scholarly journals Expression Patterns of Muscle-Specific miR-133b and miR-206 Correlate with Nutritional Status and Sarcopenia

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 297 ◽  
Author(s):  
Francesca Iannone ◽  
Alberto Montesanto ◽  
Erika Cione ◽  
Paolina Crocco ◽  
Maria Cristina Caroleo ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Nutritional Assessment ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Mediating Effect ◽  
Age Related ◽  
Poor Nutritional Status ◽  
Muscle Homeostasis

Sarcopenia and malnutrition are commonly occurring conditions in the elderly that frequently coexist, leading to substantial effects on morbidity/mortality. Evidence established muscle-specific microRNAs (miRNAs) or myomiRs as essential regulators of skeletal muscle processes, from myogenesis to muscle homeostasis. This study aimed to evaluate the association between myomiRs and sarcopenia and explore the potential of nutrition in mediating this association. qPCR was employed to characterize the myomiR-1, -133a/b, -206, -208b, and -499 expression profiles of 109 non-sarcopenic and 109 sarcopenic subjects. In our sample, the proportion malnourished or at-risk subjects was higher in sarcopenia (p < 0.001). Among the detected myomiRs (miR-133a/b and miR-206), lower levels of miR-133b was significantly associated with the presence of sarcopenia (p = 0.006); however, this relationship was not independent from nutritional status in multivariate analysis, suggesting a mediating effect of nutrition on the relationship between miR-133b and sarcopenia. Correlation analyses showed that lower miR-133b levels were associated with poor nutritional status (Mini Nutritional Assessment Long Form (MNA-LF) score, p = 0.005); furthermore, correlations with albumin, ferritin, and iron were found. Similar results were obtained for miR-206. Statistically more significant correlations were observed in subjects with sarcopenia. In conclusion, our findings highlight a nutrient-miR-133b/miR-206 pathway having a potential role in the age-related muscle decline.

Effect of the Mini Nutritional Assessment-Short Form (MNA-SF) in Elderly Burn Patients

2021 ◽  
Author(s):  
Jia-Yu Wei ◽  
Shu-Ting Shi ◽  
Dan Sun ◽  
Guo-Zhong Lyu
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Short Form ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Reference Points ◽  
Nutrition Intervention ◽  
Burn Patients ◽  
Cross Sectional

Abstract Objective Nutritional assessment can early identify patients who are malnourished and at risk of malnutrition. To examine the effect of nutritional status on wound healing in elderly burn patients, we used the MNA-SF to measure the nutritional status of elderly patients. This study aimed to examine the role of MNA-SF in elderly burn patients through the correlation analysis of wound-healing indicators and MNA-SF score. Design Prospective observational and cross-sectional study. Methods This study used the MNA-SF to investigate the elderly burn patients at the department of burn. According to the score, the patients fell into three groups: good nutritional status (more than 12 points), malnutrition risk (8~11 points), and malnutrition (0~7 points). At the same time, we measured and compared the wound-healing indicators among the three groups of patients, and detected the correlation. Results The statistical analysis found gender had a slight influence on the score of nutritional status. While age was negatively correlated with the MNA-SF score and nutrition-related indicators. There was a low positive linear correlation between the wound healing percent area change or wound healing rate of patients and the score of the MNA-SF. Conclusion This study finds malnutrition is common among hospitalized elderly burn patients. The application of the MNA-SF in elderly burn patients is efficient and accurate to identify malnutrition early and prevent further obstruction of the normal wound healing, which can provide reference points for early nutrition intervention programs.

scholarly journals Nutritional status assessment of elderly using MNA tool in rural Belagavi: a cross sectional study

2018 ◽  
Vol 5 (11) ◽  
pp. 4799
Author(s):  
D. J. Patil ◽  
M. M. Shindhe
Keyword(s):  
At Risk ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adverse Health Effects

Background: Worldwide the elderly population gradually increasing and that will definitely pose several challenges. Malnutrition is one of the major but neglected problem in elderly. They are at risk of malnutrition due to physical, psychological, social, dietary and environmental risk factors. Malnutrition in elderly is associated with adverse health effects. Hence to study the nutritional status of elderly.Methods: The study was carried out between January 2016- June 2017. 545 elderly were included in the study. Out of the 6 subcentres, 1 subcentre (Uchagaon) was selected by simple random sampling technique and house to house survey was carried out to select eligible elderly participants in the villages of selected subcentre. Data was collected from eligible elderly by using mini nutritional assessment (MNA) tool.Results: Majority of the participants (65.1%) were between the age group of 60-69 years. 55% were females. 23.5% were malnourished, 49% were at risk of malnutrition and 27.5% had normal nutritional status.Conclusions: The present study concluded that majority of the elderly were at risk of malnutrition. There is a need of actions to improve the nutritional status of the elderly.

Nutrition as a Health Determinant in Elderly Patients

2019 ◽  
Vol 26 (19) ◽  
pp. 3652-3661 ◽  
Author(s):  
Tecla Mastronuzzi ◽  
Ignazio Grattagliano
Keyword(s):  
Nutritional Status ◽  
Elderly Population ◽  
Nutritional Assessment ◽  
Caloric Intake ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Nutritional Intervention ◽  
Social Risk ◽  
Social Risk Factors ◽  
The Impact

Background: An adequate caloric intake is a major determinant for the health status especially when degenerative conditions become a predominant risk for difficult-to-treat diseases as in aging. Methods: A structured search of literature on the major databases was performed using terms as nutrition, elderly and malnutrition. Results: According to most referenced articles, it appears to be unquestionable that both organic and social risk factors [economic hardship, loneliness, institutionalization] are important as determining causes of protein-caloric malnutrition. Some anthropometric, clinical and laboratory parameters can help to make diagnosis and quantify malnutrition. However, most of them are not cheap or are not simple to perform especially in the setting of General Practice. The application of a simple questionnaire [Mini Nutritional Assessment, MNA] allows to obtain in a fast, easy and non-invasive way a valid assessment of the nutritional status in geriatric patients. The maintenance of the nutritional status is the best measure to counteract the risk of proteincaloric malnutrition and its complications which often sneakily affects elderly population and in particular frail patients. Conclusion: This review, based on updated concepts, examines all the above mentioned points together with some aspects associated with malnutrition as an indicator of disease severity and health costs in the elderly population. Finally, the impact of nutritional intervention and nutrients supplementation on general indices of malnutrition are discussed as a promising strategy.

Nutritional Status of Lebanese Hospitalized Patients With Chronic Disease: A Cross-Sectional Study

2019 ◽  
pp. 001857871986766
Author(s):  
Georges Choueiry ◽  
Nour Fattouh ◽  
Rabih Hallit ◽  
Francois Kazour ◽  
Souheil Hallit ◽  
...  
Keyword(s):  
Chronic Disease ◽  
High Risk ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Tree Model ◽  
Cross Sectional ◽  
Poor Nutritional Status

Background: In a hospitalized setting, malnutrition is known to increase patient’s mortality and lower the quality of life; therefore, it is essential to detect such cases and intervene at the earliest possible. The goal of this study is to estimate the rate of malnutrition in hospitalized Lebanese patients, explore its association with different factors, and create a simple tool to detect patients at high risk of malnutrition. Methods: One hundred and fifty Lebanese hospitalized patients, suffering at least from one chronic disease, were randomly chosen from Centre Hospitalier Universitaire Notre Dame de Secours (CHU-NDS) hospital. The Mini Nutritional Assessment (MNA) score was used to assess nutritional status. Results: A total of 34.7% of patients in our sample were at risk of malnutrition and 9.3% were malnourished. A higher risk of malnutrition was found in patients with a low body mass index, who were physically inactive or admitted to the hospital more than once in the past 6 months. The nutritional status was not associated with certain chronic diseases more than others. We designed a simple decision tree model based only on 3 questions to detect patients at high risk of malnutrition/malnourished. This tool has a sensitivity of 62% and a specificity of 77%. Conclusion: The prevalence found in our study was comparable with previous data. However, factors associated with poor nutritional status were somewhat different. Further studies are needed to validate our screening tool and to examine the effect of specific diseases on malnutrition on a larger scale.

scholarly journals Aspects of frailty syndrome, nutritional status and comorbidities in the elderly

2021 ◽  
Vol 64 (6) ◽  
pp. 20-25
Author(s):  
Felicia Lupascu-Volentir ◽  
◽  
Gabriela Soric ◽  
Ana Popescu ◽  
Anatolie Negara ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Daily Living ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Frailty Syndrome ◽  
Effective Strategies ◽  
Comorbidity Index ◽  
State Examination ◽  
Age Category

Background: Frailty syndrome is one of the most important multifactorial medical syndromes, which is characterized by a decrease in functionality of many systems and organs. Material and methods: In order to establish the nutritional determinants that contribute to the onset of frailty syndrome, a study was performed on a group of 50 patients, aged ≥65 years with chronic pathologies and geriatric syndromes. All participants were examined according to clinical features (history, clinical examination), Mini Nutritional Assessment and of the Complex Geriatric Assessment, which included: the data of the frailty tools, age category, Vulnerable Elders Survey, Charlson Comorbidity Index, autonomy – Activity Daily Living, Instrumental Activity Daily Living, Tinetti scale, psychoaffective status – by memory test Mini-Mental State Examination and the Geriatric Scale of Depression in the context of nutrition in the elderly. A clustered analysis (k-means method) of nutritional status showed that the most relevant indicators that separated the clusters were: age category, gender, clinical scale of frailty, comorbidities and polymedication. Results: Frailty through the multidimensional aspects that it meets has an increased prevalence among the elderly with an unfavorable prognosis. Following the proposed study, it was revealed that insufficient nutrition and comorbidities can lead to the weakening of the institutionalized age. The results obtained by evaluating the bio-psycho-social aspects characterize the profile of the institutionalized elderly and can be used as a basis for the development of effective strategies aimed at reducing physical, cognitive and social frailty. Conclusions: The comparative evaluation between both groups of elderly people by gender, showed a normal nutritional status with a higher share in women in the group of 75-84 years, compared to older men, and malnutrition was practically manifested equally in both groups in the study (men/women)

scholarly journals Determination of the Personal Nutritional Status of Elderly Populations Based on Basic Foodomics Elements

Foods ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2391
Author(s):  
Natalija Uršulin-Trstenjak ◽  
Ivana Dodlek Dodlek Šarkanj ◽  
Melita Sajko ◽  
David Vitez ◽  
Ivana Živoder
Keyword(s):  
Nutritional Status ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Population Group ◽  
Holistic Approach ◽  
The Elderly ◽  
Nutritional Values ◽  
Individual Approach ◽  
Elderly Populations

Nutritional status is a series of related parameters collected using different available methods. In order to determine the nutritional status of elderly populations and ensure nutritional support based on an individual approach, the implementation of the increasingly used foodomics approach is available; this approach plays a key role in personalized diets and in the optimization of diets for a population group, such as an elderly population. The Mini Nutritional Assessment (MNA) method and the Nottingham Screening Tool (NST) form were used on 50 users in a home for the elderly in northwest Croatia. A loss of body mass (BM) was statistically significantly higher for those who had the following: decreased food intake in the last week and users who had complete and partial feeding autonomy. Additionally, the obtained data on drug intake, fluid, individual nutrients, and physical activity are based on an individual approach. The available documentation provides insight into nutritional values and food preparation in an attempt to satisfy a holistic approach in the evaluation of exposure while trying to achieve as many elements of foodomics as possible.

scholarly journals Prevalence and factors associated with frailty in hospitalized older Patients

2020 ◽  
Author(s):  
Sonia HAMMAMI ◽  
Amira Zarrouk ◽  
Cecile Piron ◽  
Ioana Almas ◽  
Nabil Sakly ◽  
...  
Keyword(s):  
Cognitive Abilities ◽  
Nutritional Assessment ◽  
Complete Blood Count ◽  
Strong Association ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Cognitive Status ◽  
Related Disorder ◽  
Factors Associated ◽  
Age Related

Abstract Background: Frailty is a multidimensional syndrome that leads to an increase of an age-related disorder of several physiological systems, and cognitive abilities decline. The aim of this study was to evaluate the prevalence of frailty among older persons in Belgium and we examined the factors associated with frailty with a principal focus en cognitive, dietary status, and inflammatory parameters Methods: A total of 124 participants (90 women, 34 men; age: mean ± SD: 85.9 ± 5.5 years) were studied, recruited from the Geriatrics department, Belgium. Nutritional, cognitive status and physical activity were assessed using Mini Mental State Examination score (MMSE), Mini Nutritional Assessment score (MNA), and Katz score, respectively. Frailty syndrome was evaluated using the modified Short Emergency Geriatric Assessment (SEGA) score. Medication and medical history were recorded. Analyzed biochemical parameters included C-reactive protein (CRP), complete blood count, blood creatinine, vitamin D level, and serum protein electrophoresis. According to SEGA score, participants were divided into non-frail (n=19), frail (n=25) and severely frail patients (n= 80). Results: The SEGA score was inversely correlated with MMSE, MNA and Katz score. SEGA score was negatively correlated to albumin levels (r = -0.30; p<0.001) and positively correlated to CRP, polypharmacy and age(r = 0.28, r = 0.37, r = 0.33 and p<0.01 respectively) . Logistic regression showed a strong association between frailty, Katz score, dementia, polypharmacy and living in nursing home. Conclusion : Our results provide useful information for understanding mechanisms of frailty. This will help to develop preventive strategies for the elderly at the pre-frailty stage.

scholarly journals An evaluation of the nutritional status of elderly with the use of the MNA questionnaire and determination of factors contributing to malnutrition. A pilot study

2021 ◽  
pp. 175-183
Author(s):  
Małgorzata Kostecka ◽  
Monika Bojanowska
Keyword(s):  
Nursing Homes ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Eating Habits ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
The Body ◽  
Screening Tests ◽  
Biological Aging ◽  
Physical And Mental Health

BSTRACT Background. In the elderly, nutrition significantly influences biological aging and physiological and pathological changes in the body. A balanced diet and physical activity are the key to good physical and mental health. Objective. The aim of this study was: (1) to perform nutritional screening tests in senior citizens residing in eastern Poland and (2) to evaluate the risk of malnutrition in elderly people who live with their families, seniors who live independently, and residents of nursing homes. Material and method. The Mini Nutritional Assessment (MNA) screening tool comprising a questionnaire with 22 questions and an abbreviated and survey-adapted version of the questionnaire (KomPAN) were used to investigate eating habits and self-perception of health and nutrition. A total of 398 correctly filled out questionnaires were selected and the resulting data were subjected to statistical analyses in the Statistica 10 program. Results. The BMI values of most respondents were indicative or malnutrition or risk of malnutrition, regardless of gender (mean BMI 23.88 kg/m2 ±5.08). Most overweight and obese respondents were female (p=0.0001). The observed decreased BMI values was significantly (p=0.0012, rs= 0.6714) correlated with lower food intake. Unintentional weight loss greater than 3 kg was most frequently noted in respondents living in nursing homes and living independently (p=0.0021). Eating difficulties also considerably influenced the respondents’ nutritional status. The respondents’ BMI values were significantly correlated (p<0.0001) with their MNA scores, the average MNA score was 21.0±4.4, (rs = 0.7293). Overweight and obese respondents were more likely to consume at least three meals daily (OR=1.87; 95% CI: 1.32-2.06; p<0.001). Conclusions. The BMI values and MNA scores of the tested subjects indicate that the majority of the surveyed respondents were malnourished or at risk of malnutrition, regardless of gender. In the present study, the residential environment significantly influenced the patients’ nutritional status, in particular in respondents with impaired motor abilities and eating difficulties.

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