scholarly journals The Impact of Serum Zinc Levels on Abdominal Fat Mass in Hemodialysis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 656 ◽  
Author(s):  
Hirotaka Fukasawa ◽  
Hiroki Niwa ◽  
Kento Ishibuchi ◽  
Mai Kaneko ◽  
Takamasa Iwakura ◽  
...  

Background: Zinc deficiency is highly prevalent and is caused by inadequate dietary intake, malabsorption and removal by treatment in hemodialysis patients. This study investigated the relationship between serum zinc levels and nutritional status in hemodialysis patients. Methods: A cross-sectional study examining 87 hemodialysis patients was performed. The serum concentrations of zinc were studied to evaluate their association with nutritional status, which was assessed by measuring abdominal muscle and fat areas with computed tomography. Results: Serum zinc levels were significantly and positively correlated with subcutaneous and visceral fat areas (r = 0.299, p < 0.01, and r = 0.298, p < 0.01, respectively), but not abdominal muscle areas. Multiple regression analyses demonstrated that serum zinc levels were a significant independent predictor of visceral fat areas (p < 0.01), but not subcutaneous fat areas (p = 0.631). Conclusions: Our findings suggest that serum zinc levels could play a crucial role in determining abdominal fat mass in hemodialysis patients.

2010 ◽  
Vol 39 (12) ◽  
pp. 530-533 ◽  
Author(s):  
Jamal Ghaemmaghami ◽  
Reza Mahdavi ◽  
Elnaz Faramarzi ◽  
Noshin Mohammadpour ◽  
Hassan Argani

Author(s):  
Regina I. Ejemot-Nwadiaro ◽  
Edisua H. Itam ◽  
Emmanuel N. Ezedinachi

Introduction: Tuberculosis (TB) still remains a leading killer from a single infectious agent worldwide, especially in Asia and Africa. Achieving the Sustainable Development Goal (SDG) 3 will be contingent on addressing ways of reducing the impact of TB to the health, socio-economic and health system of populations most at risk. Micronutrients supplementation is increasingly being recognized as having great potentials to that effect. Objective: This study thus assessed the potential benefits or otherwise of zinc supplementation on tuberculosis treatment outcomes in Calabar, Nigeria. Methods: Eligible patients (81) out of the 182 assessed were randomized to receive anti-TB drug regimen plus oral administration of individual zinc, 25 mg daily for 60 days (intervention group), while the control group received anti-tuberculosis drug regimen only for 60 days. Both qualitative and quantitative data were collected. Clinical examination, Karnofsky performance scale index, direct sputum examination, anthropometric measurements and blood collection for haematological and zinc assessment were carried out before and 2 months after anti-TB treatment began.  Difference in treatment effects between and within groups for continuous variables was tested using t-test. Mantel-Haenszel summary estimate of the relative risk (RR) was used to test the clinical effectiveness of the intervention. The Pearson test was applied to determine the correlation between variables. Main Results: The mean serum zinc levels at 2 months of TB treatment were significantly higher in the intervention group (14.4 ± 0.37µmol/L) in comparison with the control (12.9 ± 0.37 µmol/L); (p = 0.004). A significant difference (p = 0.010) in the serum concentrations of zinc was observed between the two groups when adjustments were made for TB-HIV co-infection. Risk reduction of about 41% for acid fast bacilli (AFB) positivity (RR: 0.59; 95% CI 0.23 to 1.46) was observed after 2 months of anti-TB treatment in favour of the intervention group. Similarly, intervention group had significantly (p = 0.005) lower proportion of patients with serum zinc levels < 10.7 µmol/L (intervention: 5; Control 10) and (p = 0.030) BMI < 18.5 kg /m2 below the lower ranges ((intervention: 9; Control 16). There was a significant improvement in the haematological parameters as evidenced by significant higher proportion of patients in the intervention group than the control group with values above the lower ranges for these parameters with risk reductions in favour of the intervention group for lower ranges as 34%, 12%, 73% and 58% respectively for haemoglobin, albumin, serum total protein and globulins. Conclusion: Irrespective of HIV status in individuals with tuberculosis, zinc micronutrient supplementation significantly increases clinical outcomes, haematological parameters, improves nutritional status as proxied by anthropometric indices and leads to faster sputum smear conversion. The study adds to the growing body of evidence in support of the beneficial role of zinc in TB control.


2018 ◽  
Vol 22 ◽  
pp. 11-18 ◽  
Author(s):  
Sheikh Nazrul Islam ◽  
Md. Mostafa Kamal ◽  
Rudava Rahmatullah ◽  
Sheikh Khalid Saifullah Sadi ◽  
Monira Ahsan

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ling-Jun Wang ◽  
Ming-Qing Wang ◽  
Rong Hu ◽  
Yi Yang ◽  
Yu-Sheng Huang ◽  
...  

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.


2011 ◽  
Vol 12 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Sarah A Hamza ◽  
Shereen M Mousa ◽  
Shereen E Taha ◽  
Lamiaa A Adel ◽  
Hanan E Samaha ◽  
...  

2018 ◽  
Vol 51 (6) ◽  
pp. 369-377 ◽  
Author(s):  
Nobuo Nagano ◽  
Kyoko Ito ◽  
Yuko Oishi ◽  
Masami Minami ◽  
Hideki Hayashi ◽  
...  

1994 ◽  
Vol 4 (1) ◽  
pp. 54-69 ◽  
Author(s):  
Susan M. Kleiner ◽  
Terry L. Bazzarre ◽  
Barbara E. Ainsworth

The nutritional status of 11 female and 13 male elite bodybuilders at the first drug-tested USA Championship was examined through food records kept by subjects. Diets were repetitive and monotonous, and average daily energy and protein contents were relatively similar for men and women. Percent calories from protein, fat, and carbohydrate were 39%, 12%, and 48% for females, and 40%, 11%, and 49% for males, respectively. Females consumed 0% vitamin D, 52% calcium, 76% zinc (as percents of RDA) and below the Estimated Safe and Adequate Dietary Allowance amounts for copper and chromium. Males consumed 46% of vitamin D RDA. Although dietary magnesium intakes were above the RDA, serum magnesium levels in females were below reference values, which should be investigated. Serum zinc levels were high in men and women. Eighty-one percent of females reported recurrent contest-related amenorrhea for 2 ± 1 months precontest. Dietary intakes of men were adequate but the restrictive intakes of women may place them at risk for calcium, copper, and chromium deficiencies.


2021 ◽  
Author(s):  
Talita Rodrigues Azevedo e Silva ◽  
Anna Caroline Pereira Vivi ◽  
Fernando Luiz Affonso Fonseca ◽  
Cibele Wolf Lebrão ◽  
Maria Wany Louzada Strufaldi ◽  
...  

Abstract Background: Zinc is an important micronutrient involved in cell division, growth, and immune system function. Most studies evaluating the nutritional status related to zinc and prematurity were conducted with hospitalized preterm infants. These studies show controversial results regarding the prevalence of deficiency, clinical implications, and the effect of zinc supplementation on mortality, infectious diseases, and growth in these groups. This study aimed to compare serum and erythrocyte zinc levels in a group of preterm and term infants during complementary feeding and related the zinc levels to dietary intake, and current nutritional condition in both groups. Methods: Cross-sectional study with 43 preterm infants (24 to 33 weeks) aged 9-24 months (mean: 14.3±6.4 months), compared with 47 term healthy infants. Data collected: socioeconomic status and maternal health during pregnancy, dietary history, anthropometry (weight, height, and head circumference), and current dietary intake. Laboratory tests: blood count, serum and erythrocyte zinc concentrations, and C-reactive protein.Results: Males predominated (24, or 55.8%) in the preterm group; the mean birth weight was 1,245±381.7 grams. Serum zinc levels <65 µg/dL and anemia were observed in four preterm (5.1%) and four term infants (5.3%), respectively. No infant had erythrocyte zinc < 40 µg/gHb. The variables independently associated with serum zinc levels were breastfeeding at the time of evaluation (20.11 µg/dL; 95% CI 9.62 to 30.60; p<0.001) and late (4-7 months) introduction of complementary feeding (6.6 µg/dL; 95% CI 5.3 to 11.4; p<0.001). Breastfeeding was also independently and directly associated with erythrocyte zinc levels (18.8 ug/dL; 95% CI 3.7 to 33.8; p=0.015). Conclusions: No difference was observed in the nutritional status related to zinc between preterm and term infants during complementary feeding. Serum and erythrocyte zinc levels were influenced by breastfeeding and the onset of solid foods.


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