scholarly journals Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 408 ◽  
Author(s):  
Miguel Z Martín-González ◽  
Héctor Palacios ◽  
Miguel A Rodríguez ◽  
Lluís Arola ◽  
Gerard Aragonès ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Low Dose ◽  
Body Weight Gain ◽  
Total Phospholipid ◽  
Low Doses ◽  
Metabolic Disturbances ◽  
Beneficial Effects

Conjugated linoleic acid (CLA) is a dietary supplement that has been shown to improve obesity. However, some authors have associated high doses of CLA supplementation with liver impairment and insulin resistance. The aim of this study was to assess whether the consumption of low doses of CLA maintained the beneficial effects on the main metabolic disturbances associated with metabolic syndrome (MetS) but prevented the occurrence of non-desirable outcomes associated with its consumption. Male Wistar rats, fed standard or cafeteria (CAF) diet for 12 weeks, were supplemented with three different low doses of CLA in the last three weeks. Both biochemical and H1 NMR-based metabolomics profiles were analysed in serum and liver. The consumption of 100 mg/kg CLA, but not doses of 200 and 300 mg/kg, ameliorated the increase in body weight gain as well as the serum concentrations of glucose, insulin, cholesterol, triglyceride, diglyceride, and total phospholipid induced by a CAF diet. In turn, CLA reverted the increase in lactate, alanine, and glucose concentrations in the liver of these animals, but enhanced hepatic cholesterol accumulation without any detrimental effect on liver function. In conclusion, a low dose of CLA corrected the adverse effects associated with MetS without compromising other metabolic parameters.

scholarly journals Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-α

2007 ◽  
Vol 97 (2) ◽  
pp. 389-398 ◽  
Author(s):  
Patricia Pérez-Matute ◽  
Nerea Pérez-Echarri ◽  
J. Alfredo Martínez ◽  
Amelia Marti ◽  
María J. Moreno-Aliaga
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Body Weight ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Control Diet ◽  
Cafeteria Diet ◽  
High Fat ◽  
Beneficial Effects

n-3 PUFA have shown potential anti-obesity and insulin-sensitising properties. However, the mechanisms involved are not clearly established. The aim of the present study was to assess the effects of EPA administration, one of the n-3 PUFA, on body-weight gain and adiposity in rats fed on a standard or a high-fat (cafeteria) diet. The actions on white adipose tissue lipolysis, apoptosis and on several genes related to obesity and insulin resistance were also studied. Control and cafeteria-induced overweight male Wistar rats were assigned into two subgroups, one of them daily received EPA ethyl ester (1 g/kg) for 5 weeks by oral administration. The high-fat diet induced a very significant increase in both body weight and fat mass. Rats fed with the cafeteria diet and orally treated with EPA showed a marginally lower body-weight gain (P = 0·09), a decrease in food intake (P < 0·01) and an increase in leptin production (P < 0·05). EPA administration reduced retroperitoneal adipose tissue weight (P < 0·05) which could be secondary to the inhibition of the adipogenic transcription factor PPARγ gene expression (P < 0·001), and also to the increase in apoptosis (P < 0·05) found in rats fed with a control diet. TNFα gene expression was significantly increased (P < 0·05) by the cafeteria diet, while EPA treatment was able to prevent (P < 0·01) the rise in this inflammatory cytokine. Adiposity-corrected adiponectin plasma levels were increased by EPA. These actions on both TNFα and adiponectin could explain the beneficial effects of EPA on insulin resistance induced by the cafeteria diet.

Body Weight Gain Blunts Brain Beneficial Effects Of Physical Training In Old Apoe-/- Mice

2015 ◽  
Vol 47 ◽  
pp. 672-673
Author(s):  
Vincent Pialoux ◽  
Di Cataldo Vanessa ◽  
Erica N. Chirico ◽  
Emmanuelle Canet-Soulas
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Physical Training ◽  
Body Weight Gain ◽  
Beneficial Effects

scholarly journals Effects of supplemental phytase on performance and tibia ash of broilers fed different cereals based diets

2011 ◽  
Vol 49 (No. 12) ◽  
pp. 542-548 ◽  
Author(s):  
J. Pintar ◽  
B. Homen ◽  
K. Gazić ◽  
D. Grbeša ◽  
M. Sikirić ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Dietary Calcium ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Control Groups ◽  
Broiler Performance ◽  
Beneficial Effects ◽  
Tibia Ash

A 21-day experiment with day-old broilers was conducted in order to assess the effect of phytase supplementation to different cereals-soybean meal based diets on broiler performance and tibia ash. Diets were formulated to contain 4 different cereals (maize, wheat, triticale and barley), 2 levels of dietary calcium (0.6 and 1.0%) and 3 levels of supplemental phytase (0, 500 and 1 000 PU/kg). Supplemented phytase had beneficial effects on broiler performance. It significantly increased body weight gain (P &lt; 0.0003) and feed consumption (P &lt; 0.0361) by 6 and 7% in comparison with the control groups, respectively. No influence on feed conversion ratio and tibia ash was detected. Both body weight gain and feed intake were also significantly influenced by different cereals (P &lt; 0.0001 and 0.0348, respectively). The increasing dietary calcium level resulted in a significant increase in body weight gain (P &lt; 0.0024) and tibia ash (P &lt; 0.0016). Effects of 500 and 1 000 PU/kg were not statistically different between themselves. &nbsp;

Combined treatment with low-dose pioglitazone and beraprost sodium improves glucose intolerance without causing body weight gain

2013 ◽  
Vol 4 (4) ◽  
pp. 226-232 ◽  
Author(s):  
Hiroki Kumagai ◽  
Naoto Kubota ◽  
Tetsuya Kubota ◽  
Takehiro Takahashi ◽  
Mariko Inoue ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Glucose Intolerance ◽  
Low Dose ◽  
Body Weight Gain ◽  
Combined Treatment ◽  
Beraprost Sodium

Low doses of cocoa extract supplementation ameliorate diet-induced obesity and insulin resistance in rats

2019 ◽  
Vol 10 (8) ◽  
pp. 4811-4822 ◽  
Author(s):  
Paula Aranaz ◽  
Ana Romo-Hualde ◽  
David Navarro-Herrera ◽  
María Zabala ◽  
Miguel López-Yoldi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Body Weight Gain ◽  
Liver Steatosis ◽  
Low Doses ◽  
Diet Induced Obesity

Supplementation with low doses of a cocoa extract induces metabolic benefits in the prevention of metabolic syndrome in rats, reducing body-weight gain, visceral adiposity and liver steatosis and improving insulin sensitivity and glucose tolerance.

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