scholarly journals Human Milk Oligosaccharide, Phospholipid, and Ganglioside Concentrations in Breast Milk from United Arab Emirates Mothers: Results from the MISC Cohort

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2400 ◽  
Author(s):  
Paul McJarrow ◽  
Hadia Radwan ◽  
Lin Ma ◽  
Alastair K.H. MacGibbon ◽  
Mona Hashim ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
United Arab Emirates ◽  
High Performance ◽  
Post Partum ◽  
Human Breast Milk ◽  
Mature Milk ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Individual

Human milk oligosaccharides (HMOs), phospholipids (PLs), and gangliosides (GAs) are components of human breast milk that play important roles in the development of the rapidly growing infant. The differences in these components in human milk from the United Arab Emirates (UAE) were studied in a cross-sectional trial. High-performance liquid chromatography‒mass spectrometry was used to determine HMO, PL, and GA concentrations in transitional (5–15 days) and mature (at 6 months post-partum) breast milk of mothers of the United Arab Emirates (UAE). The results showed that the average HMO (12 species), PL (7 species), and GA (2 species) concentrations quantified in the UAE mothers’ transitional milk samples were (in mg/L) 8204 ± 2389, 269 ± 89, and 21.18 ± 11.46, respectively, while in mature milk, the respective concentrations were (in mg/L) 3905 ± 1466, 220 ± 85, and 20.18 ± 9.75. The individual HMO concentrations measured in this study were all significantly higher in transitional milk than in mature milk, except for 3 fucosyllactose, which was higher in mature milk. In this study, secretor and non-secretor phenotype mothers showed no significant difference in the total HMO concentration. For the PL and GA components, changes in the individual PL and GA species distribution was observed between transitional milk and mature milk. However, the changes were within the ranges found in human milk from other regions.

Gestational Hypertension and Their Impact on Activin A Concentration of the Human Milk

2021 ◽  
Author(s):  
Chiara Peila ◽  
Elena Spada ◽  
Alessandra Coscia ◽  
Stefano Sottemano ◽  
Giulia Fregnan ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Fixed Effects ◽  
Gestational Hypertension ◽  
Random Effect ◽  
Covariance Structure ◽  
Study Groups ◽  
Activin A ◽  
Mature Milk ◽  
Significant Difference

Abstract Introduction It is known that Preeclampsia affects the lactogenesis, but literature data on the effects of this syndrome on the neurobiomarkers composition and Activin A of Human Milk of the lactating mother are not available. The aim of this study is to investigate the effects of this gestational pathology on Activin A levels, a neurobiomarker known to play an important role in the development and protection of the central nervous system.Methods The women recruited in the study were divided in two different study groups: preeclamptic or healthy women. All the breast milk samples were collected using the same procedure into sterile devices BPA-free. Activin A was quantified using an ELISA test. To investigate the effect of pathology in the Activin a concentration in the 3 phases, mixed linear model with unistructural covariance structure, mother as random effect, and fixed effects were performed.Results Activin A was detected in all samples. There were no significant differences between Preeclamptic mother and Normotensive women. The only significant effect is related to the HM phase: in particular, it is significant the difference between colostrum and mature milk (p<0.01).Conclusion There is not any significant difference in Activin A breast milk composition from hypertensive and normotensive women. This result allows us to affirm that breast milk beneficial properties are maintained even if gestational hypertension occurs.

scholarly journals Lutein concentration in human milk during early lactation and its relationship with dietary lutein intake

2009 ◽  
Vol 12 (10) ◽  
pp. 1878-1884 ◽  
Author(s):  
Hellas Cena ◽  
Anna Maria Castellazzi ◽  
Amedeo Pietri ◽  
Carla Roggi ◽  
Giovanna Turconi
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Maternal Plasma ◽  
Cross Sectional Study ◽  
Early Lactation ◽  
Dietary Recommendations ◽  
Mature Milk ◽  
Cross Sectional ◽  
Pregnancy And Lactation ◽  
Age Range

AbstractObjectiveThe present study aimed to estimate the lutein concentration in human milk during early lactation and its relationship with dietary lutein intake measured through the administration of a short FFQ.DesignA cross-sectional study in which an FFQ was administered twice: on day 3 (T0) and day 30 (T1) postpartum; meanwhile two breast milk samples were collected. Maternal plasma samples were obtained at T0. The comparison of dietary lutein intakes and likewise lutein concentrations in breast milk at T0 and T1 were analysed with Student’sttest. Pearson’s correlation coefficient was used to determine the association between dietary lutein intake and lutein concentration in milk and plasma, respectively, as well as the correlation between breast milk and plasma lutein concentrations at T0.SettingPavia, northern Italy.SubjectsTwenty-one pregnant women, age range 24–42 years, were recruited during their last trimester on a voluntary basis.ResultsBoth breast milk and plasma lutein concentrations were significantly correlated with dietary lutein intake (r= 0·86,P= 0·0001 andr= 0·94,P= 0·0001, respectively). There was a clear significant correlation between milk and plasma lutein concentrations (r= 0·87,P= 0·0001). Mature milk lutein concentration, although significantly reduced at T1 (P< 0·01), maintained a fairly high correlation with dietary lutein intake (r= 0·82,P= 0·0001).ConclusionsEven though milk lutein concentration decreased during early lactation, it remained significantly correlated with daily lutein intake. Therefore, while awaiting further research, dietary recommendations advising intake of fresh fruit and vegetables rich in lutein, throughout the whole duration of pregnancy and lactation, are extremely useful.

scholarly journals Association of DHA Concentration in Human Breast Milk with Maternal Diet and Use of Supplements: A Cross-Sectional Analysis of Data from the Japanese Human Milk Study Cohort

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Hiroshi M Ueno ◽  
Satoshi Higurashi ◽  
Yuzuka Shimomura ◽  
Ryota Wakui ◽  
Hiroaki Matsuura ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Maternal Diet ◽  
Sociodemographic Factors ◽  
Dietary Habit ◽  
Study Cohort ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cross Sectional ◽  
Infant Birth

ABSTRACT Background DHA (22:6n–3) is essential for neurodevelopment in children, and its concentration in human breast milk is historically high in Japan. Dietary patterns in Japan might affect the fatty acid (FA) composition among lactating mothers. Objectives This study aimed to characterize the composition of milk FAs and to identify any dietary and sociodemographic factors associated with the variability of DHA concentration in breast milk in the Japanese population. Methods This cross-sectional study was performed as part of the Japanese Human Milk Study. Milk FAs were analyzed by GC at 1–6 mo postpartum, and maternal diet was estimated using an FFQ, including 11 types and cooking methods of seafoods, and the use of DHA supplements. The association of milk DHA with maternal diet and sociodemographic factors was investigated. Results Milk FA concentrations were measured in 78 mothers, including 24 who routinely used DHA supplements. The DHA concentration in milk (overall median: 0.62%; IQR: 0.47%–0.78%) was higher in women who took DHA supplements than in women who had never used DHA supplements (0.74%compared with 0.55%; P = 0.011). A linear regression model showed the association of milk DHA concentration with maternal dietary intake of grilled fish (β ± SE: 0.006 ± 0.003; standardized β: 0.234; r2 = 0.232, P = 0.036) after adjustment for DHA supplementation status, maternal and infant age, maternal BMI, and infant birth weight. Other FA concentrations were consistent, whereas caproic acid (6:0), undecylic acid (11:0), pentadecylic acid (15:0), palmitoleic acid (16:1n–7), and vaccenic acid (18:1n–7) varied by DHA supplementation status. Conclusions The DHA concentration in human milk may be influenced by maternal grilled fish consumption and frequent DHA supplementation in lactating Japanese women. Milk DHA concentrations may reflect a dietary habit in Japanese mothers. This trial was registered at www.umin.ac.jp/ctr as UMIN000015494.

scholarly journals LACTOFERRIN LEVELS IN MOTHER’S MILK

2012 ◽  
Vol 19 (04) ◽  
pp. 527-530
Author(s):  
SYED QAISER HUSAIN NAQVI ◽  
MOHAMMAD SHIRAZ KHAN ◽  
ALI AKBAR SIYAL ◽  
Mir Muhammad Sehto ◽  
Riaz Ahmed Qazi ◽  
...  
Keyword(s):  
Breast Milk ◽  
Cross Sectional Study ◽  
Human Breast Milk ◽  
Sectional Study ◽  
Human Breast ◽  
Mature Milk ◽  
Cross Sectional ◽  
Lactating Mothers ◽  
Mother's Milk ◽  
The Mean

Objective: This study was aimed to see the significance of Lactoferrin in human breast milk among lactating mothers of healthyand sick babies. Place and duration: This study was conducted at pathology and paediatrics departments of Peoples University of Medical andHealth Sciences Nawabshah, Shaheed Benazirabad between Jan 2011 to Dec 2011. Design: Cross sectional study. Method: Lactoferrinlevels in breast milk of 356 mothers of healthy babies were estimated and similarly lactoferrin levels in breast milk of 318 lactating mothers ofsick babies were estimated & these results were analyzed. Results: the mean lactoferrin level in breast milk of 356 lactating mothers of healthybabies was 9.37 mg/ml and the mean lactoferrin level in breast milk of 318 mothers nursing sick babies was 3.73mg/ml. Conclusions: There isdecrease in lactoferrin levels of lactating mothers of sick babies in their mature milk, which could account for the susceptibility of their babies toinfection.

scholarly journals Polyamines in human breast milk for preterm and term infants

2013 ◽  
Vol 110 (3) ◽  
pp. 524-528 ◽  
Author(s):  
J. Plaza-Zamora ◽  
M. Sabater-Molina ◽  
M. Rodríguez-Palmero ◽  
M. Rivero ◽  
V. Bosch ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Human Breast Milk ◽  
Gut Development ◽  
Human Breast ◽  
Mature Milk ◽  
Term Infants ◽  
Milk Samples ◽  
Preterm Babies ◽  
Transition Milk

Maternal milk is the first source of exogenous polyamines for the newborn. Polyamines modulate gut maturation in neonates, but no studies are available on polyamine concentration in human milk of preterm babies, even though they could be important for their immature gut. The present study aimed to determine polyamine concentration in human breast milk of mothers with preterm or term infants during the first month of lactation. Human milk samples were obtained during the first month of lactation from twenty-seven mothers with preterm babies and twelve mothers with babies born at term. The polyamine concentration in human milk was quantified by HPLC. During the first month of lactation, the total polyamine concentration was significantly higher in preterm milk than in term milk samples (7590 (sd 4990) v. 4660 (sd 4830) nmol/l, respectively (P =0·034)), as well as individual polyamine concentrations. Polyamine concentration in mature milk for preterm babies was significantly higher than that in mature milk for babies at term, and a similar trend was observed in colostrum and transition human milk. The spermidine/spermine ratio was higher in transition milk in preterm v. term samples, while in mature milk, the ratio was significantly lower in preterm than in term babies. In conclusion, the polyamine concentration was significantly higher in human milk for preterm than for term infants. This and the different spermidine/spermine ratios could influence the gut development of premature babies.

scholarly journals What Are the Maternal Factors That Potentially Intervenes in the Nutritional Composition of Human Milk?

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1587
Author(s):  
Yasmin Amaral ◽  
Leila Silva ◽  
Fernanda Soares ◽  
Daniele Marano ◽  
Sylvia Nehab ◽  
...  
Keyword(s):  
Weight Gain ◽  
Nutritional Status ◽  
Human Milk ◽  
Gestational Weight Gain ◽  
Post Partum ◽  
Cross Sectional Study ◽  
Nutritional Composition ◽  
Cross Sectional ◽  
Factors Associated ◽  
Gestational Weight

Background: To evaluate the potential factors associated with the nutritional composition of human milk of puerperal women. Methods: cross-sectional study, conducted between March 2016 and August 2017, with 107 women, selected in a Tertiary Health Care Tertiary Health Facility of the Unified Health System (SUS) in the Municipality of Rio de Janeiro. Data were collected two months after delivery. The dependent variable of the study was the nutritional composition of human milk. We divided the independent variables into hierarchical levels: distal (age, schooling, parity and pregestational nutritional status), intermediate (number of prenatal visits and gestational weight gain) and proximal (alcohol consumption, smoking, diabetes mellitus and hypertension). For data analysis, we applied the multiple linear regression, centered on the hierarchical model. Only the variables associated with the nutritional composition of breast milk remained in the final model at a 5% level of significance. Results: The nutritional composition of human milk yielded by women with pregestational overweight, smokers and hypertensive had higher amounts of lipids and energy. Conversely, women with gestational weight gain below the recommended had lower amounts of these components. Conclusion: The evaluation of factors associated with the nutritional composition of human milk is extremely important to assist post-partum care practices. In this study, we observed that lipid and energy contents were associated to pregestational nutritional status, gestational weight gain, smoking and hypertension.

Safety climate and related factors in rehabilitation nurses of hospitals in Iran

Work ◽  
2021 ◽  
pp. 1-8
Author(s):  
Javad vatani ◽  
Zahra Khanikosarkhizi ◽  
Mohammad Ali Shahabi Rabori ◽  
mohammad khandan ◽  
Mohsen aminizadeh ◽  
...  
Keyword(s):  
Safety Climate ◽  
Cross Sectional Study ◽  
P Value ◽  
Related Factors ◽  
Cross Sectional ◽  
Climate Assessment ◽  
Safety Work ◽  
Significant Difference ◽  
Training Courses ◽  
The Individual

BACKGROUND: Safety climate is a common insight of staff that indicates individuals’ attitudes toward safety and priority of safety at work. OBJECTIVES: Nursing is a risky job where paying attention to safety is crucial. The assessment of the safety climate is one of the methods to measure the safety conditions in this occupation. The aim of this study was to assess the safety climate of rehabilitation nurses working in hospitals in Tehran. METHODS: This is a cross-sectional study which was carried out on 140 rehabilitation nurses selected from all hospitals and clinics in Tehran in 2019. To collect the required data, a two-section questionnaire was used. The first section was related to demographic factors and the second part (22 statements) was to measure the safety climate using nurses’ safety climate assessment questionnaire. The collected data were analyzed by SPSS V16 using independent t-test, ANOVA, Kruskal-Wallis and Mann-Whitney U test at the 5% level. RESULTS: Findings showed that the total mean of safety climate was 3.06±0.56. According to the results, a significant difference was found between the positive and negative satisfaction of nurses with safety climates (P-value = 0.03), communication with nurses (P-value = 0.01) and supervisors’ attitude (P-value = 0.02). Furthermore, a significant difference in safety climate between the individual with the second job and the individual without second could be observed (P-value = 0.01). CONCLUSIONS: The results indicated that the safety climate was not at an acceptable level. Thus, it is essential to introduce safety training courses (e.g. safety, work-rest balance, and so on) and to improve the safety performance at work.

scholarly journals Levels of Polychlorinated Dibenzo-p-Dioxins/Furans (PCDD/Fs) and Dioxin-Like Polychlorinated Biphenyls (DL-PCBs) in Human Breast Milk in Chile: A Pilot Study

2021 ◽  
Vol 18 (9) ◽  
pp. 4825
Author(s):  
Claudia Foerster ◽  
Liliana Zúñiga-Venegas ◽  
Pedro Enríquez ◽  
Jacqueline Rojas ◽  
Claudia Zamora ◽  
...  
Keyword(s):  
High Resolution ◽  
Breast Milk ◽  
Polychlorinated Biphenyls ◽  
High Resolution Mass Spectrometry ◽  
Daily Intake ◽  
Human Breast Milk ◽  
International Studies ◽  
Cross Sectional ◽  
Pooled Samples ◽  
Chilean Women

Persistent organic pollutants (POPs) are organic compounds that resist biochemical degradation, moving long distances across the atmosphere before deposition occurs. Our goal was to provide up-to-date data on the levels of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in breast milk from Chilean women and to estimate the exposure of infants due to breast milk consumption. In Chile, we conducted a cross-sectional study based on methodologies proposed by the WHO, with a sample of 30 women recruited from three defined areas: 10 from the Arica Region (urban; Arica and Parinacota Region), 10 from Coltauco (rural; O’Higgins Region), and 10 from Molina (40% rural; Maule Region). High-resolution gas chromatography coupled with high-resolution mass spectrometry (HRGC/HRMS) was performed on pooled samples from each area. We calculated equivalent toxic concentrations (WHO-TEQ) based on the current WHO Toxic Equivalency Factors (TEF). The minimum and maximum values of ∑ PCDDs/Fs + DL-PCBs-TEQ were 4.317 pg TEQ/g fat in Coltauco and 6.31 pg TEQ/g fat in Arica. Molina had a total TEQ of 5.50 pg TEQ/g fat. The contribution of PCDD/Fs was approximately five-fold higher than that of DL-PCBs. The Estimated Daily Intake (EDI) of ∑ PCDDs/Fs + DL-PCBs based on the three pooled samples ranged between 6.71 and 26.28 pg TEQ/kg body weight (bw)/day, with a mean intake of 16.11 (±6.71) pg TEQ/kg bw/day in breastfed children from 0 to 24 months old. These levels were lower than those reported in international studies. Despite the fact that the observed levels were low compared to those in most industrialized countries, the detection of a variety of POPs in breast milk from Chilean women indicates the need for follow-up studies to determine whether such exposures during childhood could represent a health risk in adulthood.

Human Breast Milk Contains Bovine lgG. Relationship to Infant Colic?

PEDIATRICS ◽  
1991 ◽  
Vol 87 (4) ◽  
pp. 439-444
Author(s):  
Patrick S. Clyne ◽  
Anthony Kulczycki
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cow's Milk ◽  
Milk Samples ◽  
Infant Colic ◽  
Β Lactoglobulin

Previous studies have suggested that an unidentified cow's milk protein, other than β-lactoglobulin and casein, might play a pathogenetic role in infant colic. Therefore, a radioimmunoassay was used to analyze human breast milk and infant formula samples for the presence of bovine IgG. Milk samples from 88 of the 97 mothers tested contained greater than 0.1 µg/mL of bovine IgG. In a study group of 59 mothers with infants in the colic-prone 2- to 17-week age group, the 29 mothers of colicky infants had higher levels of bovine IgG in their breast milk (median 0.42 µg/mL) than the 30 mothers of noncolicky infants (median 0.32 µg/mL) (P &lt; .02). The highest concentrations of bovine IgG observed in human milk were 8.5 and 8.2 µg/mL. Most cow's milk-based infant formulas contained 0.6 to 6.4 µg/mL of bovine IgG, a concentration comparable with levels found in many human milk samples. The results suggest that appreciable quantities of bovine IgG are commonly present in human milk, that significantly higher levels are present in milk from mothers of colicky infants, and that bovine IgG may possibly be involved in the pathogenesis of infant colic.

scholarly journals Hubungan Pemberian Anestesi Regional Dengan Kelancaran ASI Pada Ibu Post Partum Sectio Caesarea Di Rumah Sakit Muhammadiyah Gresik

2020 ◽  
Vol 7 (2) ◽  
pp. 42
Author(s):  
Vina Rahmatika ◽  
Musa Ghufron ◽  
Nenny Triastuti ◽  
Syaiful Rochman
Keyword(s):  
Breast Milk ◽  
Caesarean Section ◽  
Post Partum ◽  
Secondary Data ◽  
Sampling Technique ◽  
Primary Data ◽  
Sectio Caesarea ◽  
P Value ◽  
Cross Sectional ◽  
Anesthetic Drugs

Background: The birth rate by caesarean section method is getting higher. Risk data for 2013 shows the method of birth with the operation method of 9.8 percent of the total 49,603 births during 2010 to 2013. Being in practice the mother must be given anesthetic before the surgery begins. This anesthesia will later affect the pain that will occur after SC. Purpose: The purpose of this study was to determine the correlation between regional anesthetic drugs and the smoothness of breast milk in women born in sectio caesarea at Muhammadiyah Gresik Hospital. Method: Method with Cross Sectional approach. The population in this study mothers who gave birth in a caesarean section at Muhammadiyah Hospital Gresik in December 2019 to January 2020. The sampling technique in this study is probability / random simple sampling. The sample in this study was a portion of mothers who gave birth in a caesarean section at Muhammadiyah Gresik Hospital. The instrument used was primary data collection in the form of questionnaires and secondary data in the form of patient medical records. Result: The data obtained in this study were processed using spearman correlation statistics. From the statistical test the Correlation coefficient value was 0.807, and obtained P-Value equal to 0,000 this value is less than 0.05. Conclusion: The conclusion of this study is that there is a correlation between the administration of a regional anesthetics and the smoothness of breast milk in mothers of post partum caesarea at Muhammadiyah Gresik Hospital.

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