scholarly journals Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health?

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 628 ◽  
Author(s):  
Patrizia D’Amelio ◽  
Luca Quacquarelli

The older-adult population is constantly increasing, hence aging and mechanisms leading to aging are a topic raising increasing interest. Hypovitaminosis D is common amongst old patients and has been proposed as causative of several chronic diseases. Here we review the role of hypovitaminosis D and vitamin D supplementation in sarcopenia and dementia, from bench to bedside.

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 204-205
Author(s):  
Chae-Hee Park ◽  
Kiyoji Tanaka ◽  
JaeHoon Seol ◽  
Andiara Schwingel ◽  
Wojtek Chodzko-Zajko

2020 ◽  
Vol 14 (4) ◽  
pp. 282-289
Author(s):  
Susana Cararo Confortin ◽  
Lariane Mortean Ono ◽  
Larissa Pruner Marques ◽  
Thamara Hubler Figueiró ◽  
Gilciane Ceolin ◽  
...  

OBJECTIVE: To verify associations between osteopenia/osteoporosis and vitamin D and sarcopenia in the older adult population of Florianopolis, Brazil. METHODS: A cross-sectional population-based study, with 604 older adults (60 years and over). The appendicular muscle mass index (AMMI) was used to identify sarcopenia, with cutoffs of AMMI (Kg/m2) < 7.26 kg/m2 for men and < 5.50 kg/m2 for women indicating inadequate values (sarcopenia). The independent variable osteopenia/osteoporosis was measured using bone mineral density (BMD, g/cm2): T-Scores for whole body BMD, lumbar spine BMD, and femoral neck BMD, categorized as normal (BMD ≥ -1 SD) or osteopenia/osteoporosis (BMD < -1 SD from the mean of the young adult reference population). Fasting serum samples were collected and assayed using the microparticle chemiluminescence (CMIA)/Liaison method. Vitamin D concentrations of < 30 ng/mL were defined as hypovitaminosis. Crude and adjusted logistic regression analyses were performed. RESULTS: Osteopenia/osteoporosis in the lumbar spine and femoral neck were associated with higher odds of sarcopenia in women and men. Osteopenia/osteoporosis in the whole body was associated with sarcopenia in women only. Vitamin D was not associated with sarcopenia in either sex. CONCLUSIONS: Having osteopenia/osteoporosis is associated with sarcopenia in the older adult population.


QJM ◽  
2020 ◽  
Author(s):  
M Verdoia ◽  
G De Luca

Summary Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide and displaying a broad spectrum of implications on cardiovascular and inflammatory disorders. Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-CoV-2 infection. We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic.


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