scholarly journals A Prospective Study on Changes in Nutritional Status and Growth Following Two Years of Ketogenic Diet (KD) Therapy in Children with Refractory Epilepsy

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1596 ◽  
Author(s):  
Marisa Armeno ◽  
Antonella Verini ◽  
Mariana del Pino ◽  
Maria Beatriz Araujo ◽  
Graciela Mestre ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Prospective Study ◽  
Ketogenic Diet ◽  
Refractory Epilepsy ◽  
Growth Monitoring ◽  
Male Predominance ◽  
History Of ◽  
A Prospective Study ◽  
Growth Deceleration

Introduction: Epilepsy is a neurological disorder characterized by an increased susceptibility to seizures. The ketogenic diet (KD) is currently the most important alternative non-pharmacological treatment. Despite its long history of clinical use, it is not clear how this diet affects longitudinal growth in children. Methods: A prospective study was designed to evaluate growth and nutritional status in 45 children on KD. Growth was assessed by measuring weight, height, and body mass index (BMI). Standard deviation scores (SDS) were calculated for all measurement parameters at KD initiation and at a two-year follow-up. Results: Overall, 45 patients who completed 24 months on KD were enrolled. Median age was 6.6 years (0.8 to 17.3), with a male predominance (n = 23); 74% of the 45 patients were responders on seizure reduction at three months; 26% of patients were non-responders. In our study, using −1 SDS as a cut-off point, growth deceleration was observed in 9% (n: 4) of the patients; however, the nutritional status was maintained or even improved. No correlation with age, sex, or ambulatory status was found. Conclusions: The nutritional follow-up of these patients was helpful to improve overweight and thinness but could not avoid growth deceleration in some of them. These findings confirm that children with refractory epilepsy on KD treatment require careful growth monitoring.

A prospective study: Growth and nutritional status of children treated with the ketogenic diet

2003 ◽  
Vol 103 (6) ◽  
pp. 707-712 ◽  
Author(s):  
Yeou-Mei Christiana Liu ◽  
Shelley Williams ◽  
Carlota Basualdo-Hammond ◽  
Derek Stephens ◽  
Rosalind Curtis
Keyword(s):  
Nutritional Status ◽  
Prospective Study ◽  
Ketogenic Diet ◽  
Nutritional Status Of Children ◽  
A Prospective Study

The Natural History of Subarachnoid Haemorrhage with Negative Angiography: A prospective study and 3-year follow-up

1988 ◽  
Vol 2 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Robert M. Redfern ◽  
Stefan Zygmunt ◽  
John D. Pickard ◽  
Patrick M. Foy ◽  
M. D. M. Shaw
Keyword(s):  
Natural History ◽  
Subarachnoid Haemorrhage ◽  
Prospective Study ◽  
Negative Angiography ◽  
History Of ◽  
A Prospective Study

The MCT-ketogenic diet as a treatment option in refractory childhood epilepsy: A prospective study with 2-year follow-up

2015 ◽  
Vol 51 ◽  
pp. 261-266 ◽  
Author(s):  
Danielle A.J.E. Lambrechts ◽  
Reina J.A. de Kinderen ◽  
Hans S.H. Vles ◽  
Anton J. de Louw ◽  
Albert P. Aldenkamp ◽  
...  
Keyword(s):  
Prospective Study ◽  
Ketogenic Diet ◽  
Treatment Option ◽  
Childhood Epilepsy ◽  
A Prospective Study

Foreign bodies in the throat: a prospective study of 388 cases

1991 ◽  
Vol 105 (2) ◽  
pp. 104-108 ◽  
Author(s):  
N. S. Jones ◽  
F. J. Lannigan ◽  
N. Y. Salama
Keyword(s):  
Foreign Body ◽  
Prospective Study ◽  
Significant Proportion ◽  
Careful Examination ◽  
Barium Swallow ◽  
Retained Foreign Body ◽  
History Of ◽  
A Prospective Study ◽  
Symptoms And Signs

AbstractWe present the results of a prospective study of 388 patients presenting with a history of swallowing a foreign body. We indicate whether the patients' symptoms and signs were associated with a retained foreign body. While tenderness on palpation was an unreliable sign, pooling at indirect laryngoscopy invariably predicted a retained object. In many patients, initial careful examination of the oropharynx by casualty officers would have shown a retained fishbone in the tonsil or tongue and would have resulted in 16 per cent fewer radiographs and 17 per cent fewer referrals to the ENT department. Radiography only improved management in a small minority and 35 per cent of films were interpreted incorrectly by casualty officers. A follow-up barium swallow disclosed a pathological lesion in a significant proportion of patients with bolus obstruction, whether or not this was passed spontaneously.

A prospective study on changes in blood levels of cholecystokinin-8 and leptin in patients with refractory epilepsy treated with the ketogenic diet

2016 ◽  
Vol 127 ◽  
pp. 87-92 ◽  
Author(s):  
Danielle A.J.E. Lambrechts ◽  
Evelyn Brandt-Wouters ◽  
Pauline Verschuure ◽  
Hans S.H. Vles ◽  
Marian J.M. Majoie
Keyword(s):  
Prospective Study ◽  
Ketogenic Diet ◽  
Refractory Epilepsy ◽  
Blood Levels ◽  
A Prospective Study

scholarly journals Can an early 24-hour EEG predict the response to the ketogenic diet? A prospective study in 34 children and adults with refractory epilepsy treated with the ketogenic diet

Seizure ◽  
2014 ◽  
Vol 23 (6) ◽  
pp. 468-474 ◽  
Author(s):  
Saskia C.M. Ebus ◽  
Danielle A.J.E. Lambrechts ◽  
Ingrid J.T. Herraets ◽  
Marian J.M. Majoie ◽  
Anton J. de Louw ◽  
...  
Keyword(s):  
Prospective Study ◽  
Ketogenic Diet ◽  
Refractory Epilepsy ◽  
A Prospective Study

scholarly journals Efficiency of Systematic Thrombophilia Screening in Idiopathic Venous Thrombosis: A Prospective Study in Internal Medicine

2005 ◽  
Vol 11 (3) ◽  
pp. 243-251 ◽  
Author(s):  
P. Pottier ◽  
G. Cormier ◽  
F. Truchaud ◽  
B. Planchon
Keyword(s):  
Internal Medicine ◽  
Venous Thromboembolism ◽  
Prospective Study ◽  
Lupus Anticoagulant ◽  
Primary Outcome Measure ◽  
New Strategy ◽  
Thrombophilia Screening ◽  
History Of ◽  
A Prospective Study

In case of unprovoked venous thromboembolism (VTE), the screening of thrombophilia is recommended whatever the age of the patient and the type of risk factors (RF). This prospective study was conducted in patients with unprovoked VTE to detect some predictive factors to have a higher risk of thrombophilia, focusing on age, history of venous thromboembolism, and the existence of a triggering event. From July 2000 to July 2002, in an Internal Medicine Department, unrelated patients with unprovoked VTE were included. Those unprovoked thromboembolic events were defined by the absence of association between permanent and transient RF. The primary outcome measure was the positivity of the thrombophilia screening for any type of abnormality detected (deficit of protein C, S, antithrombin, presence of a lupus anticoagulant, research of V and II mutations). Seventy-four patients were included. Eight died during the follow-up. A higher risk of thrombophilia was found in patients younger than 40 (p=0.03), or with a family but not personal history of VTE (p=0.01) or with transient RF (p=0.02). The most frequent abnormality of coagulation found in patients younger than 40 was the presence of a lupus anticoagulant. As a new strategy for the screening of thrombophilia, one could propose the following attitude: only patients with transient RF or family history of VTE could undergo a complete screening; for all the remaining patients who are younger than 40, a research of a lupus anticoagulant would be only performed. This strategy should now be balanced against the currently recommended systematic attitude in further studies.

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