scholarly journals Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1161 ◽  
Author(s):  
Astrid S. Doorduijn ◽  
Marjolein Visser ◽  
Ondine van de Rest ◽  
Maartje I. Kester ◽  
Francisca A. de Leeuw ◽  
...  
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
Nutritional Status ◽  
Cognitive Performance ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Fat Free Mass ◽  
Regression Analyses ◽  
Cognitive Domains ◽  
Gender And Education

As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.

scholarly journals Relationship Between Body Composition and Nutritional Status in Brazilian Nonagenarians

2019 ◽  
Vol 4 (1) ◽  
pp. 31-41
Author(s):  
Claudia Aline Oliveira Safian ◽  
Ângelo José Gonçalves Bós
Keyword(s):  
Body Composition ◽  
Nutritional Status ◽  
Fat Mass ◽  
Nutritional Assessment ◽  
Age Distribution ◽  
Mini Nutritional Assessment ◽  
Nutritional Risk ◽  
Joint Analysis ◽  
Anthropometric Parameters ◽  
Ideal Weight

Introduction Brazil has undergone considerable changes in age distribution, particularly in nonagenarians. Allied to this reality, there is a series of nutritional disorders in this population segment. An important factor related to quality of life and healthy aging is good nutrition throughout life. Objective To observe the possible relationship between nutritional status and body composition in nonagenarians. Methodology This is a descriptive, cross-sectional and analytical study, with participants aged 90 years or older, evaluated using the Mini Nutritional Assessment (MNA), anthropometric parameters, and Bioimpedance. Results The sample consisted of 72 nonagenarians, averaging in age 93.7 years, most female (72%), white (82%) and widowed (64%), 19.4% were in nutritional risk, based on the MNA criteria. All anthropometric parameters presented lower averages among nonagenarians in nutritional risk. Regarding the bioimpedance parameters, in general the risk-free nonagenarians presented higher averages of weight, maximum ideal weight, minimum ideal weight, BMI, lean-mass, fat-mass, percentage of fat-mass and minimum percentage of fat-mass. Conclusions Most nonagenarians were in good nutritional status. Both anthropometric and bioimpedance parameters were effective to discriminate between normal and at nutritional risk nonagenarians. We also concluded that nutritional risk assessment in nonagenarians patients requires a joint analysis of the several existing methods for the nutritional evaluation, in order to obtain global diagnosis and accurate analysis of the nutritional status of the nonagenarians.

scholarly journals Wybrane pomiary antropometryczne i MNA (mini nutritional assessment) a niektóre czynniki predykcyjne niedożywienia osób starszych

2018 ◽  
Vol 64 (4) ◽  
Author(s):  
Mariola Głowacka ◽  
Beata Haor ◽  
Paulina Zabielska ◽  
Anna Jurczak ◽  
Monika Biercewicz ◽  
...  
Keyword(s):  
Body Composition ◽  
Nutritional Status ◽  
Elderly People ◽  
Nutritional Assessment ◽  
Senior Citizens ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Overweight And Obesity ◽  
Anthropometric Measurements ◽  
Initiating Factors

ABSTRACTIntroduction: To a vast extent the body’s ageing process affects changes in the human nutritional status and body composition. The nutritional status of elderly people is assessed by means of nutritional history, physical examinations, somatometric measurements, biochemical and immunological tests. Moreover, survey tools (questionnaires, scales) are used in order to perform a screening and in-depth analysis of food intake and nutrition in the elderly. Today, an accurate assessment of body composition is conducted by means of specialist devices, such as those used for bioelectrical impedance analysis and dual X-ray absorptiometry.The objective of the thesis was to analyse the usage of selected anthropometric measurements in correspondence with an mini nutritional assessment (MNA) in studies on the identification of undernourishment in seniors, with consideration of some of the initiating factors of nourishment disorders in the population of the elderly.Methods: A review of articles considered essential from the point of view of the study objective was performed by analysing the PubMed database. The search query used was: “mini nutritional assessment MNA elderly”.Results: Nutritional status measured with the MNA may evaluate the way seniors feel. Overweight and obesity usually results in a worse assessment of the quality of the elderly’s life. A disordered nutritional status could stem from a range of medical, psychological and social factors.Conclusions: The results of anthropometric measurements are essential for an optimal identification of the risk of undernourishment in senior citizens by means of an MNA. They also complement information onthe initiating factors of eating disorders in the population of elderly people. In order to be able to widely use anthropometric measurements to complement knowledge on the nutritional status of the elderly, it is indispensable to conduct studies among healthy senior citizens to obtain information that will serve as reference data.

scholarly journals Riesgo de desnutrición y factores asociados en una muestra de adultos mayores en la comunidad e institucionalizados de Yucatán, México

2020 ◽  
Vol 70 (1) ◽  
pp. 30-39
Author(s):  
Luis Ricardo González-Franco ◽  
Rogelio González-Arellanes ◽  
Maribel Ramírez Torres ◽  
Heliodoro Alemán Mateo
Keyword(s):  
Older Adults ◽  
Regression Analysis ◽  
Nutritional Status ◽  
Associated Factors ◽  
Nutritional Assessment ◽  
Multiple Logistic Regression Analysis ◽  
Mini Nutritional Assessment ◽  
Geriatric Care ◽  
Fat Free Mass ◽  
Kolmogorov Smirnov

Evaluar la prevalencia de riesgo de desnutrición (RD) en adultos mayores de dos municipios de Yucatán, México, e identificar algunos factores asociados. Estudio transversal con muestreo intencional no probabilístico en 6 centros de atención geriátrica, una clínica universitaria y visitas domiciliares. Noventa y seis adultos mayores de 60 años (76% mujeres), 42 residentes de estancias geriátricas y 54 no institucionalizados. Se evaluó el RD con la escala de Valoración Mínima del Estado de Nutrición (VMEN), junto con variables demográficas, de funcionalidad, comorbilidades, depresión y apetito. La composición corporal se evaluó con ecuaciones basadas en antropometría e impedancia bioeléctrica. Se realizaron análisis descriptivos, t de Student, Kolmogorov-Smirnov, chi cuadrado, análisis univariado y análisis de regresión múltiple. El 47,9 % (46 sujetos; 37 mujeres y 9 varones) presentaron RD de acuerdo con la VMEN y 52,1% de los participantes fueron clasificados con estado nutricio normal de acuerdo con dicha escala. Los valores promedio de la masa corporal libre de grasa y la masa muscular esquelética en extremidades de sujetos con RD, fueron más bajos que en aquellos con estado de nutrición normal (p< 0,05). El análisis de regresión logístico múltiple ajustado por género indicó que la edad (OR=1,08, p=0,005) y la depresión (OR=3,79, p=0,017) fueron factores predictores asociados con RD. El 47,9 % de los participantes presentaron RD. Se requieren acciones para diagnosticar y atender el RD y evitar que progrese a desnutrición. La edad y la depresión se debieran incluir como posibles marcadores tempranos de desnutrición en futuros estudios poblacionales e intervenciones nutricionales en adultos mayores en comunidad e institucionalizados en Yucatán. To assess the prevalence of Malnutrition Risk (MR) in older adults from two municipalities of Yucatan, Mexico, and to identify some associated factors. Cross-sectional study, using non-probabilistic sample in six geriatric care centers, a university clinic, and home visits. Ninety-six adults over 60 years (76% women), 42 residents of geriatric care homes, and 54 non-institutionalized. The MR was assessed by the Mini Nutritional Assessment scale (MNA), along with demographic, functionality, comorbidities, depression, and appetite variables. Body composition was also assessed by bioelectrical impedance analysis. Descriptive analyzes, Student's t, Kolmogorov-Smirnov, chi-square, univariate, and multiple regression analysis were performed. Of the total sample, 47.9% (46 subjects; 37 women and 9 men) presented RD according to the VMEN and 52.1% of the participants were classified with normal nutritional status according to the scale. Mean values of fat-free mass and appendicular skeletal muscle mass were lower in subjects with MR than in those with normal nutritional status (p <0.05). The multiple logistic regression analysis adjusted by gender indicated that age (OR = 1.08, p = 0.005) and depression (OR = 3.79, p = 0.017) were predictor associated factors with MR. Almost forty eight percent of the participants present MR. Actions are required to diagnose and treat MR, avoiding progressing to malnutrition. Age and depression should be included as possible early markers of malnutrition in future population studies and nutritional interventions, in the community and institutionalized older adults in Yucatan.

scholarly journals Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Till Ittermann ◽  
Marcello R. P. Markus ◽  
Martin Bahls ◽  
Stephan B. Felix ◽  
Antje Steveling ◽  
...  
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
Cell Mass ◽  
The Elderly ◽  
Fat Free Mass ◽  
Body Cell Mass ◽  
Body Cell ◽  
Independent Population ◽  
Serum Tsh ◽  
Tsh Levels

AbstractPrevious studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania. The study population included 5656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β = 0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β = 0.35; 95% CI: 0.08 to 0.62) and FM (β = 0.32; 95% CI: 0.12 to 0.52), but not with FFM and BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.

Influence of maternal pre-pregnancy nutritional status on offspring anthropometric measurements and body composition in three Brazilian Birth Cohorts

2020 ◽  
pp. 1-13
Author(s):  
Mariane da Silva Dias ◽  
Alicia Matijasevich ◽  
Aluísio JD Barros ◽  
Ana Maria B. Menezes ◽  
Bruna Celestino Schneider ◽  
...  
Keyword(s):  
Body Composition ◽  
Birth Weight ◽  
Waist Circumference ◽  
Nutritional Status ◽  
Normal Weight ◽  
Birth Cohort Study ◽  
Birth Cohorts ◽  
Mediation Analyses ◽  
Association Pattern ◽  
Maternity Hospitals

Abstract Objective: We aimed at evaluating the association of maternal pre-pregnancy nutritional status with offspring anthropometry and body composition. We also evaluated whether these associations were modified by gender, diet and physical activity and mediated by birth weight. Design: Birth cohort study. Setting: Waist circumference was measured with an inextensible tape, and fat and lean mass were measured using dual-energy X-ray absorptiometry. Multiple linear regression was used to adjust for possible confounders and allele score of BMI. We carried out mediation analysis using G-formula. Participants: In 1982, 1993 and 2004, all maternity hospitals in Pelotas (South Brazil) were visited daily and all live births whose families lived in the urban area of the city were evaluated. These subjects have been followed up at different ages. Results: Offspring of obese mothers had on average higher BMI, waist circumference and fat mass index than those of normal weight mothers, and these differences were higher among daughters. The magnitudes of the association were similar in the cohorts, except for height, where the association pattern was not clear. In the 1982 cohort, further adjustment for a BMI allele score had no material influence on the magnitude of the associations. Mediation analyses showed that birth weight captured part of this association. Conclusions: Our findings suggest that maternal pre-pregnancy nutritional status is positively associated with offspring BMI and adiposity in offspring. And this association is higher among daughters whose mother was overweight or obese and, birth weight explains part of this association.

Association of GDF15 With Inflammation and Physical Function During Aging and Recovery After Acute Hospitalization: A Longitudinal Study of Older Patients and Age-Matched Controls

2021 ◽  
Author(s):  
Juliette Tavenier ◽  
Line Jee Hartmann Rasmussen ◽  
Aino Leegaard Andersen ◽  
Morten Baltzer Houlind ◽  
Anne Langkilde ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Physical Function ◽  
Plasma Levels ◽  
Older Patients ◽  
Nutritional Assessment ◽  
Short Form ◽  
Mini Nutritional Assessment ◽  
Acute Illness ◽  
Urokinase Plasminogen Activator Receptor

Abstract Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Its plasma levels increase during aging and acute illness. In older Patients and age-matched Controls, we evaluated whether GDF15 levels (i) were associated with recovery after acute illness, and (ii) reflected different trajectories of aging and longitudinal changes in health measures. Fifty-two older Patients (≥65 years) were included upon admission to the emergency department (ED). At 30 days after discharge (time of matching), Patients were matched 1:1 on age and sex with Controls who had not been hospitalized within 2 years of inclusion. Both groups were followed up after 1 year. We assessed plasma levels of GDF15 and inflammatory biomarkers, frailty, nutritional status (mini nutritional assessment short-form), physical and cognitive function, and metabolic biomarkers. In Patients, elevated GDF15 levels at ED admission were associated with poorer resolution of inflammation (soluble urokinase plasminogen activator receptor [suPAR]), slowing of gait speed, and declining nutritional status between admission and 30-day follow-up. At time of matching, Patients were frailer and overall less healthy than age-matched Controls. GDF15 levels were significantly associated with participant group, on average Patients had almost 60% higher GDF15 than age-matched Controls, and this difference was partly mediated by reduced physical function. Increases in GDF15 levels between time of matching and 1-year follow-up were associated with increases in levels of interleukin-6 in Patients, and tumor necrosis factor-α and suPAR in age-matched Controls. In older adults, elevated GDF15 levels were associated with signs of accelerated aging and with poorer recovery after acute illness.

Effect of the Mini Nutritional Assessment-Short Form (MNA-SF) in Elderly Burn Patients

2021 ◽  
Author(s):  
Jia-Yu Wei ◽  
Shu-Ting Shi ◽  
Dan Sun ◽  
Guo-Zhong Lyu
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Short Form ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Reference Points ◽  
Nutrition Intervention ◽  
Burn Patients ◽  
Cross Sectional

Abstract Objective Nutritional assessment can early identify patients who are malnourished and at risk of malnutrition. To examine the effect of nutritional status on wound healing in elderly burn patients, we used the MNA-SF to measure the nutritional status of elderly patients. This study aimed to examine the role of MNA-SF in elderly burn patients through the correlation analysis of wound-healing indicators and MNA-SF score. Design Prospective observational and cross-sectional study. Methods This study used the MNA-SF to investigate the elderly burn patients at the department of burn. According to the score, the patients fell into three groups: good nutritional status (more than 12 points), malnutrition risk (8~11 points), and malnutrition (0~7 points). At the same time, we measured and compared the wound-healing indicators among the three groups of patients, and detected the correlation. Results The statistical analysis found gender had a slight influence on the score of nutritional status. While age was negatively correlated with the MNA-SF score and nutrition-related indicators. There was a low positive linear correlation between the wound healing percent area change or wound healing rate of patients and the score of the MNA-SF. Conclusion This study finds malnutrition is common among hospitalized elderly burn patients. The application of the MNA-SF in elderly burn patients is efficient and accurate to identify malnutrition early and prevent further obstruction of the normal wound healing, which can provide reference points for early nutrition intervention programs.

scholarly journals Food Services Using Energy- and Protein-Fortified Meals to Assist Vulnerable Community-Residing Older Adults Meet Their Dietary Requirements and Maintain Good Health and Quality of Life: Findings from a Pilot Study

Geriatrics ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 60 ◽  
Author(s):  
Tony Arjuna ◽  
Michelle Miller ◽  
Tomoko Ueno ◽  
Renuka Visvanathan ◽  
Kylie Lange ◽  
...  
Keyword(s):  
Older Adults ◽  
Nutritional Status ◽  
G Protein ◽  
Protein Intake ◽  
Nutritional Assessment ◽  
Food Service ◽  
Mini Nutritional Assessment ◽  
Good Health ◽  
Control Group ◽  
Fortified Food

The effects of “standard (STD)” vs. “protein- and energy-enriched (HEHP)” food-service meals on the nutrient intake, nutritional status, functional capacity, and wellbeing of older adults was investigated using a 12 week, double-blinded, parallel group design. All participants received dietetics counseling and either an STD (2.3 MJ and 30 g protein per meal) or a HEHP (4.6 MJ and 60 g protein) hot lunchtime meal for at least 3 days/week; those who did not want food-service meals were included in the control group (CON). Twenty-nine participants completed the study (STD = 7; HEHP = 12; CON = 10). From baseline to week 12, the HEHP subjects increased their mean daily energy intake from 6151 ± 376 kJ to 8228 ± 642 kJ (p = 0.002 for effect of time) and protein intake from 67 ± 4 g to 86 ± 8 g (p = 0.014 for effect of time). The MNA (Mini Nutritional Assessment) score was increased significantly in HEHP by 4.0 ± 1.1 points (p = 0.001), but not in the STD and CON groups (2.8 ± 2.1 points and 1.8 ± 1.1 points, p > 0.05). No difference was found for other clinical outcomes between the groups. The findings indicate that provision of HEHP-fortified food-service meals can increase energy and protein intake and improve the nutritional status of nutritionally at-risk older people.

scholarly journals Serum Leptin Levels, Nutritional Status, and the Risk of Healthcare-Associated Infections in Hospitalized Older Adults

Nutrients ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 226
Author(s):  
Elena Paillaud ◽  
Johanne Poisson ◽  
Clemence Granier ◽  
Antonin Ginguay ◽  
Anne Plonquet ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Healthcare Associated Infections ◽  
Serum Leptin ◽  
Protein Levels ◽  
Reactive Protein ◽  
Cell Counts ◽  
Hospitalized Older Adults ◽  
Healthcare Associated

We aimed to determine whether serum leptin levels are predictive of the occurrence of healthcare-associated infections (HAIs) in hospitalized older patients. In a prospective cohort, 232 patients had available data for leptin and were monitored for HAIs for 3 months. Admission data included comorbidities, invasive procedures, the Mini Nutritional Assessment (MNA), BMI, leptin, albumin and C-reactive protein levels, and CD4 and CD8 T-cell counts. Multivariate logistic regression modelling was used to identify predictors of HAIs. Of the 232 patients (median age: 84.8; females: 72.4%), 89 (38.4%) experienced HAIs. The leptin level was associated with the BMI (p < 0.0001) and MNA (p < 0.0001) categories. Women who experienced HAIs had significantly lower leptin levels than those who did not (5.9 μg/L (2.6–17.7) and 11.8 (4.6–26.3), respectively; p = 0.01; odds ratio (OR) (95% confidence interval): 0.67 (0.49–0.90)); no such association was observed for men. In a multivariate analysis of the women, a lower leptin level was significantly associated with HAIs (OR = 0.70 (0.49–0.97)), independently of comorbidities, invasive medical procedures, and immune status. However, leptin was not significantly associated with HAIs after adjustments for malnutrition (p = 0.26) or albuminemia (p = 0.15)—suggesting that in older women, the association between serum leptin levels and subsequent HAIs is mediated by nutritional status.

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