scholarly journals Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 45 ◽  
Author(s):  
Charlotte Gröschel ◽  
Maximilian Prinz-Wohlgenannt ◽  
Ildiko Mesteri ◽  
Sobha Karuthedom George ◽  
Lena Trawnicek ◽  
...  
Keyword(s):  
Experimental Period ◽  
Healthy Diet ◽  
Preventive Strategy ◽  
Cancer Model ◽  
Disease Symptoms ◽  
Cancer Initiation ◽  
Group Feeding ◽  
Inflammatory Bowel ◽  
After Cancer ◽  
Effective Preventive Strategy

Inflammatory bowel disease increases the odds of developing colitis-associated cancer. We hypothesized that Western-style diet (WD) aggravates azoxymethane (AOM)/dextran sulfate sodium salt (DSS)-induced colitis-associated tumorigenesis and that switching to the standard AIN93G diet will ameliorate disease symptoms even after cancer initiation. Female BALB/c mice received either WD (WD group) or standard AIN93G diet (AIN group) for the whole experimental period. After five weeks, the mice received 12.5 mg/kg AOM intraperitoneally, followed by three DSS cycles. In one group of mice, the WD was switched to AIN93G the day before starting the first DSS cycle (WD/AIN group). Feeding the WD during the whole experimental period aggravated colitis symptoms, shortened the colon (p < 0.05), changed microbiota composition and increased tumor promotion. On molecular level, the WD reduced proliferation (p < 0.05) and increased expression of the vitamin D catabolizing enzyme Cyp24a1 (p < 0.001). The switch to the AIN93G diet ameliorated this effect, reflected by longer colons, fewer (p < 0.05) and smaller (p < 0.01) aberrant colonic crypt foci, comparable with the AIN group. Our results show that switching to a healthy diet, even after cancer initiation is able to revert the deleterious effect of the WD and could be an effective preventive strategy to reduce colitis symptoms and prevent tumorigenesis.

scholarly journals IMPACT OF DIET ON INFLAMMATORY BOWEL DISEASE SYMPTOMS: AN ADOLESCENT VIEWPOINT

2021 ◽  
Vol 27 (Supplement_1) ◽  
pp. S58-S59
Author(s):  
Megan Zangara ◽  
Natalie Bhesania ◽  
Wei Liu ◽  
Gail Cresci ◽  
Jacob Kurowski ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Dietary Habits ◽  
Therapeutic Option ◽  
Current Status ◽  
Dietary Modification ◽  
Continue Development ◽  
Disease Symptoms ◽  
Inflammatory Bowel ◽  
Active Disease

Abstract Background Dietary modification shows promise as therapy in inflammatory bowel disease (IBD); however, it is unknown whether adolescents are interested in a dietary approach. Methods Cross-sectional survey of adolescents with IBD ages 14–21 on disease knowledge, dietary habits, and perceptions of diet therapy. Results A total of 132 subjects (48.5% female), mean age of 17.8 years and median disease length of 5 years (range 0, 16), completed the survey. Diet was perceived as a symptom trigger by 59.8% of subjects, and 45.4% had tried using diet as a treatment for symptom resolution, often without physician supervision and with limited success. Overall, subjects reported following a diet significantly more often than documented in the electronic medical record (EMR) by the physician (25.0% vs. 15.0%, p=0.033), with 72% agreement between subject response and EMR documentation on current status of diet modification (AC1=0.59, CI=0.45, 0.73). Subjects experiencing active disease symptoms as determined by Manitoba IBD Index were more likely to be currently modifying their diet compared to subjects without active disease symptoms (OR = 4.11, CI=1.58, 10.73, p=0.003). The subjects reporting unsuccessful dietary modification compliancy (25.7%, n=34) most commonly cited perceived lack of improvement in their IBD symptoms as the primary reason for stopping the diet (48.4%, n=15). Conclusions Adolescents with IBD perceive a relationship between diet and disease symptoms and are interested in dietary modification as a symptom management option. Our study suggests that a large proportion of adolescent IBD patients may already be attempting dietary modification, and therefore would be receptive to a modified dietary plan under the guidance of their gastroenterologist and dietitian. Much is still unknown about how dietary modification will fit in with current treatment regimens, but patient interest informs us that it is necessary to continue development and research of this promising therapeutic option.

Crohn's and colitis: New research offers insights into caring for young people

2020 ◽  
Vol 1 (5) ◽  
pp. 217-218
Author(s):  
Pamela Qualter ◽  
Bernie Carter
Keyword(s):  
Mental Health ◽  
Inflammatory Bowel Disease ◽  
Young People ◽  
Social Interactions ◽  
Bowel Disease ◽  
Disease Symptoms ◽  
Health And Wellbeing ◽  
Close Friendships ◽  
Inflammatory Bowel ◽  
New Research

The unpredictable nature of inflammatory bowel disease symptoms and stigma can affect young people's ability to form close friendships and affect their social interactions. New research shows the importance of addressing the mental health and wellbeing of young people with Crohn's disease and colitis.

scholarly journals Temperament and Health-Related Quality of Life in Newly Diagnosed Pediatric Inflammatory Bowel Disease

2020 ◽  
Author(s):  
Sharon Shih ◽  
Grace Cushman ◽  
Bonney Reed
Keyword(s):  
Quality Of Life ◽  
Emotional Reactivity ◽  
Newly Diagnosed ◽  
Health Related Quality ◽  
Disease Symptoms ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related ◽  
Inflammatory Bowel

Abstract Objective Health-related quality of life (HRQOL) is typically examined from a deficit standpoint, meaning that little is known about factors associated with higher HRQOL in pediatric illness samples. The aim of the current study was to investigate demographic, disease, and temperamental factors associated with child and parent-report of HRQOL in youth newly diagnosed with inflammatory bowel disease (IBD). Methods Participants included 52 youth ages 8–17 diagnosed with IBD and their caregivers who each completed ratings of the child’s HRQOL. Parents rated their child’s emotional reactivity, conceptualized as a temperamental risk factor, and adaptability, conceptualized as a temperamental protective factor. Disease symptoms were rated by youth, and physician global assessment of disease activity was obtained. Results HRQOL was rated lower by children and their parents as self-reported disease symptoms and parent-rated emotional reactivity increased. Conversely, total HRQOL was higher for children with higher parent-ratings of adaptability. In multiple regression analyses, higher levels of adaptability along with male sex and lower child-reported disease symptoms were associated with higher child and parent-reported HRQOL. Conclusions Higher HRQOL at time of diagnosis in pediatric IBD is associated with greater adaptability when accounting for variability due to child sex and disease symptoms. Consideration of temperament, including emotional reactivity and adaptability, may offer insight into patients’ typical ways of responding when stressed and provide preliminary information about factors related to post-diagnosis HRQOL. Attention should be given to both protective and risk factors to inform future intervention development, including strengths-based approaches.

scholarly journals New generation typhoid vaccines: An effective preventive strategy to control typhoid fever in developing countries

2011 ◽  
Vol 7 (8) ◽  
pp. 883-885 ◽  
Author(s):  
Ramesh Verma ◽  
Mohan Bairwa ◽  
Suraj Chawla ◽  
Shankar Prinja ◽  
Meena Rajput
Keyword(s):  
Developing Countries ◽  
Typhoid Fever ◽  
Preventive Strategy ◽  
Typhoid Vaccines ◽  
New Generation ◽  
Effective Preventive Strategy

Some nutritional implications of group-feeding hill sheep

1973 ◽  
Vol 16 (3) ◽  
pp. 293-302 ◽  
Author(s):  
Janet Z. Foot ◽  
A. J. F. Russel
Keyword(s):  
Fatty Acid ◽  
Dry Matter ◽  
Experimental Period ◽  
The Other ◽  
Daily Group ◽  
Group Feeding ◽  
Principal Factors ◽  
Group A ◽  
Group B ◽  
High Level

SUMMARYIn the first experiment two groups of 11 Scottish Blackface ewes were given either 6·10 kg dried grass pellets plus 1·63 kg chopped dried grass daily (Group A) or 8·17 kg hay plus 1·32 kg oat pellets (Group B). During a 10-day experimental period individual dry-matter intakes ranged from 484 to 939 g/day (CV 22·3%) in Group A and from 613 to 883 g/day (CV 13·3%) in Group B. In Group B dry-matter intakes from oats were much more variable (10 to 149 g/day; CV 35·8%) than those from hay (530 to 762 g/day; CV 12·9%). Plasma protein-bound iodine (PBI) concentrations were significantly higher in the Group A sheep.In the second experiment the treatments were: group-penned, group-fed (GG); group-penned, individually fed (GI); and individually penned, individually fed (II). Within each treatment there were two groups of 12 ewes; one group was given a high level of feeding (H) and the other a low level (L) for a 7-week experimental period. Allowances of pelleted concentrates ranged from 7 to 15 g/kg in the L groups and from 18 to 26 g/kg in the H groups. The same mean quantities per kg were given to GG sheep, and food intakes ranged from 5·7 to 17·7 g/kg (CV 25·3%) in GGL and from 12·5 to 30·8 g/kg (CV 24·8%) in GGH. Plasma PBI concentrations were significantly higher in L sheep than in H sheep, and higher in GG than in II. Plasma non-esterified fatty acid concentrations were significantly higher in L sheep than in H sheep and higher in GG than in GI and II.The principal factors determining variations in food intakes between individual animals fed in groups and some of the nutritional implications of group-feeding sheep are discussed.

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