scholarly journals Effect of Postoperative Oral Intake on Prognosis for Esophageal Cancer

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1338 ◽  
Author(s):  
Genya Okada ◽  
Chika Momoki ◽  
Daiki Habu ◽  
Chisako Kambara ◽  
Tamotsu Fujii ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Nutritional Status ◽  
Enhanced Recovery ◽  
Oral Intake ◽  
Control Group ◽  
Nutritional Requirement ◽  
Lower Survival Rate ◽  
Poor Oral Intake ◽  
Prolonged Hospital ◽  
The Relationship

Background: Patients undergoing surgery for esophageal cancer are at risk of prolonged hospital stay for postoperative malnutrition. Postoperative early oral feeing is a part of the “enhanced recovery after surgery protocol” for coping with this risk. However, the usefulness of early oral intake during perioperatively is questionable. Methods: In total, 117 patients treated surgically for esophageal cancer were analyzed in the study. We assessed the oral energy sufficiency rate per nutritional requirement (oral-E/NR) at the fourth week postoperatively and classified the patients into two groups: Poor oral intake group (POI group; <25% oral-E/NR) and the control group (≥25% oral-E/NR). We analyzed the relationship among postoperative oral intake and prognoses. Results: The POI group had worse postoperative nutritional status and a lower survival rate than the control group. In a multivariate analysis, <25% oral-E/NR was one of the independent factors contributing to negative outcomes postoperatively (adjusted hazard ratio: 2.70, 95% confidence interval: 1.30–5.61). Conclusions: In patients undergoing surgery for esophageal cancer, poor postoperative oral intake negatively affected not only on their postoperative nutritional status but also their overall prognosis. It is necessary to improve the adequacy of oral intake postoperatively for patients with esophageal cancer.

Clinical benefits of a swallowing intervention for esophageal cancer patients after esophagectomy

2020 ◽  
Author(s):  
Jun Takatsu ◽  
Eiji Higaki ◽  
Takahiro Hosoi ◽  
Masahiro Yoshida ◽  
Masahiko Yamamoto ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Enhanced Recovery ◽  
Intervention Group ◽  
Oral Intake ◽  
Control Group ◽  
Recurrent Laryngeal Nerve Paralysis ◽  
Swallowing Function ◽  
Nerve Paralysis ◽  
Postoperative Stay

Summary Dysphagia after esophagectomy is the main cause of a prolonged postoperative stay. The present study investigated the effects of a swallowing intervention led by a speech–language–hearing therapist (SLHT) on postoperative dysphagia. We enrolled 276 consecutive esophageal cancer patients who underwent esophagectomy and cervical esophagogastric anastomosis between July 2015 and December 2018; 109 received standard care (control group) and 167 were treated by a swallowing intervention (intervention group). In the intervention group, swallowing function screening and rehabilitation based on each patient’s dysfunction were led by SLHT. The start of oral intake, length of oral intake rehabilitation, and length of the postoperative stay were compared in the two groups. The patient’s subgroups in the 276 patients were examined to clarify the more effectiveness of the intervention. The start of oral intake was significantly earlier in the intervention group (POD: 11 vs. 8 days; P = 0.009). In the subgroup analysis, the length of the postoperative stay was also significantly shortened by the swallowing intervention in patients without complications (POD: 18 vs. 14 days; P = 0.001) and with recurrent laryngeal nerve paralysis (RLNP) (POD: 30 vs. 21.5 days; P = 0.003). A multivariate regression analysis identified the swallowing intervention as a significant independent factor for the earlier start of oral intake and a shorter postoperative stay in patients without complications and with RLNP. Our proposed swallowing intervention is beneficial for the earlier start of oral intake and discharge after esophagectomy, particularly in patients without complications and with RLNP. This program may contribute to enhanced recovery after surgery.

Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jacques E. Chelly ◽  
Amy L. Monroe ◽  
Raymond M. Planinsic ◽  
Amit Tevar ◽  
Brittany E. Norton
Keyword(s):  
Enhanced Recovery ◽  
Randomized Study ◽  
Cranial Nerves ◽  
Oral Morphine ◽  
Oral Intake ◽  
Control Group ◽  
Hospital Data ◽  
Kidney Donor ◽  
Post Surgery ◽  
Post Operative Nausea

Abstract Objectives The purpose of this study was to investigate the role that the NSS-2 BRIDGE® device, an auricular field nerve stimulator, may play in reducing opioid requirement and pain in kidney donor surgery. It was not a randomized study. Electrophysiologic studies have demonstrated that the stimulation of the cranial nerves produced by the NSS-2 BRIDGE® device modulates the ascending/descending spinal pain pathways, especially at the level of the limbic system. Methods The design compared the effects of the NSS-2 BRIDGE® device (NSS 2-BRIDGE® device group; n=10) to a control group (n=10). In both groups, the surgery was performed using the same standard enhanced recovery after surgery protocol based on the use of a multimodal analgesic approach. For the active treatment group, the NSS-2 BRIDGE® device was placed in the post anesthesia care unit. The primary endpoint was opioid requirement (oral morphine equivalent, OME in mg) at 24 h post-surgery. Secondary endpoints included pain (0–10), at 24 and 48 h, time to discharge from the recovery room, incidence of post-operative nausea and vomiting at 24 h, time to oral intake, time to ambulation, and time to discharge from the hospital. Data was analyzed using unpaired t-test and presented as mean ± standard deviation. Results Compared to control, the use of the NSS-2 BRIDGE® was associated with a 75.4% reduction in OME (33.6 vs. 8.3 mg; p=0.03) and 41.5% reduction in pain (5 vs. 3.28; p=0.06) at 24 h and a 73.3% difference in pain at 48 h (1.6 ± 1.6 vs. 6.0 ± 2.8; p=0.0004). There was no difference in non-opioid analgesics administration between groups. Conclusions The tolerability of NSS-2 BRIDGE® device was reported by most to be excellent. This study suggests that the NSS-2 BRIDGE® device may represent a complementary approach for controlling postoperative opioid consumption and pain in patients undergoing kidney donation.

scholarly journals Body composition and lung function in adults with Cystic Fibrosis

2020 ◽  
Vol 83 (3) ◽  
pp. 239-250
Author(s):  
Aleksandra John ◽  
Joanna Goździk-Spychalska ◽  
Magdalena Durda-Masny ◽  
Wojciech Czaiński ◽  
Marta Gębala ◽  
...  
Keyword(s):  
Body Composition ◽  
Lung Function ◽  
Nutritional Status ◽  
Reference Group ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Control Group ◽  
Body Components ◽  
Group 2 ◽  
The Relationship

AbstractThe study aimed to assess: (1) differences in nutritional status and lung function between CF patients and the control group; (2) differences in body composition and lung function between groups of patients with CF designated by type of mutation; (3) the relationship between lung function and body composition in CF patients.We studied 37 CF patients aged 19 to 51 years, and 41 healthy non-CF volunteers. Nutritional status was evaluated based on the BMI and the bioelectrical impedance analysis. The lung function was described by FEV1%. CF patients were classified according to the CFTR genotype based on five classes of mutations. BMI were lower in CF patients compared to reference group (women: Z = 3.76, p <0.001, men: Z = 3.06, p = 0.002). CF patients had a lower mean content of particular body components, as well as FEV1% values. BMI differed significantly depending on the type of mutation in females (H = 10.33, p = 0.006) and males (H = 8.26, p = 0.016). The lowest values of BMI were observed in the group of patients with severe types of mutations. Also, variables describing body composition were statistically significantly lower in patients with a severe type of mutations. The CFTR gene mutation type statistically significantly differentiated FEV1% (H = 23.22, p <0.000). The results of the logistic regression analysis showed that the likelihood of dropping FEV1% below the norm was twice as high in undernourished females and males. To assess the nutritional status of CF patients, more informative methods describing the proportions of body components are required.

scholarly journals Hubungan Kondisi Fisik Rumah dan Status Gizi dengan Insiden Penyakit Tuberkulosis di Wilayah Kerja Puskesmas Rejosari Kota Pekanbaru Tahun 2020

2021 ◽  
Vol 1 (2) ◽  
pp. 538-547
Author(s):  
Fitri Zulfa Hayati ◽  
Nurhapipa Nurhapipa ◽  
Nila Puspita Sari
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Nutritional Status ◽  
Health Center ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Case Control ◽  
Control Group ◽  
Chi Square ◽  
The Relationship

Tuberkulosis Paru merupakan penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Kejadian penyakit Tuberkulosis Paru di Puskesmas Rejosari Kota Pekanbaru merupakan kasus tertinggi di kota pekanbaru sebanyak 798 kasus. Tujuan penelitian ini secara umum untuk mengetahui hubungan kondisi fisik rumah dan status gizi dengan insiden penyakit tuberkulosis paru. Penelitian ini adalah analitik kuantitatif dengan pendekatan Case Control. Populasi kasus dalam penelitian ini yaitu seluruh penderita Tuberkulosis Paru. Sampel penelitian yaitu 18 responden kelompok kasus dan 72 responden kelompok kontrol dengan menggunakan teknik Simple random sampling. Lokasi penelitian dilakukan di Wilayah Kerja Puskesmas Rejosari Kota Pekanbaru pada bulan Juli – Agustus 2020. Alat ukur yang digunakan yaitu kuesioner, roll meter, lux meter, dan timbangan berat badan. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Chi Square. Hasil uji statistik hubungan dari setiap variabel semuanya berhubungan dengan insiden penyakit tuberkulosis paru, yaitu variabel luas ventilasi (p = 0,002, OR = 7,857), kepadatan hunian (p = 0,003, OR = 5,500), pencahayaan (p = < 0,05, OR = 8,500), dan status gizi (p = 0,001, OR = 10,818). Diharapkan kepada tim pencegah dan pengendalian penyakit tuberkulosis paru Puskesmas Rejosari meningkatkan penyuluhan atau pemahaman langsung kepada masyarakat penderita TB paru serta membentuk dan melatih kader – kader untuk penanggulangan Tuberkulosis Paru. Diharapkan masyarakat selalu membuka jendela agar udara dan cahaya dapat masuk ke dalam rumah serta menjaga pola makan yang seimbang dan sehat. Pulmonary Tuberculosis is an infectious disease caused by the bacteria Mycobacterium tuberculosis. The incidence of pulmonary tuberculosis in Rejosari Primary Health Center Pekanbaru City is the highest case in Pekanbaru city with 798 cases. The purpose of this study in general was to determine the relationship between the physical condition of the house and nutritional status with the incidence of pulmonary tuberculosis. This research is a quantitative analytic with a Case Control approach. The populations of cases were all patients with pulmonary tuberculosis. The research sample was 18 respondents in the case group and 72 respondents in the control group using the simple random sampling technique. The research location was carried out in the Rejosari Public Health Center, Pekanbaru City in July - August 2020. The measuring instruments used were questionnaires, roll meters, lux meters, and weight scales. Data analysis was performed univariate and bivariate using the Chi Square test. The statistical test results of the relationship between each variable were all related to the incidence of pulmonary tuberculosis, namely the variable area of ventilation (p = 0.002, OR = 7.857), occupancy density (p = 0.003, OR = 5,500), lighting (p =0.05, OR 8.5)and nutritional status (p = 0.001, OR = 10.818). It is hoped that the team for preventing and controlling pulmonary tuberculosis at the Rejosari Community Health Center will increase direct education or understanding to people with pulmonary tuberculosis and form and train cadres to control pulmonary tuberculosis. It is hoped that people will always open windows so that air and light can enter the house and maintain a balanced and healthy diet.

scholarly journals Effect of Whole-course Nutrition Management on Patients with Esophageal Cancer Undergoing Concurrent Chemoradiotherapy: A Randomized Control Trial (P05-031-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yanfang Qiu ◽  
Jie You ◽  
Quanjun Lv ◽  
Ling Yuan
Keyword(s):  
Quality Of Life ◽  
Esophageal Cancer ◽  
Nutritional Status ◽  
Concurrent Chemoradiotherapy ◽  
Nutrition Support ◽  
Control Group ◽  
Observation Group ◽  
Skin Reactions ◽  
Nutrition Management

Abstract Objectives Malnutrition is the most common complication of patients with esophageal cancer, and can lead to poor prognosis and death. It has been shown that good nutritional status can help improve patient outcomes and reduce complications. In the absence of specific evidence of the effect of nutrition on patients with esophageal cancer, the purpose of this study was to investigate the effect of total nutrition management on the prognosis and complications of patients with esophageal cancer through a randomized controlled trial. Methods 96 patients with esophageal cancer concurrent chemoradiation were randomized to observation group (treated by whole-nutrition management from the Nutrition Support Group (NST)) and control group (treated by the general nutritional method) for 6 weeks approximately. Dietary survey, Patient-Generated Subjective Global Assessment (PG-SGA), body measurement, blood index, quality of life survey and psychological condition survey were assessed at baseline and every week/at the end of the study. Complications, the completion rates of therapy, short-term efficacy evaluation as well as clinical outcomes were measured before discharge. Results A total of 85 subjects completed the study (observation group = 45, control group = 40). There were significantly different in the changes in serum albumin, prealbumin, and total protein between two groups throughout the trial (P < 0.05). Radioactive esophagitis, skin symptom of the complications, the roles, emotional functions, social functions, and general health status in the quality of life were statistically different before and after the intervention (P < 0.05). The difference in the change of other indicators was not statistically significant. Conclusions Whole-course nutrition management can improve the nutritional status of patients with concurrent chemoradiotherapy of esophageal cancer, reduce the severity of radiation esophagitis and radiation skin reactions, improve the quality of life and relieve their depressive symptoms. Funding Sources Wu Jieping Medical Foundation Special Fund for Clinical Research of 2017.

Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

2019 ◽  
Vol 96 (1140) ◽  
pp. 600-605
Author(s):  
Tuba Tekin ◽  
Betül Çiçek ◽  
Nurefşan Konyalıgil ◽  
İnayet Güntürk ◽  
Cevat Yazıcı ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Nutritional Status ◽  
Blood Parameters ◽  
Control Group ◽  
Case Group ◽  
Hip Circumference ◽  
Anthropometric Indices ◽  
The Relationship ◽  
Positive Significant Correlation

BackgroundThis case–control study was conducted to investigate the relationship between serum nesfatin-1 levels and nutritional status and blood parameters in patients diagnosed with metabolic syndrome.MethodsThirty patients (case) diagnosed with metabolic syndrome according to National Cholesterol Education Program-Adult Treatment Panel III criteria were included. Thirty healthy subjects (control) matched with patients with metabolic syndrome in terms of age, gender and body mass index were included. Three-day food consumption records were obtained. Anthropometric indices were measured and body composition was determined by bioelectrical impedance method. Biochemical parameters and serum nesfatin-1 levels were measured after 8 hours of fasting.ResultsSerum nesfatin-1 levels were 0.245±0.272 ng/mL in the case group and 0.528±0.987 ng/mL in the control group (p>0.05). There was a positive significant correlation between serum nesfatin-1 levels and body weight, waist and hip circumferences in the case group (p<0.05). Each unit increase in hip circumference measurement affects the levels of nesfatin by 0.014 times. In the control group, there was a positive significant correlation between body weight and serum nesfatin-1 levels (p<0.05). A significant correlation was detected between HbA1c and serum nesfatin-1 levels in the case group (p<0.05). A significant relationship was detected between dietary fibre intake and the serum nesfatin-1 levels in the case group (p<0.05).ConclusionsAnthropometric indices and blood parameters were correlated with serum nesfatin-1 levels in patients with metabolic syndrome. More clinical trials may be performed to establish the relationship between serum nesfatin-1 levels and nutritional status.

scholarly journals Effect of Postoperative Oral Intake Status on Sarcopenia Six Months After Esophageal Cancer Surgery

2021 ◽  
Author(s):  
Nanako Hijikata ◽  
Aiko Ishikawa ◽  
Satoru Matsuda ◽  
Michiyuki Kawakami ◽  
Kaori Muraoka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Nutritional Status ◽  
Handgrip Strength ◽  
Tube Feeding ◽  
Multivariate Logistic Regression Analysis ◽  
Oral Intake ◽  
Skeletal Muscle Index ◽  
Swallowing Assessment

Abstract Purpose: In patients with esophageal cancer, skeletal muscle mass has been reported to decrease progressively after surgery and be independently associated with a poor prognosis. The purpose of this study was to investigate perioperative changes in dysphagia, oral intake status, and nutritional status and identify factors related to sarcopenia six months after esophagectomy.Methods: A total of 134 patients who underwent radical resection for thoracic esophageal cancer between March 2016 and July 2019 were analyzed retrospectively. The diagnosis of sarcopenia was made by CT taken six months postoperatively using the cut-off criteria of skeletal muscle index (SMI) <52.4 cm2/m2 for male and SMI <38.5 cm2/m2 for female patients. As factors related to postoperative sarcopenia, dysphagia, oral intake status, nutritional status, and physical function were extracted from the medical records. Multivariate logistic regression analysis was performed to identify perioperative risk factors related to sarcopenia six months after surgery.Results: Of the 134 patients, 34.3% were judged to be unable to start oral intake on swallowing assessment. At discharge, 30.6% received tube feeding with or without oral intake. In the non-oral intake group on swallowing assessment, a significantly higher proportion of patients received tube feeding at discharge (p=0.014). Preoperative BMI, postoperative handgrip strength, and tube feeding at discharge were independent risk factors for sarcopenia six months after esophagectomy in male patients.Conclusions: Oral intake status at discharge is significantly related to postoperative sarcopenia in patients with esophageal cancer. Identifying high-risk groups might allow early detection of malnutrition and provision of appropriate care.

scholarly journals Impact Exerted by Nutritional Risk Screening on Clinical Outcome of Patients with Esophageal Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Rui Wang ◽  
Hongfei Cai ◽  
Yang Li ◽  
Caiwen Chen ◽  
Youbin Cui
Keyword(s):  
Esophageal Cancer ◽  
Clinical Outcome ◽  
Nutritional Status ◽  
Serum Albumin ◽  
Nutritional Support ◽  
Nutritional Risk ◽  
Control Group ◽  
Risk Screening ◽  
The Impact ◽  
Nutritional Risk Screening

Objective. Preoperative nutritional status of patients is closely associated with their recovery after the surgery. This study aims to ascertain the impact exerted by the nutritional risk screening on clinical outcome of patients with esophageal cancer. Methods. 160 patients with esophageal cancer aged over 60, having got therapy at the First Hospital of Jilin University from Jun 2016 to Feb 2017 were evaluated by adopting the NRS2002. 80 cases of patients got active therapy of nutritional support, and the other patients not supported nutritionally were selected as the control group. The comparison was drawn between two groups in serum albumin, serum immunoglobulin, postoperative complications, hospitalization, and hospitalization expenses. Results. For all the patients, in 3 and 7 days after the surgery, the serum albumin in the nutritionally supported group outstripped that in group without nutritional support (P<0.05) regardless of the nutritional risk. For the patients in the risk of nutrition, the IgA in the nutritionally supported group outstripped that of group without nutritional support (P<0.05) in 3 and 7 days before the surgery, and the serum IgG outstripped that of the group without nutritional support in 1 and 3 days before the surgery (P<0.05). In terms of the patients in the risk of nutrition, the average hospitalization of nutritionally supported group was shorter (P<0.05), and the average hospitalization expenses were lower compared with those of the group without nutritional support. And for the patients in no risk, the hospitalization expenses of supported group surmounted those of group without nutritional support (P<0.05), whereas the average hospitalization took on no statistic difference (P>0.05). Conclusion. For the patients in the risk of nutrition, preoperative nutritional support can facilitate the nutritional status and immunization-relative result after surgery, which shall also decrease the average hospitalization and hospitalization cost.

scholarly journals Tuberkulosis Paru di Palembang, Sumatera Selatan

2011 ◽  
Vol 5 (5) ◽  
pp. 234
Author(s):  
Hery Unita Versitaria ◽  
Haryoto Kusnoputranto
Keyword(s):  
Nutritional Status ◽  
Age Groups ◽  
Control Group ◽  
Case Group ◽  
The Third ◽  
Source Of Infection ◽  
Lung Tuberculosis ◽  
Tract Disease ◽  
The Individual ◽  
The Relationship

Indonesia tercatat memiliki 304.787 penderita tuberkulosis yang menempatkannya pada peringkat ketiga terbanyak di dunia. Penyakit tuberkulosis merupakan penyebab kematian nomor 3 setelah penyakit kardiovaskuler dan penyakit saluran pernafasan pada semua kelompok usia serta nomor1 dari golongan penyakit infeksi. Angka kepadatan hunian rumah di Kota Palembang 5,84 lebih tinggi daripada angka ideal kepadatan hunian rumah. Penelitian ini bertujuan mengetahui hubungan antara sumber penular serumah, faktor lingkungan dalam rumah, dan karakteristik individu terhadap kejadian tuberkulosis paru basil tahan asam (BTA) (+) di Kota Palembang. Penelitian yang menggunakan desain kasus kontrol ini membandingkan kelompok kasus (BTA(+)) dan kelompok kontrol (BTA (-)) yang dilakukan di 16 wilayah kerja puskesmas dari 36 puskesmas yang ada di Kota Palembang. Model akhir diketahui bahwa variabel yang paling berpengaruh terhadap kejadian penyakit tuberkulosis paru BTA (+) adalah variabel status gizi. Seseorang yang bermukim di rumah dengan hunian kamar memiliki tingkat kepadatan tinggi (< 4 meter/orang), jenis kelamin lakilaki,dan status gizi yang buruk (indeks massa tubuh, IMT > 25,1 dan < 18,4) berisiko untuk menderita penyakit tuberkulosis paru BTA(+) 29 kali lebih besar dibanding orang yang tidak mempunyai faktor risiko tersebut. Kata kunci: Tuberkulosis, kepadatan hunian rumah, status giziAbstractIndonesia there were recorded 304.787 cases of tuberculosis that places at the third level in the world. Tuberculosis is the third level disease which caused of death after cardiovasculer and respiratori tract disease in all age groups and at the first level from all infectious disease. The residence densityrate in Palembang is higher 5,84 times than ideal rate. The objective of this study is aimed to evaluate the relationship between the source of infection in house, the environment in the house, and the individual characteristic with the occurrence of lung tuberculosis BTA (+) in Palembang City. The design of this study is case control comparing case group of tuberculosis(BTA (+)) and case of control group of BTA. This study was conducted in 16 work areas of 36 health centers in Palembang. In multivariat model, it is known that the closest relationship with the occurrence of tuberculosis is nutritional status. A person who lives with high density of residence (< 4 meter/ man), male, and bad status of nutrition (body mass index, BMI > 25,1 and < 18,4) has higher risk for having tuberculosis 29 times than who has not the risk factor.Key words: Tuberculosis, residence density rate, nutritional status

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