scholarly journals Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 363
Author(s):  
Christopher J. Martoni ◽  
Shalini Srivastava ◽  
Gregory J. Leyer
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Lactobacillus Acidophilus ◽  
Symptom Severity ◽  
Rating Scale ◽  
Controlled Trial ◽  
Pain Severity ◽  
Bowel Habits ◽  
Severity Scores ◽  
Irritable Bowel

This randomized, double-blind, placebo-controlled, multi-center study investigated the clinical efficacy of two probiotic strains on abdominal pain severity and symptomology in irritable bowel syndrome (IBS). Three hundred and thirty adults, aged 18 to 70 years, with IBS according to Rome IV criteria were allocated (1:1:1) to receive placebo, Lactobacillus acidophilus DDS-1 (1 × 1010 CFU/day) or Bifidobacterium animalis subsp. lactis UABla-12 (1 × 1010 CFU/day) over six weeks. The primary outcome was the change in Abdominal Pain Severity - Numeric Rating Scale (APS-NRS). Over the intervention period, APS-NRS was significantly improved in both probiotic groups vs. placebo in absolute terms (DDS-1: −2.59 ± 2.07, p = 0.001; UABla-12: −1.56 ± 1.83, p = 0.001) and in percentage of significant responders (DDS-1: 52.3%, p < 0.001); UABla-12 (28.2%, p = 0.031). Significant amelioration vs. placebo was observed in IBS Symptom Severity Scale (IBS-SSS) scores for L. acidophilus DDS-1 (−133.4 ± 95.19, p < 0.001) and B. lactis UABla-12 (−104.5 ± 96.08, p < 0.001) groups, including sub-scores related to abdominal pain, abdominal distension, bowel habits and quality of life. Additionally, a significant normalization was observed in stool consistency in both probiotic groups over time and as compared to placebo. In conclusion, L. acidophilus DDS-1 and B. lactis UABla-12 improved abdominal pain and symptom severity scores with a corresponding normalization of bowel habits in adults with IBS.

scholarly journals Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome

2018 ◽  
Vol 31 (2) ◽  
pp. e13509 ◽  
Author(s):  
John M. Hollier ◽  
Miranda A. L. van Tilburg ◽  
Yan Liu ◽  
Danita I. Czyzewski ◽  
Mariella M. Self ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Psychological Factors ◽  
Pain Severity ◽  
Irritable Bowel

Hypnotherapy for Children With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Controlled Trial

2007 ◽  
Vol 133 (5) ◽  
pp. 1430-1436 ◽  
Author(s):  
Arine M. Vlieger ◽  
Carla Menko–Frankenhuis ◽  
Simone C.S. Wolfkamp ◽  
Ellen Tromp ◽  
Marc A. Benninga
Keyword(s):  
Randomized Controlled Trial ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Controlled Trial ◽  
Functional Abdominal Pain ◽  
Randomized Controlled ◽  
Irritable Bowel

scholarly journals The Role of Brain-Derived Neurotrophic Factor in Irritable Bowel Syndrome

2021 ◽  
Vol 11 ◽  
Author(s):  
Thomas Jan Konturek ◽  
Cristina Martinez ◽  
Beate Niesler ◽  
Ivo van der Voort ◽  
Hubert Mönnikes ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Symptom Severity ◽  
Neurotrophic Factor ◽  
Mrna Levels ◽  
Bdnf Mrna ◽  
Protein Levels ◽  
Severity Scores ◽  
Descending Colon ◽  
Irritable Bowel

Several studies have implied a role of brain-derived neurotrophic factor (BDNF) in abdominal pain modulation in irritable bowel syndrome (IBS). The aim of this study was to establish BDNF protein expression in human colonic biopsies and to show variation in IBS compared to controls. BDNF protein and mRNA levels were correlated with IBS symptom severity based on the IBS-symptom severity score (IBS-SSS). Biopsies from the descending colon and IBS-SSS were obtained from 10 controls and 20 IBS patients. Total protein of biopsies was extracted and assessed by ELISA and Western Blot. Total mRNA was extracted and gene expression measured by nCounter analysis. In IBS patients, symptom severity scores ranged from 124 to 486 (mean ± sem: 314.2 ± 21.2, &gt;300 represents severe IBS) while controls ranged from 0 to 72 (mean ± sem: 27.7 ± 9.0, &lt;75 represents healthy subjects, p &lt; 0.001). IBS patients reported significantly more food malabsorption, former abdominal surgery and psychiatric comorbidities. BDNF protein was present in all samples and did not differ between IBS and controls or sex. Subgroup analysis showed that female IBS patients expressed significantly more BDNF mRNA compared to male patients (p &lt; 0.05) and male IBS-D patients had higher IBS symptom severity scores and lower BDNF mRNA and protein levels compared to male controls (p &lt; 0.05). Scatter plot showed a significant negative correlation between IBS-SSS and BDNF mRNA levels in the cohort of male IBS-D patients and their male controls (p &lt; 0.05). We detected a high proportion of gastrointestinal surgery in IBS patients and confirmed food intolerances and psychiatric diseases as common comorbidities. Although in a small sample, we demonstrated that BDNF is detectable in human descending colon, with higher BDNF mRNA levels in female IBS patients compared to males and lower mRNA and protein levels in male IBS-D patients compared to male controls. Further research should be directed toward subgroups of IBS since their etiologies might be different.

scholarly journals The Effect of Complex Korean Medical Treatment with Acupotomy on Irritable Bowel Syndrome: A Case Report

2020 ◽  
Vol 37 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Baek Ki Min ◽  
Joon Soo Jin ◽  
Do Eun Lee ◽  
Won Bin Shin ◽  
Jin Hyeon Shin ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Medical Center ◽  
Korean Medicine ◽  
National Medical ◽  
Gastrointestinal Symptom Rating Scale ◽  
Hospitalization Period ◽  
Irritable Bowel

The effects of complex Korean medicine treatment including acupotomy, on irritable bowel syndrome (IBS) are reported in this case study. A 54-year-old woman with diarrheal symptoms that alternatively improved and worsened for many years and worsening abdominal pain visited the emergency room and was diagnosed with IBS; she was admitted for approximately 2 weeks at the Acupuncture and Moxibustion Department of National Medical Center (NMC). Numerical rating scale (NRS), irritable bowel syndrome?quality of life (IBS-QOL), and gastrointestinal symptom rating scale (GSRS) scores were evaluated on the day of hospitalization, midway through the hospitalization period, and on the day of discharge. Abdominal pain was measured daily using NRS, and the score decreased from 8 at admission to 0 at discharge. The IBS-QOL percentile score improved from 42 points to 100 points. The total GSRS score also improved, from 30 points to 2 points. These results suggest that complex Korean medicine treatment with acupotomy, is useful for treating internal diseases, such as IBS, as well as musculoskeletal disorders.

Sign in / Sign up

Export Citation Format

Share Document