scholarly journals Impact of a Three-Week in-Hospital Multidisciplinary Body Weight Reduction Program on Body Composition, Muscle Performance and Fatigue in a Pediatric Obese Population with or without Metabolic Syndrome

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 208 ◽  
Author(s):  
Antonello Emilio Rigamonti ◽  
Gabriella Tringali ◽  
Roberta De Micheli ◽  
Alessandra De Col ◽  
Sofia Tamini ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Composition ◽  
Body Weight ◽  
Weight Reduction ◽  
Muscle Performance ◽  
Body Weight Reduction ◽  
Obese Population ◽  
Reduction Program ◽  
Obese Subjects ◽  
Age Range

Metabolic syndrome is a combination of cardiometabolic risk factors, frequently detected in obese children and adolescents. To date, few clinical studies have evaluated the effectiveness of multidisciplinary body weight reduction programs on body mass index, body composition, muscle performance and fatigue in pediatric obese subjects suffering from metabolic syndrome, which might represent a sub-population that is more difficult to be treated and worthy of more intensive interventions than a population less metabolically complicated. The aim of the present study was to compare the impact of a three-week in-hospital multidisciplinary integrated body weight reduction program (BWRP) on body mass index (BMI), body composition (particularly, fat mass (FM) and fat-free mass (FFM)), motor control (evaluated by one-leg standing balance (OLSB) test), muscle performance (evaluated by the stair climbing test (SCT)) and fatigue (evaluated by fatigue severity scale (FSS)) in a pediatric obese population with or without metabolic syndrome. A pediatric population of 548 obese subjects without metabolic syndrome (F/M = 312/236; age range: 8–18 years; BMI: 36.3 ± 6.7 kg/m2) and 96 obese subjects with metabolic syndrome (F/M = 53/43; age range: 9–18 years; BMI: 38.3 ± 6.9 kg/m2) was recruited. The BWRP significantly reduced BMI, FM (expressed as %), SCT time and FSS score, and increased OLSB time in all subgroups of obese subjects, independent of sex and metabolic syndrome, with preservation of FFM. No significant differences in |ΔBMI|, |ΔFM|, |ΔOLSB| or |ΔSCT| times and |ΔFSS| score were found when comparing subjects (males and females) with or without metabolic syndrome, apart from obese females without metabolic syndrome, who exhibited a lower weight loss and FM (expressed as %) reduction when compared to the corresponding male counterpart. In conclusion, the beneficial effects of a three-week BWRP on BMI, body composition, muscle performance and fatigue in a pediatric obese population were not found to be different in patients with or without metabolic syndrome, thus indicating that the more metabolically compromised patient is as responsive to a short-term BWRP as the patient without metabolic syndrome. More prolonged follow-up studies are, however, necessary in order to verify whether the adherence to the multidisciplinary recommendations at home and the long-term maintenance of the positive effects in the two subgroups of patients will remain similar or not.

scholarly journals Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1495 ◽  
Author(s):  
Antonello E. Rigamonti ◽  
Sabrina Cicolini ◽  
Diana Caroli ◽  
Alessandra De Col ◽  
Massimo Scacchi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Body Weight ◽  
Weight Reduction ◽  
Hdl Cholesterol ◽  
Muscle Performance ◽  
Weight Reduction Program ◽  
Body Weight Reduction ◽  
Reduction Program ◽  
Obese Subjects

Background. In clinical practice, there is the diffuse conviction that obese subjects with metabolic syndrome may be more difficult to treat. Objectives and Methods. The aim of the present study was that to investigate the effectiveness of a 3-week in-hospital body weight reduction program (BWRP) in a large population of obese subjects with and without metabolic syndrome (n = 1922; 222 men and 1700 women, age range 18–83 yr). Outcomes such as body mass index (BMI), total (TOT) and HDL cholesterol, systolic and diastolic blood pressures (SBP and DBP, respectively), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair climbing test (SCT) time were evaluated before and after the intervention (Δ). A sex-, BMI-, and age-related stratification of the obese population with or without metabolic syndrome was applied. Results. When compared to obese subjects without metabolic syndrome, at the basal conditions, obese subjects had a poorer cardiometabolic profile, as demonstrated by higher triglycerides, TOT-cholesterol, DBP, SBP, and CHD score, and a more compromised muscle performance (evaluated by SCT), associated with more perception of fatigue (measured by FSS). Nevertheless, obese subjects with metabolic syndrome obtained more benefits from BWRP than those without metabolic syndrome for some outcomes (i.e., ΔTOT-cholesterol, ΔSBP, and ΔCHD score). Despite these differences, the BWRP-induced weight loss was similar between the two groups (i.e., ΔBMI) as well as the gain of muscle performance (i.e., ΔSCT) and the reduction of fatigue (i.e., ΔFSS). Interestingly, the potentially deleterious fall in HDL-cholesterol levels after BWRP was less evident in obese subjects with metabolic syndrome than those without metabolic syndrome. When pooling all data, the ΔCHD score was associated with age, sex, and metabolic syndrome. The remaining outcomes, such as ΔBMI, ΔFSS, and ΔSCT time, were associated with sex and age but not with metabolic syndrome. Finally, ΔBMI was positively correlated with ΔCHD score, ΔFSS, and ΔSCT time in both obese subjects without metabolic syndrome and obese subjects with metabolic syndrome. Conclusions. When comparing obese subjects undergoing a BWRP, metabolic syndrome is not a negative predictive factor affecting the effectiveness of this intervention in terms of weight loss, muscle performance, and psychological well-being.

Erratum to: APJDM 2, 93-96 (2008)Body Weight Reduction Program for Metabolic Syndrome

2009 ◽  
Vol 3 (1) ◽  
pp. 32E-32E
Author(s):  
Mio Takimoto ◽  
Miwa Kibushi ◽  
Yumi Okoshi ◽  
Tohru Nakagawa ◽  
Masataka Irokawa ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Weight Reduction ◽  
Weight Reduction Program ◽  
Body Weight Reduction ◽  
Reduction Program

scholarly journals Body Weight Reduction Program for Metabolic Syndrome

2008 ◽  
Vol 2 (4) ◽  
pp. 119-122
Author(s):  
Miwa Kibushi ◽  
Mio Takimoto ◽  
Yumi Okoshi ◽  
Tohru Nakagawa ◽  
Masataka Irokawa ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Weight Reduction ◽  
Weight Reduction Program ◽  
Body Weight Reduction ◽  
Reduction Program

scholarly journals Body Weight Reduction Program for Metabolic Syndrome

2008 ◽  
Vol 2 (3) ◽  
pp. 93-96 ◽  
Author(s):  
Mio Takimoto ◽  
Miwa Kibushi ◽  
Yumi Okoshi ◽  
Tohru Nakagawa ◽  
Masataka Irokawa ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Weight Reduction ◽  
Weight Reduction Program ◽  
Body Weight Reduction ◽  
Reduction Program

scholarly journals Předsoutěžní redukce tělesné hmotnosti a její vliv na tělesné složení

2013 ◽  
Vol 7 (1) ◽  
pp. 121-126
Author(s):  
Klára Coufalová ◽  
Ivana Kinkorová ◽  
Lucia Malá ◽  
Jan Heller
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Reduction ◽  
Negative Impact ◽  
Fat Free Mass ◽  
Extracellular Water ◽  
The Czech Republic ◽  
Body Weight Reduction ◽  
Multifrequency Bioimpedance ◽  
Total Body

The aim of our study was to monitor changes in individual components of body composition due to reduction in body weight in judo. This precontest weight reduction is very common in combat sports and it can have negative impact not only on performance but also on health. Research group consisted of 11 judoists at the age of 17-27 years belonging to the representation of the Czech Republic. The measurement of body composition had two parts; the first was before body weight reduction and the second part at the end of body weight reduction. For the measurement of body composition we used multifrequency bioimpedance analyzer BIA 2000 - M. The results of our study show that rapid intensive weight reduction is reflected in varying degrees in all parameters of body composition. We noticed a reduction of body weight by an average of 4.7% (approximately 3.8 kg), the weight loss ranged from 1.6 kg to 8.1 kg. The greatest changes in the parameters of body composition were detected in the extracellular water (ECW), there was a decrease of this parameter on average by 13.8 %, while total body water (TBW) decreased by 6.0 %. There was also a reduction in the amount of body fat by 13.2 %, the amount of extracellular mass (ECM) decreased by 9.8 %, the ratio of ECM/BCM by 8.9 % and the amount of fat-free mass (FFM) decreased by 4.0 %. Only in intracellular water (ICW), we noticed a slight increase by 1.4 %, which may be due to the redistribution of body fluids. Changes of particular parameters of body composition were statistically and substantively significant.

SH2B1 CpG-SNP Is Associated with Body Weight Reduction in Obese Subjects Following a Dietary Restriction Program

2014 ◽  
Vol 66 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Maria Luisa Mansego ◽  
Fermin Ignacio Milagro ◽  
Maria Angeles Zulet ◽  
José Alfredo Martinez
Keyword(s):  
Dna Methylation ◽  
Body Weight ◽  
Weight Reduction ◽  
Molecular Mechanisms ◽  
White Blood Cells ◽  
The Body ◽  
Mrna Levels ◽  
Bdnf Mrna ◽  
Body Weight Reduction ◽  
Obese Subjects

The objective of this study was to examine whether 7 SNPs previously associated with obesity-related traits that add or remove potential sites of DNA methylation are accompanied by differential DNA methylation and subsequently affect adiposity variables or body weight reduction in WBC from obese subjects under an energy-restricted program. Material and Methods: Anthropometric measurements were assessed in 47 volunteers recruited within the RESMENA study (Spain). At baseline, DNA from white blood cells was isolated and 7 obesity-related trait CpG-SNPs were genotyped by TaqMan-PCR. Then, methylation levels of CpG-SNP sites were quantified by MassArray® EpiTyper™ or MS-HRM approaches. Results: Differential DNA methylation levels were observed by genotypes in all of the CpG-SNPs analyzed. The FTO and BDNF methylation levels were further correlated with baseline body weight and, BDNF mRNA levels and body weight change, respectively. Moreover, the rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction. Conclusions: Our results reveal the interaction of epigenetic and genetic variations in CpG-SNPs, especially in BDNF and SH2B1 genes, and how allele-specific methylation may contribute to elucidate the possible molecular mechanisms as these SNPs are affecting the decrease of mRNA levels and contributing to a lower body weight reduction. © 2014 S. Karger AG, Basel

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