the risk of a placebo effect. However, a Low Fermentable Oligo-, Di- and Mono-saccharides And Polyols (FODMAP) Diet (LFD) and Gluten Free Diet (GFD) are among the most frequently suggested diets. This paper aims to evaluate their possible role in IBS management. A GFD is less restrictive and easier to implement in everyday life and can be suggested for patients who clearly recognize gluten as a trigger of their symptoms. An LFD, being more restrictive and less easy to learn and to follow, needs the close supervision of a skilled nutritionist and should be reserved for patients who recognize that the trigger of their symptoms is not, or not only, gluten. Even if the evidence is of very low-quality for both diets, the LFD is the most effective among the dietary interventions suggested for treating IBS, and it is included in the most updated guidelines.

scholarly journals The gluten free diet in depth

2017 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
Caroline Kanaan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Neuropsychiatric Disorders ◽  
Healthy Diet ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Irritable Bowel ◽  
New Research ◽  
New Diagnosis

The gluten free diet has been gaining recognition globally and is being applied by many patients. This diet was first developed for Celiac's patients however with the emergence of a new diagnosis: non-celiac gluten sensitivity (NCGS), more patients are finding relief from their symptoms when following this diet. The symptoms of NCGS also overlap with those of Irritable Bowel Syndrome and there are studies that suggest a possible link between NCGS and neuropsychiatric disorders, like autism and others. In this presentation we will review the new research about gluten and also answer the following questions. Where is gluten found? How to remove it from the diet? How to follow a healthy diet?.

scholarly journals Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Ioana-Miruna Balmus ◽  
Roxana-Oana Cojocariu ◽  
Alin Ciobica ◽  
Stefan Strungaru ◽  
Roxana Strungaru-Jijie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Irritable Bowel Syndrome ◽  
Visual Analogue Scale ◽  
Quality Index ◽  
Analogue Scale ◽  
Sleep Disturbances ◽  
Oxidative Stress Status ◽  
Irritable Bowel ◽  
Age And Sex

According to the latest gastrointestinal disorders diagnostic criteria (ROME IV), the irritable bowel syndrome (IBS) is mainly characterized by the presence of abdominal pain and changes in intestinal transit. However, both sleep impairments and oxidative status changes (in patients’ sera, mucosal level, and other body fluids) were reported IBS. Thus, in this study, we aimed to evaluate several aspects regarding the oxidative stress status in patients’ tears as well as sleep disturbances by comparison with the intensity of IBS symptoms, as assessed by the visual analogue scale for irritable bowel syndrome (VAS-IBS). Ten IBS patients and fourteen healthy sex- and age-matched volunteers were recruited from the Oftaprof Ophthalmological Clinic (Iași, Romania). Visual analogue scale for irritable bowel syndrome and the Pittsburgh Sleep Quality Index (PSQI) questionnaires were administered to all the patients. Tear samples were collected using the Schirmer test procedure and were subjected to biochemical analysis—superoxide dismutase and glutathione peroxidase activities, malondialdehyde, and total soluble proteins levels were determined. Standard statistical analysis was applied. We found significant differences in oxidative stress marker dynamics in IBS patients as compared to healthy age- and sex-matched controls: increased superoxide dismutase activity (p=0.02), increased malondialdehyde (p=0.007), and total soluble proteins levels (p=0.019). We found no significant differences in tear glutathione peroxidase activity in IBS patients as compared to healthy age- and sex-matched controls (p=0.55). Furthermore, we observed that the oxidative stress tear markers are correlated with gastrointestinal symptoms severity (as evaluated by VAS-IBS) but not correlated to the sleep quality index and items (as evaluated by PSQI), with significant differences according to patient sex and IBS subtype stratification. In this way, this study brings additional evidence of the oxidative stress role in IBS pathology alongside the evaluation of tear fluid molecular dynamics in IBS for the first time in our best knowledge.

Further Validation of the Visual Analogue Scale for Irritable Bowel Syndrome After Use in Clinical Practice

2013 ◽  
Vol 36 (3) ◽  
pp. 188-198 ◽  
Author(s):  
Mariette Bengtsson ◽  
Jesper Persson ◽  
Kristina Sjölund ◽  
Bodil Ohlsson
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Practice ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Irritable Bowel

374 Effects of low-FODMAP and gluten-free diets in Irritable Bowel Syndrome patients. A double-blind randomized controlled clinical study

2014 ◽  
Vol 79 (5) ◽  
pp. AB402
Author(s):  
Daria Piacentino ◽  
Sara Rossi ◽  
Valeria Alvino ◽  
Rosanna Cantarini ◽  
Danilo Badiali ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Study ◽  
Gluten Free ◽  
Double Blind ◽  
Randomized Controlled ◽  
Irritable Bowel ◽  
Controlled Clinical Study

374 Effects of Low-Fodmap and Gluten-Free Diets in Irritable Bowel Syndrome Patients. A Double-Blind Randomized Controlled Clinical Study

2014 ◽  
Vol 146 (5) ◽  
pp. S-82 ◽  
Author(s):  
Daria Piacentino ◽  
Sara Rossi ◽  
Valeria Alvino ◽  
Rosanna Cantarini ◽  
Danilo Badiali ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Study ◽  
Gluten Free ◽  
Double Blind ◽  
Randomized Controlled ◽  
Irritable Bowel ◽  
Controlled Clinical Study

scholarly journals Gluten-Associated Pathology: Focusing on Patients with Irritable Bowel Syndrome

2020 ◽  
Vol 16 (30) ◽  
pp. 66-73
Author(s):  
O.V. Gaus ◽  
◽  
M.A. Livzan ◽  
D.V. Popello
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Clinical Symptoms ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Wheat Allergy ◽  
The World ◽  
Wheat Products ◽  
Irritable Bowel ◽  
The Many

Wheat is an essential part of the diet of many people around the world. Despite the many beneficial aspects of eating wheat products, they can be associated with the development of a variety of diseases. The spectrum of gluten-associated pathologies includes celiac disease, wheat allergy, and non-celiac gluten sensitivity (NCGS). The clinical symptoms of gluten-associated pathology are similar to those of irritable bowel syndrome (IBS). Diagnosis of celiac disease and wheat allergy is now straightforward. NCGS remains a diagnosis of exclusion due to the lack of specific biomarkers and standardized research methods. Many patients with IBS consider themselves gluten-sensitive and their symptoms are relieved by a gluten-free diet. Most likely it is NCGS that occurs in a heterogeneous group of patients with IBS. However it remains controversial whether the development of symptoms in this case is associated with gluten itself or with other components of wheat, such as non-gluten proteins and FODMAPs.

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