scholarly journals High Relative Abundance of Lactobacillus reuteri and Fructose Intake are Associated with Adiposity and Cardiometabolic Risk Factors in Children from Mexico City

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1207 ◽  
Author(s):  
Eira E. Huerta-Ávila ◽  
Ivonne Ramírez-Silva ◽  
Luisa E. Torres-Sánchez ◽  
Cinthya E. Díaz-Benítez ◽  
Yaneth C. Orbe-Orihuela ◽  
...  
Keyword(s):  
Relative Abundance ◽  
Metabolic Disorders ◽  
Cardiometabolic Risk ◽  
Lactobacillus Reuteri ◽  
High Tertile ◽  
Fructose Intake ◽  
Obesity And Diabetes ◽  
Cardiometabolic Risk Markers ◽  
Cardiometabolic Markers ◽  
Analysis Models

In Mexico, 3 of 10 children are overweight. Fructose intake and relative abundance (RA) of Lactobacillus reuteri (L. reuteri) in the intestinal microbiota are associated with obesity and diabetes in adults, but studies in children are limited. This study evaluates the association between fructose intake and L. reuteri RA with adiposity and cardiometabolic risk markers in Mexican children dietary information, microbiota profiles, adiposity indicators (Body Mass Index, BMI and Waste Circumference, WC), and cardiometabolic markers were analyzed in 1087 children aged 6–12 years. Linear regression and path analysis models were used. High-tertile fructose intake and L. reuteri RA were positively associated with BMI (βTertil 3 vs. Tertil 1 = 0.24 (95% CI, 0.04; 0.44) and βT3 vs. T1 = 0.52 (95% CI, 0.32; 0.72)) and WC (βT3 vs. T1 = 2.40 (95% CI, 0.93; 3.83) and βT3 vs. T1 = 3.40 (95% CI, 1.95; 4.90)), respectively. Also, these factors mediated by adiposity were positively correlated with high triglycerides and insulin concentrations and HOMA-IR (p ≤ 0.03) and negatively associated with HDL-C concentration (p < 0.01). High-tertile fructose intake and L. reuteri RA were directly associated with adiposity and indirectly associated though adiposity with metabolic disorders in children. In conclusion, fructose intake and L. reuteri RA were directly associated with adiposity and indirectly associated with metabolic disorders in children, mediated by adiposity.

Abstract 48: Plant-based Diet Index and Cardiometabolic Risk Markers: Exploring the Role of the Gut Microbiome

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Yanping Li ◽  
Ambika Satija ◽  
Dong Wang ◽  
Kerry L Ivey ◽  
Jun Li ◽  
...  
Keyword(s):  
Relative Abundance ◽  
Gut Microbiome ◽  
Cardiometabolic Risk ◽  
Linear Models ◽  
Risk Markers ◽  
Microbial Composition ◽  
Microbial Profile ◽  
Haemophilus Parainfluenzae ◽  
Using Data ◽  
Cardiometabolic Risk Markers

Objectives: To investigate the association between a plant-based diet index and microbial composition and functionality, as well as the inter-relationships between plant-based diets, gut microbiome, and cardiometabolic risk markers. Design and method: Metagenomic profiling was performed on 916 fecal samples collected among 301 men who participated in the Men’s Lifestyle Validation Study. Using data from a food frequency questionnaire, a Plant-based Diet Index (PDI) was derived to assess the adherence to a plant-based diets. The associations between PDI adherence and the relative abundance of microbial species and pathways were evaluated using Multivariate Association with Linear Models (MaAsLin2). P values below 0.25 after false discovery rate correction following the Benjamini-Hochberg method were considered statistically significant. Results: After multivariate adjustment, the value of the PDI score was significantly and positively associated with the ratio of Firmicutes to Bacteroidetes (Spearman r=0.10, P=0.005). Specifically, the PDI was significantly associated with the relative abundance of 77 taxa (including 39 species) out of 506 filtered taxa and 15 pathways (out of 80 filtered features). In particular, a higher adherence to the PDI was significantly, positively, associated with of the relative abundance of Firmicutes and of pathways involving degradation of complex plant carbohydrates. It was also inversely associated with the relative abundance of Bacteroidetes and Proteobacteria, as well as pathways involved in the urea cycle and amino acid biosynthesis. We also found that 14 species significantly interacted with PDI in modulating plasma ratio of TG to HDL-C. The association of PDI with lower TG to HDL ratio was significantly strengthened in the presence of the species positively correlated with the PDI score, such as Ruminococcus lactaris , Haemophilus parainfluenzae, and Methanobrevibacter smithii or in the absence of the species inversely correlated with the PDI score, such as Paraprevotella spp. Conclusions: A greater adherence to a plant-based diet was associated with a microbial profile featured by higher abundance of species in Firmicutes and depletion of species in Bacteroidetes and Proteobacteria, and such a profile may further strengthen the favorable associations between plant-based diets and human cardiometabolic risk.

The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling

2021 ◽  
Author(s):  
Junchao Wang ◽  
Wenjuan Xu ◽  
Rongjuan Wang ◽  
Rongrong Cheng ◽  
Zhengquan Tang ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Metabolic Disorders ◽  
Therapeutic Effects ◽  
Akkermansia Muciniphila ◽  
Intestinal Mucus ◽  
Obesity And Diabetes

Akkermansia muciniphila is a probiotic inhabiting host intestinal mucus layers and displays evident easing or therapeutic effects on host enteritis and metabolic disorders such as obesity and diabetes. The outer...

Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren

2021 ◽  
Author(s):  
Mariana De Santis Filgueiras ◽  
Milene Cristine Pessoa ◽  
Josefina Bressan ◽  
Fernanda Martins de Albuquerque ◽  
Lara Gomes Suhett ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Risk Markers ◽  
Anti Inflammatory ◽  
Cardiometabolic Risk Markers

scholarly journals Greater Fructose Consumption Is Associated with Cardiometabolic Risk Markers and Visceral Adiposity in Adolescents

2011 ◽  
Vol 142 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Norman K. Pollock ◽  
Vanessa Bundy ◽  
William Kanto ◽  
Catherine L. Davis ◽  
Paul J. Bernard ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Visceral Adiposity ◽  
Risk Markers ◽  
Cardiometabolic Risk Markers

Maternal fructose intake predisposes rat offspring to metabolic disorders via abnormal hepatic programming

2021 ◽  
Vol 35 (12) ◽  
Author(s):  
Eiji Munetsuna ◽  
Hiroya Yamada ◽  
Mirai Yamazaki ◽  
Yoshitaka Ando ◽  
Genki Mizuno ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Rat Offspring ◽  
Fructose Intake

scholarly journals Epigenetics as a Mechanism of Developmental Embodiment of Stress, Resilience, and Cardiometabolic Risk Across Generations of Latinx Immigrant Families

2021 ◽  
Vol 12 ◽  
Author(s):  
Elizabeth S. Clausing ◽  
Amy L. Non
Keyword(s):  
Blood Pressure ◽  
Dna Methylation ◽  
Cardiometabolic Risk ◽  
Immigrant Mothers ◽  
Mothers And Children ◽  
Related Stress ◽  
Cardiometabolic Risk Markers ◽  
The Life Course ◽  
Sociopolitical Climate

Psychosocial stressors can become embodied to alter biology throughout the life course in ways that may have lasting health consequences. Immigrants are particularly vulnerable to high burdens of stress, which have heightened in the current sociopolitical climate. This study is an investigation of how immigration-related stress (IRS) may impact the cardiometabolic risk and epigenetic markers of Latinx immigrant mothers and children in Nashville, TN. We compared stress and resilience factors reported by Latina immigrant mothers and their children (aged 5–13) from two time points spanning the 2016 U.S. presidential election (June 2015–June 2016 baseline, n = 81; March–September 2018 follow-up, n = 39) with cardiometabolic risk markers (BMI, waist circumference, and blood pressure). We also analyzed these factors in relation to DNA methylation in saliva of stress-related candidate genes (SLC6A4 and FKBP5), generated via bisulfite pyrosequencing (complete case n's range from 67–72 baseline and 29–31 follow-up) (n's range from 80 baseline to 36 follow-up). We found various associations with cardiometabolic risk, such as higher social support and greater acculturation were associated with lower BMI in mothers; discrimination and school stress associated with greater waist circumferences in children. Very few exposures associated with FKBP5, but various stressors associated with methylation at many sites in SLC6A4, including immigrant-related stress in both mothers and children, and fear of parent deportation in children. Additionally, in the mothers, total maternal stress, health stress, and subjective social status associated with methylation at multiple sites of SLC6A4. Acculturation associated with methylation in mothers in both genes, though directions of effect varied over time. We also find DNA methylation at SLC6A4 associates with measures of adiposity and blood pressure, suggesting that methylation may be on the pathway linking stress with cardiometabolic risk. More research is needed to determine the role of these epigenetic differences in contributing to embodiment of stress across generations.

scholarly journals Reducing prolonged sedentary time using a treadmill desk acutely improves cardiometabolic risk markers in male and female adults

2018 ◽  
Vol 36 (21) ◽  
pp. 2484-2491 ◽  
Author(s):  
Rachael B Champion ◽  
Lindsey R Smith ◽  
Jennifer Smith ◽  
Bogdana Hirlav ◽  
Benjamin D Maylor ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Sedentary Time ◽  
Risk Markers ◽  
Male And Female ◽  
Cardiometabolic Risk Markers

Associations of Vigorous Gardening With Cardiometabolic Risk Markers for Middle-Aged and Older Adults

2021 ◽  
pp. 1-7
Author(s):  
Jonathan Kingsley ◽  
Nyssa Hadgraft ◽  
Neville Owen ◽  
Takemi Sugiyama ◽  
David W. Dunstan ◽  
...  
Keyword(s):  
Older Adults ◽  
Cardiometabolic Risk ◽  
Cross Sectional Study ◽  
Cardiometabolic Health ◽  
Risk Markers ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Vigorous Intensity ◽  
And Gender ◽  
Cardiometabolic Risk Markers

This study investigates the associations of vigorous-intensity gardening time with cardiometabolic health risk markers. This cross-sectional study (AusDiab) analyzed 2011–2012 data of 3,664 adults (55% women, mean [range], age = 59.3 [34–94] years) in Australia. Multiple linear regression models examined associations of time spent participating in vigorous gardening (0, <150 min/week, ≥150 min/week) with a clustered cardiometabolic risk (CMR) score and its components, for the whole sample and stratified by age and gender. Of participants, 61% did no vigorous gardening, 23% reported <150 min/week, and 16% reported ≥150 min/week. In the whole sample, spending ≥150 min/week in vigorous gardening was associated with lower CMR (lower CMR score, waist circumference, diastolic blood pressure, and triglycerides) compared with no vigorous gardening. Stratified analyses suggested that these associations were almost exclusively observed for older adults and women. These findings suggest the public health potential of vigorous-intensity gardening in reducing CMR.

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