scholarly journals Cow’s Milk Allergy: Immunomodulation by Dietary Intervention

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1399 ◽  
Author(s):  
Enza D’Auria ◽  
Silvia Salvatore ◽  
Elena Pozzi ◽  
Cecilia Mantegazza ◽  
Marco Ugo Andrea Sartorio ◽  
...  
Keyword(s):  
Immune System ◽  
Dietary Intervention ◽  
Physiological Mechanism ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Dietary Management ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

Cow’s milk proteins cause allergic symptoms in 2% to 3% of all infants. In these individuals, the physiological mechanism of tolerance is broken with subsequent possible sensitization to antigens, which can lead eventually to allergic responses. The present review aims to provide an overview of different aspects of immune modulation by dietary intervention in cow’s milk allergy (CMA). It focuses on pathogenetic mechanisms of different CMA related disorders, e.g., gastroesophageal reflux and eosinophilic esophagitis, highlighting the role of dietary management on innate and adaptive immune systems. The traditional dietary management of CMA has greatly changed in the last years, moving from a passive approach, consisting of an elimination diet to relieve symptoms, to a “proactive” one, meaning the possibility to actively modulate the immune system. Thus, new insights into the role of hydrolysates and baked milk in immunomodulation are addressed here. Additionally, nutritional components, such as pre- and probiotics, may target the immune system via microbiota, offering a possible road map for new CMA prevention and treatment strategies.

scholarly journals Role of maternal elimination diets and human milk IgA in the development of cow's milk allergy in the infants

2013 ◽  
Vol 44 (1) ◽  
pp. 69-78 ◽  
Author(s):  
K. M. Järvinen ◽  
J. E. Westfall ◽  
M. S. Seppo ◽  
A. K. James ◽  
A. J. Tsuang ◽  
...  
Keyword(s):  
Human Milk ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy

2001 ◽  
Vol 31 (10) ◽  
pp. 1599-1606 ◽  
Author(s):  
L. Vila ◽  
K. Beyer ◽  
K.-M. Järvinen ◽  
P. Chatchatee ◽  
L. Bardina ◽  
...  
Keyword(s):  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Linear Epitopes

Managing chronic functional constipation: Role of cow's milk allergy

2016 ◽  
Vol 48 ◽  
pp. e245-e246
Author(s):  
P. Poli ◽  
F. Scavuzzo ◽  
L. Squassabia ◽  
L. Fiorica ◽  
E. Zini ◽  
...  
Keyword(s):  
Functional Constipation ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

scholarly journals Evaluating the role of clinical history and laboratorial tests in IgE mediated cow's milk allergy diagnosis

2015 ◽  
Vol 8 ◽  
pp. A124
Author(s):  
Beni Morgenstern ◽  
Cleonir Beck ◽  
Cristina Jacob ◽  
Andrea Gushken ◽  
Antonio Carlos Pastorino ◽  
...  
Keyword(s):  
Clinical History ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Allergy Diagnosis ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Ige Mediated

scholarly journals Oral Immunotherapy for Children with Cow’s Milk Allergy

Pathogens ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1328
Author(s):  
Mika Ogata ◽  
Jun Kido ◽  
Kimitoshi Nakamura
Keyword(s):  
Oral Immunotherapy ◽  
Cow’S Milk Allergy ◽  
Food Allergies ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Long Time

Cow’s milk allergy (CMA) is one of the most common IgE-dependent food allergies in children. Some children develop severe and persistent CMA, with near-fatal reactions after exposure to trace amounts of cow’s milk (CM). Because milk and dairy products are included in various processed food products, it is difficult to completely remove milk, which negatively affects the quality of life of children with CMA. Oral immunotherapy (OIT) can alleviate food allergen-induced anaphylaxis under continuous ingestion of a little of the causative food. Children with severe CMA may benefit from OIT, but the treatment requires a long time and poses a risk of anaphylaxis. Moreover, in recent years, new therapies, including omalizumab, sublingual immunotherapy, and epicutaneous immunotherapy, have played the role of optional OIT. In this review, we present the current methods of and other attempts at OIT, and discuss OIT for safely treating CMA.

scholarly journals Hydrolysed Formulas in the Management of Cow’s Milk Allergy: New Insights, Pitfalls and Tips

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2762
Author(s):  
Enza D’Auria ◽  
Silvia Salvatore ◽  
Miriam Acunzo ◽  
Diego Peroni ◽  
Erica Pendezza ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Functional Gastrointestinal Disorders ◽  
Cow’S Milk Allergy ◽  
Current Evidence ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Hypoallergenic Formula ◽  
Cow's Milk Allergy ◽  
First Choice

An allergy to cow’s milk requires the avoidance of cow’s milk proteins and, in some infants, the use of a hypoallergenic formula. This review aims to summarize the current evidence concerning different types of hydrolysed formulas (HF), and recommendations for the treatment of IgE- and non-IgE-mediated cow’s milk allergy and functional gastrointestinal disorders in infancy, for which some dietary intervention and HF may be of benefit to both immune and motor mechanisms. Current guidelines recommend cow’s milk protein (i.e., whey or casein) extensively hydrolysed formula (eHF) as the first choice for cow’s milk allergy treatment, and amino acid formulas for more severe cases or those with reactions to eHF. Rice hydrolysed formulas (rHF) have also become available in recent years. Both eHF and rHF are well tolerated by the majority of children allergic to cow’s milk, with no concerns regarding body growth or adverse effects. Some hydrolysates may have a pro-active effect in modulating the immune system due to the presence of small peptides and additional components, like biotics. Despite encouraging results on tolerance acquisition, evidence is still not conclusive, thus hampering our ability to draw firm conclusions. In clinical practice, the choice of hypoallergenic formula should be based on the infant’s age, the severity, frequency and persistence of symptoms, immune phenotype, growth pattern, formula cost, and in vivo proof of tolerance and efficacy.

Role of parental atopy in cow's milk allergy: a population-based study

2013 ◽  
Vol 110 (4) ◽  
pp. 279-283 ◽  
Author(s):  
Michael Goldberg ◽  
Eli Eisenberg ◽  
Arnon Elizur ◽  
Nellie Rajuan ◽  
Marianna Rachmiel ◽  
...  
Keyword(s):  
Population Based ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Population Based Study ◽  
Cow's Milk ◽  
Cow's Milk Allergy
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