scholarly journals Threshold-Effect Association of Dietary Cholesterol Intake with Dyslipidemia in Chinese Adults: Results from the China Health and Nutrition Survey in 2015

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2885 ◽  
Author(s):  
Qiumin Huang ◽  
Hongru Jiang ◽  
Bing Zhang ◽  
Huijun Wang ◽  
Xiaofang Jia ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Dietary Cholesterol ◽  
Density Lipoprotein ◽  
Threshold Effect ◽  
Chinese Adults ◽  
Nutrition Survey ◽  
Chinese Adult ◽  
Health And Nutrition ◽  
Intake Level ◽  
Cholesterol Intake

The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 4383 participants aged 18–59 years who were free of diabetes, apoplexy, and myocardial infarction disease. Information was obtained on dietary intake, anthropometric measurements, and blood laboratory measurements. Dietary cholesterol intake was calculated based on the data collected by consecutive 3 days 24 h recalls combined with the weighing of household seasonings and categorized by 11 levels: The first 10 levels in ranges of 50 mg/day and the 11th level at ≥500 mg/day. Dyslipidemia, hypercholesterolemia, hypertriglyceridemia, low-density lipoprotein (LDL)-hypercholesterolemia, and high-density lipoprotein (HDL)-hypocholesterolemia were defined based on the Chinese adult dyslipidemia prevention guide (2016 edition). Multivariable logistic regressions were performed to examine the association of dietary cholesterol intake levels with dyslipidemia and subtypes. The prevalence of dyslipidemia was 37.5% among Chinese adults in 2015 (hypercholesterolemia 9.6%, HDL-hypocholesterolemia 21.1%, LDL-hypercholesterolemia 12.7%, and hypertriglyceridemia 15.2%). The lowest prevalence of hypercholesterolemia and LDL-hypercholesterolemia was 6.7% and 9.4%, respectively, which was relative to a dietary cholesterol intake level of 100.0 to <150.0 mg/day. After adjusting for all potential confounders, adults with the highest dietary cholesterol intake level of ≥500 mg/day compared with the dietary cholesterol intake of 100.0 to <150.0 mg/day showed one-time higher odds of hypercholesterolemia (odds ratios (OR) 2.0, 95% confidence intervals (CI) 1.3–3.3), as well as LDL-hypercholesterolemia (OR 2.0, 95% CI 1.3–3.0), but a null association of dietary cholesterol intake with dyslipidemia, hypertriglyceridemia, and HDL-hypocholesterolemia. The study suggested that a dietary cholesterol intake level of 500 mg/day and above may be a threshold point for high odds of hypercholesterolemia and LDL-hypercholesterolemia.

scholarly journals Association between Dietary Cholesterol and Their Food Sources and Risk for Hypercholesterolemia: The 2012–2016 Korea National Health and Nutrition Examination Survey

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 846 ◽  
Author(s):  
Dongjoo Cha ◽  
Yongsoon Park
Keyword(s):  
Low Density Lipoprotein ◽  
Dietary Cholesterol ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Food Sources ◽  
Direct Effects ◽  
Low Density Lipoprotein Cholesterol ◽  
Processed Meats ◽  
Health And Nutrition ◽  
Cholesterol Intake

It remains unclear whether cholesterol intake can increase serum cholesterol. Therefore, the present study aimed to investigate the hypothesis that the risk for hypercholesterolemia was not associated with intake of dietary cholesterol after adjusting for saturated fatty acid (SFA). Based on the data from the 2012–2016 KNHANES, dietary cholesterol was positively associated with the risk for abnormalities in total cholesterol (TC) (odds ratio (OR): 1.153, 95% confidence interval (CI): 0.995–1.337; p = 0.028) and low-density lipoprotein cholesterol (LDL-C) (OR: 1.186, 95% CI: 1.019–1.382; p = 0.018) levels before adjusting for SFA; after adjusting for SFA, no significant associations were found between these variables. The mediation analysis showed that dietary cholesterol had no direct effects on the serum levels of TC and LDL-C; in contrast, SFA had significant indirect effects on the association between dietary cholesterol and serum levels of TC and LDL-C. Furthermore, processed meats, but not eggs and other meats, were positively associated with the risk for abnormalities in both TC (OR: 1.220, 95% CI: 1.083–1.374; p = 0.001) and LDL-C (OR: 1.193, 95% CI: 1.052–1.354; p = 0.004) levels. The present study suggested that higher intake of processed meats with high SFA, but not dietary cholesterol was associated with higher risk for abnormalities in TC and LDL-C levels.

scholarly journals Association between High Waist-to-Height Ratio and Cardiovascular Risk among Adults Sampled by the 2016 Half-Way National Health and Nutrition Survey in Mexico (ENSANUT MC 2016)

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1402 ◽  
Author(s):  
Eduardo Rangel-Baltazar ◽  
Lucia Cuevas-Nasu ◽  
Teresa Shamah-Levy ◽  
Sonia Rodríguez-Ramírez ◽  
Ignacio Méndez-Gómez-Humarán ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
National Health ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Height Ratio ◽  
Nutrition Survey ◽  
Health And Nutrition ◽  
Mexican Adults ◽  
Waist To Height Ratio

Little evidence exists regarding the association between waist-to-height ratio (WHtR) and cardiovascular risk (CVR) factors in Mexican adults. Our study pursued a twofold objective: To describe the association between a high WHtR and CVR indicators among Mexican adults canvassed by the 2016 Half-Way National Health and Nutrition Survey, and to examine the interaction of sex and age on this association. We analyzed data from the adult sample (≥20 years old) and classified in two groups using WHtRs ≥0.5 considered high and low otherwise. The following CVR factors were analyzed: High-total-cholesterol (≥200 mg/dL), low high-density-lipoprotein-cholesterol (HDL-c < 40 mg/dL), high low-density-lipoprotein-cholesterol (LDL-c ≥ 130 mg/dL), high triglycerides (≥150 mg/dL), insulin resistance (IR) (HOMA-IR) (≥2.6), and hypertension (HBP) (≥140/≥90 mmHg). We estimated prevalence ratios (PR) to analyze the association between high WHtRs and CVR indicators. Over 90% of participants had high WHtRs and were at greater risk for dyslipidemias, HBP, and IR compared to those that had low WHtRs. PR for men with high WHtRs were between 1.3 to 2.3 for dyslipidemias, 3.4 for HBP and 7.6 for IR; among women were between 1.8 to 2.4 for dyslipidemias and HBP and 5.9 for IR (p < 0.05). A high WHtR is associated with CVR factors in Mexican adults.

scholarly journals Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e024731 ◽  
Author(s):  
Ji Hyung Nam ◽  
Jaeyong Shin ◽  
Sung-In Jang ◽  
Ji Hyun Kim ◽  
Kyu-Tae Han ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Correlation Coefficients ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Nutrition Survey ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Unit Increase

ObjectivesDyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers.DesignA cross-sectional study.SettingThe data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015.Participants2884 adolescents aged 12–18 years and their mothers were included.Primary outcome measuresOutcome variables were adolescents’ lipid levels. Mothers’ lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents’ lipid levels for each unit increase of their mothers’ lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers.ResultsThe mean levels of adolescents’ lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r,95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother’s TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother’s characteristics.ConclusionsMothers’ lipid levels are associated with adolescents’ lipids; therefore, they can serve as a reference for the screening of adolescent’s dyslipidaemia.

Absorption and metabolism of cholesterol in familial hypercholesterolemia

1989 ◽  
Vol 76 (3) ◽  
pp. 297-301 ◽  
Author(s):  
Helena Gylling ◽  
Tatu A. Miettinen
Keyword(s):  
Cholesterol Synthesis ◽  
Familial Hypercholesterolaemia ◽  
Cholesterol Metabolism ◽  
Low Density Lipoprotein ◽  
Dietary Cholesterol ◽  
Density Lipoprotein ◽  
Cholesterol Absorption ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Cholesterol Intake

1. The present study investigated the role of intestinal cholesterol absorption in the regulation of cholesterol metabolism and serum lipoprotein levels in 22 patients with heterozygous familial hypercholesterolaemia on low to normal cholesterol intake. 2. The results showed that the higher the dietary cholesterol absorption, the lower was the overall synthesis of cholesterol. Efficient cholesterol absorption actually reduced the elimination of cholesterol as faecal neutral sterols but not consistently as bile acids. 3. In multifactorial analysis, body mass index and dietary plant sterols were negatively associated with cholesterol absorption, but were unrelated to cholesterol synthesis. 4. Fractional cholesterol absorption was related only to the serum very-low-density triacylglycerol level. It was not associated with the total or low-density lipoprotein cholesterol levels. On the other hand, cholesterol synthesis was significantly associated with the serum concentrations of very-low-density lipoprotein and intermediate-density lipoprotein cholesterol and triacylglycerols, and with those of low-density lipoprotein triacylglycerols. 5. In conclusion, dietary cholesterol absorption is an essential regulator of cholesterol homoeostasis in familial hypercholesterolaemia, even in patients on low cholesterol intake.

scholarly journals Are Dietary Cholesterol Intake and Serum Cholesterol Levels Related to Nonalcoholic Fatty Liver Disease in Obese Children?

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Dimitrios Papandreou ◽  
Zaharoula Karabouta ◽  
Israel Rousso
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Low Density Lipoprotein ◽  
Dietary Cholesterol ◽  
Density Lipoprotein ◽  
Obese Children ◽  
Nonalcoholic Fatty Liver ◽  
Cholesterol Intake

Background. Nonalcoholic fatty liver disease (NAFLD) in children has been recognized as a major health burden. Serum lipids as well as dietary cholesterol (DC) intake may positively relate to development of NAFLD. The purpose of this study was to investigate anthropometric, biochemical, and dietary intake parameters of obese Greek children with and without NAFLD. Materials and Methods. Eighty-five obese children aged 8–15 (45 boys/40 girls) participated in the study. NAFLD was diagnosed by ultrasonography (US) in all subjects. Liver indexes were measured in all children. A 3-day dietary was recorded for all subjects. Results. 38 out of 85 children (44.7%) were found to have fatty liver. Obese children with increased levels of TC (95% CI: 1.721–3.191), low density lipoprotein (LDL) (95% CI: 1.829–3.058), and increased dietary cholesterol intakes (95% CI: 1.511–2.719) were 2.541, 2.612, and 2.041 times more likely to develop NAFLD compared with the children without NAFLD. Conclusion. The present study showed that TC, LDL, and DC were the strongest risk factors of development of NAFLD. Reducing body weight and dietary cholesterol intakes as well as decreasing serum TC and LDL levels are urgently necessary in order to prevent NAFLD and possible other health implications later in life.

scholarly journals Evaluation of dietary cholesterol intake in elderly Chinese: a longitudinal study from the China Health and Nutrition Survey

BMJ Open ◽  
2016 ◽  
Vol 6 (8) ◽  
pp. e011074 ◽  
Author(s):  
Xiaofang Jia ◽  
Chang Su ◽  
Zhihong Wang ◽  
Huijun Wang ◽  
Hongru Jiang ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Dietary Cholesterol ◽  
Nutrition Survey ◽  
Health And Nutrition ◽  
Elderly Chinese ◽  
Cholesterol Intake

scholarly journals Gender differences in the relationships between housework and metabolic markers: a longitudinal cohort study in China

2020 ◽  
Author(s):  
Xiao-qin Wang ◽  
Xiao-han Ren ◽  
Wen-jing Kou ◽  
Yang Li ◽  
Zhao-zhao Hui ◽  
...  
Keyword(s):  
Gender Differences ◽  
Metabolic Diseases ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Binary Logistic Regression ◽  
Nutrition Survey ◽  
Metabolic Markers ◽  
Major Health ◽  
Health And Nutrition ◽  
Using Data

Abstract Background: Metabolic syndrome has become a major health threat of the world, there are few studies focused on the effects of housework on human metabolism. The aims of this study were to explore the associations between housework and metabolic markers, and to examine whether there are gender differences in the relationships of housework intensity on metabolic markers.Methods: Using data of 2,624 participants were obtained from the China Health and Nutrition Survey. Binary logistic regression was used to analyze the associations between housework and metabolic markers (triglyceride, high- and low-density lipoprotein cholesterol, hemoglobin, blood glucose, cholesterol and blood pressure), with adjusting for the covariates.Results: No associations were observed between housework and metabolic markers for men. Women who engaged housework had a higher risk of triglycerides than non-housework (OR=1.16, 95%CI:1.16-4.25). Compared with the low-intensity, women with moderate- and high-intensity had a higher risk of triglycerides (OR=1.78, 95%CI:1.14-2.78; OR=1.91, 95%CI: 1.22-2.98), MetS (OR=1.54, 95%CI: 0.98-2.43; OR=1.68, 95%CI: 1.07-2.66), pre-hypertension (OR=1.68, 95%CI: 1.08-2.62; OR=1.63, 95%CI: 1.04-2.55) and overweight (OR=1.65, 95%CI: 1.01-2.70; OR=1.66, 95%CI: 1.01-2.72).Conclusion: Housework was associated with high levels of women’s metabolic markers such as triglycerides, MetS and pre-hypertension, and there were gender differences between the associations of housework intensity and metabolism markers. This may be a mechanism through which housework was associated with metabolic diseases.

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