scholarly journals Uric Acid and Plant-Based Nutrition

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1736 ◽  
Author(s):  
Jakše ◽  
Jakše ◽  
Pajek ◽  
Pajek
Keyword(s):  
Uric Acid ◽  
Additional Data ◽  
Great Majority ◽  
Food Sources ◽  
Limited Data ◽  
Acid Generation ◽  
Purine Content ◽  
Brassica Vegetables ◽  
Short And Long Term

Plant-based diets (PBDs) are associated with decreased risk of morbidity and mortality associated with important noncommunicable chronic diseases. Similar to animal-based food sources (e.g., meat, fish, and animal visceral organs), some plant-based food sources (e.g., certain soy legume products, sea vegetables, and brassica vegetables) also contain a high purine load. Suboptimally designed PBDs might consequently be associated with increased uric acid levels and gout development. Here, we review the available data on this topic, with a great majority of studies showing reduced risk of hyperuricemia and gout with vegetarian (especially lacto-vegetarian) PBDs. Additionally, type of ingested purines, fiber, vitamin C, and certain lifestyle factors work in concordance to reduce uric acid generation in PBDs. Recent limited data show that even with an exclusive PBD, uric acid concentrations remain in the normal range in short- and long-term dieters. The reasonable consumption of plant foods with a higher purine content as a part of PBDs may therefore be safely tolerated in normouricemic individuals, but additional data is needed in hyperuricemic individuals, especially those with chronic kidney disease.

scholarly journals Tourism Demand Forecasting: A Decomposed Deep Learning Approach

2020 ◽  
pp. 004728752091952 ◽  
Author(s):  
Yishuo Zhang ◽  
Gang Li ◽  
Birgit Muskat ◽  
Rob Law
Keyword(s):  
Deep Learning ◽  
Additional Data ◽  
Explanatory Variable ◽  
Demand Forecasting ◽  
Tourism Demand ◽  
Limited Data ◽  
Methodological Issues ◽  
Demand Modeling ◽  
Short And Long Term

Tourism planners rely on accurate demand forecasting. However, despite numerous advancements, crucial methodological issues remain unaddressed. This study aims to further improve the modeling accuracy and advance the artificial intelligence (AI)-based tourism demand forecasting methods. Deep learning models that predict tourism demand are often highly complex and encounter overfitting, which is mainly caused by two underlying problems: (1) access to limited data volumes and (2) additional explanatory variable requirement. To address these issues, we use a decomposition method that achieves high accuracy in short- and long-term AI-based forecasting models. The proposed method effectively decomposes the data and increases accuracy without additional data requirement. In conclusion, this study alleviates the overfitting issue and provides a methodological contribution by proposing a highly accurate deep learning method for AI-based tourism demand modeling.

scholarly journals COVID-19 Infection during Pregnancy: Risk of Vertical Transmission, Fetal, and Neonatal Outcomes

2021 ◽  
Vol 11 (6) ◽  
pp. 483
Author(s):  
Marwa Saadaoui ◽  
Manoj Kumar ◽  
Souhaila Al Khodor
Keyword(s):  
Pregnant Women ◽  
Vertical Transmission ◽  
Current Knowledge ◽  
Limited Data ◽  
Pregnancy Risk ◽  
Public Health Challenge ◽  
Short And Long Term ◽  
Critical Public Health ◽  
The Impact

The COVID-19 pandemic is a worldwide, critical public health challenge and is considered one of the most communicable diseases that the world had faced so far. Response and symptoms associated with COVID-19 vary between the different cases recorded, but it is amply described that symptoms become more aggressive in subjects with a weaker immune system. This includes older subjects, patients with chronic diseases, patients with immunosuppression treatment, and pregnant women. Pregnant women are receiving more attention not only because of their altered physiological and immunological function but also for the potential risk of viral vertical transmission to the fetus or infant. However, very limited data about the impact of maternal infection during pregnancy, such as the possibility of vertical transmission in utero, during birth, or via breastfeeding, is available. Moreover, the impact of infection on the newborn in the short and long term remains poorly understood. Therefore, it is vital to collect and analyze data from pregnant women infected with COVID-19 to understand the viral pathophysiology during pregnancy and its effects on the offspring. In this article, we review the current knowledge about pre-and post-natal COVID-19 infection, and we discuss whether vertical transmission takes place in pregnant women infected with the virus and what are the current recommendations that pregnant women should follow in order to be protected from the virus.

Advances in therapies for non-Hodgkin lymphoma in children

Hematology ◽  
2015 ◽  
Vol 2015 (1) ◽  
pp. 522-528 ◽  
Author(s):  
Rachel Kobos ◽  
William Terry
Keyword(s):  
Overall Survival ◽  
Hodgkin Lymphoma ◽  
Pediatric Patients ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Newly Diagnosed ◽  
Limited Data ◽  
Non Hodgkin Lymphoma ◽  
Short And Long Term

Pediatric patients with newly diagnosed, non-Hodgkin Lymphoma (NHL) have an excellent overall survival. However, therapy regimens are associated with acute toxicity and late effects. Furthermore, patients with relapsed or refractory disease have relatively few options with proven clinical benefit. Both histologic and molecular differences exist between adult and pediatric NHL preventing simple translation of adult NHL successes into improvements in pediatric NHL treatment. This review summarizes the introduction of targeted therapies into frontline treatments for patients with anaplastic large-cell lymphoma and CD20–positive tumors, with the goal of improving overall survival while limiting both short- and long-term toxicities. In addition, newer approaches that have limited data in children but may have a significant role in how we treat pediatric NHL in the future are reviewed, which include CD19 directed therapy, Notch inhibition, the tri-functional antibody, FBTA05, and EZH2 inhibition.

scholarly journals Optogenetic induction of appetitive and aversive taste memories in Drosophila

2021 ◽  
Author(s):  
Meghan Jelen ◽  
Pierre-Yves Musso ◽  
Pierre Junca ◽  
Michael D Gordon
Keyword(s):  
Dopaminergic Neurons ◽  
Closed Loop ◽  
Food Sources ◽  
Direct Stimulation ◽  
Taste System ◽  
Food Acceptance ◽  
Aversive Taste ◽  
Short And Long Term ◽  
Stimulation Of

Tastes are typically thought to evoke innate appetitive or aversive behaviours, prompting food acceptance or rejection. However, research in Drosophila melanogaster indicates that taste responses can be modified through experience-dependent changes in mushroom body circuits. In this study, we develop a novel taste learning paradigm using closed-loop optogenetics. We find that appetitive and aversive taste memories can be formed by pairing gustatory stimuli with optogenetic activation of sensory or dopaminergic neurons associated with reward or punishment. As with olfactory memories, distinct dopaminergic subpopulations drive the parallel formation of short- and long-term appetitive memories. Long-term memories are protein synthesis-dependent and have energetic requirements that are satisfied by a variety of caloric food sources or by direct stimulation of MB-MP1 dopaminergic neurons. Our paradigm affords new opportunities to probe plasticity mechanisms within the taste system and understand the extent to which taste responses are experience dependent.

scholarly journals Advances in therapies for non-Hodgkin lymphoma in children

Hematology ◽  
2015 ◽  
Vol 2015 (1) ◽  
pp. 522-528 ◽  
Author(s):  
Rachel Kobos ◽  
William Terry
Keyword(s):  
Overall Survival ◽  
Hodgkin Lymphoma ◽  
Pediatric Patients ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Newly Diagnosed ◽  
Limited Data ◽  
Non Hodgkin Lymphoma ◽  
Short And Long Term

Abstract Pediatric patients with newly diagnosed, non-Hodgkin Lymphoma (NHL) have an excellent overall survival. However, therapy regimens are associated with acute toxicity and late effects. Furthermore, patients with relapsed or refractory disease have relatively few options with proven clinical benefit. Both histologic and molecular differences exist between adult and pediatric NHL preventing simple translation of adult NHL successes into improvements in pediatric NHL treatment. This review summarizes the introduction of targeted therapies into frontline treatments for patients with anaplastic large-cell lymphoma and CD20–positive tumors, with the goal of improving overall survival while limiting both short- and long-term toxicities. In addition, newer approaches that have limited data in children but may have a significant role in how we treat pediatric NHL in the future are reviewed, which include CD19 directed therapy, Notch inhibition, the tri-functional antibody, FBTA05, and EZH2 inhibition.

scholarly journals Agribusiness higher education development – ahead: The project results at a glance

2009 ◽  
Vol 3 (1-2) ◽  
pp. 95-98
Author(s):  
László Kárpáti
Keyword(s):  
Higher Education ◽  
National Economy ◽  
Rapid Development ◽  
Great Majority ◽  
Time Span ◽  
Basic Information ◽  
High Quality ◽  
Education Development ◽  
Short And Long Term

his booklet that has caught your attention contains basic information about the AHEAD project sponsored by the EU’s TEMPUS grant. This project was carried out between University of Zagreb (and other Croatian partners) and four EU-based universities. The project was very ambitious and it is my pleasure to state that the great majority of the objectives were carried out with high quality during the 3 years project time span. The main results of the AHEAD project can be found in this booklet, and I would like to mention just a few of them: • A new MBA training started in Zagreb with international recognition • 61 subjects of 3 BSc/MSc trainings were reviewed and modified, • a study was created in order to determine the short – and long – term expert demand of the Croatian national economy, • computers, equipment and modern textbooks were purchased from European grant and • finally a personal note: it was spectacular to see the rapid development of University of Zagreb and generally the whole Croatia during the last 3 years. If our project contributed just a little bit to it, the effort certainly was worthwhile.

Short- and Long-term Association Between Uric Acid and a Natural Disaster

1997 ◽  
Vol 59 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Maurizio Trevisan ◽  
Erin O'Leary ◽  
Eduardo Farinaro ◽  
Fabrizio Jossa ◽  
Rocco Galasso ◽  
...  
Keyword(s):  
Uric Acid ◽  
Natural Disaster ◽  
Short And Long Term

scholarly journals RECOMMENDATION ON USE OF METHOTREXATE IN SARCOIDOSIS PATIENTS (WASOG, 2013) AND THE BACKGROUND FOR ITS UPDATE

2021 ◽  
Vol 29 (3) ◽  
pp. 53-57
Author(s):  
І. O. Merenkova ◽  
◽  
N. A. Vlasova
Keyword(s):  
Case Series ◽  
Concomitant Administration ◽  
Pulmonary Sarcoidosis ◽  
Research Data ◽  
Limited Data ◽  
World Association ◽  
Short And Long Term ◽  
The Moment ◽  
New Research

RECOMMENDATION ON USE OF METHOTREXATE IN SARCOIDOSIS PATIENTS (WASOG, 2013) AND THE BACKGROUND FOR ITS UPDATE І. O. Merenkova, N. A. Vlasova Abstract In 2013 the experts of World Association of Sarcoidosis and Other Granulomatous disorders (WASOG) have published the recommendations on use of methotrexate (MTX) in sarcoidosis patients. Considering the fact that by the moment of publishing of the recommendations, there were data presented from only one small (n=24) randomized trial (Baughman R. P. et al., 2000) and limited data from observational studies, the recommendations were mainly based on case series reports and sarcoidosis experts’ opinion, collected from appropriate survey. Since that time several trials on efficacy and safety of MTX, including large retrospective studies (Fang C., et al., 2019; Vizel A. A. et al., 2020; Baughman R. P. et al., 2020) have been accomplished. Current statement of WASOG has considered these new data. Upon review of recommendations the authors concluded that based on rich body research data on short and long-term outcomes of MTX use in pulmonary sarcoidosis, published during last 8 years, MTX may be prescribed as first line medication in patients with newly diagnosed pulmonary sarcoidosis. A safety profile of MTX allows to use it at initial dose of 15 mg/week. The concomitant administration of folic acid should be limited by cases of MTX intolerance, until new research data on this matter become available. In authors’ opinion, recommendations # 4-10, in connection with MTX safety, are up-to-date and should not be revised. Key words: pulmonary sarcoidosis, methotrexate, recommendations of WASOG-2013. Ukr. Pulmonol. J. 2021;29(3):53–57.

Purine and uric acid contents of common edible insects in Southwest China

2019 ◽  
Vol 5 (4) ◽  
pp. 293-299 ◽  
Author(s):  
Z. He ◽  
M. Zhao ◽  
C.Y. Wang ◽  
L. Sun ◽  
Y.Y. Jiang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Southwest China ◽  
Single Species ◽  
Food Sources ◽  
Edible Insects ◽  
Purine Content ◽  
Potential Risks ◽  
Insects As Food ◽  
Meat Samples ◽  
Potential Food

Edible insects have recently been considered as a potential food source that may solve problems of malnutrition and starvation worldwide. However, studies exploring insects as food sources are mainly focused on entomophagy and nutrition rather than the potential risks of excessive metabolite contents, such as purine and uric acid. In this study, we analysed guanine, hypoxanthine, xanthine, adenine and uric acid concentrations in 11 species of edible insects from Yunnan and Guizhou provinces in Southwest China, including 5 species of dragonfly, 3 species of wasp and a single species of locust, mealworm and silkworm. Purine and uric acid contents differed distinctly between these insects, and guanine and xanthine were the dominant purines in all samples. The proportions of 4 purines in the total purine content of these insects differed markedly from those in meat samples from poultry and livestock, and uric acid contents varied significantly between aquatic insects and terricolous insects, such as silkworm pupa. Taken together, the present data show that most edible insects are potent food sources of purine.

P6395Elevated serum uric acid is associated with a greater inflammatory response and with short- and long-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percu

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Mandurino Mirizzi ◽  
S Cornara ◽  
A Somaschini ◽  
A Demarchi ◽  
M Galazzi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Inflammatory Response ◽  
Serum Uric Acid ◽  
Neutrophil Count ◽  
Elevated Serum ◽  
St Segment Elevation ◽  
St Segment ◽  
Short And Long Term ◽  
Long Term Mortality

Abstract Introduction Elevated serum uric acid (eSUA) has been identified as independent risk factors for cardiovascular diseases, including coronary artery disease, and it has been associated with increased mortality in the general population. However, whether eSUA is associated with adverse outcomes in the setting of ST-segment elevation myocardial infarction (STEMI) is still controversial. Although the mechanisms of this possible relationship is similarly unsettled it has been suggested that eSUA could trigger oxidative stress and inflammatory response. Aim This study sought to investigate the association between eSUA with short- and long-term mortality and with inflammatory response in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). Methods We prospectively enrolled all STEMI patients undergoing pPCI in our hospital between 2005 and 2017. Blood samples were collected on admission and at 24 and 48 hours after pPCI: SUA and the inflammatory biomarkers C-reactive protein (CRP), neutrophil count and neutrophil to lymphocytes ratio (NLR) were parameter of interest. NLR was obtained by dividing the total count of neutrophil by the total count of lymphocyte. eSUA was defined as >6.8 mg/dl. Cumulative 30-days and 1-year mortalities were estimated using the Kaplan-Meyer analysis and compared with the long-rank test. Landmark analysis was set at 365 days. Multivariable analyses were performed by Cox proportional hazard models. Results Out of the dataset of 2959 STEMI patients treated with pPCI, we analyzed 2369 patients who had SUA data. Overall age was 63 (p25-p75: 54–73) years, men were 2295 (75.5%), anterior MI 1390 (45.8%). eSUA was present in 563 patients (23.8%). 30-day mortality was 5.8% (n=31) among patients with eSUA and 2% (n=34) among patient with normal SUA level (p<0.001); 1-year mortality was 8.5% (n=46) vs 4% (n=70), respectively (p<0.001). Landmark analysis is shown in Figure 1. At multivariable analyses eSUA was an independent predictor after adjusting for age, female gender, BMI, diabetes, previous MI, serum creatinine, Hb, acute glycemia, Killip class >2 (30-day mortality HR 1.196, 95% CI 1.006–1.321, p=0.042; 1-year mortality HR 1.178, 95% CI 1.052–1.320, p=0.005). On admission CRP was higher in the group with eSUA as compared with the group with normal SUA levels (respectively, 1.27 [0.57–3.37] mg/dl vs 0.72 [0.30–1.8] mg/dl, p<0.001). On admission neutrophil count and NLR did not differ among the groups (respectively, p=0.205 and p=0.399), but eSUA patients presented higher values in neutrophil count and NLR at 24 hours (respectively, p=0.020 and p<0.001) and at 48 hours (p=0.018 and both p<0.001). Figure 1 Conclusions Elevated serum uric acid is associated with higher short- and long-term mortality and with a greater inflammatory response after reperfusion in patients with STEMI treated with primary PCI.

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