scholarly journals Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1053 ◽  
Author(s):  
Anna Bednarska-Czerwińska ◽  
Katarzyna Olszak-Wąsik ◽  
Anita Olejek ◽  
Michał Czerwiński ◽  
Andrzej Tukiendorf
Keyword(s):  
Vitamin D ◽  
Change Point ◽  
Controlled Ovarian Hyperstimulation ◽  
Infertility Treatment ◽  
Point Problem ◽  
Vitro Fertilization ◽  
Change Point Problem ◽  
Vitamin D Levels ◽  
The Relationship

Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH ≥ 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/mL; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing “change-point problem” was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment.

BAYESIAN IDENTIFICATION OF OUTLIERS AND CHANGE-POINTS IN MEASUREMENT ERROR MODELS

2005 ◽  
Vol 08 (04) ◽  
pp. 433-449 ◽  
Author(s):  
FERNANDO A. QUINTANA ◽  
PILAR L. IGLESIAS ◽  
HELENO BOLFARINE
Keyword(s):  
Linear Regression ◽  
Outlier Detection ◽  
Change Point ◽  
Regression Models ◽  
Point Problem ◽  
Linear Regression Models ◽  
Outlier Identification ◽  
Change Point Problem ◽  
Error In Variables ◽  
The Relationship

The problem of outlier and change-point identification has received considerable attention in traditional linear regression models from both, classical and Bayesian standpoints. In contrast, for the case of regression models with measurement errors, also known as error-in-variables models, the corresponding literature is scarce and largely focused on classical solutions for the normal case. The main object of this paper is to propose clustering algorithms for outlier detection and change-point identification in scale mixture of error-in-variables models. We propose an approach based on product partition models (PPMs) which allows one to study clustering for the models under consideration. This includes the change-point problem and outlier detection as special cases. The outlier identification problem is approached by adapting the algorithms developed by Quintana and Iglesias [32] for simple linear regression models. A special algorithm is developed for the change-point problem which can be applied in a more general setup. The methods are illustrated with two applications: (i) outlier identification in a problem involving the relationship between two methods for measuring serum kanamycin in blood samples from babies, and (ii) change-point identification in the relationship between the monthly dollar volume of sales on the Boston Stock Exchange and the combined monthly dollar volumes for the New York and American Stock Exchanges.

scholarly journals Association between Vitamin D Levels and Fertility Outcomes in Patients Undergoing IVF/ICSI

2020 ◽  
Vol 02 (03) ◽  
pp. 85-92
Author(s):  
Anh N. Ha ◽  
Toan D. Pham ◽  
Lan N. Vuong
Keyword(s):  
Vitamin D ◽  
Pregnancy Rates ◽  
Ongoing Pregnancy ◽  
Ongoing Pregnancy Rate ◽  
Metabolizing Enzymes ◽  
Vitro Fertilization ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Icsi Outcomes

Background: Several studies have demonstrated that vitamin D (vitD) might play an important role in the reproductive system due to expression of vitD receptor and vitD-metabolizing enzymes in many reproductive tissues. VitD deficiency has been associated with increased risk of obstetric complications. However, the effect of vitD levels on in vitro fertilization (IVF)/ICSI outcomes is not fully understood. Evidence shows that women with adequate vitD levels might have higher pregnancy rates. This study evaluated the association between serum vitD levels and IVF/ICSI outcomes. Methods: This multicenter, retrospective cohort study was conducted at IVFMD, My Duc Hospital and IVFMDPN, My Duc Phu Nhuan Hospital, Ho Chi Minh City, Vietnam between November 2017 and July 2019. Vietnamese patients aged 18–40 years with serum vitD (25(OH)D) samples collected before starting controlled ovarian stimulation and undergoing embryo transfer were eligible. Patients were divided into four groups based on 25(OH)D levels: <10 ng/mL, 10 to <20 ng/mL, 20 to <30 ng/mL, and [Formula: see text]30 ng/mL. The primary outcome was ongoing pregnancy rate. Results: Of 3779 patients recruited, 25(OH)D levels were <10 ng/mL in 564 (14.9%), 10 to <20 ng/mL in 436 (11.5%), 20 to <30 in 1,142 (30.2%), and [Formula: see text]30 ng/mL in 1,637 (43.3%). Ongoing pregnancy rates were similar across the four subgroups (36%, 40%, 36%, and 36%, respectively; p = 0.409). The number of oocytes retrieved, embryos, clinical pregnancy, implantation, and miscarriage rates did not differ significantly between subgroups. Conclusions: In this analysis, serum vitD levels did not appear to be correlated with pregnancy outcomes in patients undergoing IVF/ICSI.

Is there a role for vitamin D in human reproduction?

2016 ◽  
Vol 25 (1) ◽  
Author(s):  
Anindita Nandi ◽  
Nandita Sinha ◽  
Erwyn Ong ◽  
Halis Sonmez ◽  
Leonid Poretsky
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Human Reproduction ◽  
Bone Modeling ◽  
Metabolizing Enzymes ◽  
Vitro Fertilization ◽  
Vitamin D Levels ◽  
Autoimmune Conditions

AbstractVitamin D is a steroid hormone with canonical roles in calcium metabolism and bone modeling. However, in recent years there has been a growing body of literature presenting associations between vitamin D levels and a variety of disease processes, including metabolic disorders such as diabetes and prediabetes and autoimmune conditions such as thyroid disease. This review focuses on the potential role of vitamin D in both male and female reproductive function. The vitamin D receptor (VDR) is expressed throughout central and peripheral organs of reproduction. VDR is often co-localized with its metabolizing enzymes, suggesting the importance of tissue specific modulation of active vitamin D levels. Both animal and human studies in males links vitamin D deficiency with hypogonadism and decreased fertility. In females, there is evidence for its role in polycystic ovary syndrome (PCOS), endometriosis, leiomyomas, in-vitro fertilization, and pregnancy outcomes. Studies evaluating the effects of replacing vitamin D have shown variable results. There remains some concern that the effects of vitamin D on reproduction are not direct, but rather secondary to the accompanying hypocalcemia or estrogen dysregulation.

Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles

2014 ◽  
Vol 101 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Briana J. Rudick ◽  
Sue Ann Ingles ◽  
Karine Chung ◽  
Frank Z. Stanczyk ◽  
Richard J. Paulson ◽  
...  
Keyword(s):  
Vitamin D ◽  
In Vitro Fertilization ◽  
Vitro Fertilization ◽  
Vitamin D Levels

Thickness of endometrium: predictor of the effectiveness of IVF/ICSI programs (literature review)

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 113-116
Author(s):  
L A Bagdasaryan ◽  
I E Korneyeva
Keyword(s):  
Assisted Reproductive Technologies ◽  
Endometrial Thickness ◽  
Molecular Genetic ◽  
Uterine Cavity ◽  
Reproductive Technologies ◽  
Genetic Characteristics ◽  
Vitro Fertilization ◽  
Need To Evaluate ◽  
The Relationship

The aim of the study is to systematically analyze the data available in the modern literature on the relationship between endometrial thickness and the frequency of pregnancy in the program of assisted reproductive technologies (ART). Materials and methods. The review includes data from foreign and domestic articles found in PubMed on this topic. Results. The article presents data on the relationship between the thickness of the endometrium and the frequency of pregnancy in ART programs. The greatest number of studies is devoted to the evaluation of the relationship between the thickness of the endometrium and the frequency of pregnancy on the day of the ovulation trigger. Data are presented on the existence of a correlation between the thickness of the endometrium measured on the day of the ovulation trigger and the frequency of clinical pregnancy, as well as data on the need to evaluate the structure of the endometrium and the state of subendometric blood flow. The importance of multilayered (three-layered) endometrium as a prognostic marker of success in in vitro fertilization/intracytoplasmic sperm injection programs in the ovum is emphasized. The conclusion. The thickness of the endometrium can not be used as an argument for canceling the cycle or abolishing embryo transfer to the uterine cavity. Further studies in this direction are needed with a study of the morphological and molecular genetic characteristics of the endometrium, which in the future will allow us to evaluate the relationship between the thickness of the endometrium and the probability of pregnancy.

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