scholarly journals Natural Choline from Egg Yolk Phospholipids Is More Efficiently Absorbed Compared with Choline Bitartrate; Outcomes of A Randomized Trial in Healthy Adults

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2758 ◽  
Author(s):  
Lotte Smolders ◽  
Nicole J.W. de Wit ◽  
Michiel G.J. Balvers ◽  
Rima Obeid ◽  
Marc M.M. Vissers ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Food Industry ◽  
Functional Foods ◽  
Area Under The Curve ◽  
Egg Yolk ◽  
Choline Uptake ◽  
Double Blind ◽  
Natural Form ◽  
Choline Bitartrate ◽  
Essential Nutrient

Choline is a vitamin-like essential nutrient, important throughout one’s lifespan. Therefore, choline salts are added to infant formula, supplements and functional foods. However, if choline is present in a natural form, e.g. bound to phospholipids, it may be more efficiently absorbed. The study’s aim was to evaluate if choline uptake is improved after consumption of an egg yolk phospholipid drink, containing 3 g of phospholipid bound choline, compared to a control drink with 3 g of choline bitartrate. We performed a randomized, double blind, cross-over trial with 18 participants. Plasma choline, betaine and dimethylglycine concentrations were determined before and up to six hours after consumption of the drinks. The plasma choline response, as determined by the incremental area under the curve, was four times higher after consumption of the egg yolk phospholipid drink compared with the control drink (p < 0.01). Similar outcomes were also observed for choline’s main metabolites, betaine (p < 0.01) and dimethylglycine (p = 0.01). Consumption of natural choline from egg yolk phospholipids improved choline absorption compared to consumption of chemically produced choline bitartrate. This information is of relevance for the food industry, instead of adding choline-salts, adding choline from egg yolk phospholipids can improve choline uptake and positively impact health.

scholarly journals 322 – Prevention of Recurrent Idiopathic Gastroduodenal Ulcer Bleeding: A 2-Year Double-Blind Randomized Trial (NRT STUDY)

2019 ◽  
Vol 156 (6) ◽  
pp. S-62-S-63
Author(s):  
Louis Ho Shing Lau ◽  
Jessica Y. Ching ◽  
Yee Kit Tse ◽  
Rachel Ling ◽  
Francis K. Chan ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Gastroduodenal Ulcer ◽  
Ulcer Bleeding ◽  
Double Blind ◽  
Gastroduodenal Ulcer Bleeding

scholarly journals Single Ingestion of Trehalose Enhances Prolonged Exercise Performance by Effective Use of Glucose and Lipid in Healthy Men

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1439
Author(s):  
Naomi Hamada ◽  
Tsuyoshi Wadazumi ◽  
Yoko Hirata ◽  
Mayumi Kuriyama ◽  
Kanji Watanabe ◽  
...  
Keyword(s):  
Exercise Performance ◽  
Prolonged Exercise ◽  
Insulin Response ◽  
Area Under The Curve ◽  
Constant Load ◽  
Bicycle Ergometer ◽  
The Body ◽  
Water Control ◽  
Double Blind ◽  
Healthy Men

Trehalose increases blood glucose levels slowly and induces a slight insulin response. The present study aimed to study the effect of trehalose on prolonged exercise performance. The participants were 12 healthy men (age: 21.3 ± 0.9 y). After an overnight fast (12 h), they first exercised with a constant load (intensity: 40% V˙O2peak) for 60 min using a bicycle ergometer. They continued to exercise with a constant load (40% V˙O2peak) for 30 min between four sets of the 30-s Wingate test. After the 1st set, each participant ingested 500 mL water (control), 8% glucose, or 8% trehalose in three trials. These three trials were at least one week apart and were conducted in a double-blind and randomized crossover manner. Blood was collected for seven biochemical parameters at 12 time points during the experiment. The area under the curve of adrenaline after ingestion of trehalose was significantly lower than that for water and tended to be lower than that for glucose in the later stage of the exercise. Lower secretion of adrenaline after a single dose of 8% trehalose during prolonged exercise reflected the preservation of carbohydrates in the body in the later stage of the exercise. In conclusion, a single ingestion of trehalose helped to maintain prolonged exercise performance.

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