scholarly journals First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3042 ◽  
Author(s):  
Isabelle Monier ◽  
Amandine Baptiste ◽  
Vassilis Tsatsaris ◽  
Marie-Victoire Senat ◽  
Jacques Jani ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Skin Color ◽  
First Trimester ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
First Trimester Of Pregnancy ◽  
Maternal Vitamin D Status ◽  
Multicenter Prospective Cohort

Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97–2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02–8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.

High Fetal Fraction on First Trimester Cell-Free DNA Aneuploidy Screening and Adverse Pregnancy Outcomes

2019 ◽  
Vol 37 (01) ◽  
pp. 008-013 ◽  
Author(s):  
Lydia L. Shook ◽  
Mark A. Clapp ◽  
Penelope S. Roberts ◽  
Sarah N. Bernstein ◽  
Ilona T. Goldfarb
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
First Trimester ◽  
Hypertensive Disorders Of Pregnancy ◽  
Aneuploidy Screening ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Adverse Pregnancy ◽  
Fetal Fraction

Abstract Objective To test the hypothesis that high fetal fraction (FF) on first trimester cell-free deoxyribonucleic acid (cfDNA) aneuploidy screening is associated with adverse perinatal outcomes. Study Design This is a single-institution retrospective cohort study of women who underwent cfDNA screening at <14 weeks' gestation and delivered a singleton infant between July 2016 and June 2018. Women with abnormal results were excluded. Women with high FF (≥95th percentile) were compared with women with normal FF (5th–95th percentiles). Outcomes investigated were preterm birth, small for gestational age, and hypertensive disorders of pregnancy. Results A total of 2,033 women met inclusion criteria. The mean FF was 10.0%, and FF >16.5% was considered high (n = 102). Women with high FF had a greater chance of delivering a small for gestational age infant <fifth percentile, with an adjusted odds ratio of 2.4 (95% confidence interval: 1.1–4.8, p = 0.039). There was no significant association between high FF and either preterm birth or hypertensive disorders of pregnancy. Conclusion Women with a high FF in the first trimester are at increased risk of delivering a small for gestational age infant <fifth percentile. Further investigation into the clinical implications of a high FF is warranted.

Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices

2015 ◽  
Vol 29 (7) ◽  
pp. 1190-1194 ◽  
Author(s):  
Júlio Augusto Gurgel Alves ◽  
Sammya Bezerra Maia e Holanda Moura ◽  
Edward Araujo Júnior ◽  
Gabriele Tonni ◽  
Wellington P. Martins ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Ophthalmic Artery ◽  
First Trimester ◽  
First Trimester Of Pregnancy ◽  
Doppler Indices

scholarly journals Maternal Serum 25-Hydroxyvitamin D Concentrations Are Associated with Small-for-Gestational Age Births in White Women

2010 ◽  
Vol 140 (5) ◽  
pp. 999-1006 ◽  
Author(s):  
Lisa M. Bodnar ◽  
Janet M. Catov ◽  
Joseph M. Zmuda ◽  
Margaret E. Cooper ◽  
Meredith S. Parrott ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
White Women ◽  
Maternal Serum ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Alcohol consumption during pregnancy and perinatal results: a cohort study

2016 ◽  
Vol 134 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Mariana Sbrana ◽  
Carlos Grandi ◽  
Murilo Brazan ◽  
Natacha Junquera ◽  
Marina Stevaux Nascimento ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Preterm Birth ◽  
Alcohol Consumption ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Perinatal Outcomes ◽  
First Trimester ◽  
World Health

ABSTRACT CONTEXT AND OBJECTIVE: Alcohol consumption during pregnancy is a significant social problem that may be associated with adverse perinatal outcomes. The aim of this study was to describe alcohol consumption during pregnancy and to study its association with low birth weight, newborns small for gestational age and preterm birth. DESIGN AND SETTING: Nested cohort study, in the city of Ribeirão Preto, São Paulo, Brazil. METHODS: 1,370 women and their newborns were evaluated. A standardized questionnaire on health and lifestyle habits was applied to the mothers. Anthropometry was performed on the newborns. Alcohol consumption was defined as low, moderate or high, as defined by the World Health Organization. Adjusted logistic regression analysis was used. RESULTS: 23% of the women consumed alcohol during pregnancy. Consumption mainly occurred in the first trimester (14.8%) and decreased as the pregnancy progressed. The median alcohol intake was 3.89 g (interquartile range, IQR = 8 g) per day. In the unadjusted analysis, alcohol consumption increased the risk of low birth weight almost twofold (odds ratio, OR 1.91; 95% confidence interval, CI: 1.25-2.92). The risk was lower in the adjusted analysis (OR 1.62; 95% CI: 1.03-2.54). Alcohol consumption did not show associations with small for gestational age or preterm birth. There was greater risk of low birth weight and newborns small for gestational age and preterm birth among mothers who were both smokers and drinkers. CONCLUSIONS: The alcohol consumption rate during pregnancy was 23% and was independently associated with low birth weight, but there was no risk of newborns small for gestational age or preterm birth.

scholarly journals Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants

2012 ◽  
Vol 22 (8) ◽  
pp. 581-586 ◽  
Author(s):  
Heather H. Burris ◽  
Sheryl L. Rifas-Shiman ◽  
Carlos A. Camargo ◽  
Augusto A. Litonjua ◽  
Susanna Y. Huh ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Hydroxyvitamin D ◽  
Black And White ◽  
25 Hydroxyvitamin D

Decreased Bone Mineral Content in Small-for-Gestational-Age Infants Compared with Appropriate-for-Gestational-Age Infants: Normal Serum 25-Hydroxyvitamin D and Decreasing Parathyroid Hormone

PEDIATRICS ◽  
1983 ◽  
Vol 71 (3) ◽  
pp. 383-388
Author(s):  
Stephen D. Minton ◽  
Jean J. Steichen ◽  
Reginald C. Tsang
Keyword(s):  
Parathyroid Hormone ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Mineral Content ◽  
Normal Serum ◽  
Hydroxyvitamin D ◽  
Normal Limits ◽  
25 Hydroxyvitamin D

Bone mineral content was determined by photon absorptiometry, adapted for use in neonates, in 23 small-for-gestational-age (SGA) infants of 31 to 42 weeks of gestational age, for 12 weeks. At birth, term SGA infants had lower bone mineral content than term appropiate-for-gestational-age (AGA) infants; postnatal increase in bone mineral content was slow and lagged significantly behind that of term AGA infants. Preterm SGA infants had bone mineral content that was similar to that of preterm AGA infants at birth; postnatal bone mineral content was similar to that of preterm AGA infants, but was decreased compared with the expected intrauterine bone mineral content. Serum 25-hydroxyvitamin D concentrations and parathyroid hormone levels were the same for SGA and AGA infants. Serum 25-hydroxyvitamin D concentrations decreased slightly with postnatal age and remained within normal limits. Serum parathyroid hormone concentrations decreased in both SGA and AGA infants and reached undetectable levels at 10 to 12 weeks of age.

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