scholarly journals Exploring the Science behind Bifidobacterium breve M-16V in Infant Health

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1724 ◽  
Author(s):  
Chyn Boon Wong ◽  
Noriyuki Iwabuchi ◽  
Jin-zhong Xiao
Keyword(s):  
Infant Health ◽  
Probiotic Strain ◽  
Allergic Diseases ◽  
Strain Specificity ◽  
Bifidobacterium Breve ◽  
Birth Complications ◽  
Beneficial Effects ◽  
Immune Balance ◽  
Health Related ◽  
High Risk Infants

Probiotics intervention has been proposed as a feasible preventative approach against adverse health-related complications in infants. Nevertheless, the umbrella concept of probiotics has led to a massive application of probiotics in a range of products for promoting infant health, for which the strain-specificity, safety and efficacy findings associated with a specific probiotics strain are not clearly defined. Bifidobacterium breve M-16V is a commonly used probiotic strain in infants. M-16V has been demonstrated to offer potential in protecting infants from developing the devastating necrotising enterocolitis (NEC) and allergic diseases. This review comprehends the potential beneficial effects of M-16V on infant health particularly in the prevention and treatment of premature birth complications and immune-mediated disorders in infants. Mechanistic studies supporting the use of M-16V implicated that M-16V is capable of promoting early gut microbial colonisation and may be involved in the regulation of immune balance and inflammatory response to protect high-risk infants from NEC and allergies. Summarised information on M-16V has provided conceptual proof of the use of M-16V as a potential probiotics candidate aimed at promoting infant health, particularly in the vulnerable preterm population.

Infant health-related Quality of life Instrument

2018 ◽  
Author(s):  
Ruslan Jabrayilov ◽  
◽  
Antoinette D. I. van Asselt ◽  
Karin M. Vermeulen ◽  
Sheri Volger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Infant Health ◽  
Health Related Quality ◽  
Life Instrument ◽  
Related Quality ◽  
Health Related

scholarly journals Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1602
Author(s):  
Guangsu Zhu ◽  
Jianxin Zhao ◽  
Hao Zhang ◽  
Wei Chen ◽  
Gang Wang
Keyword(s):  
Gut Microbiome ◽  
Dietary Intervention ◽  
Neuroprotective Effects ◽  
Bifidobacterium Breve ◽  
Beneficial Effects ◽  
Behavioral Abnormalities ◽  
Fibronectin Type Iii ◽  
Fibronectin Type Iii Domain ◽  
The Brain ◽  
Fibronectin Type

Psychobiotics are used to treat neurological disorders, including mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, the mechanisms underlying their neuroprotective effects remain unclear. Herein, we report that the administration of bifidobacteria in an AD mouse model improved behavioral abnormalities and modulated gut dysbiosis. Bifidobacterium breve CCFM1025 and WX treatment significantly improved synaptic plasticity and increased the concentrations of brain-derived neurotrophic factor (BDNF), fibronectin type III domain-containing protein 5 (FNDC5), and postsynaptic density protein 95 (PSD-95). Furthermore, the microbiome and metabolomic profiles of mice indicate that specific bacterial taxa and their metabolites correlate with AD-associated behaviors, suggesting that the gut–brain axis contributes to the pathophysiology of AD. Overall, these findings reveal that B. breve CCFM1025 and WX have beneficial effects on cognition via the modulation of the gut microbiome, and thus represent a novel probiotic dietary intervention for delaying the progression of AD.

scholarly journals Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 701
Author(s):  
Aroa Lopez-Santamarina ◽  
Esther Gonzalez Gonzalez ◽  
Alexandre Lamas ◽  
Alicia del Carmen Mondragon ◽  
Patricia Regal ◽  
...  
Keyword(s):  
Allergic Diseases ◽  
Urban Environments ◽  
Probiotic Bacteria ◽  
Health Concern ◽  
Global Public Health ◽  
Cytokine Release ◽  
Public Health Concern ◽  
Beneficial Effects ◽  
Opportunistic Bacteria

Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.

scholarly journals Valuing Health Status in the First Year of Life: The Infant Health-Related Quality of Life Instrument

2019 ◽  
Vol 22 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Ruslan Jabrayilov ◽  
Karin M. Vermeulen ◽  
Patrick Detzel ◽  
Livia Dainelli ◽  
Antoinette D.I. van Asselt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Infant Health ◽  
First Year ◽  
Health Related Quality ◽  
Life Instrument ◽  
Related Quality ◽  
Health Related ◽  
First Year Of Life

scholarly journals Estrogen replacement and skeletal muscle: mechanisms and population health

2013 ◽  
Vol 115 (5) ◽  
pp. 569-578 ◽  
Author(s):  
Peter M. Tiidus ◽  
Dawn A. Lowe ◽  
Marybeth Brown
Keyword(s):  
Skeletal Muscle ◽  
Postmenopausal Women ◽  
Muscle Mass ◽  
Enhanced Recovery ◽  
Rapid Onset ◽  
Metabolic Dysfunction ◽  
Skeletal Muscle Function ◽  
Strong Argument ◽  
Beneficial Effects ◽  
Health Related

There is a growing body of information supporting the beneficial effects of estrogen and estrogen-based hormone therapy (HT) on maintenance and enhancement of muscle mass, strength, and connective tissue. These effects are also evident in enhanced recovery from muscle atrophy or damage and have significant implications particularly for the muscular health of postmenopausal women. Evidence suggests that HT will also help maintain or increase muscle mass, improve postatrophy muscle recovery, and enhance muscle strength in aged females. This is important because this population, in particular, is at risk for a rapid onset of frailty. The potential benefits of estrogen and HT relative to skeletal muscle function and composition combined with other health-related enhancements associated with reduced risk of cardiovascular events, overall mortality, and metabolic dysfunction, as well as enhanced cognition and bone health cumulate in a strong argument for more widespread and prolonged consideration of HT if started proximal to menopausal onset in most women. Earlier reports of increased health risks with HT use in postmenopausal women has led to a decline in HT use. However, recent reevaluation regarding the health effects of HT indicates a general lack of risks and a number of significant health benefits of HT use when initiated at the onset of menopause. Although further research is still needed to fully delineate its mechanisms of action, the general use of HT by postmenopausal women, to enhance muscle mass and strength, as well as overall health, with initiation soon after the onset of menopause should be considered.

scholarly journals Association Between Breastmilk Microbiota and Food Allergy in Infants

2022 ◽  
Vol 11 ◽  
Author(s):  
Shuo Wang ◽  
Yuan Wei ◽  
Luyan Liu ◽  
Zailing Li
Keyword(s):  
Food Allergy ◽  
Infant Health ◽  
Intestinal Flora ◽  
16S Rrna Gene Sequencing ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Infant Food ◽  
Rrna Gene ◽  
Protective Effects ◽  
The Relationship

Regulating the composition of human breastmilk has the potential to prevent allergic diseases early in life. The composition of breastmilk is complex, comprising varying levels of oligosaccharides, immunoactive molecules, vitamins, metabolites, and microbes. Although several studies have examined the relationship between different components of breastmilk and infant food allergies, few have investigated the relationship between microorganisms in breastmilk and infant food allergy. In the present study, we selected 135 healthy pregnant women and their full-term newborns from a cohort of 202 mother–infant pairs. Among them, 69 infants were exclusively breastfed until 6 mo after birth. At follow-up, 11 of the 69 infants developed a food allergy in infancy while 22 showed no signs of allergy. Thirty-three breastmilk samples were collected within 1 mo after delivery, and 123 infant fecal samples were collected at five time points following their birth. These samples were analyzed using microbial 16S rRNA gene sequencing. The abundance and evenness of the milk microbiota and the number of differential bacteria were higher in the breastmilk samples from the non-allergy group than in those from the food allergy group. The non-allergy group showed relatively high abundance of Bifidobacterium, Akkermansia, Clostridium IV, Clostridium XIVa, Veillonella, and butyrate-producing bacteria such as Fusobacterium, Lachnospiraceae incertae sedis, Roseburia, and Ruminococcus. In contrast, the abundance of Proteobacteria, Acinetobacter, and Pseudomonas in breastmilk was higher in the food allergy group. A comparison of the changes in dominant differential breastmilk microbiota in the intestinal flora of the two groups of infants over time revealed that the changes in Bifidobacterium abundance were consistent with those in the breastmilk flora. Functional pathway prediction of breastmilk microflora showed that the enhancement of the metabolic pathways of tyrosine, tryptophan, and fatty acids was significantly different between the groups. We suggest that changes in the breastmilk microbiota can influence the development of food allergies. Breastmilk contains several microbes that have protective effects against food allergies, both by influencing the colonization of intestinal microbiota and by producing butyrate. This study may provide new ideas for improving infant health through early intervention with probiotics.

scholarly journals „CHildhood Allergy and tolerance: bioMarkers and Predictors” (CHAMP) -A call for prediction and quality of life

2021 ◽  
Author(s):  
Jana Eckert ◽  
Julia Kahle ◽  
Andreas Böck ◽  
Kathrin Zeber ◽  
Kathrin Urner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Diseases ◽  
Patient Survey ◽  
Childhood Diseases ◽  
Related Quality ◽  
Translational Allergy ◽  
Health Related ◽  
Asthma And Allergy ◽  
Underlying Mechanisms

Background: Allergic diseases are the most prevalent chronic childhood diseases resulting in a massive societal and economic burden for the community and a significant reduction of health-related quality of life (HRQoL) for affected families. The project CHAMP (CHildhood Allergy and tolerance: bioMarkers and Predictors) was funded in 2017 by the German Federal Ministry for Education and Research. Methods: CHAMP investigates the determinants of different allergic diseases from birth to adolescence to identify clinically relevant biomarkers predicting onset, progression, remission and severity. Data on HRQoL and patient’s needs and requirements were collected, supported by the German Asthma and Allergy Association (DAAB). Using validated questionnaires and outpatient visits, eight subprojects analysed allergic diseases in epidemiological or clinical cohorts (more than 2500 children/adolescents), sampling numerous biomaterials to assess omics on several levels. Murine models disentangled underlying mechanisms of early tolerance, translating findings from the cohorts to models and vice versa. Results: The DAAB survey, including 851 participants, showed that 83% were interested in prediction of the course of different current allergic diseases and future manifestation. 86% of participants considered doctor’s specialized training and their education as highly important, over 70% chose research for allergy understanding and prevention as critical. CHAMP addresses these needs. Common SOPs have been established and recruitment is ongoing. Conclusion: The DAAB patient survey confirmed the critical need for translational allergy research. CHAMP envisions to predict onset, tolerance and remission of allergic diseases and to identify disease sub-phenotypes for future development of preventive strategies and novel avenues for therapeutic options.

scholarly journals Beneficial effects of Enterococcus faecium EF9a administration in rabbit diet

2020 ◽  
Vol 28 (4) ◽  
pp. 169
Author(s):  
Monika Pogány Simonová ◽  
Andrea Lauková ◽  
Ľubica Chrastinová ◽  
Iveta Plachá ◽  
Renáta Szabóová ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Live Weight ◽  
Probiotic Strain ◽  
Good Health ◽  
Health Condition ◽  
Daily Weight Gain ◽  
Commercial Diet ◽  
Beneficial Effects ◽  
Access To Water ◽  
And Control

<p>Forty-eight rabbits aged five weeks (Hycole breed, both sexes) were divided into experimental (EG) and control (CG) groups, 24 animals in each, and fed a commercial diet with access to water <em>ad libitum</em>. Rabbits in EG had Enterococcus faecium EF9a probiotic strain added to their drinking water (1.0×10<sup>9</sup> colony forming units/mL 500 μL/d/animal) for 28 d (between 35 and 63 d). The experiment lasted for 42 d. The animals remained in good health condition throughout the experiment, and no morbidity and mortality was noted. There was a higher live weight at 63 d of age (+34 g; <em>P</em>&lt;0.0001), final live weight at 77 d of age (+158 g; <em>P</em>=0.0483), and average daily weight gain between 63 and 77 d of age in the EG group rabbits than in CG group rabbits (+8 g/d; <em>P</em>&lt;0.0001). No significant changes in caecal lactic acid and total volatile fatty acid concentrations, jejunal morphological parameters and phagocytic activity were noted during the treatment. The tested serum parameters were within the range of the reference values. EF9a strain sufficiently established itself in the rabbit’s gastrointestinal tract. At 63 d of age, a significant decrease in coliforms (<em>P</em>&lt;0.05), coagulase-positive staphylococci (<em>P</em>&lt;0.01), pseudomonads (<em>P</em>&lt;0.01) and coagulasenegative staphylococci (CoNS, <em>P</em>&lt;0.001) was noted in the faeces of the EG group rabbits compared to the CG rabbits. Antimicrobial effects of EF9a strain in the caecum against coliforms (<em>P</em>&lt;0.001), CoNS (<em>P</em>=0.0002) and pseudomonads (<em>P</em>=0.0603) and in the appendix (coliforms, <em>P</em>&lt;0.05) were detected.</p>

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