scholarly journals Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 922 ◽  
Author(s):  
Siew Lim ◽  
Vincent L. Versace ◽  
Sharleen O’Reilly ◽  
Edward Janus ◽  
James Dunbar
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Weight Change ◽  
Diabetes Prevention ◽  
Density Lipoprotein ◽  
The Other ◽  
Postpartum Women ◽  
Weight Loss Group ◽  
History Of

Weight gain after childbirth is a significant risk factor for type 2 diabetes (T2DM) development after gestational diabetes mellitus (GDM). The level of weight loss achieved in diabetes prevention programs for women after GDM is often low but its effects on the cardiometabolic risk are not known. In a secondary analysis of a diabetes prevention program in postpartum women with history of gestational diabetes, we evaluated the effect of weight change on the cardiometabolic outcomes at 1-year follow-up. Of the 284 women randomized to the intervention arm, 206 with the final outcome measurements were included in the analyses. Participants were categorized into weight loss (>2 kg, n = 74), weight stable (±2 kg, n = 74) or weight gain (>2 kg, n = 58) groups. The weight loss group had significantly greater decrease in glycated hemoglobin (HbA1c) than the weight gain group (−0.1 + 0.4% vs. 0 + 0.4%, p = 0.049). The weight loss group had significantly greater decrease in total cholesterol and low-density lipoprotein cholesterol cholesterol than the other two groups (p < 0.05). The weight gain group had significantly greater increase in triglyceride and triglyceride:high-density lipoprotein cholesterol ratio compare with the other groups (p < 0.01). Overall, a small amount of weight loss and prevention of further weight gain was beneficial to the cardiometabolic outcomes of postpartum women after GDM.

Abstract P051: Lifestyle Change In Mid-life And Long-term Weight Gain In Women With And Without History Of Gestational Diabetes Mellitus

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Jiaxi Yang ◽  
Janet Rich-Edwards ◽  
Molin Wang ◽  
Wafaie W Fawzi ◽  
Cuilin Zhang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Body Weight ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Weight Change ◽  
Lifestyle Change ◽  
History Of

Introduction: Identifying strategies to mitigate gradual long-term weight gain is critical for preventing obesity and its related chronic diseases, particularly for persons at high risk, such as women with a history of gestational diabetes mellitus (GDM). We prospectively examined the independent associations between lifestyle changes in mid-life with long-term weight change among women with and without a history of GDM. Hypothesis: We hypothesized that favorable improvements in lifestyle would be associated with less long-term weight gain, particularly among women with a history of GDM. Methods: We used data from the longitudinal Nurses’ Health Study II, with self-reported lifestyle, diet via food frequency questionnaire, and body weight updated every 2-4 years. We analyzed repeated 4-year changes of the following lifestyle factors among parous women after age 40: adherence to a healthy dietary pattern (Alternate Healthy Eating Index score [AHEI]), physical activity (MET-hrs/wk), moderate alcohol intake (servings/d), and non-smoking, in relation to concurrent 4-year change in body weight (lb). We used multivariable generalized estimating equation models to estimate the least-squares mean of 4-year weight change and 95% confidence interval (CI) for each lifestyle change category (e.g., decrease, remain stable, and increase). Results: Our analysis included 61,637 women, of which 3,444 (5.6%) had a history of GDM. Mean of repeated 4-year weight change after age 40 was 3.0 lb (SD=14.3). Improving diet was associated with favorable 4-year weight change, particularly among women with a history of GDM vs. without GDM (AHEI score change from low to high: -6.3 lb [CI: -9.3, -3.4] vs. -2.7 lb [CI: -3.2, -2.2], respectively; p-interaction=0.04). Increasing physical activity was associated with weight maintenance for GDM women only (MET-hrs/wk change from low to high: 0.6 lb [95% CI: -0.6, 1.7] vs. 2.0 lb [95% CI: 1.8, 2.2] for GDM vs. non-GDM, respectively; p-interaction=0.01). Reducing alcohol (decreased servings/d: 1.9 lb [95% CI: 1.2, 2.6] and 2.8 lb [95% CI: 2.6, 2.9] for GDM vs. non-GDM, respectively) and smoking cessation (recent quitter: 9.8 lb [95% CI: 7.1, 12.5] and 8.5 lb [95% CI: 8.0, 9.1] for GDM vs. non-GDM, respectively) were associated with similar patterns in weight change for women with and without prior GDM. Further, the joint association of improving both diet and physical activity from low to high was related to -12.3 lb (95% CI: -19.5, -5.0) and -6.1 lb (95% CI: -8.0, -4.2) of weight loss for GDM vs. non-GDM women, respectively. Conclusions: We observed that attainable improvements in diet quality and physical activity were associated with weight gain prevention. These findings support continued efforts to improve lifestyle as a beneficial strategy to prevent long-term weight gain, particularly among women with a history of GDM.

scholarly journals Lifestyle Changes and Long-Term Weight Gain in Women With and Without a History of Gestational Diabetes Mellitus: A Prospective Study of 54,062 Women in the Nurses' Health Study II

2021 ◽  
Author(s):  
Jiaxi Yang ◽  
Cuilin Zhang ◽  
Jorge E. Chavarro ◽  
Janet W. Rich-Edwards ◽  
Molin Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Diet Quality ◽  
Weight Change ◽  
Healthy Eating Index ◽  
Health Study ◽  
Total N ◽  
History Of

<b>Objective</b> We examined lifestyle factors with mid-life weight change according to history of gestational diabetes mellitus (GDM) in a large longitudinal female cohort. <p><b>Research Design and Methods </b>In the Nurses’ Health Study II, we categorized change in lifestyle within 4-year periods and estimated their associations with concurrent change in body weight (kg) among parous women after age 40 for the following: diet quality (Alternate Healthy Eating Index [AHEI]), leisure-time physical activity (PA), alcohol, and smoking, by GDM history status <a>(total n=54,062, 5</a>.3% with a history of GDM). </p> <p><b>Results </b>Over a median follow-up of 13 years, average 4-year weight gain was 1.10 kg and 1.33 kg for women with and without prior GDM, respectively. Women improving diet quality had favorable 4-year weight change, particularly among women with a history of GDM (AHEI change from low to high: -2.97 kg [CI: -4.34, -1.60] vs. -1.19 kg [CI: -1.41, -0.96] for GDM vs. non-GDM, respectively; <i>p</i>-heterogeneity=0.04). Increasing PA was associated with weight maintenance for GDM women only (PA increase from low to high: 0.26 kg [95% CI: -0.25, 0.77] vs. 0.90 kg [95% CI: 0.80, 1.01] for GDM vs. non-GDM, respectively; <i>p</i>-heterogeneity=0.02). For both GDM and non-GDM women, weight change did not differ significantly with change in alcohol, while women who quit smoking had significant weight gain (4.38 kg for GDM and 3.85 kg for non-GDM).</p> <p><b>Conclusions </b>Improvements in diet quality and PA were related to less weight gain in mid-life among parous women, and the benefit of such improvements on weight management was particularly pronounced among women with a history of GDM.</p>

scholarly journals Lifestyle Changes and Long-Term Weight Gain in Women With and Without a History of Gestational Diabetes Mellitus: A Prospective Study of 54,062 Women in the Nurses' Health Study II

2021 ◽  
Author(s):  
Jiaxi Yang ◽  
Cuilin Zhang ◽  
Jorge E. Chavarro ◽  
Janet W. Rich-Edwards ◽  
Molin Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Diet Quality ◽  
Weight Change ◽  
Healthy Eating Index ◽  
Health Study ◽  
Total N ◽  
History Of

<b>Objective</b> We examined lifestyle factors with mid-life weight change according to history of gestational diabetes mellitus (GDM) in a large longitudinal female cohort. <p><b>Research Design and Methods </b>In the Nurses’ Health Study II, we categorized change in lifestyle within 4-year periods and estimated their associations with concurrent change in body weight (kg) among parous women after age 40 for the following: diet quality (Alternate Healthy Eating Index [AHEI]), leisure-time physical activity (PA), alcohol, and smoking, by GDM history status <a>(total n=54,062, 5</a>.3% with a history of GDM). </p> <p><b>Results </b>Over a median follow-up of 13 years, average 4-year weight gain was 1.10 kg and 1.33 kg for women with and without prior GDM, respectively. Women improving diet quality had favorable 4-year weight change, particularly among women with a history of GDM (AHEI change from low to high: -2.97 kg [CI: -4.34, -1.60] vs. -1.19 kg [CI: -1.41, -0.96] for GDM vs. non-GDM, respectively; <i>p</i>-heterogeneity=0.04). Increasing PA was associated with weight maintenance for GDM women only (PA increase from low to high: 0.26 kg [95% CI: -0.25, 0.77] vs. 0.90 kg [95% CI: 0.80, 1.01] for GDM vs. non-GDM, respectively; <i>p</i>-heterogeneity=0.02). For both GDM and non-GDM women, weight change did not differ significantly with change in alcohol, while women who quit smoking had significant weight gain (4.38 kg for GDM and 3.85 kg for non-GDM).</p> <p><b>Conclusions </b>Improvements in diet quality and PA were related to less weight gain in mid-life among parous women, and the benefit of such improvements on weight management was particularly pronounced among women with a history of GDM.</p>

1386-P: Long-Term Weight Change after Pregnancy and Type 2 Diabetes Risk in Women with a History of Gestational Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1386-P
Author(s):  
SYLVIA E. BADON ◽  
FEI XU ◽  
CHARLES QUESENBERRY ◽  
ASSIAMIRA FERRARA ◽  
MONIQUE M. HEDDERSON
Keyword(s):  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Weight Change ◽  
Diabetes Risk ◽  
History Of

scholarly journals Depression-related weight change and incident diabetes in a community sample

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eva Graham ◽  
Tristan Watson ◽  
Sonya S. Deschênes ◽  
Kristian B. Filion ◽  
Mélanie Henderson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Weight Gain ◽  
Weight Change ◽  
Short Form ◽  
Community Sample ◽  
Overweight And Obesity ◽  
Community Dwelling ◽  
Increased Risk

AbstractThis cohort study aimed to compare the incidence of type 2 diabetes in adults with depression-related weight gain, depression-related weight loss, depression with no weight change, and no depression. The study sample included 59,315 community-dwelling adults in Ontario, Canada. Depression-related weight change in the past 12 months was measured using the Composite International Diagnostic Interview—Short Form. Participants were followed for up to 20 years using administrative health data. Cox proportional hazards models compared the incidence of type 2 diabetes in adults with depression-related weight change and in adults with no depression. Adults with depression-related weight gain had an increased risk of type 2 diabetes compared to adults no depression (HR 1.70, 95% CI 1.32–2.20), adults with depression-related weight loss (HR 1.62, 95% CI 1.09–2.42), and adults with depression with no weight change (HR 1.39, 95% CI 1.03–1.86). Adults with depression with no weight change also had an increased risk of type 2 diabetes compared to those with no depression (HR 1.23, 95% CI 1.04–1.45). Associations were stronger among women and persisted after adjusting for attained overweight and obesity. Identifying symptoms of weight change in depression may aid in identifying adults at higher risk of type 2 diabetes and in developing tailored prevention strategies.

scholarly journals Patterns of Weight Change in Aging and Dying

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 491-491
Author(s):  
Stephen Thielke
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Risk Factor ◽  
Weight Change ◽  
Population Level ◽  
Chronological Age ◽  
Average Weight ◽  
Remaining Life ◽  
Entire Cohort ◽  
History Of

Abstract Little research has characterized the natural history of weight change in older adults. Different changes may occur during aging and dying. We analyzed 18 years of weight measures from a cohort of 736,361 Veterans, all of whom had died at age 70 or older. We produced summary measures that accounted for both chronological age and number of years before death. Several clear population-level trends appeared. (1) The average weight of the sample declined across all ages at a rate of about 0.18 BMI points per year. (2) Starting about seven years before death, the amount of loss began to accelerate, reaching a decline of 0.75 BMI points in the year before death. (3) Changes in weight relative to years of remaining life were independent of chronologic age. People who died at age 70 experienced, on average, the same type and duration of terminal decline as did those who died at age 95. (4) The dying process involved a cumulative loss of about 1.3 BMI points. (5) The distribution of weights during advancing age both declined and narrowed. (6) Disproportionate deaths occurred at the lower BMI ranges (below a BMI of 24), and especially below 18, regardless of age. (7) The finding in #5 is explained by the entire cohort losing weight, with death of the thinnest members. These findings argue for examining survival time in studies of weight change. They indicate that weight loss may be a natural part of dying, rather than a risk factor for it.

scholarly journals Cardiometabolic and mental health in women with early gestational diabetes mellitus: A prospective cohort study

2021 ◽  
Author(s):  
Dan Yedu Quansah ◽  
Justine Gross ◽  
Leah Gilbert ◽  
Amelie Pauchet ◽  
Antje Horsch ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Weight Gain ◽  
Gestational Age ◽  
Prospective Cohort ◽  
Gestational Weight ◽  
Pregnancy And Postpartum ◽  
History Of

Abstract Context Early diagnosis and treatment of gestational diabetes (GDM) may reduce adverse obstetric and neonatal outcomes, especially in high-risk women. However, there is a lack of data for other outcomes. Objective We compared cardiometabolic and mental health outcomes in women with early (eGDM) and classical (cGDM) GDM. Methods This prospective cohort included 1185 women with cGDM and 76 women with eGDM. eGDM had GDM-risk factors (BMI &gt;30kg/m 2, family history of diabetes, history of GDM, ethnicity), were tested at &lt;20 weeks gestational age and diagnosed using ADA prediabetes criteria. Women underwent lifestyle adaptations. Obstetric, neonatal, mental, cardiometabolic outcomes were assessed during pregnancy and postpartum. Results eGDM had lower gestational weight gain than cGDM (10.7±6.2 vs 12.6±6.4, p=0.03), but needed more medical treatment (66% vs 42%, p&lt;0.001). They had similar rates of adverse maternal and neonatal outcomes, except for increased large-for-gestational-age infants (25% vs 15%, p=0.02). Mental health during pregnancy and postpartum did not differ between groups. eGDM had more atherogenic postpartum lipid profile than cGDM (p≤0.001). In eGDM, the postpartum prevalence of metabolic syndrome (MetS) was 1.8-times, prediabetes was 3.1-times and diabetes was 7.4-times higher than cGDM (MetS-waist circumference-based: 62% vs 34%/MetS-BMI-based: 46% vs 24%; prediabetes: 47.5% vs 15.3%; diabetes: 11.9% vs 1.6%, all p&lt;0.001). These differences remained unchanged after adjusting for GDM-risk factors. Conclusion Compared to cGDM, eGDM was not associated with differences in mental health, but with increased adverse cardiometabolic outcomes, independent of GDM-risk factors and gestational weight gain. This hints to a pre-existing risk-profile in eGDM.

Abstract P668: Clinically Meaningful Weight Gain Before Menopause and Risk of Stroke

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Maria D Zambrano Espinoza ◽  
Emma Kersey ◽  
Amelia K Boehme ◽  
Joshua Willey ◽  
Eliza C Miller
Keyword(s):  
Weight Gain ◽  
Weight Change ◽  
Stroke Risk ◽  
Cox Regression ◽  
Reference Group ◽  
Weight Changes ◽  
Younger Women ◽  
Hazard Ratios ◽  
History Of ◽  
Using Data

Background: Obesity is an independent risk factor for stroke. Weight gain has been associated with a higher risk of cardiovascular diseases in postmenopausal women. It is unclear, however, if weight changes before menopause have similar effects. We hypothesized that clinically meaningful premenopausal weight gain, defined as Body Mass Index (BMI) change >5%, would be associated with a higher stroke risk later in life. Methods: Using data from the California Teachers Study, we identified women aged < 55 with no history of stroke. We used weight changes between 1995-2006 as proxy for premenopausal weight gain. We defined weight change as modest or moderate using BMI changes of 5-10% and >10% respectively. Stroke outcomes were obtained from linkage to California hospitalization records. We used Cox regression models to calculate hazard ratios with 95% confidence intervals for the association of weight change and future stroke, adjusting for vascular risk factors. Results: Of 17,295 women included in the study, 113 had a stroke. In comparison to women who maintained a stable weight, women with moderate weight gain during premenopausal years had 2.0 times the risk of stroke. In the adjusted analysis, women with moderate weight gain had 89.6% higher risk of stroke, compared to the reference group. We found no significant association with stroke in women who had modest weight changes. Conclusion: Moderate premenopausal weight gain significantly increased stroke risk in women. Younger women should be educated about the effects of weight gain on future brain health. Count: 1836/1950

Sign in / Sign up

Export Citation Format

Share Document